GO:0035655
JSON
interleukin-18-mediated signaling pathway
Biological Process
Definition (GO:0035655 GONUTS page)
The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
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interleukin-18-mediated signalling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0035655
Child Term | Relationship to GO:0035655 |
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positive regulation of interleukin-18-mediated signaling pathway
|
positively_regulates |
regulation of interleukin-18-mediated signaling pathway
|
regulates |
interleukin-18 receptor activity
|
part_of |
negative regulation of interleukin-18-mediated signaling pathway
|
negatively_regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035655 based on ALL annotations
The top 100 of 503 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-18-mediated signaling pathway
|
114,333.59 | 100.00 | 1,705 | 1,705 |
interleukin-18 receptor activity
|
114,333.60 | 77.13 | 1,315 | 1,315 |
interleukin-18 binding
|
73,227.66 | 29.18 | 595 | 929 |
positive regulation of smooth muscle cell proliferation
|
17,519.23 | 10.01 | 382 | 2,493 |
interleukin-18 receptor complex
|
114,333.60 | 9.97 | 170 | 170 |
positive regulation of type II interferon production
|
13,296.85 | 9.93 | 690 | 5,933 |
interleukin-1 receptor activity
|
12,762.14 | 8.43 | 437 | 3,915 |
positive regulation of T-helper 1 cell cytokine production
|
34,831.41 | 8.39 | 177 | 581 |
positive regulation of vascular associated smooth muscle cell dedifferentiation
|
112,069.56 | 5.80 | 99 | 101 |
positive regulation of metanephric mesenchymal cell migration
|
110,970.85 | 5.80 | 99 | 102 |
Totals | 14431 | 127281 |
No co-occurrence statistics for GO:0035655 based on MANUAL annotations
The top 100 of 449 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-18-mediated signaling pathway
|
25,835.98 | 100.00 | 50 | 50 |
interleukin-18 receptor activity
|
25,076.10 | 64.71 | 33 | 34 |
interleukin-18 receptor binding
|
25,835.98 | 20.00 | 10 | 10 |
positive regulation of T-helper 1 cell cytokine production
|
7,200.19 | 18.09 | 17 | 61 |
interleukin-18 receptor complex
|
25,835.98 | 18.00 | 9 | 9 |
interleukin-18 binding
|
10,109.73 | 14.06 | 9 | 23 |
T-helper 1 cell differentiation
|
3,229.50 | 6.52 | 6 | 48 |
natural killer cell activation
|
2,403.35 | 6.25 | 8 | 86 |
cellular response to interleukin-18
|
15,501.59 | 5.77 | 3 | 5 |
positive regulation of type II interferon production
|
1,500.85 | 5.56 | 28 | 482 |
Totals | 426 | 6336 |
Change Log
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Timestamp | Action | Category | Detail |
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2022-03-14 | Deleted | DEFINITION | A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2014-12-20 | Added | RELATION | part of GO:0071351 (cellular response to interleukin-18) |
2014-12-20 | Deleted | RELATION | is a GO:0071351 (cellular response to interleukin-18) |
2012-01-18 | Deleted | DEFINITION | A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor. |
2012-01-18 | Added | DEFINITION | A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2011-01-30 | Added | SYNONYM | interleukin-18-mediated signalling pathway |
2011-01-30 | Added | RELATION | is a GO:0019221 (cytokine-mediated signaling pathway) |
2011-01-30 | Added | RELATION | is a GO:0071351 (cellular response to interleukin-18) |
2011-01-30 | Added | TERM | interleukin-18-mediated signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-01-30 | Added | TERM | interleukin-18-mediated signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Deleted | DEFINITION | A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2012-01-18 | Deleted | DEFINITION | A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor. |
2012-01-18 | Added | DEFINITION | A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2011-01-30 | Added | SYNONYM | interleukin-18-mediated signalling pathway |
2011-01-30 | Added | DEFINITION | A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-12-20 | Added | RELATION | part of GO:0071351 (cellular response to interleukin-18) |
2014-12-20 | Deleted | RELATION | is a GO:0071351 (cellular response to interleukin-18) |
2011-01-30 | Added | RELATION | is a GO:0019221 (cytokine-mediated signaling pathway) |
2011-01-30 | Added | RELATION | is a GO:0071351 (cellular response to interleukin-18) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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