This term is obsolete.

GO:0031994 JSON

insulin-like growth factor I binding

Molecular Function

Definition (GO:0031994 GONUTS page)

Binding to insulin-like growth factor I.

6,074 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
IGF-I binding exact

Ancestor Chart

Ancestor chart for GO:0031994
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0031994 insulin-like growth factor I binding Never in Taxon 2 Bacteria
GO:0031994 insulin-like growth factor I binding Never in Taxon 2157 Archaea
GO:0031994 insulin-like growth factor I binding Never in Taxon 4751 Fungi

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0031994 based on ALL annotations
The top 100 of 555 co-occurring terms
Co-occurring Term PR S% #Together #Compared
insulin-like growth factor I binding
32,516.90 100.00 5,995 5,995
insulin-like growth factor II binding
32,398.93 91.32 5,493 5,513
regulation of insulin-like growth factor receptor signaling pathway
31,405.46 87.25 5,397 5,588
insulin-like growth factor binding
17,590.26 51.24 5,435 10,047
fibronectin binding
10,491.02 23.56 2,794 8,660
growth factor binding
7,040.30 19.76 4,154 19,186
neuregulin binding
7,228.06 5.24 385 1,732
alphav-beta3 integrin-IGF-1-IGF1R complex
23,862.53 4.66 284 387
positive regulation of insulin-like growth factor receptor signaling pathway
10,211.23 3.74 244 777
type B pancreatic cell proliferation
6,600.77 3.51 244 1,202
Totals 41846 285565
No co-occurrence statistics for GO:0031994 based on MANUAL annotations
The top 100 of 495 co-occurring terms
Co-occurring Term PR S% #Together #Compared
insulin-like growth factor I binding
9,936.92 100.00 130 130
insulin-like growth factor II binding
9,227.14 75.36 104 112
regulation of insulin-like growth factor receptor signaling pathway
9,220.74 74.64 103 111
fibronectin binding
2,299.81 17.32 53 229
neuregulin binding
4,742.62 13.73 21 44
nail development
4,968.46 8.45 12 24
integrin alpha6-beta1 complex
8,280.76 7.58 10 12
lymphoid lineage cell migration
7,097.80 7.46 10 14
skin morphogenesis
2,168.05 6.94 12 55
integrin alpha6-beta4 complex
9,936.92 6.92 9 9
Totals 998 10944

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2021-05-24 Added DEFINITION Binding to insulin-like growth factor I.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with insulin-like growth factor I.
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with insulin-like growth factor I.
2009-07-03 Deleted DEFINITION Interacting selectively with insulin-like growth factor I.
Timestamp Action Category Detail
2005-12-25 Added TERM insulin-like growth factor I binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to insulin-like growth factor I.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with insulin-like growth factor I.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with insulin-like growth factor I.
2009-07-03 Deleted DEFINITION Interacting selectively with insulin-like growth factor I.
2008-05-13 Added DEFINITION Interacting selectively with insulin-like growth factor I.
2008-05-12 Deleted DEFINITION Interacting selectively with insulin-like growth factor I.
2007-08-09 Added SYNONYM IGF-I binding
2007-08-09 Deleted SYNONYM IGF-I binding
2005-12-25 Added DEFINITION Interacting selectively with insulin-like growth factor I.
2005-12-25 Added SYNONYM IGF-I binding
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0005520 (insulin-like growth factor binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
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