This term is obsolete.

GO:0033744 JSON

L-methionine:thioredoxin-disulfide S-oxidoreductase activity

Molecular Function

Definition (GO:0033744 GONUTS page)

Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

Secondary IDs

GO:0000317

51,788 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
L-methionine-(S)-S-oxide reductase activity narrow
methionine sulfoxide reductase activity broad
methionine-S-oxide reductase activity exact
L-methionine:oxidized-thioredoxin S-oxidoreductase activity related
fSMsr related
free-methionine (S)-S-oxide reductase activity related
methyl sulfoxide reductase I and II activity related
acetylmethionine sulfoxide reductase activity related

Ancestor Chart

Ancestor chart for GO:0033744
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0033744

Child Term Relationship to
GO:0033744
L-methionine-(S)-S-oxide reductase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.8.4.13
KEGG_REACTION R07606
MetaCyc 1.8.4.13-RXN
RHEA 19993

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:50058 L-cystine residue
has_participant CHEBI CHEBI:58772 L-methionine (S)-S-oxide zwitterion
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:29950 L-cysteine residue
has_participant CHEBI CHEBI:57844 L-methionine zwitterion

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0033744 based on ALL annotations
The top 97 of 97 co-occurring terms
Co-occurring Term PR S% #Together #Compared
L-methionine:thioredoxin-disulfide S-oxidoreductase activity
6,224.83 100.00 31,833 31,833
peptide-methionine (S)-S-oxide reductase activity
3,037.35 48.79 31,827 65,227
L-methionine-(S)-S-oxide reductase activity
2,585.77 19.05 8,283 19,940
protein modification process
709.19 11.37 31,191 273,774
peptide-methionine (R)-S-oxide reductase activity
555.62 6.06 5,044 56,510
cellular response to oxidative stress
207.57 3.05 8,286 248,495
protein repair
149.71 1.84 2,301 95,671
response to oxidative stress
32.71 0.49 2,307 439,037
bacteriocin immunity
92.95 0.33 135 9,041
oxidoreductase activity
16.06 0.26 31,833 12,339,325
Totals 164511 324808374
No co-occurrence statistics for GO:0033744 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term PR S% #Together #Compared
L-methionine:thioredoxin-disulfide S-oxidoreductase activity
352,883.25 100.00 4 4
symbiont-mediated detoxification of host-generated reactive oxygen species
88,220.81 14.29 1 4
response to nitrosative stress
12,168.39 3.13 1 29
peptide-methionine (S)-S-oxide reductase activity
3,688.68 1.04 3 287
molybdenum ion binding
2,735.53 0.76 1 129
L-methionine-(S)-S-oxide reductase activity
2,511.62 0.71 2 281
anaerobic respiration
1,326.63 0.37 1 266
response to oxidative stress
416.14 0.12 2 1,696
cellular response to oxidative stress
380.13 0.11 3 2,785
outer membrane-bounded periplasmic space
348.35 0.10 1 1,013
Totals 24 440302

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM methyl sulfoxide reductase I and II activity
2020-10-08 Deleted SYNONYM acetylmethionine sulfoxide reductase activity
2020-10-08 Added SYNONYM L-methionine:oxidized-thioredoxin S-oxidoreductase activity
2020-10-08 Deleted SYNONYM L-methionine:oxidized-thioredoxin S-oxidoreductase activity
2020-10-08 Added SYNONYM methyl sulfoxide reductase I and II activity
2020-10-08 Deleted SYNONYM free-methionine (S)-S-oxide reductase activity
2020-10-08 Added SYNONYM free-methionine (S)-S-oxide reductase activity
2020-10-08 Added SYNONYM acetylmethionine sulfoxide reductase activity
2019-06-20 Added XREF KEGG_REACTION:R07606
2019-06-20 Deleted XREF KEGG:R07606
Timestamp Action Category Detail
2013-11-29 Updated TERM L-methionine:thioredoxin-disulfide S-oxidoreductase activity
2007-11-08 Added TERM L-methionine-(S)-S-oxide reductase activity
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM methyl sulfoxide reductase I and II activity
2020-10-08 Deleted SYNONYM acetylmethionine sulfoxide reductase activity
2020-10-08 Added SYNONYM L-methionine:oxidized-thioredoxin S-oxidoreductase activity
2020-10-08 Deleted SYNONYM L-methionine:oxidized-thioredoxin S-oxidoreductase activity
2020-10-08 Added SYNONYM methyl sulfoxide reductase I and II activity
2020-10-08 Deleted SYNONYM free-methionine (S)-S-oxide reductase activity
2020-10-08 Added SYNONYM free-methionine (S)-S-oxide reductase activity
2020-10-08 Added SYNONYM acetylmethionine sulfoxide reductase activity
2013-11-29 Deleted SYNONYM L-methionine:thioredoxin-disulfide S-oxidoreductase activity
2013-11-29 Added SYNONYM L-methionine-(S)-S-oxide reductase activity
2010-09-03 Added SYNONYM methionine-S-oxide reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2007-12-06 Deleted SYNONYM L-methionine-(S)-S-oxide reductase activity
2007-11-27 Added DEFINITION Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2007-11-08 Added SYNONYM methyl sulfoxide reductase I and II activity
2007-11-08 Added SYNONYM free-methionine (S)-S-oxide reductase activity
2007-11-08 Added SYNONYM fSMsr
2007-11-08 Added SYNONYM L-methionine-(S)-S-oxide reductase activity
2007-11-08 Added SYNONYM L-methionine:oxidized-thioredoxin S-oxidoreductase activity
2007-11-08 Added SYNONYM L-methionine:thioredoxin-disulfide S-oxidoreductase activity
2007-11-08 Added SYNONYM acetylmethionine sulfoxide reductase activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase activity
Timestamp Action Category Detail
2010-09-03 Added RELATION is a GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)
2010-09-03 Deleted RELATION is a GO:0000317 (methionine-S-oxide reductase activity)
2008-04-01 Updated RELATION is a GO:0000317 (methionine-S-oxide reductase activity)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R07606
2019-06-20 Deleted XREF KEGG:R07606
2018-07-13 Added XREF RHEA:19993
2018-07-13 Deleted XREF RHEA:19996
2013-11-29 Added XREF RHEA:19996
2013-11-29 Added XREF KEGG:R07606
2013-11-29 Deleted XREF RHEA:19995
2011-09-16 Added XREF RHEA:19995
2009-05-21 Added XREF MetaCyc:1.8.4.13-RXN
2007-11-08 Added XREF EC:1.8.4.13
Timestamp Action Category Detail
2010-09-03 Added SECONDARY GO:0000317 (methionine-S-oxide reductase activity)
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