GO:0035197
JSON
siRNA binding
Molecular Function
Definition (GO:0035197 GONUTS page)
Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. PMID:15066275 PMID:15066283
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
small interfering RNA binding | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | B1WC40 | 10116 | NCBP2_RAT | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P52298 | 9606 | NCBP2_HUMAN | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:7478990 | |
NOT-qualified manual | protein | P52299 | 8355 | NCBP2_XENLA | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q15287 | 9606 | RNPS1_HUMAN | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22388736 | |
NOT-qualified manual | protein | Q23500 | 6239 | ACOHC_CAEEL | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12438312 | |
NOT-qualified manual | protein | Q52KI8 | 10090 | SRRM1_MOUSE | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: PMID:9531537 | |
NOT-qualified manual | protein | Q6AYK1 | 10116 | RNPS1_RAT | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q6QN14 | 9606 | U17L6_HUMAN | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17109758 | |
NOT-qualified manual | protein | Q9CQ49 | 10090 | NCBP2_MOUSE | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9YH12 | 8319 | LSM14_PLEWA | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9851867 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR028605 | RISC-loading complex subunit TRBP2 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035197 based on ALL annotations
The top 100 of 765 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
siRNA binding
|
21,886.02 | 100.00 | 8,907 | 8,907 |
regulation of regulatory ncRNA processing
|
21,639.19 | 41.14 | 3,682 | 3,724 |
RISC-loading complex
|
13,173.20 | 34.99 | 4,055 | 6,737 |
regulatory ncRNA-mediated heterochromatin formation
|
4,845.06 | 16.71 | 3,608 | 16,298 |
siRNA processing
|
3,011.64 | 11.77 | 3,994 | 29,025 |
endoribonuclease activity, cleaving siRNA-paired mRNA
|
18,374.46 | 9.91 | 900 | 1,072 |
RISC complex assembly
|
11,041.49 | 9.68 | 953 | 1,889 |
miRNA binding
|
3,824.00 | 9.38 | 1,500 | 8,585 |
miRNA-mediated gene silencing by mRNA destabilization
|
11,601.44 | 9.09 | 881 | 1,662 |
pre-miRNA processing
|
3,183.31 | 8.77 | 1,611 | 11,076 |
Totals | 58340 | 842358 |
No co-occurrence statistics for GO:0035197 based on MANUAL annotations
The top 100 of 628 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
siRNA binding
|
5,641.04 | 100.00 | 229 | 229 |
regulation of regulatory ncRNA processing
|
5,297.08 | 32.91 | 77 | 82 |
RISC-loading complex
|
2,960.77 | 30.16 | 95 | 181 |
RISC complex
|
1,375.18 | 18.39 | 98 | 402 |
regulatory ncRNA-mediated heterochromatin formation
|
1,208.80 | 14.60 | 72 | 336 |
RISC complex assembly
|
2,399.06 | 13.26 | 37 | 87 |
siRNA processing
|
565.22 | 8.89 | 101 | 1,008 |
global gene silencing by mRNA cleavage
|
2,744.29 | 7.26 | 18 | 37 |
positive regulation of interferon-alpha production
|
833.34 | 6.86 | 26 | 176 |
cellular response to virus
|
606.37 | 6.56 | 33 | 307 |
Totals | 1751 | 16126 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2018-02-15 | Added | RELATION | is a GO:0061980 (regulatory RNA binding) |
2018-02-15 | Deleted | RELATION | is a GO:0003723 (RNA binding) |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2008-05-13 | Added | DEFINITION | Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2008-04-01 | Updated | RELATION | is a GO:0003723 (RNA binding) |
2007-08-09 | Added | SYNONYM | small interfering RNA binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-07-22 | Added | TERM | siRNA binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2008-05-13 | Added | DEFINITION | Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2007-08-09 | Added | SYNONYM | small interfering RNA binding |
2007-08-09 | Deleted | SYNONYM | small interfering RNA binding |
2004-07-22 | Added | DEFINITION | Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
2004-07-22 | Added | SYNONYM | small interfering RNA binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-02-15 | Added | RELATION | is a GO:0061980 (regulatory RNA binding) |
2018-02-15 | Deleted | RELATION | is a GO:0003723 (RNA binding) |
2008-04-01 | Updated | RELATION | is a GO:0003723 (RNA binding) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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