This term is obsolete.

GO:0031511 JSON

Mis6-Sim4 complex

Cellular Component

Definition (GO:0031511 GONUTS page)

A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. PMID:12719471 PMID:15897182

4,181 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Mis6 centromere subcomplex narrow
Mcm21 related
Sim4 complex exact
Mis6-Mal2-Sim4 centromere complex exact

Ancestor Chart

Ancestor chart for GO:0031511
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0031511 Mis6-Sim4 complex Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0000793 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y7L4 10116 A0A8I5Y7L4_RAT GO:0005694 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0000793 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A1Z8P9 7227 TPR_DROME GO:0000776 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19273613
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0000793 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6ILF7 10116 A6ILF7_RAT GO:0000793 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JGV8 10116 A6JGV8_RAT GO:0000776 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8QWW8 10116 A8QWW8_RAT GO:0000793 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZS29 10116 D3ZS29_RAT GO:0000793 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PT83 10116 E9PT83_RAT GO:0000776 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR025207 Kinetochore Sim4 complex subunit Fta4

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0031511 based on ALL annotations
The top 99 of 99 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Mis6-Sim4 complex
46,826.52 100.00 4,163 4,163
centromere complex assembly
20,997.83 31.87 2,182 4,866
kinetochore
1,083.33 2.30 3,121 134,904
chromosome, centromeric region
922.70 1.94 2,193 111,294
inner kinetochore
1,189.24 1.22 96 3,780
chromosome
123.96 0.26 2,194 828,779
chromosome segregation
106.91 0.23 927 406,033
Ctf18 RFC-like complex
126.28 0.20 33 12,237
nuclear body
84.07 0.17 84 46,786
condensed chromosome, centromeric region
51.43 0.09 16 14,567
Totals 17618 258885852
No co-occurrence statistics for GO:0031511 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Mis6-Sim4 complex
13,890.31 100.00 93 93
inner kinetochore
1,038.53 4.17 8 107
condensed chromosome, centromeric region
249.53 1.43 6 334
CENP-A containing chromatin assembly
231.51 1.22 4 240
mitotic sister chromatid segregation
176.72 1.15 10 786
chromosome, centromeric core domain
365.53 0.77 1 38
spindle attachment to meiosis I kinetochore
122.92 0.49 1 113
chromosome segregation
69.57 0.48 9 1,797
kinetochore
60.39 0.42 11 2,530
attachment of mitotic spindle microtubules to kinetochore
58.98 0.36 2 471
Totals 192 659584

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2022-09-18 Added SYNONYM Mcm21
2021-03-28 Added DEFINITION A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2021-03-28 Deleted DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2019-09-12 Deleted RELATION is a GO:0044427 (obsolete chromosomal part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2011-04-01 Added SYNONYM Mis6-Mal2-Sim4 centromere complex
2008-05-13 Added DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2008-05-12 Deleted DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
Timestamp Action Category Detail
2005-10-05 Updated TERM Mis6-Sim4 complex
2005-07-23 Added TERM Mis6 centromere subcomplex
Timestamp Action Category Detail
2022-09-18 Added SYNONYM Mcm21
2021-03-28 Added DEFINITION A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2021-03-28 Deleted DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2011-04-01 Added SYNONYM Mis6-Mal2-Sim4 centromere complex
2008-05-13 Added DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2008-05-12 Deleted DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2007-08-09 Added SYNONYM Sim4 complex
2007-08-09 Added SYNONYM Mis6 centromere subcomplex
2007-08-09 Deleted SYNONYM Mis6 centromere subcomplex
2007-08-09 Deleted SYNONYM Sim4 complex
2005-10-05 Deleted SYNONYM Mis6-Sim4 complex
2005-10-05 Added SYNONYM Mis6 centromere subcomplex
2005-10-05 Added SYNONYM Sim4 complex
2005-10-04 Updated DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
2005-07-23 Added SYNONYM Mis6-Sim4 complex
2005-07-23 Added DEFINITION A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. Two known subunits are called Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human; additional subunits may also exist.
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044427 (obsolete chromosomal part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION part of GO:0000939 (inner kinetochore)
2008-04-01 Updated RELATION is a GO:0044427 (obsolete chromosomal part)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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