This term is obsolete.

GO:0034979 JSON

NAD-dependent protein lysine deacetylase activity

Molecular Function

Definition (GO:0034979 GONUTS page)

Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide.

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

190,250 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protein lysine deacetylase broad
NAD(+)-dependent protein deacetylase exact
protein lysine deacylase broad
NAD-dependent protein deacetylase activity broad
protein acetyllysine N-acetyltransferase broad
NAD(+)-dependent protein deacylase broad

Ancestor Chart

Ancestor chart for GO:0034979
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0034979

Child Term Relationship to
GO:0034979
NAD-dependent protein lysine delactylase activity
is_a
histone deacetylase activity, NAD-dependent
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2K6D8 10116 A0A0G2K6D8_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J1T8 10116 A6J1T8_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B2RZ30 10116 B2RZ30_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein G3V641 10116 G3V641_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 2.3.1.286
InterPro IPR026587 Sirtuin, class II
InterPro IPR028628 Sirtuin, class U
RHEA 43636
RHEA 54172
Reactome R-HSA-3371467
Reactome R-HSA-5211239
Reactome R-HSA-5685953
Reactome R-HSA-5688289
Reactome R-HSA-5688294

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:83767 2''-O-acetyl-ADP-D-ribose(2-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:17154 nicotinamide
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:61930 N(6)-acetyl-L-lysine residue
has_participant CHEBI CHEBI:138087 O-acyl-ADP-D-ribose(2-)
has_participant CHEBI CHEBI:29969 L-lysinium residue
has_participant CHEBI CHEBI:137967 N(6)-acyl-L-lysine residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0034979 based on ALL annotations
The top 100 of 595 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD-dependent protein lysine deacetylase activity
7,991.59 100.00 24,393 24,393
histone H3K56 deacetylase activity, NAD-dependent
7,455.50 63.39 16,202 17,367
histone H3K14 deacetylase activity, NAD-dependent
7,465.24 63.38 16,183 17,324
histone H3K4 deacetylase activity, NAD-dependent
7,463.08 63.10 16,112 17,253
histone H3K18 deacetylase activity, NAD-dependent
6,998.39 60.98 16,284 18,595
histone H4K16 deacetylase activity, NAD-dependent
6,913.05 60.32 16,242 18,776
histone H3K9 deacetylase activity, NAD-dependent
6,823.40 59.87 16,273 19,059
protein-succinyllysine desuccinylase activity
7,297.19 54.14 13,924 15,249
protein-malonyllysine demalonylase activity
7,293.67 53.84 13,847 15,172
histone deacetylase activity, NAD-dependent
3,363.02 41.79 23,988 57,003
Totals 253605 12882805
No co-occurrence statistics for GO:0034979 based on MANUAL annotations
The top 100 of 394 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD-dependent protein lysine deacetylase activity
30,041.84 100.00 43 43
protein deacetylation
16,308.43 32.20 19 35
NAD-dependent protein demyristoylase activity
30,041.84 30.23 13 13
NAD-dependent protein depalmitoylase activity
30,041.84 30.23 13 13
peptidyl-lysine deacetylation
21,458.46 21.28 10 14
histone H3K18 deacetylase activity, NAD-dependent
12,239.27 18.64 11 27
histone H3K9 deacetylase activity, NAD-dependent
11,395.18 18.03 11 29
negative regulation of peptidyl-lysine acetylation
13,061.67 17.86 10 23
protein lysine deacetylase activity
6,486.31 16.96 19 88
NAD-dependent protein-lysine depropionylase activity
30,041.84 16.28 7 7
Totals 646 4623

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9854463
2024-11-05 Deleted XREF Reactome:R-HSA-9854463
2024-11-03 Added XREF Reactome:R-HSA-9854463
2024-11-02 Deleted XREF Reactome:R-HSA-9854463
2024-11-01 Added XREF Reactome:R-HSA-9854463
2024-10-26 Deleted XREF Reactome:R-HSA-9854463
2024-10-09 Added XREF Reactome:R-HSA-9854463
2024-10-08 Deleted XREF Reactome:R-HSA-9854463
2024-09-21 Deleted RELATION is a GO:0033558 (protein lysine deacetylase activity)
2024-09-21 Added RELATION is a GO:0141218 (NAD-dependent protein lysine deacylase activity)
Timestamp Action Category Detail
2024-04-09 Updated TERM NAD-dependent protein lysine deacetylase activity
2008-10-02 Added TERM NAD-dependent protein deacetylase activity
Timestamp Action Category Detail
2024-09-21 Added DEFINITION Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide.
2024-09-21 Deleted DEFINITION Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide.
2024-09-21 Added SYNONYM NAD(+)-dependent protein deacetylase
2024-09-21 Added SYNONYM NAD(+)-dependent protein deacylase
2024-09-21 Deleted SYNONYM NAD(+)-dependent protein deacetylase
2024-09-21 Added SYNONYM protein lysine deacylase
2024-04-09 Added SYNONYM protein lysine deacetylase
2024-04-09 Added SYNONYM NAD(+)-dependent protein deacetylase
2024-04-09 Added SYNONYM protein acetyllysine N-acetyltransferase
2024-04-09 Added SYNONYM NAD-dependent protein deacetylase activity
2024-04-09 Deleted DEFINITION Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
2024-04-09 Added DEFINITION Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide.
2008-10-02 Added DEFINITION Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
Timestamp Action Category Detail
2024-09-21 Deleted RELATION is a GO:0033558 (protein lysine deacetylase activity)
2024-09-21 Added RELATION is a GO:0141218 (NAD-dependent protein lysine deacylase activity)
2024-09-20 Added RELATION is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
2008-10-02 Added RELATION is a GO:0033558 (protein lysine deacetylase activity)
Timestamp Action Category Detail
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Timestamp Action Category Detail
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