GO:0033744
JSON
L-methionine:thioredoxin-disulfide S-oxidoreductase activity
Molecular Function
Definition (GO:0033744 GONUTS page)
Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
Secondary IDs
GO:0000317
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
L-methionine-(S)-S-oxide reductase activity | narrow |
methionine sulfoxide reductase activity | broad |
methionine-S-oxide reductase activity | exact |
L-methionine:oxidized-thioredoxin S-oxidoreductase activity | related |
fSMsr | related |
free-methionine (S)-S-oxide reductase activity | related |
methyl sulfoxide reductase I and II activity | related |
acetylmethionine sulfoxide reductase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0033744
Child Term | Relationship to GO:0033744 |
---|---|
L-methionine-(S)-S-oxide reductase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.8.4.13 | |
KEGG_REACTION | R07606 | |
MetaCyc | 1.8.4.13-RXN | |
RHEA | 19993 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:50058 | L-cystine residue |
has_participant | CHEBI | CHEBI:58772 | L-methionine (S)-S-oxide zwitterion |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:29950 | L-cysteine residue |
has_participant | CHEBI | CHEBI:57844 | L-methionine zwitterion |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0033744 based on ALL annotations
The top 97 of 97 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-methionine:thioredoxin-disulfide S-oxidoreductase activity
|
6,224.83 | 100.00 | 31,833 | 31,833 |
peptide-methionine (S)-S-oxide reductase activity
|
3,037.35 | 48.79 | 31,827 | 65,227 |
L-methionine-(S)-S-oxide reductase activity
|
2,585.77 | 19.05 | 8,283 | 19,940 |
protein modification process
|
709.19 | 11.37 | 31,191 | 273,774 |
peptide-methionine (R)-S-oxide reductase activity
|
555.62 | 6.06 | 5,044 | 56,510 |
cellular response to oxidative stress
|
207.57 | 3.05 | 8,286 | 248,495 |
protein repair
|
149.71 | 1.84 | 2,301 | 95,671 |
response to oxidative stress
|
32.71 | 0.49 | 2,307 | 439,037 |
bacteriocin immunity
|
92.95 | 0.33 | 135 | 9,041 |
oxidoreductase activity
|
16.06 | 0.26 | 31,833 | 12,339,325 |
Totals | 164511 | 324808374 |
No co-occurrence statistics for GO:0033744 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-methionine:thioredoxin-disulfide S-oxidoreductase activity
|
352,883.25 | 100.00 | 4 | 4 |
symbiont-mediated detoxification of host-generated reactive oxygen species
|
88,220.81 | 14.29 | 1 | 4 |
response to nitrosative stress
|
12,168.39 | 3.13 | 1 | 29 |
peptide-methionine (S)-S-oxide reductase activity
|
3,688.68 | 1.04 | 3 | 287 |
molybdenum ion binding
|
2,735.53 | 0.76 | 1 | 129 |
L-methionine-(S)-S-oxide reductase activity
|
2,511.62 | 0.71 | 2 | 281 |
anaerobic respiration
|
1,326.63 | 0.37 | 1 | 266 |
response to oxidative stress
|
416.14 | 0.12 | 2 | 1,696 |
cellular response to oxidative stress
|
380.13 | 0.11 | 3 | 2,785 |
outer membrane-bounded periplasmic space
|
348.35 | 0.10 | 1 | 1,013 |
Totals | 24 | 440302 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | methyl sulfoxide reductase I and II activity |
2020-10-08 | Deleted | SYNONYM | acetylmethionine sulfoxide reductase activity |
2020-10-08 | Added | SYNONYM | L-methionine:oxidized-thioredoxin S-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L-methionine:oxidized-thioredoxin S-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | methyl sulfoxide reductase I and II activity |
2020-10-08 | Deleted | SYNONYM | free-methionine (S)-S-oxide reductase activity |
2020-10-08 | Added | SYNONYM | free-methionine (S)-S-oxide reductase activity |
2020-10-08 | Added | SYNONYM | acetylmethionine sulfoxide reductase activity |
2019-06-20 | Added | XREF | KEGG_REACTION:R07606 |
2019-06-20 | Deleted | XREF | KEGG:R07606 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-11-29 | Updated | TERM | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
2007-11-08 | Added | TERM | L-methionine-(S)-S-oxide reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | methyl sulfoxide reductase I and II activity |
2020-10-08 | Deleted | SYNONYM | acetylmethionine sulfoxide reductase activity |
2020-10-08 | Added | SYNONYM | L-methionine:oxidized-thioredoxin S-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L-methionine:oxidized-thioredoxin S-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | methyl sulfoxide reductase I and II activity |
2020-10-08 | Deleted | SYNONYM | free-methionine (S)-S-oxide reductase activity |
2020-10-08 | Added | SYNONYM | free-methionine (S)-S-oxide reductase activity |
2020-10-08 | Added | SYNONYM | acetylmethionine sulfoxide reductase activity |
2013-11-29 | Deleted | SYNONYM | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
2013-11-29 | Added | SYNONYM | L-methionine-(S)-S-oxide reductase activity |
2010-09-03 | Added | SYNONYM | methionine-S-oxide reductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. |
2007-12-06 | Deleted | SYNONYM | L-methionine-(S)-S-oxide reductase activity |
2007-11-27 | Added | DEFINITION | Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. |
2007-11-08 | Added | SYNONYM | methyl sulfoxide reductase I and II activity |
2007-11-08 | Added | SYNONYM | free-methionine (S)-S-oxide reductase activity |
2007-11-08 | Added | SYNONYM | fSMsr |
2007-11-08 | Added | SYNONYM | L-methionine-(S)-S-oxide reductase activity |
2007-11-08 | Added | SYNONYM | L-methionine:oxidized-thioredoxin S-oxidoreductase activity |
2007-11-08 | Added | SYNONYM | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
2007-11-08 | Added | SYNONYM | acetylmethionine sulfoxide reductase activity |
2007-11-08 | Added | SYNONYM | methionine sulfoxide reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-09-03 | Added | RELATION | is a GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor) |
2010-09-03 | Deleted | RELATION | is a GO:0000317 (methionine-S-oxide reductase activity) |
2008-04-01 | Updated | RELATION | is a GO:0000317 (methionine-S-oxide reductase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R07606 |
2019-06-20 | Deleted | XREF | KEGG:R07606 |
2018-07-13 | Added | XREF | RHEA:19993 |
2018-07-13 | Deleted | XREF | RHEA:19996 |
2013-11-29 | Added | XREF | RHEA:19996 |
2013-11-29 | Added | XREF | KEGG:R07606 |
2013-11-29 | Deleted | XREF | RHEA:19995 |
2011-09-16 | Added | XREF | RHEA:19995 |
2009-05-21 | Added | XREF | MetaCyc:1.8.4.13-RXN |
2007-11-08 | Added | XREF | EC:1.8.4.13 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-09-03 | Added | SECONDARY | GO:0000317 (methionine-S-oxide reductase activity) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link