This term is obsolete.
Note that this term was reinstated from obsolete.

GO:0034335 JSON

DNA negative supercoiling activity

Molecular Function

Definition (GO:0034335 GONUTS page)

Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

Comments

Note that this term was reinstated from obsolete.

166,534 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DNA gyrase activity related
DNA-gyrase activity related

Ancestor Chart

Ancestor chart for GO:0034335
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein O67108 224324 TOP4A_AQUAE GO:0034335 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21076033
NOT-qualified manual protein O67137 224324 TOP4B_AQUAE GO:0034335 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21076033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 5.6.2.2

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0034335 based on ALL annotations
The top 100 of 404 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA negative supercoiling activity
1,190.00 100.00 166,516 166,516
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
883.80 73.86 165,275 222,537
DNA topoisomerase activity
597.36 48.99 158,707 316,161
DNA topological change
569.23 47.76 165,941 346,909
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
968.50 40.23 73,784 90,659
chromosome organization
578.75 23.68 52,582 108,117
DNA-templated DNA replication
171.80 11.81 65,580 454,259
chromosome
136.13 10.53 94,867 829,301
extrinsic component of plasma membrane
537.33 6.17 11,110 24,605
chromosome segregation
63.11 3.98 22,917 432,091
Totals 1517388 166188454
No co-occurrence statistics for GO:0034335 based on MANUAL annotations
The top 23 of 23 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA negative supercoiling activity
70,576.65 100.00 20 20
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
3,506.91 4.62 8 161
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
2,219.39 2.87 5 159
negative regulation of DNA-templated DNA replication
4,411.04 2.86 1 16
DNA topological change
467.40 0.65 4 604
DNA-templated transcription
232.16 0.32 2 608
chloroplast nucleoid
232.93 0.31 1 303
peptidoglycan-based cell wall
173.83 0.24 2 812
ATP-dependent activity, acting on DNA
120.64 0.17 2 1,170
response to xenobiotic stimulus
114.29 0.16 2 1,235
Totals 77 650504

Change Log

Timestamp Action Category Detail
2024-08-16 Added XREF EC:5.6.2.2
2019-08-30 Added DEFINITION Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
2019-08-30 Deleted SYNONYM DNA gyrase activity
2019-08-30 Deleted SYNONYM DNA-gyrase activity
2019-08-30 Added SYNONYM DNA-gyrase activity
2019-08-30 Added SYNONYM DNA gyrase activity
2019-08-30 Updated TERM DNA negative supercoiling activity
2019-08-30 Deleted DEFINITION Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
2015-12-20 Added RELATION is a GO:0003918 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity)
2015-12-20 Added DEFINITION Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
Timestamp Action Category Detail
2019-08-30 Updated TERM DNA negative supercoiling activity
2015-12-20 Updated TERM DNA supercoiling activity
2015-06-18 Updated TERM obsolete DNA supercoiling activity
2010-06-08 Updated TERM DNA supercoiling activity
2008-03-20 Added TERM DNA supercoiling activity
Timestamp Action Category Detail
2019-08-30 Added DEFINITION Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
2019-08-30 Deleted SYNONYM DNA gyrase activity
2019-08-30 Deleted SYNONYM DNA-gyrase activity
2019-08-30 Added SYNONYM DNA-gyrase activity
2019-08-30 Added SYNONYM DNA gyrase activity
2019-08-30 Deleted DEFINITION Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
2015-12-20 Added DEFINITION Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
2015-12-20 Deleted DEFINITION OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2015-12-20 Added SYNONYM DNA-gyrase activity
2015-12-20 Added SYNONYM DNA gyrase activity
2015-12-20 Deleted SYNONYM DNA supercoiling activity
2015-06-18 Added SYNONYM DNA supercoiling activity
2008-05-16 Added DEFINITION OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-16 Deleted DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-15 Added DEFINITION OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-15 Updated DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-15 Deleted DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-14 Updated DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-13 Added DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-13 Deleted DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-13 Added DEFINITION OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-05-12 Deleted DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
2008-04-27 Added DEFINITION Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule.
Timestamp Action Category Detail
2015-12-20 Added RELATION is a GO:0003918 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity)
2010-06-08 Deleted RELATION is a GO:0008369 (obsolete molecular function)
2008-05-03 Deleted RELATION is a GO:0016853 (isomerase activity)
2008-05-03 Added RELATION is a GO:0008369 (obsolete molecular function)
2008-04-01 Updated RELATION is a GO:0016853 (isomerase activity)
Timestamp Action Category Detail
2024-08-16 Added XREF EC:5.6.2.2
Timestamp Action Category Detail
2015-12-20 Deleted OBSOLETION consider GO:0032392 (DNA geometric change)
2015-12-20 Deleted OBSOLETION consider GO:0015616 (DNA translocase activity)
2008-06-03 Added OBSOLETION consider GO:0032392 (DNA geometric change)
2008-06-03 Added OBSOLETION consider GO:0015616 (DNA translocase activity)
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