GO:0034979
JSON
NAD-dependent protein lysine deacetylase activity
Molecular Function
Definition (GO:0034979 GONUTS page)
Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide.
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
protein lysine deacetylase | broad |
NAD(+)-dependent protein deacetylase | exact |
protein lysine deacylase | broad |
NAD-dependent protein deacetylase activity | broad |
protein acetyllysine N-acetyltransferase | broad |
NAD(+)-dependent protein deacylase | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0034979
Child Term | Relationship to GO:0034979 |
---|---|
NAD-dependent protein lysine delactylase activity
|
is_a |
histone deacetylase activity, NAD-dependent
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0G2K6D8 | 10116 | A0A0G2K6D8_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J1T8 | 10116 | A6J1T8_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B2RZ30 | 10116 | B2RZ30_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | G3V641 | 10116 | G3V641_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.1.286 | |
InterPro | IPR026587 | Sirtuin, class II |
InterPro | IPR028628 | Sirtuin, class U |
RHEA | 43636 | |
RHEA | 54172 | |
Reactome | R-HSA-3371467 | |
Reactome | R-HSA-5211239 | |
Reactome | R-HSA-5685953 | |
Reactome | R-HSA-5688289 | |
Reactome | R-HSA-5688294 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:83767 | 2''-O-acetyl-ADP-D-ribose(2-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:17154 | nicotinamide |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:61930 | N(6)-acetyl-L-lysine residue |
has_participant | CHEBI | CHEBI:138087 | O-acyl-ADP-D-ribose(2-) |
has_participant | CHEBI | CHEBI:29969 | L-lysinium residue |
has_participant | CHEBI | CHEBI:137967 | N(6)-acyl-L-lysine residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0034979 based on ALL annotations
The top 100 of 595 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD-dependent protein lysine deacetylase activity
|
7,991.59 | 100.00 | 24,393 | 24,393 |
histone H3K56 deacetylase activity, NAD-dependent
|
7,455.50 | 63.39 | 16,202 | 17,367 |
histone H3K14 deacetylase activity, NAD-dependent
|
7,465.24 | 63.38 | 16,183 | 17,324 |
histone H3K4 deacetylase activity, NAD-dependent
|
7,463.08 | 63.10 | 16,112 | 17,253 |
histone H3K18 deacetylase activity, NAD-dependent
|
6,998.39 | 60.98 | 16,284 | 18,595 |
histone H4K16 deacetylase activity, NAD-dependent
|
6,913.05 | 60.32 | 16,242 | 18,776 |
histone H3K9 deacetylase activity, NAD-dependent
|
6,823.40 | 59.87 | 16,273 | 19,059 |
protein-succinyllysine desuccinylase activity
|
7,297.19 | 54.14 | 13,924 | 15,249 |
protein-malonyllysine demalonylase activity
|
7,293.67 | 53.84 | 13,847 | 15,172 |
histone deacetylase activity, NAD-dependent
|
3,363.02 | 41.79 | 23,988 | 57,003 |
Totals | 253605 | 12882805 |
No co-occurrence statistics for GO:0034979 based on MANUAL annotations
The top 100 of 394 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD-dependent protein lysine deacetylase activity
|
30,041.84 | 100.00 | 43 | 43 |
protein deacetylation
|
16,308.43 | 32.20 | 19 | 35 |
NAD-dependent protein demyristoylase activity
|
30,041.84 | 30.23 | 13 | 13 |
NAD-dependent protein depalmitoylase activity
|
30,041.84 | 30.23 | 13 | 13 |
peptidyl-lysine deacetylation
|
21,458.46 | 21.28 | 10 | 14 |
histone H3K18 deacetylase activity, NAD-dependent
|
12,239.27 | 18.64 | 11 | 27 |
histone H3K9 deacetylase activity, NAD-dependent
|
11,395.18 | 18.03 | 11 | 29 |
negative regulation of peptidyl-lysine acetylation
|
13,061.67 | 17.86 | 10 | 23 |
protein lysine deacetylase activity
|
6,486.31 | 16.96 | 19 | 88 |
NAD-dependent protein-lysine depropionylase activity
|
30,041.84 | 16.28 | 7 | 7 |
Totals | 646 | 4623 |
Change Log
- All changes
- All changes
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9854463 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9854463 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9854463 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9854463 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-09-21 | Deleted | RELATION | is a GO:0033558 (protein lysine deacetylase activity) |
2024-09-21 | Added | RELATION | is a GO:0141218 (NAD-dependent protein lysine deacylase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-04-09 | Updated | TERM | NAD-dependent protein lysine deacetylase activity |
2008-10-02 | Added | TERM | NAD-dependent protein deacetylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-21 | Added | DEFINITION | Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide. |
2024-09-21 | Deleted | DEFINITION | Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. |
2024-09-21 | Added | SYNONYM | NAD(+)-dependent protein deacetylase |
2024-09-21 | Added | SYNONYM | NAD(+)-dependent protein deacylase |
2024-09-21 | Deleted | SYNONYM | NAD(+)-dependent protein deacetylase |
2024-09-21 | Added | SYNONYM | protein lysine deacylase |
2024-04-09 | Added | SYNONYM | protein lysine deacetylase |
2024-04-09 | Added | SYNONYM | NAD(+)-dependent protein deacetylase |
2024-04-09 | Added | SYNONYM | protein acetyllysine N-acetyltransferase |
2024-04-09 | Added | SYNONYM | NAD-dependent protein deacetylase activity |
2024-04-09 | Deleted | DEFINITION | Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. |
2024-04-09 | Added | DEFINITION | Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. |
2008-10-02 | Added | DEFINITION | Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-21 | Deleted | RELATION | is a GO:0033558 (protein lysine deacetylase activity) |
2024-09-21 | Added | RELATION | is a GO:0141218 (NAD-dependent protein lysine deacylase activity) |
2024-09-20 | Added | RELATION | is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups) |
2008-10-02 | Added | RELATION | is a GO:0033558 (protein lysine deacetylase activity) |
Timestamp | Action | Category | Detail |
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2024-11-06 | Added | XREF | Reactome:R-HSA-9854463 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9854463 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9854463 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9854463 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-09-21 | Added | XREF | EC:2.3.1.286 |
2024-09-21 | Added | XREF | RHEA:54172 |
2024-09-21 | Added | XREF | Reactome:R-HSA-9854463 |
2024-09-20 | Deleted | XREF | EC:2.3.1.286 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-09-19 | Added | XREF | Reactome:R-HSA-9854463 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-09-10 | Added | XREF | Reactome:R-HSA-9854463 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-09-07 | Added | XREF | Reactome:R-HSA-9854463 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-09-05 | Added | XREF | Reactome:R-HSA-9854463 |
2024-09-02 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-08-20 | Added | XREF | Reactome:R-HSA-9854463 |
2024-08-16 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-08-15 | Added | XREF | Reactome:R-HSA-9854463 |
2024-08-08 | Added | XREF | Reactome:R-HSA-9854463 |
2024-08-08 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-08-05 | Added | XREF | Reactome:R-HSA-9854463 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-07-27 | Added | XREF | Reactome:R-HSA-9854463 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-07-25 | Added | XREF | Reactome:R-HSA-9854463 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-07-19 | Added | XREF | Reactome:R-HSA-9854463 |
2024-07-18 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-07-14 | Added | XREF | Reactome:R-HSA-9854463 |
2024-07-11 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-07-10 | Added | XREF | Reactome:R-HSA-9854463 |
2024-07-09 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-07-06 | Added | XREF | Reactome:R-HSA-9854463 |
2024-07-04 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-07-03 | Added | XREF | Reactome:R-HSA-9854463 |
2024-06-30 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-06-29 | Added | XREF | Reactome:R-HSA-9854463 |
2024-06-28 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-06-27 | Added | XREF | Reactome:R-HSA-9854463 |
2024-06-26 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-06-23 | Added | XREF | Reactome:R-HSA-9854463 |
2024-06-20 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-06-19 | Added | XREF | Reactome:R-HSA-9854463 |
2024-06-14 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-06-13 | Added | XREF | Reactome:R-HSA-9854463 |
2024-06-12 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-06-11 | Added | XREF | Reactome:R-HSA-9854463 |
2024-06-07 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-06-01 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-31 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-30 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-29 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-25 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-24 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-23 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-22 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-16 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-15 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-14 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-11 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-09 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-09 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-08 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-05 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-03 | Added | XREF | Reactome:R-HSA-9854463 |
2024-05-02 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-05-01 | Added | XREF | Reactome:R-HSA-9854463 |
2024-04-25 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-04-24 | Added | XREF | Reactome:R-HSA-9854463 |
2024-04-21 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-04-19 | Added | XREF | Reactome:R-HSA-9854463 |
2024-04-18 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-04-14 | Added | XREF | Reactome:R-HSA-9854463 |
2024-04-13 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-04-12 | Added | XREF | Reactome:R-HSA-9854463 |
2024-04-11 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-04-09 | Added | XREF | Reactome:R-HSA-9854463 |
2024-04-09 | Added | XREF | RHEA:43636 |
2024-04-09 | Added | XREF | EC:2.3.1.286 |
2024-04-07 | Deleted | XREF | Reactome:R-HSA-9854463 |
2024-04-06 | Added | XREF | Reactome:R-HSA-9854463 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9667952 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3371467 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5688294 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5688294 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5211239 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3371467 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5688289 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9620532 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9620532 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5685953 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5685953 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5211239 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5688289 |
2019-02-09 | Added | XREF | reactome:R-HSA-9620532 |
2019-01-29 | Deleted | XREF | reactome:R-HSA-9620532 |
2019-01-26 | Added | XREF | reactome:R-HSA-9620532 |
2018-12-11 | Added | XREF | reactome:R-HSA-5211239 |
2018-12-11 | Added | XREF | reactome:R-HSA-5685953 |
2018-12-11 | Added | XREF | reactome:R-HSA-5688289 |
2018-12-11 | Added | XREF | reactome:R-HSA-5688294 |
2018-12-11 | Added | XREF | reactome:R-HSA-3371467 |
Timestamp | Action | Category | Detail |
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