This term is obsolete.

GO:0034122 JSON

negative regulation of toll-like receptor signaling pathway

Biological Process

Definition (GO:0034122 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. PMID:16551253 PMID:17328678

4,970 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation of TLR signaling pathway exact
negative regulation of toll-like receptor signalling pathway exact

Ancestor Chart

Ancestor chart for GO:0034122
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0034122

Child Term Relationship to
GO:0034122
negative regulation of MyD88-independent toll-like receptor signaling pathway
is_a
negative regulation of toll-like receptor 21 signaling pathway
is_a
negative regulation of MyD88-dependent toll-like receptor signaling pathway
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0034122 based on ALL annotations
The top 100 of 542 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of toll-like receptor signaling pathway
85,913.96 100.00 2,269 2,269
regulation of protein K48-linked deubiquitination
85,913.96 36.76 834 834
negative regulation of interleukin-1-mediated signaling pathway
48,812.12 28.94 842 1,482
K63-linked deubiquitinase activity
7,241.92 7.38 842 9,989
negative regulation of lipopolysaccharide-mediated signaling pathway
23,130.68 6.38 175 650
negative regulation of tumor necrosis factor production
6,072.20 4.92 316 4,471
negative regulation of interleukin-12 production
8,768.02 3.98 139 1,362
metanephric glomerulus development
82,178.58 3.87 88 92
negative regulation of innate immune response
4,869.46 3.85 244 4,305
negative regulation of calcium ion export across plasma membrane
32,173.55 3.76 91 243
Totals 12989 170068
No co-occurrence statistics for GO:0034122 based on MANUAL annotations
The top 100 of 432 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of toll-like receptor signaling pathway
10,171.65 100.00 127 127
negative regulation of interleukin-1-mediated signaling pathway
4,544.78 13.73 21 47
forebrain cell migration
5,289.26 9.35 13 25
secretion by cell
2,404.21 7.69 13 55
ovulation cycle
2,241.21 7.51 13 59
negative regulation of lipopolysaccharide-mediated signaling pathway
2,283.43 6.67 11 49
negative regulation of innate immune response
956.31 6.49 22 234
K63-linked deubiquitinase activity
827.92 5.77 21 258
negative regulation of NF-kappaB transcription factor activity
791.13 4.78 14 180
apoptotic cell clearance
773.28 4.56 13 171
Totals 730 14184

Change Log

Timestamp Action Category Detail
2022-07-26 Added RELATION is a GO:0002683 (negative regulation of immune system process)
2020-02-22 Deleted RELATION is a GO:0002683 (negative regulation of immune system process)
2011-01-16 Deleted RELATION is a GO:0035467 (negative regulation of signaling pathway)
2011-01-16 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-04-21 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-04-21 Added RELATION is a GO:0035467 (negative regulation of signaling pathway)
2008-05-13 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
2008-05-12 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
2008-04-01 Added RELATION negatively regulates GO:0002224 (toll-like receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0034121 (regulation of toll-like receptor signaling pathway)
Timestamp Action Category Detail
2008-01-07 Added TERM negative regulation of toll-like receptor signaling pathway
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
2008-05-12 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
2008-01-27 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
2008-01-07 Added SYNONYM negative regulation of TLR signaling pathway
2008-01-07 Added SYNONYM negative regulation of toll-like receptor signalling pathway
Timestamp Action Category Detail
2022-07-26 Added RELATION is a GO:0002683 (negative regulation of immune system process)
2020-02-22 Deleted RELATION is a GO:0002683 (negative regulation of immune system process)
2011-01-16 Deleted RELATION is a GO:0035467 (negative regulation of signaling pathway)
2011-01-16 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-04-21 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-04-21 Added RELATION is a GO:0035467 (negative regulation of signaling pathway)
2008-04-01 Added RELATION negatively regulates GO:0002224 (toll-like receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0034121 (regulation of toll-like receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
2008-04-01 Updated RELATION is a GO:0002683 (negative regulation of immune system process)
Timestamp Action Category Detail
Timestamp Action Category Detail
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