GO:0031648
JSON
protein destabilization
Biological Process
Definition (GO:0031648 GONUTS page)
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| negative regulation of protein stability | exact |
| protein destabilisation | exact |
Ancestor Chart
Ancestor chart for GO:0031648
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | A0A8I5ZYZ0 | 10116 | A0A8I5ZYZ0_RAT | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | D4A3L4 | 10116 | D4A3L4_RAT | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | F1MA98 | 10116 | TPR_RAT | GO:0031647 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
| NOT-qualified manual | protein | F6ZDS4 | 10090 | TPR_MOUSE | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
| NOT-qualified manual | protein | O18515 | 6087 | O18515_HYDVU | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
| NOT-qualified manual | protein | P12270 | 9606 | TPR_HUMAN | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:21613532 | |
| NOT-qualified manual | protein | Q07666 | 9606 | KHDR1_HUMAN | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21613532 | |
| NOT-qualified manual | protein | Q5EE04 | 8355 | TPR_XENLA | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
| NOT-qualified manual | protein | Q8BGE7 | 10090 | TRIM6_MOUSE | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22328504 | |
| NOT-qualified manual | protein | Q91V33 | 10116 | KHDR1_RAT | GO:0031647 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Replaces
This term can be used instead of these obsolete terms:
| GO Identifier | GO Term Name | Reason |
|---|---|---|
| GO:1903993 | obsolete negative regulation of protein stabilization | consider GO:0031648 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0031648 based on ALL annotations
The top 100 of 2,087 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
protein destabilization
|
44,549.21 | 100.00 | 4,448 | 4,448 |
|
inclusion body
|
13,329.37 | 6.47 | 339 | 1,133 |
|
ubiquitin-specific protease binding
|
7,429.61 | 4.54 | 261 | 1,565 |
|
positive regulation of type 2 mitophagy
|
12,154.65 | 4.49 | 227 | 832 |
|
negative regulation of fibroblast proliferation
|
5,214.41 | 4.23 | 276 | 2,358 |
|
regulation of mitochondrion organization
|
4,136.15 | 4.18 | 314 | 3,382 |
|
negative regulation of filamentous growth
|
39,245.73 | 4.14 | 185 | 210 |
|
Pho85-Pho80 CDK-cyclin complex
|
38,766.37 | 4.04 | 181 | 208 |
|
amyloid fibril formation
|
7,972.35 | 3.97 | 216 | 1,207 |
|
positive regulation of phospholipid biosynthetic process
|
21,971.13 | 3.91 | 181 | 367 |
| Totals | 21447 | 205397 | ||
No co-occurrence statistics for GO:0031648 based on MANUAL annotations
The top 100 of 1,920 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
protein destabilization
|
5,832.78 | 100.00 | 242 | 242 |
|
positive regulation of circadian rhythm
|
1,270.51 | 6.85 | 22 | 101 |
|
regulation of mitochondrion organization
|
771.99 | 6.44 | 27 | 204 |
|
positive regulation of proteolysis
|
533.28 | 5.71 | 32 | 350 |
|
p53 binding
|
475.87 | 5.50 | 35 | 429 |
|
obsolete cellular response to organic cyclic compound
|
578.83 | 5.44 | 26 | 262 |
|
HLA-A specific activating MHC class I receptor activity
|
5,832.78 | 5.37 | 13 | 13 |
|
dichotomous subdivision of terminal units involved in lung branching
|
5,832.78 | 5.37 | 13 | 13 |
|
neuropeptide catabolic process
|
5,416.15 | 5.35 | 13 | 14 |
|
positive regulation of peptidase activity
|
3,990.85 | 5.24 | 13 | 19 |
| Totals | 1449 | 11577 | ||
Change Log
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2016-03-09 | Added | SYNONYM | protein destabilisation |
| 2008-05-13 | Added | DEFINITION | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. |
| 2008-05-12 | Deleted | DEFINITION | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. |
| 2008-04-01 | Updated | RELATION | is a GO:0031647 (regulation of protein stability) |
| 2007-08-09 | Added | SYNONYM | negative regulation of protein stability |
| 2007-08-09 | Deleted | SYNONYM | negative regulation of protein stability |
| 2005-10-15 | Added | TERM | protein destabilization |
| 2005-10-15 | Added | SYNONYM | negative regulation of protein stability |
| 2005-10-15 | Added | DEFINITION | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2005-10-15 | Added | TERM | protein destabilization |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2016-03-09 | Added | SYNONYM | protein destabilisation |
| 2008-05-13 | Added | DEFINITION | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. |
| 2008-05-12 | Deleted | DEFINITION | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. |
| 2007-08-09 | Added | SYNONYM | negative regulation of protein stability |
| 2007-08-09 | Deleted | SYNONYM | negative regulation of protein stability |
| 2005-10-15 | Added | SYNONYM | negative regulation of protein stability |
| 2005-10-15 | Added | DEFINITION | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-04-01 | Updated | RELATION | is a GO:0031647 (regulation of protein stability) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|
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