GO:0034602
JSON
oxoglutarate dehydrogenase (NAD+) activity
Molecular Function
Definition (GO:0034602 GONUTS page)
Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.
Ancestor Chart
Ancestor chart for GO:0034602
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0034602
| Child Term | Relationship to GO:0034602 |
|---|---|
|
oxoglutarate dehydrogenase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
| IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
| IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
| IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
| IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
| IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
| NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
| NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
| Database | ID | Description |
|---|---|---|
| EC | 1.2.1.105 | |
| KEGG_REACTION | R08549 | |
| MetaCyc | 2OXOGLUTARATEDEH-RXN | |
| RHEA | 27786 |
Cross-Ontology Relations
| Relation | Other Ontology | ID | Term |
|---|---|---|---|
| has_participant | CHEBI | CHEBI:16526 | carbon dioxide |
| has_participant | CHEBI | CHEBI:57292 | succinyl-CoA(5-) |
| has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
| has_participant | CHEBI | CHEBI:16810 | 2-oxoglutarate(2-) |
| has_participant | CHEBI | CHEBI:57287 | coenzyme A(4-) |
| has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0034602 based on ALL annotations
The top 46 of 46 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
oxoglutarate dehydrogenase (NAD+) activity
|
2,201,720.80 | 100.00 | 90 | 90 |
|
olfactory bulb mitral cell layer development
|
1,069,407.10 | 47.22 | 85 | 175 |
|
tangential migration from the subventricular zone to the olfactory bulb
|
508,549.62 | 22.79 | 85 | 368 |
|
cerebellar cortex development
|
353,106.16 | 15.89 | 85 | 530 |
|
pyramidal neuron development
|
346,567.16 | 15.60 | 85 | 540 |
|
striatum development
|
195,147.30 | 8.82 | 85 | 959 |
|
thalamus development
|
157,796.17 | 7.14 | 85 | 1,186 |
|
hippocampus development
|
46,939.59 | 2.12 | 74 | 3,471 |
|
oxoadipate dehydrogenase complex
|
15,080.28 | 0.53 | 2 | 292 |
|
intracellular amino acid homeostasis
|
9,917.66 | 0.32 | 1 | 222 |
| Totals | 1685 | 85305911 | ||
No co-occurrence statistics for GO:0034602 based on MANUAL annotations
The top 35 of 35 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
oxoglutarate dehydrogenase (NAD+) activity
|
201,647.58 | 100.00 | 7 | 7 |
|
olfactory bulb mitral cell layer development
|
50,411.90 | 15.38 | 2 | 8 |
|
oxoadipate dehydrogenase complex
|
44,810.57 | 14.29 | 2 | 9 |
|
tangential migration from the subventricular zone to the olfactory bulb
|
31,022.70 | 11.11 | 2 | 13 |
|
cerebellar cortex development
|
12,221.07 | 5.26 | 2 | 33 |
|
pyramidal neuron development
|
9,378.96 | 4.17 | 2 | 43 |
|
branched-chain alpha-keto acid dehydrogenase activity
|
11,202.64 | 4.17 | 1 | 18 |
|
intracellular amino acid homeostasis
|
8,401.98 | 3.33 | 1 | 24 |
|
branched-chain alpha-ketoacid dehydrogenase complex
|
8,401.98 | 3.33 | 1 | 24 |
|
striatum development
|
7,201.70 | 3.28 | 2 | 56 |
| Totals | 75 | 276735 | ||
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-11-06 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-11-06 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-11-05 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-11-05 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-11-03 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-11-03 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-11-02 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-11-02 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-11-01 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-11-01 | Deleted | XREF | Reactome:R-HSA-71037 |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-07-18 | Added | TERM | oxoglutarate dehydrogenase (NAD+) activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-07-18 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2019-07-13 | Deleted | RELATION | is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor) |
| 2019-07-13 | Added | RELATION | is a GO:0034601 (oxoglutarate dehydrogenase [NAD(P)+] activity) |
| 2011-04-18 | Added | RELATION | is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor) |
| 2011-04-18 | Deleted | RELATION | is a GO:0034601 (oxoglutarate dehydrogenase [NAD(P)+] activity) |
| 2008-07-18 | Added | RELATION | is a GO:0034601 (oxoglutarate dehydrogenase [NAD(P)+] activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-11-06 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-11-06 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-11-05 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-11-05 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-11-03 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-11-03 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-11-02 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-11-02 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-11-01 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-11-01 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-10-26 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-10-26 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-10-09 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-10-09 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-10-08 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-10-08 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-09-21 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-09-21 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-09-20 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-09-20 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-09-19 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-09-19 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-09-13 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-09-13 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-09-10 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-09-10 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-09-08 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-09-08 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-09-07 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-09-07 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-09-06 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-09-06 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-09-05 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-09-05 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-09-02 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-09-02 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-08-20 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-08-20 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-08-16 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-08-16 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-08-15 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-08-15 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-08-08 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-08-08 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-08-08 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-08-08 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-08-06 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-08-06 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-08-05 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-08-05 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-07-28 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-07-28 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-07-27 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-07-27 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-07-26 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-07-26 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-07-25 | Deleted | XREF | Reactome:R-HSA-71401 |
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| 2024-07-14 | Deleted | XREF | Reactome:R-HSA-71037 |
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| 2024-06-30 | Added | XREF | Reactome:R-HSA-71037 |
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| 2024-06-29 | Deleted | XREF | Reactome:R-HSA-71401 |
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| 2024-06-28 | Added | XREF | Reactome:R-HSA-71401 |
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| 2024-06-27 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-06-27 | Deleted | XREF | Reactome:R-HSA-71401 |
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| 2024-06-20 | Added | XREF | Reactome:R-HSA-71037 |
| 2024-06-19 | Deleted | XREF | Reactome:R-HSA-71037 |
| 2024-06-19 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-06-14 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-06-13 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-06-12 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-06-11 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-06-07 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-06-01 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-05-31 | Added | XREF | Reactome:R-HSA-71401 |
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| 2024-05-29 | Added | XREF | Reactome:R-HSA-71401 |
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| 2024-05-24 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-05-23 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-05-22 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-05-16 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-05-15 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-05-14 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-05-11 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-05-09 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-05-09 | Deleted | XREF | Reactome:R-HSA-71401 |
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| 2024-05-01 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-04-25 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-04-24 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-04-21 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-04-19 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-04-18 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-04-14 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-04-13 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-04-12 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-04-11 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-04-09 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2024-04-07 | Added | XREF | Reactome:R-HSA-71401 |
| 2024-04-06 | Deleted | XREF | Reactome:R-HSA-71401 |
| 2021-04-20 | Deleted | XREF | EC:1.2.1.- |
| 2021-04-20 | Added | XREF | EC:1.2.1.105 |
| 2021-01-04 | Added | XREF | EC:1.2.1.- |
| 2021-01-04 | Deleted | XREF | EC:1.2.1 |
| 2020-06-22 | Added | XREF | RHEA:27786 |
| 2019-06-20 | Added | XREF | KEGG_REACTION:R08549 |
| 2019-06-20 | Deleted | XREF | KEGG:R08549 |
| 2019-04-01 | Deleted | XREF | reactome:R-HSA-71037 |
| 2019-04-01 | Deleted | XREF | reactome:R-HSA-71401 |
| 2019-04-01 | Added | XREF | Reactome:R-HSA-71037 |
| 2019-04-01 | Added | XREF | Reactome:R-HSA-71401 |
| 2018-12-11 | Added | XREF | reactome:R-HSA-71401 |
| 2018-12-11 | Added | XREF | reactome:R-HSA-71037 |
| 2016-10-03 | Deleted | XREF | EC:1.2.1.- |
| 2016-10-03 | Added | XREF | EC:1.2.1 |
| 2010-10-08 | Added | XREF | KEGG:R08549 |
| 2010-10-08 | Added | XREF | EC:1.2.1.- |
| 2010-10-08 | Added | XREF | MetaCyc:2OXOGLUTARATEDEH-RXN |
| 2010-10-08 | Deleted | XREF | MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN |
| 2010-10-08 | Deleted | XREF | EC:1.2.1.52 |
| 2009-05-21 | Deleted | XREF | MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN |
| 2009-05-21 | Added | XREF | MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN |
| 2008-07-18 | Added | XREF | MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN |
| 2008-07-18 | Added | XREF | EC:1.2.1.52 |
| Timestamp | Action | Category | Detail |
|---|
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