This term is obsolete.

GO:0034138 JSON

toll-like receptor 3 signaling pathway

Biological Process

Definition (GO:0034138 GONUTS page)

The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3. PMID:16551253 PMID:17328678

2,421 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
toll-like receptor 3 signalling pathway exact
TLR3 signaling pathway exact

Ancestor Chart

Ancestor chart for GO:0034138
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0034138

Child Term Relationship to
GO:0034138
negative regulation of toll-like receptor 3 signaling pathway
negatively_regulates
positive regulation of toll-like receptor 3 signaling pathway
positively_regulates
regulation of toll-like receptor 3 signaling pathway
regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0034138 toll-like receptor 3 signaling pathway Never in Taxon 4895 Schizosaccharomyces
GO:0034138 toll-like receptor 3 signaling pathway Never in Taxon 4932 Saccharomyces cerevisiae

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZQ02 10116 A0A8I5ZQ02_RAT GO:0034138 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZWL2 10116 A0A8I5ZWL2_RAT GO:0034138 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K6K8 10116 A6K6K8_RAT GO:0034138 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZPA7 10116 D3ZPA7_RAT GO:0034138 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6AZY7 9606 SCAR3_HUMAN GO:0034138 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25204797
NOT-qualified manual protein Q9VJN5 7227 WEK_DROME GO:0002218 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:16782008
NOT-qualified manual protein Q9XF04 3702 CLV3_ARATH GO:0002221 1 NOT-qualified manual annotation exists with evidence code ECO:0000270 from this reference: PMID:22923673

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0034138 based on ALL annotations
The top 100 of 613 co-occurring terms
Co-occurring Term PR S% #Together #Compared
toll-like receptor 3 signaling pathway
81,769.63 100.00 2,384 2,384
toll-like receptor 9 signaling pathway
59,361.90 34.92 959 1,321
toll-like receptor 2 signaling pathway
55,977.36 31.91 892 1,303
toll-like receptor 7 signaling pathway
38,286.53 28.45 1,002 2,140
Toll-like receptor binding
26,811.17 21.32 903 2,754
toll-like receptor signaling pathway
5,499.90 6.22 1,079 16,042
response to exogenous dsRNA
8,607.33 5.57 252 2,394
T cell antigen processing and presentation
40,709.34 4.64 116 233
positive regulation of interleukin-12 production
6,472.45 4.46 221 2,792
cellular response to exogenous dsRNA
6,613.98 4.18 190 2,349
Totals 18365 343088
No co-occurrence statistics for GO:0034138 based on MANUAL annotations
The top 100 of 496 co-occurring terms
Co-occurring Term PR S% #Together #Compared
toll-like receptor 3 signaling pathway
14,679.53 100.00 88 88
toll-like receptor 9 signaling pathway
7,489.56 22.32 25 49
toll-like receptor 7 signaling pathway
7,658.89 21.82 24 46
toll-like receptor 2 signaling pathway
5,382.50 17.46 22 60
Toll-like receptor binding
3,899.25 12.59 17 64
T cell antigen processing and presentation
6,459.00 10.78 11 25
CD40 signaling pathway
3,290.24 9.77 13 58
positive regulation of interleukin-12 production
1,423.02 7.17 19 196
negative regulation of T cell anergy
14,679.54 6.82 6 6
positive regulation of B cell activation
2,302.67 6.11 8 51
Totals 813 13120

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2022-07-26 Added DEFINITION The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3.
2022-07-26 Deleted DEFINITION The series of molecular signals initiated by a ligand binding to toll-like receptor 3.
2022-07-26 Deleted RELATION is a GO:0002224 (toll-like receptor signaling pathway)
2022-07-26 Added RELATION is a GO:0140894 (endolysosomal toll-like receptor signaling pathway)
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to toll-like receptor 3.
2022-03-14 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
Timestamp Action Category Detail
2008-01-07 Added TERM toll-like receptor 3 signaling pathway
Timestamp Action Category Detail
2022-07-26 Added DEFINITION The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3.
2022-07-26 Deleted DEFINITION The series of molecular signals initiated by a ligand binding to toll-like receptor 3.
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to toll-like receptor 3.
2022-03-14 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
2008-01-27 Added DEFINITION Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
2008-01-07 Added SYNONYM TLR3 signaling pathway
2008-01-07 Added SYNONYM toll-like receptor 3 signalling pathway
Timestamp Action Category Detail
2022-07-26 Deleted RELATION is a GO:0002224 (toll-like receptor signaling pathway)
2022-07-26 Added RELATION is a GO:0140894 (endolysosomal toll-like receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0002224 (toll-like receptor signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
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