This term is obsolete.

GO:0034028 JSON

5-(carboxyamino)imidazole ribonucleotide synthase activity

Molecular Function

Definition (GO:0034028 GONUTS page)

Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate.

27,044 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity related
N5-CAIR synthetase activity related
N5-carboxyaminoimidazole ribonucleotide synthetase activity related
PurK related

Ancestor Chart

Ancestor chart for GO:0034028
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.3.4.18
KEGG_REACTION R07404
MetaCyc RXN0-742
RHEA 19317

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:17544 hydrogencarbonate
has_participant CHEBI CHEBI:137981 5-amino-1-(5-phosphonato-beta-D-ribosyl)imidazol-3-ium
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:58730 5-carboxylatoamino-1-(5-O-phosphonato-D-ribosyl)imidazole(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0034028 based on ALL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term PR S% #Together #Compared
5-(carboxyamino)imidazole ribonucleotide synthase activity
7,327.40 100.00 27,043 27,043
phosphoribosylaminoimidazole carboxylase activity
5,908.48 80.17 26,850 33,298
'de novo' IMP biosynthetic process
384.82 5.25 26,837 511,006
purine nucleotide biosynthetic process
260.55 3.56 26,941 757,654
ligase activity
64.56 0.88 27,043 3,069,286
cytosol
13.49 0.18 25,764 13,989,509
ATP binding
10.39 0.14 26,985 19,024,482
metal ion binding
9.08 0.12 26,962 21,769,638
lyase activity
4.17 0.06 2,577 4,523,172
5-(carboxyamino)imidazole ribonucleotide mutase activity
5.54 0.04 29 38,362
Totals 217449 227359382
No co-occurrence statistics for GO:0034028 based on MANUAL annotations
The top 4 of 4 co-occurring terms
Co-occurring Term PR S% #Together #Compared
5-(carboxyamino)imidazole ribonucleotide synthase activity
1,411,533.00 100.00 1 1
phosphoribosylaminoimidazole carboxylase activity
128,321.19 9.09 1 11
ATP binding
206.09 0.01 1 6,849
cytosol
15.76 0.00 1 89,580
Totals 4 96441

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate.
2020-10-08 Added SYNONYM N5-CAIR synthetase activity
2020-10-08 Added SYNONYM N5-carboxyaminoimidazole ribonucleotide synthetase activity
2020-10-08 Added SYNONYM 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity
2020-10-08 Deleted SYNONYM N5-carboxyaminoimidazole ribonucleotide synthetase activity
2020-10-08 Deleted SYNONYM N5-CAIR synthetase activity
2020-10-08 Deleted SYNONYM 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity
2019-06-20 Deleted XREF KEGG:R07404
2019-06-20 Added XREF KEGG_REACTION:R07404
Timestamp Action Category Detail
2007-12-14 Added TERM 5-(carboxyamino)imidazole ribonucleotide synthase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate.
2020-10-08 Added SYNONYM N5-CAIR synthetase activity
2020-10-08 Added SYNONYM N5-carboxyaminoimidazole ribonucleotide synthetase activity
2020-10-08 Added SYNONYM 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity
2020-10-08 Deleted SYNONYM N5-carboxyaminoimidazole ribonucleotide synthetase activity
2020-10-08 Deleted SYNONYM N5-CAIR synthetase activity
2020-10-08 Deleted SYNONYM 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
2010-10-11 Added DEFINITION Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate.
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
2007-12-27 Added DEFINITION Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
2007-12-14 Added SYNONYM 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity
2007-12-14 Added SYNONYM PurK
2007-12-14 Added SYNONYM N5-CAIR synthetase activity
2007-12-14 Added SYNONYM N5-carboxyaminoimidazole ribonucleotide synthetase activity
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R07404
2019-06-20 Added XREF KEGG_REACTION:R07404
2018-07-13 Deleted XREF RHEA:19320
2018-07-13 Added XREF RHEA:19317
2010-10-11 Added XREF RHEA:19320
2010-10-11 Added XREF KEGG:R07404
2010-10-11 Added XREF MetaCyc:RXN0-742
2007-12-14 Added XREF EC:6.3.4.18
Timestamp Action Category Detail
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