See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
GO:0035014
JSON
phosphatidylinositol 3-kinase regulator activity
Molecular Function
Definition (GO:0035014 GONUTS page)
Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. PMID:9255069
Comments
See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| phosphoinositide 3-kinase regulator activity | exact |
| PI3K regulator activity | exact |
Ancestor Chart
Ancestor chart for GO:0035014
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0035014
| Child Term | Relationship to GO:0035014 |
|---|---|
|
phosphatidylinositol 3-kinase inhibitor activity
|
is_a |
|
phosphatidylinositol 3-kinase activator activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Cross-references
| Database | ID | Description |
|---|---|---|
| InterPro | IPR001720 | PI3K p85/p55 subunit |
Replaces
This term can be used instead of these obsolete terms:
| GO Identifier | GO Term Name | Reason |
|---|---|---|
| GO:0043551 | obsolete regulation of phosphatidylinositol 3-kinase activity | consider GO:0035014 |
| GO:0061903 | obsolete positive regulation of 1-phosphatidylinositol-3-kinase activity | consider GO:0035014 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035014 based on ALL annotations
The top 100 of 403 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
phosphatidylinositol 3-kinase regulator activity
|
38,801.68 | 100.00 | 5,131 | 5,131 |
|
phosphatidylinositol 3-kinase inhibitor activity
|
34,825.97 | 41.94 | 2,260 | 2,518 |
|
extrinsic component of phagophore assembly site membrane
|
36,762.07 | 28.69 | 1,496 | 1,579 |
|
extrinsic component of omegasome membrane
|
36,279.57 | 28.58 | 1,496 | 1,600 |
|
phosphatidylinositol 3-kinase complex, class III
|
29,661.38 | 26.75 | 1,496 | 1,957 |
|
autophagosome membrane docking
|
28,491.41 | 26.36 | 1,495 | 2,036 |
|
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
|
6,436.05 | 13.35 | 2,083 | 12,558 |
|
early endosome to late endosome transport
|
5,629.21 | 12.25 | 2,260 | 15,578 |
|
aggrephagy
|
3,516.45 | 7.34 | 1,427 | 15,746 |
|
autophagosome
|
1,464.99 | 3.61 | 2,282 | 60,441 |
| Totals | 43408 | 3133533 | ||
No co-occurrence statistics for GO:0035014 based on MANUAL annotations
The top 100 of 315 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
phosphatidylinositol 3-kinase regulator activity
|
14,250.62 | 100.00 | 99 | 99 |
|
extrinsic component of phagophore assembly site membrane
|
13,412.35 | 31.68 | 32 | 34 |
|
extrinsic component of omegasome membrane
|
13,029.14 | 31.37 | 32 | 35 |
|
autophagosome membrane docking
|
8,291.27 | 26.23 | 32 | 55 |
|
phosphatidylinositol 3-kinase complex, class III
|
8,143.21 | 26.02 | 32 | 56 |
|
early endosome to late endosome transport
|
2,028.73 | 11.85 | 41 | 288 |
|
phosphatidylinositol 3-kinase inhibitor activity
|
4,750.21 | 9.09 | 11 | 33 |
|
ErbB-3 class receptor binding
|
3,958.50 | 4.46 | 5 | 18 |
|
positive regulation of endoplasmic reticulum unfolded protein response
|
3,562.65 | 4.39 | 5 | 20 |
|
early endosome membrane
|
608.73 | 4.01 | 39 | 913 |
| Totals | 737 | 23050 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2023-05-20 | Deleted | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2023-05-20 | Added | DEFINITION | Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2023-05-16 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| 2022-09-16 | Deleted | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
| 2012-01-15 | Added | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
| 2011-01-30 | Updated | TERM | phosphatidylinositol 3-kinase regulator activity |
| 2011-01-30 | Added | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2011-01-30 | Added | SYNONYM | phosphoinositide 3-kinase regulator activity |
| 2011-01-30 | Deleted | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2010-06-15 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2011-01-30 | Updated | TERM | phosphatidylinositol 3-kinase regulator activity |
| 2003-09-11 | Added | TERM | phosphoinositide 3-kinase regulator activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2023-05-20 | Deleted | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2023-05-20 | Added | DEFINITION | Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2011-01-30 | Added | DEFINITION | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2011-01-30 | Added | SYNONYM | phosphoinositide 3-kinase regulator activity |
| 2011-01-30 | Deleted | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2008-05-13 | Added | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2008-05-12 | Deleted | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2007-08-09 | Deleted | SYNONYM | PI3K regulator activity |
| 2007-08-09 | Added | SYNONYM | PI3K regulator activity |
| 2005-12-09 | Added | SYNONYM | PI3K regulator activity |
| 2004-07-22 | Updated | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2004-01-08 | Updated | DEFINITION | Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| 2003-09-11 | Added | DEFINITION | Modulates the rate or extent of activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2023-05-16 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| 2022-09-16 | Deleted | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
| 2012-01-15 | Added | RELATION | part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity) |
| 2010-06-15 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| 2010-06-14 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| 2010-06-08 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| 2009-02-25 | Deleted | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| 2009-02-22 | Added | RELATION | regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity) |
| 2008-04-01 | Updated | RELATION | is a GO:0019207 (kinase regulator activity) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|
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