This term is obsolete.

GO:0032937 JSON

SREBP-SCAP-Insig complex

Cellular Component

Definition (GO:0032937 GONUTS page)

A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane. PMID:12923525

2,133 annotations

Ancestor Chart

Ancestor chart for GO:0032937
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0032937 SREBP-SCAP-Insig complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0D1E8X3 237631 A0A0D1E8X3_USTMA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A0G2JZ79 10116 SIR1_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0032937 based on ALL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SREBP-SCAP-Insig complex
92,213.23 100.00 2,114 2,114
SREBP-SCAP complex retention in endoplasmic reticulum
92,167.57 95.41 2,018 2,019
SREBP signaling pathway
14,031.44 15.22 2,114 13,893
cellular response to insulin stimulus
12,431.22 13.38 2,003 14,858
cholesterol biosynthetic process
8,588.86 9.27 2,018 21,666
response to sterol depletion
61,008.00 7.90 174 263
cranial suture morphogenesis
38,477.47 7.38 174 417
negative regulation of steroid biosynthetic process
28,298.24 6.94 174 567
middle ear morphogenesis
8,923.86 4.65 174 1,798
negative regulation of protein exit from endoplasmic reticulum
92,213.24 4.30 91 91
Totals 25603 159861474
No co-occurrence statistics for GO:0032937 based on MANUAL annotations
The top 78 of 78 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SREBP-SCAP-Insig complex
33,123.05 100.00 39 39
SREBP-SCAP complex retention in endoplasmic reticulum
28,391.19 80.00 36 42
SREBP signaling pathway
6,557.36 19.80 39 197
cholesterol biosynthetic process
3,657.76 10.94 36 326
cellular response to sterol
7,643.78 6.12 3 13
negative regulation of protein exit from endoplasmic reticulum
33,123.05 5.13 2 2
cellular response to insulin stimulus
1,635.71 4.92 36 729
oxysterol binding
1,851.60 4.71 9 161
negative regulation of cargo loading into COPII-coated vesicle
7,360.68 4.35 2 9
response to sterol depletion
7,360.68 4.35 2 9
Totals 354 860328

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2022-08-26 Added RELATION part of GO:0005789 (endoplasmic reticulum membrane)
2022-08-26 Deleted RELATION part of GO:0030176 (obsolete integral component of endoplasmic reticulum membrane)
2020-11-03 Added RELATION is a GO:0140534 (endoplasmic reticulum protein-containing complex)
2020-09-13 Deleted RELATION part of GO:0005783 (endoplasmic reticulum)
2019-09-12 Deleted RELATION is a GO:0044432 (obsolete endoplasmic reticulum part)
2019-09-12 Added RELATION part of GO:0005783 (endoplasmic reticulum)
2015-06-25 Deleted RELATION is a GO:0044425 (obsolete membrane part)
2015-06-25 Deleted RELATION is a GO:0043234 (protein complex)
2015-05-11 Added RELATION is a GO:0098796 (membrane protein complex)
Timestamp Action Category Detail
2007-02-23 Added TERM SREBP-SCAP-Insig complex
Timestamp Action Category Detail
2012-08-24 Added DEFINITION A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane.
2012-08-24 Deleted DEFINITION A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane.
2008-05-13 Added DEFINITION A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane.
2008-05-12 Deleted DEFINITION A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane.
2007-02-23 Added DEFINITION A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane.
Timestamp Action Category Detail
2022-08-26 Added RELATION part of GO:0005789 (endoplasmic reticulum membrane)
2022-08-26 Deleted RELATION part of GO:0030176 (obsolete integral component of endoplasmic reticulum membrane)
2020-11-03 Added RELATION is a GO:0140534 (endoplasmic reticulum protein-containing complex)
2020-09-13 Deleted RELATION part of GO:0005783 (endoplasmic reticulum)
2019-09-12 Deleted RELATION is a GO:0044432 (obsolete endoplasmic reticulum part)
2019-09-12 Added RELATION part of GO:0005783 (endoplasmic reticulum)
2015-06-25 Deleted RELATION is a GO:0044425 (obsolete membrane part)
2015-06-25 Deleted RELATION is a GO:0043234 (protein complex)
2015-05-11 Added RELATION is a GO:0098796 (membrane protein complex)
2008-10-21 Added RELATION is a GO:0044432 (obsolete endoplasmic reticulum part)
2008-04-01 Updated RELATION part of GO:0030176 (obsolete integral component of endoplasmic reticulum membrane)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044425 (obsolete membrane part)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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