This term is obsolete.

GO:0035197 JSON

siRNA binding

Molecular Function

Definition (GO:0035197 GONUTS page)

Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. PMID:15066275 PMID:15066283

8,966 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
small interfering RNA binding exact

Ancestor Chart

Ancestor chart for GO:0035197
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein B1WC40 10116 NCBP2_RAT GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P52298 9606 NCBP2_HUMAN GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:7478990
NOT-qualified manual protein P52299 8355 NCBP2_XENLA GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q15287 9606 RNPS1_HUMAN GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22388736
NOT-qualified manual protein Q23500 6239 ACOHC_CAEEL GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12438312
NOT-qualified manual protein Q52KI8 10090 SRRM1_MOUSE GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: PMID:9531537
NOT-qualified manual protein Q6AYK1 10116 RNPS1_RAT GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6QN14 9606 U17L6_HUMAN GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17109758
NOT-qualified manual protein Q9CQ49 10090 NCBP2_MOUSE GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9YH12 8319 LSM14_PLEWA GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9851867

Cross-references

Database ID Description
InterPro IPR028605 RISC-loading complex subunit TRBP2

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0035197 based on ALL annotations
The top 100 of 765 co-occurring terms
Co-occurring Term PR S% #Together #Compared
siRNA binding
21,886.02 100.00 8,907 8,907
regulation of regulatory ncRNA processing
21,639.19 41.14 3,682 3,724
RISC-loading complex
13,173.20 34.99 4,055 6,737
regulatory ncRNA-mediated heterochromatin formation
4,845.06 16.71 3,608 16,298
siRNA processing
3,011.64 11.77 3,994 29,025
endoribonuclease activity, cleaving siRNA-paired mRNA
18,374.46 9.91 900 1,072
RISC complex assembly
11,041.49 9.68 953 1,889
miRNA binding
3,824.00 9.38 1,500 8,585
miRNA-mediated gene silencing by mRNA destabilization
11,601.44 9.09 881 1,662
pre-miRNA processing
3,183.31 8.77 1,611 11,076
Totals 58340 842358
No co-occurrence statistics for GO:0035197 based on MANUAL annotations
The top 100 of 628 co-occurring terms
Co-occurring Term PR S% #Together #Compared
siRNA binding
5,641.04 100.00 229 229
regulation of regulatory ncRNA processing
5,297.08 32.91 77 82
RISC-loading complex
2,960.77 30.16 95 181
RISC complex
1,375.18 18.39 98 402
regulatory ncRNA-mediated heterochromatin formation
1,208.80 14.60 72 336
RISC complex assembly
2,399.06 13.26 37 87
siRNA processing
565.22 8.89 101 1,008
global gene silencing by mRNA cleavage
2,744.29 7.26 18 37
positive regulation of interferon-alpha production
833.34 6.86 26 176
cellular response to virus
606.37 6.56 33 307
Totals 1751 16126

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2018-02-15 Added RELATION is a GO:0061980 (regulatory RNA binding)
2018-02-15 Deleted RELATION is a GO:0003723 (RNA binding)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2009-07-03 Deleted DEFINITION Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2008-05-13 Added DEFINITION Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2008-05-12 Deleted DEFINITION Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2008-04-01 Updated RELATION is a GO:0003723 (RNA binding)
2007-08-09 Added SYNONYM small interfering RNA binding
Timestamp Action Category Detail
2004-07-22 Added TERM siRNA binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2009-07-03 Deleted DEFINITION Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2008-05-13 Added DEFINITION Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2008-05-12 Deleted DEFINITION Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2007-08-09 Added SYNONYM small interfering RNA binding
2007-08-09 Deleted SYNONYM small interfering RNA binding
2004-07-22 Added DEFINITION Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2004-07-22 Added SYNONYM small interfering RNA binding
Timestamp Action Category Detail
2018-02-15 Added RELATION is a GO:0061980 (regulatory RNA binding)
2018-02-15 Deleted RELATION is a GO:0003723 (RNA binding)
2008-04-01 Updated RELATION is a GO:0003723 (RNA binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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