This term is obsolete.

GO:0032755 JSON

positive regulation of interleukin-6 production

Biological Process

Definition (GO:0032755 GONUTS page)

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

Secondary IDs

GO:0045410, GO:2000778

9,637 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
activation of interleukin-6 production narrow
stimulation of interleukin-6 production narrow
up regulation of interleukin-6 production exact
up-regulation of interleukin-6 production exact
upregulation of interleukin-6 production exact
positive regulation of IL-6 production exact
positive regulation of interleukin-6 biosynthetic process narrow
positive regulation of interleukin-6 secretion narrow

Ancestor Chart

Ancestor chart for GO:0032755
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to terms describing protein or chemical production Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0032755 positive regulation of interleukin-6 production Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A6ID83 10116 A6ID83_RAT GO:0032675 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A3I1 10116 D4A3I1_RAT GO:0032675 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P9WNV7 83332 DNAJ2_MYCTU GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487
NOT-qualified manual protein Q7TS55 10090 TNF18_MOUSE GO:0032675 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24107315
NOT-qualified manual protein Q8IZ20-1 9606 ZN683_HUMAN GO:0010628 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26179882
NOT-qualified manual protein Q90998 9031 Q90998_CHICK GO:0010468 3 NOT-qualified manual annotations exist with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q90999 9031 TGFR2_CHICK GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q96AE4 9606 FUBP1_HUMAN GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:8125259
NOT-qualified manual protein Q9USK2 284812 SET9_SCHPO GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15550243

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0032755 based on ALL annotations
The top 100 of 3,032 co-occurring terms
Co-occurring Term PR S% #Together #Compared
positive regulation of interleukin-6 production
20,945.40 100.00 9,307 9,307
pattern recognition receptor activity
13,145.85 30.51 3,467 5,524
positive regulation of tumor necrosis factor production
8,804.26 23.84 3,306 7,865
positive regulation of chemokine production
13,423.29 20.20 2,120 3,308
canonical NF-kappaB signal transduction
6,961.72 20.04 3,121 9,390
positive regulation of interleukin-8 production
9,234.75 20.03 2,499 5,668
positive regulation of interleukin-1 beta production
10,648.66 15.95 1,755 3,452
toll-like receptor signaling pathway
4,443.16 15.51 3,403 16,042
positive regulation of interleukin-12 production
11,988.09 15.22 1,598 2,792
positive regulation of macrophage cytokine production
10,555.81 12.03 1,270 2,520
Totals 88425 609592
No co-occurrence statistics for GO:0032755 based on MANUAL annotations
The top 100 of 2,856 co-occurring terms
Co-occurring Term PR S% #Together #Compared
positive regulation of interleukin-6 production
2,593.97 100.00 498 498
positive regulation of tumor necrosis factor production
1,259.27 29.81 217 447
positive regulation of interleukin-8 production
1,318.11 24.04 156 307
positive regulation of interleukin-12 production
1,482.27 19.24 112 196
positive regulation of chemokine production
1,489.44 15.78 89 155
positive regulation of interleukin-1 beta production
933.83 15.65 108 300
positive regulation of interferon-alpha production
1,238.03 14.24 84 176
positive regulation of type II interferon production
570.46 12.13 106 482
positive regulation of macrophage cytokine production
1,384.92 11.39 63 118
positive regulation of interferon-beta production
876.67 11.39 73 216
Totals 4535 26303

Change Log

Timestamp Action Category Detail
2024-04-04 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2020-06-06 Added SECONDARY GO:0045410 (positive regulation of interleukin-6 biosynthetic process)
2020-06-06 Added SECONDARY GO:2000778 (positive regulation of interleukin-6 secretion)
2020-06-06 Added SYNONYM positive regulation of interleukin-6 biosynthetic process
2020-06-06 Added SYNONYM positive regulation of interleukin-6 secretion
2008-05-13 Added DEFINITION Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2008-05-12 Deleted DEFINITION Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2008-04-01 Added RELATION positively regulates GO:0032635 (interleukin-6 production)
2008-04-01 Updated RELATION is a GO:0001819 (positive regulation of cytokine production)
2008-04-01 Updated RELATION is a GO:0032675 (regulation of interleukin-6 production)
Timestamp Action Category Detail
2006-12-06 Added TERM positive regulation of interleukin-6 production
Timestamp Action Category Detail
2020-06-06 Added SYNONYM positive regulation of interleukin-6 biosynthetic process
2020-06-06 Added SYNONYM positive regulation of interleukin-6 secretion
2008-05-13 Added DEFINITION Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2008-05-12 Deleted DEFINITION Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2007-08-09 Deleted SYNONYM positive regulation of IL-6 production
2007-08-09 Deleted SYNONYM stimulation of interleukin-6 production
2007-08-09 Deleted SYNONYM activation of interleukin-6 production
2007-08-09 Added SYNONYM stimulation of interleukin-6 production
2007-08-09 Added SYNONYM up regulation of interleukin-6 production
2007-08-09 Deleted SYNONYM up regulation of interleukin-6 production
2007-08-09 Added SYNONYM upregulation of interleukin-6 production
2007-08-09 Added SYNONYM positive regulation of IL-6 production
2007-08-09 Added SYNONYM activation of interleukin-6 production
2007-08-09 Deleted SYNONYM upregulation of interleukin-6 production
2007-08-09 Deleted SYNONYM up-regulation of interleukin-6 production
2007-08-09 Added SYNONYM up-regulation of interleukin-6 production
2007-02-23 Added SYNONYM up regulation of interleukin-6 production
2007-02-23 Added SYNONYM up-regulation of interleukin-6 production
2007-02-23 Added SYNONYM upregulation of interleukin-6 production
2007-02-23 Added SYNONYM activation of interleukin-6 production
2007-02-23 Added SYNONYM stimulation of interleukin-6 production
2006-12-08 Added SYNONYM positive regulation of IL-6 production
2006-12-06 Added DEFINITION Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
Timestamp Action Category Detail
2008-04-01 Added RELATION positively regulates GO:0032635 (interleukin-6 production)
2008-04-01 Updated RELATION is a GO:0001819 (positive regulation of cytokine production)
2008-04-01 Updated RELATION is a GO:0032675 (regulation of interleukin-6 production)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-04-04 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2020-06-06 Added SECONDARY GO:0045410 (positive regulation of interleukin-6 biosynthetic process)
2020-06-06 Added SECONDARY GO:2000778 (positive regulation of interleukin-6 secretion)
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