GO:0035539
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8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
Molecular Function
Definition (GO:0035539 GONUTS page)
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. PMID:17804481 PMID:7782328 PMID:7859359
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity | exact |
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity | exact |
8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity | exact |
8-oxo-dGTP pyrophosphohydrolase activity | exact |
8-oxo-dGTPase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.6.1.55 | |
RHEA | 31575 | |
Reactome | R-HSA-2395849 | |
Reactome | R-HSA-2395869 | |
Reactome | R-HSA-9750555 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:77896 | 8-oxo-dGTP(4-) |
has_participant | CHEBI | CHEBI:63224 | 8-oxo-dGMP(2-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035539 based on ALL annotations
The top 100 of 180 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
|
5,882.81 | 100.00 | 33,137 | 33,137 |
8-oxo-GDP phosphatase activity
|
5,633.05 | 80.40 | 27,628 | 28,853 |
8-oxo-dGDP phosphatase activity
|
4,843.65 | 70.73 | 27,631 | 33,559 |
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
|
4,702.34 | 70.03 | 28,155 | 35,223 |
dGTP catabolic process
|
266.19 | 3.33 | 3,701 | 81,791 |
DNA replication
|
85.04 | 1.44 | 22,746 | 1,573,447 |
thiamine biosynthetic process
|
74.09 | 1.15 | 3,825 | 303,716 |
DNA repair
|
61.22 | 1.04 | 27,917 | 2,682,566 |
pyroglutamyl-peptidase activity
|
119.22 | 0.53 | 236 | 11,645 |
DNA protection
|
121.32 | 0.52 | 226 | 10,959 |
Totals | 225496 | 104618491 |
No co-occurrence statistics for GO:0035539 based on MANUAL annotations
The top 53 of 53 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
|
11,533.92 | 100.00 | 112 | 112 |
dGTP catabolic process
|
3,149.06 | 24.92 | 83 | 304 |
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
|
5,092.90 | 21.94 | 34 | 77 |
8-oxo-GDP phosphatase activity
|
5,880.04 | 18.98 | 26 | 51 |
8-oxo-dGDP phosphatase activity
|
2,306.78 | 12.72 | 29 | 145 |
2-hydroxy-dATP hydrolase activity
|
11,533.92 | 3.57 | 4 | 4 |
2-hydroxy-ATP hydrolase activity
|
11,533.92 | 3.57 | 4 | 4 |
ATP diphosphatase activity
|
9,227.14 | 3.54 | 4 | 5 |
DNA protection
|
858.91 | 3.52 | 7 | 94 |
purine nucleotide catabolic process
|
5,766.96 | 3.45 | 4 | 8 |
Totals | 499 | 609794 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9750555 |
2021-01-30 | Added | XREF | EC:3.6.1.55 |
2021-01-30 | Added | DEFINITION | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
2021-01-30 | Deleted | DEFINITION | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2395849 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2395849 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2395869 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2395869 |
2018-12-11 | Added | XREF | reactome:R-HSA-2395869 |
2018-12-11 | Added | XREF | reactome:R-HSA-2395849 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-05-13 | Added | TERM | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-30 | Added | DEFINITION | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
2021-01-30 | Deleted | DEFINITION | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
2010-09-15 | Added | DEFINITION | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
2010-09-15 | Deleted | DEFINITION | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-Oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-Oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
2010-05-13 | Added | SYNONYM | 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity |
2010-05-13 | Added | DEFINITION | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-Oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-Oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
2010-05-13 | Added | SYNONYM | 8-oxo-dGTPase activity |
2010-05-13 | Added | SYNONYM | 8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity |
2010-05-13 | Added | SYNONYM | 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity |
2010-05-13 | Added | SYNONYM | 8-oxo-dGTP pyrophosphohydrolase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-05-13 | Added | RELATION | is a GO:0047429 (nucleoside triphosphate diphosphatase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9750555 |
2021-01-30 | Added | XREF | EC:3.6.1.55 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2395849 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2395849 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2395869 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2395869 |
2018-12-11 | Added | XREF | reactome:R-HSA-2395869 |
2018-12-11 | Added | XREF | reactome:R-HSA-2395849 |
2018-07-13 | Deleted | XREF | RHEA:31578 |
2018-07-13 | Added | XREF | RHEA:31575 |
2012-09-16 | Added | XREF | RHEA:31578 |
Timestamp | Action | Category | Detail |
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