This term is obsolete.
See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.

GO:0035014 JSON

phosphatidylinositol 3-kinase regulator activity

Molecular Function

Definition (GO:0035014 GONUTS page)

Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. PMID:9255069

Comments

See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.

7,665 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
phosphoinositide 3-kinase regulator activity exact
PI3K regulator activity exact

Ancestor Chart

Ancestor chart for GO:0035014
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035014

Child Term Relationship to
GO:0035014
phosphatidylinositol 3-kinase inhibitor activity
is_a
phosphatidylinositol 3-kinase activator activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Cross-references

Database ID Description
InterPro IPR001720 PI3K p85/p55 subunit

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0043551 obsolete regulation of phosphatidylinositol 3-kinase activity consider GO:0035014
GO:0061903 obsolete positive regulation of 1-phosphatidylinositol-3-kinase activity consider GO:0035014

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0035014 based on ALL annotations
The top 100 of 397 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphatidylinositol 3-kinase regulator activity
39,832.20 100.00 4,894 4,894
phosphatidylinositol 3-kinase inhibitor activity
35,424.61 41.87 2,162 2,431
extrinsic component of phagophore assembly site membrane
37,574.08 28.73 1,431 1,517
extrinsic component of omegasome membrane
37,061.04 28.61 1,431 1,538
phosphatidylinositol 3-kinase complex, class III
30,094.97 26.71 1,431 1,894
autophagosome membrane docking
28,884.40 26.31 1,430 1,972
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
6,484.62 13.14 1,985 12,193
early endosome to late endosome transport
5,673.07 12.07 2,162 15,180
aggrephagy
3,578.89 7.29 1,364 15,181
protein-membrane adaptor activity
1,549.67 3.56 1,431 36,782
Totals 42216 3982275
No co-occurrence statistics for GO:0035014 based on MANUAL annotations
The top 100 of 316 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphatidylinositol 3-kinase regulator activity
14,353.32 100.00 90 90
extrinsic component of phagophore assembly site membrane
13,396.44 30.43 28 30
extrinsic component of omegasome membrane
12,964.29 30.11 28 31
autophagosome membrane docking
7,880.26 24.78 28 51
phosphatidylinositol 3-kinase complex, class III
7,728.71 24.56 28 52
early endosome to late endosome transport
1,990.61 11.66 38 274
phosphatidylinositol 3-kinase inhibitor activity
4,784.44 9.82 11 33
ErbB-3 class receptor binding
3,987.03 4.85 5 18
positive regulation of endoplasmic reticulum unfolded protein response
2,760.25 4.50 5 26
early endosome membrane
610.06 4.00 36 847
Totals 681 21577

Change Log

Timestamp Action Category Detail
2023-05-20 Deleted DEFINITION Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2023-05-20 Added DEFINITION Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2023-05-16 Deleted RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
2022-09-16 Deleted RELATION part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity)
2012-01-15 Added RELATION part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity)
2011-01-30 Updated TERM phosphatidylinositol 3-kinase regulator activity
2011-01-30 Added SYNONYM phosphoinositide 3-kinase regulator activity
2011-01-30 Deleted DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2011-01-30 Added DEFINITION Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2010-06-15 Added RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
Timestamp Action Category Detail
2011-01-30 Updated TERM phosphatidylinositol 3-kinase regulator activity
2003-09-11 Added TERM phosphoinositide 3-kinase regulator activity
Timestamp Action Category Detail
2023-05-20 Deleted DEFINITION Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2023-05-20 Added DEFINITION Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2011-01-30 Added SYNONYM phosphoinositide 3-kinase regulator activity
2011-01-30 Deleted DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2011-01-30 Added DEFINITION Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2008-05-13 Added DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2008-05-12 Deleted DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2007-08-09 Added SYNONYM PI3K regulator activity
2007-08-09 Deleted SYNONYM PI3K regulator activity
2005-12-09 Added SYNONYM PI3K regulator activity
2004-07-22 Updated DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2004-01-08 Updated DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2003-09-11 Added DEFINITION Modulates the rate or extent of activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
Timestamp Action Category Detail
2023-05-16 Deleted RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
2022-09-16 Deleted RELATION part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity)
2012-01-15 Added RELATION part of GO:0043551 (obsolete regulation of phosphatidylinositol 3-kinase activity)
2010-06-15 Added RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
2010-06-14 Deleted RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
2010-06-08 Added RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
2009-02-25 Deleted RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
2009-02-22 Added RELATION regulates GO:0035004 (obsolete phosphatidylinositol 3-kinase activity)
2008-04-01 Updated RELATION is a GO:0019207 (kinase regulator activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.