This term is obsolete.

GO:0035325 JSON

Toll-like receptor binding

Molecular Function

Definition (GO:0035325 GONUTS page)

Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. PMID:19076341

7,377 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
TLR binding exact

Ancestor Chart

Ancestor chart for GO:0035325
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035325

Child Term Relationship to
GO:0035325
Toll-like receptor 4 binding
is_a
Toll-like receptor 2 binding
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O95970 9606 LGI1_HUMAN GO:0005102 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein Q8K4Y5 10116 LGI1_RAT GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR043268 Protein unc-93 homolog B1

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0035325 based on ALL annotations
The top 100 of 501 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Toll-like receptor binding
70,783.87 100.00 2,754 2,754
TIR domain binding
57,502.04 47.20 1,459 1,796
Toll signaling pathway
30,014.51 30.75 1,454 3,429
MyD88-dependent toll-like receptor signaling pathway
30,230.83 30.71 1,438 3,367
toll-like receptor 9 signaling pathway
48,385.95 28.47 903 1,321
toll-like receptor 7 signaling pathway
29,868.15 22.63 903 2,140
toll-like receptor 3 signaling pathway
26,811.17 21.32 903 2,384
toll-like receptor 4 signaling pathway
12,310.24 15.07 1,460 8,395
defense response to Gram-positive bacterium
5,436.62 7.29 1,614 21,014
toll-like receptor TLR6:TLR2 signaling pathway
37,358.16 5.88 171 324
Totals 24652 189767
No co-occurrence statistics for GO:0035325 based on MANUAL annotations
The top 100 of 457 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Toll-like receptor binding
20,184.36 100.00 64 64
Toll signaling pathway
4,856.39 19.39 32 133
toll-like receptor 7 signaling pathway
7,459.44 18.28 17 46
toll-like receptor 9 signaling pathway
7,002.74 17.71 17 49
toll-like receptor 4 signaling pathway
2,922.62 12.65 32 221
toll-like receptor 3 signaling pathway
3,899.25 12.59 17 88
toll-like receptor 8 signaling pathway
7,689.28 10.39 8 21
toll-like receptor TLR6:TLR2 signaling pathway
6,374.01 7.79 6 19
T cell antigen processing and presentation
4,844.25 7.23 6 25
positive regulation of cellular response to macrophage colony-stimulating factor stimulus
13,456.24 6.06 4 6
Totals 568 6381

Change Log

Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
2021-05-24 Added DEFINITION Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
2010-02-28 Added RELATION is a GO:0005102 (signaling receptor binding)
2010-02-28 Added TERM Toll-like receptor binding
2010-02-28 Added SYNONYM TLR binding
2010-02-28 Added DEFINITION Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
Timestamp Action Category Detail
2010-02-28 Added TERM Toll-like receptor binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
2021-05-24 Added DEFINITION Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
2010-02-28 Added SYNONYM TLR binding
2010-02-28 Added DEFINITION Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
Timestamp Action Category Detail
2010-02-28 Added RELATION is a GO:0005102 (signaling receptor binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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