GO:0031511
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Mis6-Sim4 complex
Cellular Component
Definition (GO:0031511 GONUTS page)
A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. PMID:12719471 PMID:15897182
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
Mis6 centromere subcomplex | narrow |
Mcm21 | related |
Sim4 complex | exact |
Mis6-Mal2-Sim4 centromere complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0031511 | Mis6-Sim4 complex | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0000793 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y7L4 | 10116 | A0A8I5Y7L4_RAT | GO:0005694 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0000793 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A1Z8P9 | 7227 | TPR_DROME | GO:0000776 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19273613 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0000793 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6ILF7 | 10116 | A6ILF7_RAT | GO:0000793 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JGV8 | 10116 | A6JGV8_RAT | GO:0000776 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8QWW8 | 10116 | A8QWW8_RAT | GO:0000793 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZS29 | 10116 | D3ZS29_RAT | GO:0000793 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PT83 | 10116 | E9PT83_RAT | GO:0000776 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR025207 | Kinetochore Sim4 complex subunit Fta4 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0031511 based on ALL annotations
The top 99 of 99 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Mis6-Sim4 complex
|
46,826.52 | 100.00 | 4,163 | 4,163 |
centromere complex assembly
|
20,997.83 | 31.87 | 2,182 | 4,866 |
kinetochore
|
1,083.33 | 2.30 | 3,121 | 134,904 |
chromosome, centromeric region
|
922.70 | 1.94 | 2,193 | 111,294 |
inner kinetochore
|
1,189.24 | 1.22 | 96 | 3,780 |
chromosome
|
123.96 | 0.26 | 2,194 | 828,779 |
chromosome segregation
|
106.91 | 0.23 | 927 | 406,033 |
Ctf18 RFC-like complex
|
126.28 | 0.20 | 33 | 12,237 |
nuclear body
|
84.07 | 0.17 | 84 | 46,786 |
condensed chromosome, centromeric region
|
51.43 | 0.09 | 16 | 14,567 |
Totals | 17618 | 258885852 |
No co-occurrence statistics for GO:0031511 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Mis6-Sim4 complex
|
13,890.31 | 100.00 | 93 | 93 |
inner kinetochore
|
1,038.53 | 4.17 | 8 | 107 |
condensed chromosome, centromeric region
|
249.53 | 1.43 | 6 | 334 |
CENP-A containing chromatin assembly
|
231.51 | 1.22 | 4 | 240 |
mitotic sister chromatid segregation
|
176.72 | 1.15 | 10 | 786 |
chromosome, centromeric core domain
|
365.53 | 0.77 | 1 | 38 |
spindle attachment to meiosis I kinetochore
|
122.92 | 0.49 | 1 | 113 |
chromosome segregation
|
69.57 | 0.48 | 9 | 1,797 |
kinetochore
|
60.39 | 0.42 | 11 | 2,530 |
attachment of mitotic spindle microtubules to kinetochore
|
58.98 | 0.36 | 2 | 471 |
Totals | 192 | 659584 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2022-09-18 | Added | SYNONYM | Mcm21 |
2021-03-28 | Added | DEFINITION | A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2021-03-28 | Deleted | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2019-09-12 | Deleted | RELATION | is a GO:0044427 (obsolete chromosomal part) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2011-04-01 | Added | SYNONYM | Mis6-Mal2-Sim4 centromere complex |
2008-05-13 | Added | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2008-05-12 | Deleted | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-10-05 | Updated | TERM | Mis6-Sim4 complex |
2005-07-23 | Added | TERM | Mis6 centromere subcomplex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-18 | Added | SYNONYM | Mcm21 |
2021-03-28 | Added | DEFINITION | A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2021-03-28 | Deleted | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2011-04-01 | Added | SYNONYM | Mis6-Mal2-Sim4 centromere complex |
2008-05-13 | Added | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2008-05-12 | Deleted | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2007-08-09 | Added | SYNONYM | Sim4 complex |
2007-08-09 | Added | SYNONYM | Mis6 centromere subcomplex |
2007-08-09 | Deleted | SYNONYM | Mis6 centromere subcomplex |
2007-08-09 | Deleted | SYNONYM | Sim4 complex |
2005-10-05 | Deleted | SYNONYM | Mis6-Sim4 complex |
2005-10-05 | Added | SYNONYM | Mis6 centromere subcomplex |
2005-10-05 | Added | SYNONYM | Sim4 complex |
2005-10-04 | Updated | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
2005-07-23 | Added | SYNONYM | Mis6-Sim4 complex |
2005-07-23 | Added | DEFINITION | A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. Two known subunits are called Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human; additional subunits may also exist. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044427 (obsolete chromosomal part) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2008-04-01 | Updated | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | part of GO:0000939 (inner kinetochore) |
2008-04-01 | Updated | RELATION | is a GO:0044427 (obsolete chromosomal part) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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