This term is obsolete.

GO:0035655 JSON

interleukin-18-mediated signaling pathway

Biological Process

Definition (GO:0035655 GONUTS page)

The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

3,166 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
interleukin-18-mediated signalling pathway exact

Ancestor Chart

Ancestor chart for GO:0035655
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035655

Child Term Relationship to
GO:0035655
regulation of interleukin-18-mediated signaling pathway
regulates
negative regulation of interleukin-18-mediated signaling pathway
negatively_regulates
positive regulation of interleukin-18-mediated signaling pathway
positively_regulates
interleukin-18 receptor activity
part_of

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
Reactome R-HSA-9012546

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0035655 based on ALL annotations
The top 100 of 491 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-18-mediated signaling pathway
114,939.02 100.00 1,724 1,724
interleukin-18 receptor activity
114,939.02 77.44 1,335 1,335
interleukin-18 binding
73,443.46 29.08 600 939
positive regulation of smooth muscle cell proliferation
17,587.06 9.94 381 2,490
positive regulation of type II interferon production
13,377.61 9.91 691 5,937
interleukin-18 receptor complex
114,939.02 9.86 170 170
interleukin-1 receptor activity
12,662.29 8.34 440 3,994
positive regulation of T-helper 1 cell cytokine production
34,878.05 8.27 176 580
positive regulation of vascular associated smooth muscle cell dedifferentiation
112,662.99 5.74 99 101
positive regulation of metanephric mesenchymal cell migration
111,558.45 5.73 99 102
Totals 14478 124397
No co-occurrence statistics for GO:0035655 based on MANUAL annotations
The top 100 of 450 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-18-mediated signaling pathway
26,139.50 100.00 54 54
interleukin-18 receptor activity
25,451.62 67.27 37 38
interleukin-18 receptor binding
26,139.50 18.52 10 10
positive regulation of T-helper 1 cell cytokine production
7,284.78 17.35 17 61
interleukin-18 receptor complex
26,139.50 16.67 9 9
interleukin-18 binding
10,228.50 13.24 9 23
T-helper 1 cell differentiation
3,409.50 6.38 6 46
natural killer cell activation
2,349.62 5.93 8 89
positive regulation of type II interferon production
1,550.20 5.64 29 489
adaptive immune response
1,499.81 5.56 35 610
Totals 442 6536

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-9012546
2022-03-14 Added DEFINITION The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2014-12-20 Deleted RELATION is a GO:0071351 (cellular response to interleukin-18)
2014-12-20 Added RELATION part of GO:0071351 (cellular response to interleukin-18)
2012-01-18 Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor.
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2011-01-30 Added SYNONYM interleukin-18-mediated signalling pathway
2011-01-30 Added RELATION is a GO:0019221 (cytokine-mediated signaling pathway)
2011-01-30 Added RELATION is a GO:0071351 (cellular response to interleukin-18)
Timestamp Action Category Detail
2011-01-30 Added TERM interleukin-18-mediated signaling pathway
Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor.
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2011-01-30 Added SYNONYM interleukin-18-mediated signalling pathway
2011-01-30 Added DEFINITION A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor.
Timestamp Action Category Detail
2014-12-20 Deleted RELATION is a GO:0071351 (cellular response to interleukin-18)
2014-12-20 Added RELATION part of GO:0071351 (cellular response to interleukin-18)
2011-01-30 Added RELATION is a GO:0019221 (cytokine-mediated signaling pathway)
2011-01-30 Added RELATION is a GO:0071351 (cellular response to interleukin-18)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-9012546
Timestamp Action Category Detail
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