This term is obsolete.

GO:0031508 JSON

pericentric heterochromatin formation

Biological Process

Definition (GO:0031508 GONUTS page)

The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA. PMID:14612388 PMID:20206496 PMID:22729156

Secondary IDs

GO:0030702, GO:1990141

4,624 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
chromatin silencing at centromere outer repeat region narrow
heterochromatic silencing at centromere exact
centromeric heterochromatin formation exact
pericentric heterochromatin assembly exact
centromeric heterochromatin biosynthesis exact
centromere chromatin silencing exact
centromeric silencing exact
chromatin silencing at pericentric region related
centric heterochromatin formation related
chromatin silencing at centromere exact

Ancestor Chart

Ancestor chart for GO:0031508
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031508

Child Term Relationship to
GO:0031508
positive regulation of pericentric heterochromatin formation
positively_regulates
siRNA-mediated pericentric heterochromatin formation
is_a
regulation of pericentric heterochromatin formation
regulates

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein O94603 284812 JHD1_SCHPO GO:0031507 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25831549
NOT-qualified manual protein P9WNV7 83332 DNAJ2_MYCTU GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487
NOT-qualified manual protein Q15170 9606 TCAL1_HUMAN GO:0010629 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:7971997
NOT-qualified manual protein Q8INR6 7227 DOT1L_DROME GO:0031508 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:15371351
NOT-qualified manual protein Q90998 9031 Q90998_CHICK GO:0010468 3 NOT-qualified manual annotations exist with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q90999 9031 TGFR2_CHICK GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q96AE4 9606 FUBP1_HUMAN GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:8125259
NOT-qualified manual protein Q9USK2 284812 SET9_SCHPO GO:0031508 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15550243
NOT-qualified manual protein Q9USK2 284812 SET9_SCHPO GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15550243

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0031508 based on ALL annotations
The top 100 of 565 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pericentric heterochromatin formation
52,986.90 100.00 3,679 3,679
lymphocyte proliferation
36,604.61 31.02 1,325 1,918
pericentric heterochromatin
16,877.36 28.20 2,616 8,213
DNA methylation-dependent constitutive heterochromatin formation
11,571.79 19.14 2,235 10,234
mating-type region heterochromatin
16,172.89 17.55 1,075 3,522
subtelomeric heterochromatin
45,317.74 5.25 195 228
negative regulation of gene expression via chromosomal CpG island methylation
2,847.40 5.19 2,237 41,628
heterochromatin island
34,035.38 4.66 176 274
chromosome, subtelomeric region
16,613.05 4.64 190 606
siRNA-independent facultative heterochromatin formation
27,373.90 4.45 171 331
Totals 28896 1550662
No co-occurrence statistics for GO:0031508 based on MANUAL annotations
The top 100 of 412 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pericentric heterochromatin formation
14,848.27 100.00 87 87
mating-type region heterochromatin
6,705.67 23.14 28 62
lymphocyte proliferation
5,345.38 15.13 18 50
subtelomeric heterochromatin
8,315.03 14.29 14 25
subtelomeric heterochromatin formation
1,922.32 10.28 29 224
histone H3K56 deacetylase activity, NAD-dependent
14,848.26 9.20 8 8
pericentric heterochromatin
1,361.09 8.41 44 480
silent mating-type cassette heterochromatin formation
2,211.44 8.38 14 94
ketone biosynthetic process
12,992.23 7.95 7 8
chromosome, subtelomeric region
4,949.42 7.77 8 24
Totals 739 6931

Change Log

Timestamp Action Category Detail
2023-02-28 Deleted RELATION part of GO:0034508 (centromere complex assembly)
2023-01-16 Deleted RELATION is a GO:0031048 (regulatory ncRNA-mediated heterochromatin formation)
2022-08-26 Added RELATION is a GO:0031048 (regulatory ncRNA-mediated heterochromatin formation)
2022-07-02 Added DEFINITION The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA.
2022-07-02 Deleted DEFINITION The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA.
2022-07-02 Updated TERM pericentric heterochromatin formation
2022-07-02 Added SYNONYM pericentric heterochromatin assembly
2022-06-26 Deleted RELATION is a GO:0031055 (chromatin remodeling at centromere)
2022-06-26 Deleted RELATION is a GO:0140462 (pericentric heterochromatin organization)
2021-11-22 Deleted RELATION is a GO:0031048 (regulatory ncRNA-mediated heterochromatin formation)
Timestamp Action Category Detail
2022-07-02 Updated TERM pericentric heterochromatin formation
2014-08-22 Updated TERM pericentric heterochromatin assembly
2011-11-30 Updated TERM centromeric heterochromatin assembly
2010-03-20 Updated TERM centromeric heterochromatin formation
2010-01-22 Updated TERM centromeric heterochromatin assembly
2008-06-14 Updated TERM centromeric heterochromatin formation
2005-06-23 Added TERM centric heterochromatin formation
Timestamp Action Category Detail
2022-07-02 Added DEFINITION The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA.
2022-07-02 Deleted DEFINITION The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA.
2022-07-02 Added SYNONYM pericentric heterochromatin assembly
2020-04-06 Added DEFINITION The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA.
2020-04-06 Deleted DEFINITION The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA
2020-03-30 Added DEFINITION The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA
2020-03-30 Deleted DEFINITION The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
2020-03-30 Added SYNONYM centromere chromatin silencing
2020-03-30 Added SYNONYM centromeric silencing
2020-03-30 Added SYNONYM chromatin silencing at centromere outer repeat region
2020-03-30 Added SYNONYM chromatin silencing at pericentric region
2020-03-30 Added SYNONYM chromatin silencing at centromere
2020-03-30 Added SYNONYM heterochromatic silencing at centromere
2014-08-22 Added DEFINITION The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
2014-08-22 Deleted DEFINITION The assembly of chromatin into heterochromatin near the centromere.
2011-11-30 Deleted SYNONYM centromeric heterochromatin assembly
2011-11-30 Added SYNONYM centromeric heterochromatin formation
2010-01-22 Added SYNONYM centric heterochromatin formation
2010-01-22 Deleted SYNONYM centric heterochromatin formation
2008-06-14 Added SYNONYM centromeric heterochromatin assembly
2008-06-14 Added SYNONYM centric heterochromatin formation
2008-06-14 Deleted SYNONYM centromeric heterochromatin formation
2008-06-14 Deleted SYNONYM centric heterochromatin assembly
2008-05-13 Added DEFINITION The assembly of chromatin into heterochromatin near the centromere.
2008-05-12 Deleted DEFINITION The assembly of chromatin into heterochromatin near the centromere.
2007-08-09 Deleted SYNONYM centric heterochromatin assembly
2007-08-09 Deleted SYNONYM centromeric heterochromatin formation
2007-08-09 Added SYNONYM centric heterochromatin assembly
2007-08-09 Added SYNONYM centromeric heterochromatin biosynthesis
2007-08-09 Added SYNONYM centromeric heterochromatin formation
2007-08-09 Deleted SYNONYM centromeric heterochromatin biosynthesis
2007-01-15 Added SYNONYM centromeric heterochromatin biosynthesis
2005-07-04 Added SYNONYM centric heterochromatin assembly
2005-06-23 Added SYNONYM centromeric heterochromatin formation
2005-06-23 Added DEFINITION The assembly of chromatin into heterochromatin near the centromere.
Timestamp Action Category Detail
2023-02-28 Deleted RELATION part of GO:0034508 (centromere complex assembly)
2023-01-16 Deleted RELATION is a GO:0031048 (regulatory ncRNA-mediated heterochromatin formation)
2022-08-26 Added RELATION is a GO:0031048 (regulatory ncRNA-mediated heterochromatin formation)
2022-06-26 Deleted RELATION is a GO:0031055 (chromatin remodeling at centromere)
2022-06-26 Deleted RELATION is a GO:0140462 (pericentric heterochromatin organization)
2021-11-22 Deleted RELATION is a GO:0031048 (regulatory ncRNA-mediated heterochromatin formation)
2021-11-22 Added RELATION is a GO:0140719 (constitutive heterochromatin formation)
2021-11-15 Added RELATION is a GO:0031048 (regulatory ncRNA-mediated heterochromatin formation)
2021-11-15 Deleted RELATION is a GO:0031507 (heterochromatin formation)
2021-11-01 Deleted RELATION is a GO:0010629 (negative regulation of gene expression)
2021-11-01 Deleted RELATION is a GO:0031497 (chromatin assembly)
2021-11-01 Added RELATION is a GO:0031507 (heterochromatin formation)
2021-08-30 Deleted RELATION is a GO:0031507 (heterochromatin formation)
2021-08-30 Added RELATION is a GO:0031497 (chromatin assembly)
2020-05-09 Added RELATION is a GO:0140462 (pericentric heterochromatin organization)
2020-04-24 Added RELATION is a GO:0010629 (negative regulation of gene expression)
2020-04-24 Deleted RELATION is a GO:0006342 (chromatin silencing)
2020-03-30 Added RELATION is a GO:0006342 (chromatin silencing)
2008-06-14 Added RELATION part of GO:0034508 (centromere complex assembly)
2008-04-01 Updated RELATION is a GO:0031507 (heterochromatin formation)
2008-04-01 Updated RELATION is a GO:0031055 (chromatin remodeling at centromere)
Timestamp Action Category Detail
Timestamp Action Category Detail
2020-03-30 Added SECONDARY GO:0030702 (chromatin silencing at centromere)
2020-03-30 Added SECONDARY GO:1990141 (chromatin silencing at centromere outer repeat region)
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