This term is obsolete.

GO:0035925 JSON

mRNA 3'-UTR AU-rich region binding

Molecular Function

Definition (GO:0035925 GONUTS page)

Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. PMID:31511872 PMID:7892223 PMID:8578590

Secondary IDs

GO:0017091

46,037 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ARE binding related
AU-rich element binding related
mRNA 3'-UTR adenylate/uridylate-rich element binding exact
adenylate/uridylate-rich element binding exact

Ancestor Chart

Ancestor chart for GO:0035925
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein B1WC40 10116 NCBP2_RAT GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P16568 7227 BICD_DROME GO:0003729 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:12446149
NOT-qualified manual protein P52298 9606 NCBP2_HUMAN GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:7478990
NOT-qualified manual protein P52299 8355 NCBP2_XENLA GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q15287 9606 RNPS1_HUMAN GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22388736
NOT-qualified manual protein Q23500 6239 ACOHC_CAEEL GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12438312
NOT-qualified manual protein Q52KI8 10090 SRRM1_MOUSE GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: PMID:9531537
NOT-qualified manual protein Q6AYK1 10116 RNPS1_RAT GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6QN14 9606 U17L6_HUMAN GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17109758
NOT-qualified manual protein Q9CQ49 10090 NCBP2_MOUSE GO:0003723 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0035925 based on ALL annotations
The top 100 of 767 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA 3'-UTR AU-rich region binding
4,252.96 100.00 45,836 45,836
NADPH:quinone reductase activity
3,363.80 48.73 25,638 32,415
U1 snRNA 3'-end processing
4,168.26 26.69 12,302 12,552
U5 snRNA 3'-end processing
4,112.56 26.60 12,302 12,722
nuclear mRNA surveillance
2,221.67 21.66 12,382 23,703
cytoplasmic exosome (RNase complex)
1,522.89 20.76 15,161 42,340
nuclear polyadenylation-dependent rRNA catabolic process
1,725.92 19.26 12,293 30,292
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
1,711.03 19.19 12,302 30,578
TRAMP-dependent tRNA surveillance pathway
1,703.38 19.13 12,285 30,673
U4 snRNA 3'-end processing
1,512.06 18.14 12,386 34,838
Totals 331909 22945033
No co-occurrence statistics for GO:0035925 based on MANUAL annotations
The top 100 of 581 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA 3'-UTR AU-rich region binding
1,616.77 100.00 799 799
U1 snRNA 3'-end processing
1,598.08 42.59 342 346
U5 snRNA 3'-end processing
1,566.39 42.22 342 353
nuclear mRNA surveillance
807.21 30.07 344 689
TRAMP-dependent tRNA surveillance pathway
702.59 27.49 342 787
nuclear polyadenylation-dependent rRNA catabolic process
697.27 27.36 342 793
U4 snRNA 3'-end processing
634.90 25.85 344 876
rRNA catabolic process
615.08 25.57 350 920
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
580.81 24.27 342 952
cytoplasmic exosome (RNase complex)
558.61 23.94 350 1,013
Totals 6142 45382

Change Log

Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
2021-05-24 Added DEFINITION Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
2020-11-24 Added SYNONYM AU-rich element binding
2020-11-24 Deleted RELATION is a GO:0017091 (AU-rich element binding)
2020-11-24 Deleted DEFINITION Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
2020-11-24 Added SECONDARY GO:0017091 (AU-rich element binding)
2020-11-24 Added SYNONYM ARE binding
2020-11-24 Added SYNONYM adenylate/uridylate-rich element binding
2020-11-24 Added DEFINITION Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
2011-07-21 Added TERM mRNA 3'-UTR AU-rich region binding
Timestamp Action Category Detail
2011-07-21 Added TERM mRNA 3'-UTR AU-rich region binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
2021-05-24 Added DEFINITION Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
2020-11-24 Added SYNONYM AU-rich element binding
2020-11-24 Deleted DEFINITION Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
2020-11-24 Added SYNONYM ARE binding
2020-11-24 Added SYNONYM adenylate/uridylate-rich element binding
2020-11-24 Added DEFINITION Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
2011-07-21 Added SYNONYM mRNA 3'-UTR adenylate/uridylate-rich element binding
2011-07-21 Added DEFINITION Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
Timestamp Action Category Detail
2020-11-24 Deleted RELATION is a GO:0017091 (AU-rich element binding)
2011-07-21 Added RELATION is a GO:0003730 (mRNA 3'-UTR binding)
2011-07-21 Added RELATION is a GO:0017091 (AU-rich element binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2020-11-24 Added SECONDARY GO:0017091 (AU-rich element binding)
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