GO:0034028
JSON
5-(carboxyamino)imidazole ribonucleotide synthase activity
Molecular Function
Definition (GO:0034028 GONUTS page)
Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity | related |
N5-CAIR synthetase activity | related |
N5-carboxyaminoimidazole ribonucleotide synthetase activity | related |
PurK | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.3.4.18 | |
KEGG_REACTION | R07404 | |
MetaCyc | RXN0-742 | |
RHEA | 19317 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:17544 | hydrogencarbonate |
has_participant | CHEBI | CHEBI:137981 | 5-amino-1-(5-phosphonato-beta-D-ribosyl)imidazol-3-ium |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:58730 | 5-carboxylatoamino-1-(5-O-phosphonato-D-ribosyl)imidazole(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0034028 based on ALL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
5-(carboxyamino)imidazole ribonucleotide synthase activity
|
7,327.40 | 100.00 | 27,043 | 27,043 |
phosphoribosylaminoimidazole carboxylase activity
|
5,908.48 | 80.17 | 26,850 | 33,298 |
'de novo' IMP biosynthetic process
|
384.82 | 5.25 | 26,837 | 511,006 |
purine nucleotide biosynthetic process
|
260.55 | 3.56 | 26,941 | 757,654 |
ligase activity
|
64.56 | 0.88 | 27,043 | 3,069,286 |
cytosol
|
13.49 | 0.18 | 25,764 | 13,989,509 |
ATP binding
|
10.39 | 0.14 | 26,985 | 19,024,482 |
metal ion binding
|
9.08 | 0.12 | 26,962 | 21,769,638 |
lyase activity
|
4.17 | 0.06 | 2,577 | 4,523,172 |
5-(carboxyamino)imidazole ribonucleotide mutase activity
|
5.54 | 0.04 | 29 | 38,362 |
Totals | 217449 | 227359382 |
No co-occurrence statistics for GO:0034028 based on MANUAL annotations
The top 4 of 4 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
5-(carboxyamino)imidazole ribonucleotide synthase activity
|
1,411,533.00 | 100.00 | 1 | 1 |
phosphoribosylaminoimidazole carboxylase activity
|
128,321.19 | 9.09 | 1 | 11 |
ATP binding
|
206.09 | 0.01 | 1 | 6,849 |
cytosol
|
15.76 | 0.00 | 1 | 89,580 |
Totals | 4 | 96441 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate. |
2020-10-08 | Added | SYNONYM | N5-CAIR synthetase activity |
2020-10-08 | Added | SYNONYM | N5-carboxyaminoimidazole ribonucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity |
2020-10-08 | Deleted | SYNONYM | N5-carboxyaminoimidazole ribonucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | N5-CAIR synthetase activity |
2020-10-08 | Deleted | SYNONYM | 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity |
2019-06-20 | Deleted | XREF | KEGG:R07404 |
2019-06-20 | Added | XREF | KEGG_REACTION:R07404 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-12-14 | Added | TERM | 5-(carboxyamino)imidazole ribonucleotide synthase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate. |
2020-10-08 | Added | SYNONYM | N5-CAIR synthetase activity |
2020-10-08 | Added | SYNONYM | N5-carboxyaminoimidazole ribonucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity |
2020-10-08 | Deleted | SYNONYM | N5-carboxyaminoimidazole ribonucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | N5-CAIR synthetase activity |
2020-10-08 | Deleted | SYNONYM | 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole. |
2007-12-27 | Added | DEFINITION | Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole. |
2007-12-14 | Added | SYNONYM | 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity |
2007-12-14 | Added | SYNONYM | PurK |
2007-12-14 | Added | SYNONYM | N5-CAIR synthetase activity |
2007-12-14 | Added | SYNONYM | N5-carboxyaminoimidazole ribonucleotide synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R07404 |
2019-06-20 | Added | XREF | KEGG_REACTION:R07404 |
2018-07-13 | Deleted | XREF | RHEA:19320 |
2018-07-13 | Added | XREF | RHEA:19317 |
2010-10-11 | Added | XREF | RHEA:19320 |
2010-10-11 | Added | XREF | KEGG:R07404 |
2010-10-11 | Added | XREF | MetaCyc:RXN0-742 |
2007-12-14 | Added | XREF | EC:6.3.4.18 |
Timestamp | Action | Category | Detail |
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