GO:0035925
JSON
mRNA 3'-UTR AU-rich region binding
Molecular Function
Definition (GO:0035925 GONUTS page)
Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. PMID:31511872 PMID:7892223 PMID:8578590
Secondary IDs
GO:0017091
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ARE binding | related |
AU-rich element binding | related |
mRNA 3'-UTR adenylate/uridylate-rich element binding | exact |
adenylate/uridylate-rich element binding | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | B1WC40 | 10116 | NCBP2_RAT | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P16568 | 7227 | BICD_DROME | GO:0003729 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:12446149 | |
NOT-qualified manual | protein | P52298 | 9606 | NCBP2_HUMAN | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:7478990 | |
NOT-qualified manual | protein | P52299 | 8355 | NCBP2_XENLA | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q15287 | 9606 | RNPS1_HUMAN | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22388736 | |
NOT-qualified manual | protein | Q23500 | 6239 | ACOHC_CAEEL | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12438312 | |
NOT-qualified manual | protein | Q52KI8 | 10090 | SRRM1_MOUSE | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: PMID:9531537 | |
NOT-qualified manual | protein | Q6AYK1 | 10116 | RNPS1_RAT | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q6QN14 | 9606 | U17L6_HUMAN | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17109758 | |
NOT-qualified manual | protein | Q9CQ49 | 10090 | NCBP2_MOUSE | GO:0003723 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035925 based on ALL annotations
The top 100 of 767 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
mRNA 3'-UTR AU-rich region binding
|
4,252.96 | 100.00 | 45,836 | 45,836 |
NADPH:quinone reductase activity
|
3,363.80 | 48.73 | 25,638 | 32,415 |
U1 snRNA 3'-end processing
|
4,168.26 | 26.69 | 12,302 | 12,552 |
U5 snRNA 3'-end processing
|
4,112.56 | 26.60 | 12,302 | 12,722 |
nuclear mRNA surveillance
|
2,221.67 | 21.66 | 12,382 | 23,703 |
cytoplasmic exosome (RNase complex)
|
1,522.89 | 20.76 | 15,161 | 42,340 |
nuclear polyadenylation-dependent rRNA catabolic process
|
1,725.92 | 19.26 | 12,293 | 30,292 |
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
|
1,711.03 | 19.19 | 12,302 | 30,578 |
TRAMP-dependent tRNA surveillance pathway
|
1,703.38 | 19.13 | 12,285 | 30,673 |
U4 snRNA 3'-end processing
|
1,512.06 | 18.14 | 12,386 | 34,838 |
Totals | 331909 | 22945033 |
No co-occurrence statistics for GO:0035925 based on MANUAL annotations
The top 100 of 581 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
mRNA 3'-UTR AU-rich region binding
|
1,616.77 | 100.00 | 799 | 799 |
U1 snRNA 3'-end processing
|
1,598.08 | 42.59 | 342 | 346 |
U5 snRNA 3'-end processing
|
1,566.39 | 42.22 | 342 | 353 |
nuclear mRNA surveillance
|
807.21 | 30.07 | 344 | 689 |
TRAMP-dependent tRNA surveillance pathway
|
702.59 | 27.49 | 342 | 787 |
nuclear polyadenylation-dependent rRNA catabolic process
|
697.27 | 27.36 | 342 | 793 |
U4 snRNA 3'-end processing
|
634.90 | 25.85 | 344 | 876 |
rRNA catabolic process
|
615.08 | 25.57 | 350 | 920 |
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
|
580.81 | 24.27 | 342 | 952 |
cytoplasmic exosome (RNase complex)
|
558.61 | 23.94 | 350 | 1,013 |
Totals | 6142 | 45382 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. |
2021-05-24 | Added | DEFINITION | Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. |
2020-11-24 | Added | SYNONYM | AU-rich element binding |
2020-11-24 | Deleted | RELATION | is a GO:0017091 (AU-rich element binding) |
2020-11-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule. |
2020-11-24 | Added | SECONDARY | GO:0017091 (AU-rich element binding) |
2020-11-24 | Added | SYNONYM | ARE binding |
2020-11-24 | Added | SYNONYM | adenylate/uridylate-rich element binding |
2020-11-24 | Added | DEFINITION | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. |
2011-07-21 | Added | TERM | mRNA 3'-UTR AU-rich region binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-07-21 | Added | TERM | mRNA 3'-UTR AU-rich region binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. |
2021-05-24 | Added | DEFINITION | Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. |
2020-11-24 | Added | SYNONYM | AU-rich element binding |
2020-11-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule. |
2020-11-24 | Added | SYNONYM | ARE binding |
2020-11-24 | Added | SYNONYM | adenylate/uridylate-rich element binding |
2020-11-24 | Added | DEFINITION | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. |
2011-07-21 | Added | SYNONYM | mRNA 3'-UTR adenylate/uridylate-rich element binding |
2011-07-21 | Added | DEFINITION | Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-24 | Deleted | RELATION | is a GO:0017091 (AU-rich element binding) |
2011-07-21 | Added | RELATION | is a GO:0003730 (mRNA 3'-UTR binding) |
2011-07-21 | Added | RELATION | is a GO:0017091 (AU-rich element binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-24 | Added | SECONDARY | GO:0017091 (AU-rich element binding) |
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