Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
GO:0033085
JSON
negative regulation of T cell differentiation in thymus
Biological Process
Definition (GO:0033085 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.
Comments
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
negative regulation of thymocyte cell differentiation | exact |
negative regulation of T cell development in thymus | related |
negative regulation of thymic T cell differentiation | exact |
negative regulation of thymocyte differentiation | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0033085
Child Term | Relationship to GO:0033085 |
---|---|
negative regulation of immature T cell proliferation in thymus
|
is_a |
negative regulation of positive thymic T cell selection
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0033085 | negative regulation of T cell differentiation in thymus | Never in Taxon | 4890 | Ascomycota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0033081 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0033081 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0033081 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O08573 | 10090 | LEG9_MOUSE | GO:0033081 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25065622 | |
NOT-qualified manual | protein | P16047 | 9031 | TGFB3_CHICK | GO:0007162 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:17587820 | |
NOT-qualified manual | protein | P97840 | 10116 | LEG9_RAT | GO:0033081 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q90999 | 9031 | TGFR2_CHICK | GO:0007162 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:17587820 | |
NOT-qualified manual | protein | Q90999 | 9031 | TGFR2_CHICK | GO:0022408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0033085 based on ALL annotations
The top 100 of 567 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of T cell differentiation in thymus
|
432,236.78 | 100.00 | 451 | 451 |
negative regulation of alpha-beta T cell differentiation
|
297,723.25 | 31.56 | 166 | 241 |
negative regulation of immature T cell proliferation in thymus
|
185,521.86 | 27.09 | 191 | 445 |
epithelial-mesenchymal cell signaling
|
208,114.00 | 26.70 | 169 | 351 |
trachea development
|
184,952.38 | 26.12 | 181 | 423 |
bud dilation involved in lung branching
|
432,236.78 | 22.84 | 103 | 103 |
negative regulation of glomerulus development
|
420,003.66 | 22.69 | 103 | 106 |
negative regulation of metanephric comma-shaped body morphogenesis
|
416,078.38 | 22.64 | 103 | 107 |
negative regulation of metanephric S-shaped body morphogenesis
|
416,078.38 | 22.64 | 103 | 107 |
intermediate mesodermal cell differentiation
|
416,078.38 | 22.64 | 103 | 107 |
Totals | 10353 | 30094 |
No co-occurrence statistics for GO:0033085 based on MANUAL annotations
The top 100 of 517 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of T cell differentiation in thymus
|
53,824.96 | 100.00 | 24 | 24 |
positive regulation of thymocyte apoptotic process
|
21,529.98 | 22.22 | 8 | 20 |
negative regulation of alpha-beta T cell differentiation
|
32,294.98 | 21.43 | 6 | 10 |
B cell homeostatic proliferation
|
30,757.12 | 14.81 | 4 | 7 |
negative regulation of immature T cell proliferation in thymus
|
14,041.29 | 14.63 | 6 | 23 |
camera-type eye photoreceptor cell fate commitment
|
53,824.96 | 12.50 | 3 | 3 |
negative regulation of eye pigmentation
|
53,824.96 | 12.50 | 3 | 3 |
central tolerance induction
|
53,824.96 | 12.50 | 3 | 3 |
positive regulation of central B cell tolerance induction
|
53,824.96 | 12.50 | 3 | 3 |
positive regulation of alpha-beta T cell differentiation
|
10,417.73 | 12.24 | 6 | 31 |
Totals | 292 | 1718 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4890 (Ascomycota) |
2017-01-12 | Deleted | RELATION | is a GO:2000399 (negative regulation of thymocyte aggregation) |
2015-03-19 | Added | RELATION | is a GO:2000399 (negative regulation of thymocyte aggregation) |
2010-10-15 | Added | SYNONYM | negative regulation of T cell development in thymus |
2010-10-06 | Updated | TERM | negative regulation of T cell differentiation in thymus |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2008-04-01 | Updated | RELATION | is a GO:0033081 (regulation of T cell differentiation in thymus) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-06 | Updated | TERM | negative regulation of T cell differentiation in thymus |
2007-03-30 | Added | TERM | negative regulation of T cell differentiation in the thymus |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-15 | Added | SYNONYM | negative regulation of T cell development in thymus |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2007-08-09 | Deleted | SYNONYM | negative regulation of thymocyte cell differentiation |
2007-08-09 | Added | SYNONYM | negative regulation of thymocyte cell differentiation |
2007-08-09 | Deleted | SYNONYM | negative regulation of thymic T cell differentiation |
2007-08-09 | Deleted | SYNONYM | negative regulation of thymocyte differentiation |
2007-08-09 | Added | SYNONYM | negative regulation of thymic T cell differentiation |
2007-08-09 | Added | SYNONYM | negative regulation of thymocyte differentiation |
2007-04-20 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus. |
2007-03-30 | Added | SYNONYM | negative regulation of thymocyte differentiation |
2007-03-30 | Added | SYNONYM | negative regulation of thymocyte cell differentiation |
2007-03-30 | Added | SYNONYM | negative regulation of thymic T cell differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-01-12 | Deleted | RELATION | is a GO:2000399 (negative regulation of thymocyte aggregation) |
2015-03-19 | Added | RELATION | is a GO:2000399 (negative regulation of thymocyte aggregation) |
2008-04-01 | Updated | RELATION | is a GO:0033081 (regulation of T cell differentiation in thymus) |
2008-04-01 | Updated | RELATION | is a GO:0045581 (negative regulation of T cell differentiation) |
2008-04-01 | Added | RELATION | negatively regulates GO:0033077 (T cell differentiation in thymus) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4890 (Ascomycota) |
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