GO:0035325
JSON
Toll-like receptor binding
Molecular Function
Definition (GO:0035325 GONUTS page)
Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. PMID:19076341
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| TLR binding | exact |
Ancestor Chart
Ancestor chart for GO:0035325
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0035325
| Child Term | Relationship to GO:0035325 |
|---|---|
|
Toll-like receptor 4 binding
|
is_a |
|
Toll-like receptor 2 binding
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | O95970 | 9606 | LGI1_HUMAN | GO:0005102 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223 | |
| NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
| NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
| NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
| NOT-qualified manual | protein | Q8K4Y5 | 10116 | LGI1_RAT | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
| Database | ID | Description |
|---|---|---|
| InterPro | IPR043268 | Protein unc-93 homolog B1 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035325 based on ALL annotations
The top 100 of 495 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
Toll-like receptor binding
|
70,367.49 | 100.00 | 2,816 | 2,816 |
|
TIR domain binding
|
57,230.71 | 47.55 | 1,503 | 1,848 |
|
MyD88-dependent toll-like receptor signaling pathway
|
30,330.11 | 31.04 | 1,481 | 3,436 |
|
Toll signaling pathway
|
30,034.42 | 31.04 | 1,499 | 3,512 |
|
toll-like receptor 9 signaling pathway
|
48,433.41 | 28.54 | 923 | 1,341 |
|
toll-like receptor 7 signaling pathway
|
29,985.78 | 22.74 | 923 | 2,166 |
|
toll-like receptor 3 signaling pathway
|
26,783.17 | 21.38 | 923 | 2,425 |
|
toll-like receptor 4 signaling pathway
|
12,445.56 | 15.32 | 1,503 | 8,498 |
|
defense response to Gram-positive bacterium
|
5,454.69 | 7.35 | 1,656 | 21,363 |
|
toll-like receptor signaling pathway
|
4,510.74 | 5.79 | 1,050 | 16,380 |
| Totals | 25049 | 192998 | ||
No co-occurrence statistics for GO:0035325 based on MANUAL annotations
The top 100 of 455 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
Toll-like receptor binding
|
19,604.63 | 100.00 | 72 | 72 |
|
toll-like receptor 9 signaling pathway
|
7,767.87 | 20.19 | 21 | 53 |
|
Toll signaling pathway
|
4,935.43 | 20.11 | 36 | 143 |
|
toll-like receptor 7 signaling pathway
|
7,624.02 | 20.00 | 21 | 54 |
|
toll-like receptor 3 signaling pathway
|
4,333.65 | 14.38 | 21 | 95 |
|
toll-like receptor 4 signaling pathway
|
2,940.69 | 13.04 | 36 | 240 |
|
toll-like receptor 8 signaling pathway
|
6,032.19 | 8.89 | 8 | 26 |
|
toll-like receptor TLR6:TLR2 signaling pathway
|
6,190.93 | 7.06 | 6 | 19 |
|
T cell antigen processing and presentation
|
4,705.11 | 6.59 | 6 | 25 |
|
early phagosome
|
1,837.93 | 5.66 | 9 | 96 |
| Totals | 600 | 6677 | ||
Change Log
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2021-05-24 | Added | DEFINITION | Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| 2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| 2010-02-28 | Added | DEFINITION | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| 2010-02-28 | Added | RELATION | is a GO:0005102 (signaling receptor binding) |
| 2010-02-28 | Added | TERM | Toll-like receptor binding |
| 2010-02-28 | Added | SYNONYM | TLR binding |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2010-02-28 | Added | TERM | Toll-like receptor binding |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2021-05-24 | Added | DEFINITION | Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| 2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| 2010-02-28 | Added | DEFINITION | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| 2010-02-28 | Added | SYNONYM | TLR binding |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2010-02-28 | Added | RELATION | is a GO:0005102 (signaling receptor binding) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|
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