This term is obsolete.

GO:0035539 JSON

8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Molecular Function

Definition (GO:0035539 GONUTS page)

Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. PMID:17804481 PMID:7782328 PMID:7859359

33,169 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity exact
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity exact
8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity exact
8-oxo-dGTP pyrophosphohydrolase activity exact
8-oxo-dGTPase activity exact

Ancestor Chart

Ancestor chart for GO:0035539
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.6.1.55
RHEA 31575
Reactome R-HSA-2395849
Reactome R-HSA-2395869
Reactome R-HSA-9750555

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:77896 8-oxo-dGTP(4-)
has_participant CHEBI CHEBI:63224 8-oxo-dGMP(2-)
has_participant CHEBI CHEBI:33019 diphosphate(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0035539 based on ALL annotations
The top 100 of 180 co-occurring terms
Co-occurring Term PR S% #Together #Compared
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
5,882.81 100.00 33,137 33,137
8-oxo-GDP phosphatase activity
5,633.05 80.40 27,628 28,853
8-oxo-dGDP phosphatase activity
4,843.65 70.73 27,631 33,559
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
4,702.34 70.03 28,155 35,223
dGTP catabolic process
266.19 3.33 3,701 81,791
DNA replication
85.04 1.44 22,746 1,573,447
thiamine biosynthetic process
74.09 1.15 3,825 303,716
DNA repair
61.22 1.04 27,917 2,682,566
pyroglutamyl-peptidase activity
119.22 0.53 236 11,645
DNA protection
121.32 0.52 226 10,959
Totals 225496 104618491
No co-occurrence statistics for GO:0035539 based on MANUAL annotations
The top 53 of 53 co-occurring terms
Co-occurring Term PR S% #Together #Compared
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
11,533.92 100.00 112 112
dGTP catabolic process
3,149.06 24.92 83 304
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
5,092.90 21.94 34 77
8-oxo-GDP phosphatase activity
5,880.04 18.98 26 51
8-oxo-dGDP phosphatase activity
2,306.78 12.72 29 145
2-hydroxy-dATP hydrolase activity
11,533.92 3.57 4 4
2-hydroxy-ATP hydrolase activity
11,533.92 3.57 4 4
ATP diphosphatase activity
9,227.14 3.54 4 5
DNA protection
858.91 3.52 7 94
purine nucleotide catabolic process
5,766.96 3.45 4 8
Totals 499 609794

Change Log

Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9750555
2021-01-30 Added XREF EC:3.6.1.55
2021-01-30 Added DEFINITION Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
2021-01-30 Deleted DEFINITION Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
2019-04-01 Deleted XREF reactome:R-HSA-2395849
2019-04-01 Added XREF Reactome:R-HSA-2395849
2019-04-01 Added XREF Reactome:R-HSA-2395869
2019-04-01 Deleted XREF reactome:R-HSA-2395869
2018-12-11 Added XREF reactome:R-HSA-2395869
2018-12-11 Added XREF reactome:R-HSA-2395849
Timestamp Action Category Detail
2010-05-13 Added TERM 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
Timestamp Action Category Detail
2021-01-30 Added DEFINITION Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
2021-01-30 Deleted DEFINITION Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
2010-09-15 Added DEFINITION Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
2010-09-15 Deleted DEFINITION Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-Oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-Oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
2010-05-13 Added SYNONYM 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity
2010-05-13 Added DEFINITION Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-Oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-Oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
2010-05-13 Added SYNONYM 8-oxo-dGTPase activity
2010-05-13 Added SYNONYM 8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity
2010-05-13 Added SYNONYM 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity
2010-05-13 Added SYNONYM 8-oxo-dGTP pyrophosphohydrolase activity
Timestamp Action Category Detail
2010-05-13 Added RELATION is a GO:0047429 (nucleoside triphosphate diphosphatase activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9750555
2021-01-30 Added XREF EC:3.6.1.55
2019-04-01 Deleted XREF reactome:R-HSA-2395849
2019-04-01 Added XREF Reactome:R-HSA-2395849
2019-04-01 Added XREF Reactome:R-HSA-2395869
2019-04-01 Deleted XREF reactome:R-HSA-2395869
2018-12-11 Added XREF reactome:R-HSA-2395869
2018-12-11 Added XREF reactome:R-HSA-2395849
2018-07-13 Deleted XREF RHEA:31578
2018-07-13 Added XREF RHEA:31575
2012-09-16 Added XREF RHEA:31578
Timestamp Action Category Detail
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