GO:0034122
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negative regulation of toll-like receptor signaling pathway
Biological Process
Definition (GO:0034122 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. PMID:16551253 PMID:17328678
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
negative regulation of TLR signaling pathway | exact |
negative regulation of toll-like receptor signalling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0034122
Child Term | Relationship to GO:0034122 |
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negative regulation of MyD88-independent toll-like receptor signaling pathway
|
is_a |
negative regulation of toll-like receptor 21 signaling pathway
|
is_a |
negative regulation of MyD88-dependent toll-like receptor signaling pathway
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0034122 based on ALL annotations
The top 100 of 542 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of toll-like receptor signaling pathway
|
85,913.96 | 100.00 | 2,269 | 2,269 |
regulation of protein K48-linked deubiquitination
|
85,913.96 | 36.76 | 834 | 834 |
negative regulation of interleukin-1-mediated signaling pathway
|
48,812.12 | 28.94 | 842 | 1,482 |
K63-linked deubiquitinase activity
|
7,241.92 | 7.38 | 842 | 9,989 |
negative regulation of lipopolysaccharide-mediated signaling pathway
|
23,130.68 | 6.38 | 175 | 650 |
negative regulation of tumor necrosis factor production
|
6,072.20 | 4.92 | 316 | 4,471 |
negative regulation of interleukin-12 production
|
8,768.02 | 3.98 | 139 | 1,362 |
metanephric glomerulus development
|
82,178.58 | 3.87 | 88 | 92 |
negative regulation of innate immune response
|
4,869.46 | 3.85 | 244 | 4,305 |
negative regulation of calcium ion export across plasma membrane
|
32,173.55 | 3.76 | 91 | 243 |
Totals | 12989 | 170068 |
No co-occurrence statistics for GO:0034122 based on MANUAL annotations
The top 100 of 432 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of toll-like receptor signaling pathway
|
10,171.65 | 100.00 | 127 | 127 |
negative regulation of interleukin-1-mediated signaling pathway
|
4,544.78 | 13.73 | 21 | 47 |
forebrain cell migration
|
5,289.26 | 9.35 | 13 | 25 |
secretion by cell
|
2,404.21 | 7.69 | 13 | 55 |
ovulation cycle
|
2,241.21 | 7.51 | 13 | 59 |
negative regulation of lipopolysaccharide-mediated signaling pathway
|
2,283.43 | 6.67 | 11 | 49 |
negative regulation of innate immune response
|
956.31 | 6.49 | 22 | 234 |
K63-linked deubiquitinase activity
|
827.92 | 5.77 | 21 | 258 |
negative regulation of NF-kappaB transcription factor activity
|
791.13 | 4.78 | 14 | 180 |
apoptotic cell clearance
|
773.28 | 4.56 | 13 | 171 |
Totals | 730 | 14184 |
Change Log
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Timestamp | Action | Category | Detail |
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2022-07-26 | Added | RELATION | is a GO:0002683 (negative regulation of immune system process) |
2020-02-22 | Deleted | RELATION | is a GO:0002683 (negative regulation of immune system process) |
2011-01-16 | Deleted | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2011-01-16 | Added | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2010-04-21 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2010-04-21 | Added | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. |
2008-04-01 | Added | RELATION | negatively regulates GO:0002224 (toll-like receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0034121 (regulation of toll-like receptor signaling pathway) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-01-07 | Added | TERM | negative regulation of toll-like receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. |
2008-01-27 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. |
2008-01-07 | Added | SYNONYM | negative regulation of TLR signaling pathway |
2008-01-07 | Added | SYNONYM | negative regulation of toll-like receptor signalling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-26 | Added | RELATION | is a GO:0002683 (negative regulation of immune system process) |
2020-02-22 | Deleted | RELATION | is a GO:0002683 (negative regulation of immune system process) |
2011-01-16 | Deleted | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2011-01-16 | Added | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2010-04-21 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2010-04-21 | Added | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2008-04-01 | Added | RELATION | negatively regulates GO:0002224 (toll-like receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0034121 (regulation of toll-like receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2008-04-01 | Updated | RELATION | is a GO:0002683 (negative regulation of immune system process) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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