GO:0032937
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SREBP-SCAP-Insig complex
Cellular Component
Definition (GO:0032937 GONUTS page)
A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane. PMID:12923525
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0032937 | SREBP-SCAP-Insig complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0D1E8X3 | 237631 | A0A0D1E8X3_USTMA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A0G2JZ79 | 10116 | SIR1_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0032937 based on ALL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SREBP-SCAP-Insig complex
|
92,213.23 | 100.00 | 2,114 | 2,114 |
SREBP-SCAP complex retention in endoplasmic reticulum
|
92,167.57 | 95.41 | 2,018 | 2,019 |
SREBP signaling pathway
|
14,031.44 | 15.22 | 2,114 | 13,893 |
cellular response to insulin stimulus
|
12,431.22 | 13.38 | 2,003 | 14,858 |
cholesterol biosynthetic process
|
8,588.86 | 9.27 | 2,018 | 21,666 |
response to sterol depletion
|
61,008.00 | 7.90 | 174 | 263 |
cranial suture morphogenesis
|
38,477.47 | 7.38 | 174 | 417 |
negative regulation of steroid biosynthetic process
|
28,298.24 | 6.94 | 174 | 567 |
middle ear morphogenesis
|
8,923.86 | 4.65 | 174 | 1,798 |
negative regulation of protein exit from endoplasmic reticulum
|
92,213.24 | 4.30 | 91 | 91 |
Totals | 25603 | 159861474 |
No co-occurrence statistics for GO:0032937 based on MANUAL annotations
The top 78 of 78 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SREBP-SCAP-Insig complex
|
33,123.05 | 100.00 | 39 | 39 |
SREBP-SCAP complex retention in endoplasmic reticulum
|
28,391.19 | 80.00 | 36 | 42 |
SREBP signaling pathway
|
6,557.36 | 19.80 | 39 | 197 |
cholesterol biosynthetic process
|
3,657.76 | 10.94 | 36 | 326 |
cellular response to sterol
|
7,643.78 | 6.12 | 3 | 13 |
negative regulation of protein exit from endoplasmic reticulum
|
33,123.05 | 5.13 | 2 | 2 |
cellular response to insulin stimulus
|
1,635.71 | 4.92 | 36 | 729 |
oxysterol binding
|
1,851.60 | 4.71 | 9 | 161 |
negative regulation of cargo loading into COPII-coated vesicle
|
7,360.68 | 4.35 | 2 | 9 |
response to sterol depletion
|
7,360.68 | 4.35 | 2 | 9 |
Totals | 354 | 860328 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2022-08-26 | Added | RELATION | part of GO:0005789 (endoplasmic reticulum membrane) |
2022-08-26 | Deleted | RELATION | part of GO:0030176 (obsolete integral component of endoplasmic reticulum membrane) |
2020-11-03 | Added | RELATION | is a GO:0140534 (endoplasmic reticulum protein-containing complex) |
2020-09-13 | Deleted | RELATION | part of GO:0005783 (endoplasmic reticulum) |
2019-09-12 | Deleted | RELATION | is a GO:0044432 (obsolete endoplasmic reticulum part) |
2019-09-12 | Added | RELATION | part of GO:0005783 (endoplasmic reticulum) |
2015-06-25 | Deleted | RELATION | is a GO:0044425 (obsolete membrane part) |
2015-06-25 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2015-05-11 | Added | RELATION | is a GO:0098796 (membrane protein complex) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-02-23 | Added | TERM | SREBP-SCAP-Insig complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-08-24 | Added | DEFINITION | A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane. |
2012-08-24 | Deleted | DEFINITION | A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane. |
2008-05-13 | Added | DEFINITION | A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane. |
2008-05-12 | Deleted | DEFINITION | A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane. |
2007-02-23 | Added | DEFINITION | A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-08-26 | Added | RELATION | part of GO:0005789 (endoplasmic reticulum membrane) |
2022-08-26 | Deleted | RELATION | part of GO:0030176 (obsolete integral component of endoplasmic reticulum membrane) |
2020-11-03 | Added | RELATION | is a GO:0140534 (endoplasmic reticulum protein-containing complex) |
2020-09-13 | Deleted | RELATION | part of GO:0005783 (endoplasmic reticulum) |
2019-09-12 | Deleted | RELATION | is a GO:0044432 (obsolete endoplasmic reticulum part) |
2019-09-12 | Added | RELATION | part of GO:0005783 (endoplasmic reticulum) |
2015-06-25 | Deleted | RELATION | is a GO:0044425 (obsolete membrane part) |
2015-06-25 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2015-05-11 | Added | RELATION | is a GO:0098796 (membrane protein complex) |
2008-10-21 | Added | RELATION | is a GO:0044432 (obsolete endoplasmic reticulum part) |
2008-04-01 | Updated | RELATION | part of GO:0030176 (obsolete integral component of endoplasmic reticulum membrane) |
2008-04-01 | Updated | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | is a GO:0044425 (obsolete membrane part) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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