This term is obsolete.

GO:0033739 JSON

preQ1 synthase activity

Molecular Function

Definition (GO:0033739 GONUTS page)

Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH.

22,373 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
QueF related
YkvM related
preQ0 oxidoreductase activity related
preQ0 reductase activity related
7-cyano-7-deazaguanine reductase activity related
queuine synthase activity related
queuine:NADP+ oxidoreductase activity related
7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity exact

Ancestor Chart

Ancestor chart for GO:0033739
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.7.1.13
InterPro IPR029500 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF
KEGG_REACTION R07605
MetaCyc RXN0-4022
RHEA 13409

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:58703 7-ammoniomethyl-7-deazaguanine
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:45075 7-cyano-7-deazaguanine
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0033739 based on ALL annotations
The top 69 of 69 co-occurring terms
Co-occurring Term PR S% #Together #Compared
preQ1 synthase activity
8,713.52 100.00 22,372 22,372
queuosine biosynthetic process
973.11 11.16 22,264 199,359
tRNA modification
274.10 3.14 20,459 650,376
oxidoreductase activity
15.45 0.18 21,114 11,906,003
cytoplasm
7.42 0.09 21,540 25,285,876
oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
18.18 0.03 9 4,313
GTP cyclohydrolase I activity
1.77 0.01 11 54,173
D-ribulokinase activity
1.48 0.01 3 17,623
D-xylulokinase activity
0.99 0.01 3 26,415
xylulose metabolic process
0.90 0.01 3 29,138
Totals 108286 284479698
No co-occurrence statistics for GO:0033739 based on MANUAL annotations
The top 3 of 3 co-occurring terms
Co-occurring Term PR S% #Together #Compared
preQ1 synthase activity
1,291,799.00 100.00 1 1
queuosine biosynthetic process
15,020.92 1.16 1 86
cytosol
15.34 0.00 1 84,217
Totals 3 84304

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH.
2022-05-26 Deleted RELATION is a GO:0016657 (obsolete oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor)
2022-05-26 Added RELATION is a GO:0046857 (oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor)
2020-10-08 Deleted SYNONYM 7-cyano-7-deazaguanine reductase activity
2020-10-08 Deleted SYNONYM preQ0 oxidoreductase activity
2020-10-08 Deleted SYNONYM preQ0 reductase activity
2020-10-08 Added SYNONYM preQ0 oxidoreductase activity
2020-10-08 Added SYNONYM 7-cyano-7-deazaguanine reductase activity
2020-10-08 Added SYNONYM preQ0 reductase activity
Timestamp Action Category Detail
2011-05-27 Updated TERM preQ1 synthase activity
2007-11-08 Added TERM queuine synthase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH.
2020-10-08 Deleted SYNONYM 7-cyano-7-deazaguanine reductase activity
2020-10-08 Deleted SYNONYM preQ0 oxidoreductase activity
2020-10-08 Deleted SYNONYM preQ0 reductase activity
2020-10-08 Added SYNONYM preQ0 oxidoreductase activity
2020-10-08 Added SYNONYM 7-cyano-7-deazaguanine reductase activity
2020-10-08 Added SYNONYM preQ0 reductase activity
2011-05-27 Added SYNONYM queuine:NADP+ oxidoreductase activity
2011-05-27 Added SYNONYM queuine synthase activity
2011-05-27 Deleted SYNONYM queuine:NADP+ oxidoreductase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: queuine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: queuine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: queuine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+.
2007-12-06 Deleted SYNONYM queuine synthase activity
2007-11-27 Added DEFINITION Catalysis of the reaction: queuine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+.
2007-11-08 Added SYNONYM preQ0 oxidoreductase activity
2007-11-08 Added SYNONYM YkvM
2007-11-08 Added SYNONYM QueF
2007-11-08 Added SYNONYM 7-cyano-7-deazaguanine reductase activity
2007-11-08 Added SYNONYM 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity
2007-11-08 Added SYNONYM queuine synthase activity
2007-11-08 Added SYNONYM queuine:NADP+ oxidoreductase activity
2007-11-08 Added SYNONYM preQ0 reductase activity
Timestamp Action Category Detail
2022-05-26 Deleted RELATION is a GO:0016657 (obsolete oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor)
2022-05-26 Added RELATION is a GO:0046857 (oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0016657 (obsolete oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R07605
2019-06-20 Added XREF KEGG_REACTION:R07605
2018-07-13 Added XREF RHEA:13409
2018-07-13 Deleted XREF RHEA:13412
2010-10-11 Added XREF RHEA:13412
2010-10-11 Added XREF MetaCyc:RXN0-4022
2010-10-11 Added XREF KEGG:R07605
2007-11-08 Added XREF EC:1.7.1.13
Timestamp Action Category Detail
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