Note that this term was reinstated from obsolete.
GO:0034335
JSON
DNA negative supercoiling activity
Molecular Function
Definition (GO:0034335 GONUTS page)
Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
Comments
Note that this term was reinstated from obsolete.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
DNA-gyrase activity | related |
DNA gyrase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | O67108 | 224324 | TOP4A_AQUAE | GO:0034335 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21076033 | |
NOT-qualified manual | protein | O67137 | 224324 | TOP4B_AQUAE | GO:0034335 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21076033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 5.6.2.2 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0034335 based on ALL annotations
The top 100 of 409 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA negative supercoiling activity
|
1,172.64 | 100.00 | 166,239 | 166,239 |
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
|
882.10 | 74.80 | 164,998 | 219,344 |
DNA topoisomerase activity
|
602.51 | 50.10 | 158,386 | 308,259 |
DNA topological change
|
568.21 | 48.38 | 165,670 | 341,901 |
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
|
962.30 | 40.24 | 73,345 | 89,377 |
chromosome organization
|
582.60 | 24.01 | 52,737 | 106,148 |
DNA-templated DNA replication
|
171.64 | 11.93 | 65,268 | 445,900 |
chromosome
|
134.09 | 10.53 | 94,773 | 828,779 |
extrinsic component of plasma membrane
|
546.99 | 6.29 | 11,265 | 24,150 |
chromosome segregation
|
67.02 | 4.23 | 23,205 | 406,033 |
Totals | 1524033 | 152543064 |
No co-occurrence statistics for GO:0034335 based on MANUAL annotations
The top 23 of 23 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA negative supercoiling activity
|
64,589.95 | 100.00 | 20 | 20 |
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
|
3,312.31 | 4.76 | 8 | 156 |
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
|
2,153.00 | 3.03 | 5 | 150 |
negative regulation of DNA-templated DNA replication
|
4,036.87 | 2.86 | 1 | 16 |
DNA topological change
|
458.90 | 0.69 | 4 | 563 |
chloroplast nucleoid
|
230.68 | 0.33 | 1 | 280 |
DNA-templated transcription
|
206.36 | 0.31 | 2 | 626 |
peptidoglycan-based cell wall
|
163.31 | 0.25 | 2 | 791 |
ATP-dependent activity, acting on DNA
|
116.48 | 0.18 | 2 | 1,109 |
response to xenobiotic stimulus
|
104.60 | 0.16 | 2 | 1,235 |
Totals | 77 | 601063 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:5.6.2.2 |
2019-08-30 | Added | DEFINITION | Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. |
2019-08-30 | Added | SYNONYM | DNA gyrase activity |
2019-08-30 | Deleted | DEFINITION | Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. |
2019-08-30 | Added | SYNONYM | DNA-gyrase activity |
2019-08-30 | Deleted | SYNONYM | DNA-gyrase activity |
2019-08-30 | Deleted | SYNONYM | DNA gyrase activity |
2019-08-30 | Updated | TERM | DNA negative supercoiling activity |
2015-12-20 | Deleted | OBSOLETION | consider GO:0032392 (DNA geometric change) |
2015-12-20 | Updated | TERM | DNA supercoiling activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-08-30 | Updated | TERM | DNA negative supercoiling activity |
2015-12-20 | Updated | TERM | DNA supercoiling activity |
2015-06-18 | Updated | TERM | obsolete DNA supercoiling activity |
2010-06-08 | Updated | TERM | DNA supercoiling activity |
2008-03-20 | Added | TERM | DNA supercoiling activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-08-30 | Added | DEFINITION | Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. |
2019-08-30 | Added | SYNONYM | DNA gyrase activity |
2019-08-30 | Deleted | DEFINITION | Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. |
2019-08-30 | Added | SYNONYM | DNA-gyrase activity |
2019-08-30 | Deleted | SYNONYM | DNA-gyrase activity |
2019-08-30 | Deleted | SYNONYM | DNA gyrase activity |
2015-12-20 | Added | SYNONYM | DNA-gyrase activity |
2015-12-20 | Added | SYNONYM | DNA gyrase activity |
2015-12-20 | Deleted | SYNONYM | DNA supercoiling activity |
2015-12-20 | Deleted | DEFINITION | OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2015-12-20 | Added | DEFINITION | Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. |
2015-06-18 | Added | SYNONYM | DNA supercoiling activity |
2008-05-16 | Deleted | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-16 | Added | DEFINITION | OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-15 | Updated | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-15 | Added | DEFINITION | OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-15 | Deleted | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-14 | Updated | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-13 | Added | DEFINITION | OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-13 | Added | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-13 | Deleted | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
2008-04-27 | Added | DEFINITION | Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-12-20 | Added | RELATION | is a GO:0003918 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity) |
2010-06-08 | Deleted | RELATION | is a GO:0008369 (obsolete molecular function) |
2008-05-03 | Deleted | RELATION | is a GO:0016853 (isomerase activity) |
2008-05-03 | Added | RELATION | is a GO:0008369 (obsolete molecular function) |
2008-04-01 | Updated | RELATION | is a GO:0016853 (isomerase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:5.6.2.2 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-12-20 | Deleted | OBSOLETION | consider GO:0032392 (DNA geometric change) |
2015-12-20 | Deleted | OBSOLETION | consider GO:0015616 (DNA translocase activity) |
2008-06-03 | Added | OBSOLETION | consider GO:0015616 (DNA translocase activity) |
2008-06-03 | Added | OBSOLETION | consider GO:0032392 (DNA geometric change) |
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