This term is obsolete.

GO:0031648 JSON

protein destabilization

Biological Process

Definition (GO:0031648 GONUTS page)

Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.

4,552 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation of protein stability exact
protein destabilisation exact

Ancestor Chart

Ancestor chart for GO:0031648
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Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZYZ0 10116 A0A8I5ZYZ0_RAT GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A3L4 10116 D4A3L4_RAT GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1MA98 10116 TPR_RAT GO:0031647 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein F6ZDS4 10090 TPR_MOUSE GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein O18515 6087 O18515_HYDVU GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P12270 9606 TPR_HUMAN GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:21613532
NOT-qualified manual protein Q07666 9606 KHDR1_HUMAN GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21613532
NOT-qualified manual protein Q5EE04 8355 TPR_XENLA GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q8BGE7 10090 TRIM6_MOUSE GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22328504
NOT-qualified manual protein Q91V33 10116 KHDR1_RAT GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:1903993 obsolete negative regulation of protein stabilization consider GO:0031648

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0031648 based on ALL annotations
The top 100 of 2,099 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein destabilization
43,767.13 100.00 4,454 4,454
inclusion body
13,149.42 6.50 341 1,135
ubiquitin-specific protease binding
7,303.85 4.53 261 1,564
positive regulation of type 2 mitophagy
11,979.48 4.51 228 833
negative regulation of fibroblast proliferation
5,128.38 4.23 277 2,364
regulation of mitochondrion organization
4,019.56 4.15 314 3,419
negative regulation of filamentous growth
38,556.75 4.13 185 210
Pho85-Pho80 CDK-cyclin complex
38,139.93 4.08 183 210
amyloid fibril formation
7,838.89 3.97 216 1,206
positive regulation of phospholipid biosynthetic process
21,646.98 3.94 183 370
Totals 21700 217144
No co-occurrence statistics for GO:0031648 based on MANUAL annotations
The top 100 of 1,931 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein destabilization
5,338.01 100.00 242 242
positive regulation of circadian rhythm
1,162.74 6.85 22 101
regulation of mitochondrion organization
706.50 6.44 27 204
positive regulation of proteolysis
519.20 5.94 32 329
p53 binding
436.52 5.51 35 428
HLA-A specific activating MHC class I receptor activity
5,338.01 5.37 13 13
dichotomous subdivision of terminal units involved in lung branching
5,338.01 5.37 13 13
cellular response to organic cyclic compound
515.94 5.36 26 269
neuropeptide catabolic process
4,956.73 5.35 13 14
positive regulation of peptidase activity
3,652.32 5.24 13 19
Totals 1456 11599

Change Log

Timestamp Action Category Detail
2016-03-09 Added SYNONYM protein destabilisation
2008-05-13 Added DEFINITION Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
2008-05-12 Deleted DEFINITION Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
2008-04-01 Updated RELATION is a GO:0031647 (regulation of protein stability)
2007-08-09 Added SYNONYM negative regulation of protein stability
2007-08-09 Deleted SYNONYM negative regulation of protein stability
2005-10-15 Added TERM protein destabilization
2005-10-15 Added DEFINITION Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
2005-10-15 Added SYNONYM negative regulation of protein stability
Timestamp Action Category Detail
2005-10-15 Added TERM protein destabilization
Timestamp Action Category Detail
2016-03-09 Added SYNONYM protein destabilisation
2008-05-13 Added DEFINITION Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
2008-05-12 Deleted DEFINITION Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
2007-08-09 Added SYNONYM negative regulation of protein stability
2007-08-09 Deleted SYNONYM negative regulation of protein stability
2005-10-15 Added DEFINITION Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
2005-10-15 Added SYNONYM negative regulation of protein stability
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0031647 (regulation of protein stability)
Timestamp Action Category Detail
Timestamp Action Category Detail
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