See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
GO:0035014
JSON
phosphatidylinositol 3-kinase regulator activity
Molecular Function
Definition (GO:0035014 GONUTS page)
Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. PMID:9255069
Comments
See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
phosphoinositide 3-kinase regulator activity | exact |
PI3K regulator activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0035014
Child Term | Relationship to GO:0035014 |
---|---|
phosphatidylinositol 3-kinase inhibitor activity
|
is_a |
phosphatidylinositol 3-kinase activator activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001720 | PI3K p85/p55 subunit |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0043551 | obsolete regulation of phosphatidylinositol 3-kinase activity | consider GO:0035014 |
GO:0061903 | obsolete positive regulation of 1-phosphatidylinositol-3-kinase activity | consider GO:0035014 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035014 based on ALL annotations
The top 100 of 397 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphatidylinositol 3-kinase regulator activity
|
39,832.20 | 100.00 | 4,894 | 4,894 |
phosphatidylinositol 3-kinase inhibitor activity
|
35,424.61 | 41.87 | 2,162 | 2,431 |
extrinsic component of phagophore assembly site membrane
|
37,574.08 | 28.73 | 1,431 | 1,517 |
extrinsic component of omegasome membrane
|
37,061.04 | 28.61 | 1,431 | 1,538 |
phosphatidylinositol 3-kinase complex, class III
|
30,094.97 | 26.71 | 1,431 | 1,894 |
autophagosome membrane docking
|
28,884.40 | 26.31 | 1,430 | 1,972 |
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
|
6,484.62 | 13.14 | 1,985 | 12,193 |
early endosome to late endosome transport
|
5,673.07 | 12.07 | 2,162 | 15,180 |
aggrephagy
|
3,578.89 | 7.29 | 1,364 | 15,181 |
protein-membrane adaptor activity
|
1,549.67 | 3.56 | 1,431 | 36,782 |
Totals | 42216 | 3982275 |
No co-occurrence statistics for GO:0035014 based on MANUAL annotations
The top 100 of 316 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphatidylinositol 3-kinase regulator activity
|
14,353.32 | 100.00 | 90 | 90 |
extrinsic component of phagophore assembly site membrane
|
13,396.44 | 30.43 | 28 | 30 |
extrinsic component of omegasome membrane
|
12,964.29 | 30.11 | 28 | 31 |
autophagosome membrane docking
|
7,880.26 | 24.78 | 28 | 51 |
phosphatidylinositol 3-kinase complex, class III
|
7,728.71 | 24.56 | 28 | 52 |
early endosome to late endosome transport
|
1,990.61 | 11.66 | 38 | 274 |
phosphatidylinositol 3-kinase inhibitor activity
|
4,784.44 | 9.82 | 11 | 33 |
ErbB-3 class receptor binding
|
3,987.03 | 4.85 | 5 | 18 |
positive regulation of endoplasmic reticulum unfolded protein response
|
2,760.25 | 4.50 | 5 | 26 |
early endosome membrane
|
610.06 | 4.00 | 36 | 847 |
Totals | 681 | 21577 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-05-20 | Deleted | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2023-05-20 | Added | DEFINITION | Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2023-05-16 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
2022-09-16 | Deleted | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
2012-01-15 | Added | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
2011-01-30 | Updated | TERM | phosphatidylinositol 3-kinase regulator activity |
2011-01-30 | Added | SYNONYM | phosphoinositide 3-kinase regulator activity |
2011-01-30 | Deleted | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2011-01-30 | Added | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2010-06-15 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-01-30 | Updated | TERM | phosphatidylinositol 3-kinase regulator activity |
2003-09-11 | Added | TERM | phosphoinositide 3-kinase regulator activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-05-20 | Deleted | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2023-05-20 | Added | DEFINITION | Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2011-01-30 | Added | SYNONYM | phosphoinositide 3-kinase regulator activity |
2011-01-30 | Deleted | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2011-01-30 | Added | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2008-05-13 | Added | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2008-05-12 | Deleted | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2007-08-09 | Added | SYNONYM | PI3K regulator activity |
2007-08-09 | Deleted | SYNONYM | PI3K regulator activity |
2005-12-09 | Added | SYNONYM | PI3K regulator activity |
2004-07-22 | Updated | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2004-01-08 | Updated | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
2003-09-11 | Added | DEFINITION | Modulates the rate or extent of activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-05-16 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
2022-09-16 | Deleted | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
2012-01-15 | Added | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
2010-06-15 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
2010-06-14 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
2010-06-08 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
2009-02-25 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
2009-02-22 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0019207 (kinase regulator activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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