This term is obsolete.
This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.

GO:0036055 JSON

protein-succinyllysine desuccinylase activity

Molecular Function

Definition (GO:0036055 GONUTS page)

Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. PMID:22076378

Comments

This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.

15,422 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
succinyl lysine desuccinylase activity broad
succinyllysine desuccinylase activity broad
peptidyl-succinyllysine desuccinylase activity exact

Ancestor Chart

Ancestor chart for GO:0036055
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
InterPro IPR027546 Sirtuin, class III
RHEA 47668

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:87832 2''-O-succinyl-ADP-D-ribose(3-)
has_participant CHEBI CHEBI:87830 N(6)-succinyl-L-lysine(1-) residue
has_participant CHEBI CHEBI:17154 nicotinamide
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:29969 L-lysinium residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0036055 based on ALL annotations
The top 100 of 185 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-succinyllysine desuccinylase activity
12,916.69 100.00 15,341 15,341
protein-malonyllysine demalonylase activity
12,916.69 99.32 15,236 15,236
NAD-dependent protein lysine deacetylase activity
7,300.96 53.60 13,989 24,749
histone H3K4 deacetylase activity, NAD-dependent
6,558.38 36.47 8,654 17,044
histone H3K56 deacetylase activity, NAD-dependent
6,557.99 36.47 8,654 17,045
histone H3K14 deacetylase activity, NAD-dependent
6,531.17 36.36 8,654 17,115
histone H3K18 deacetylase activity, NAD-dependent
6,165.36 35.12 8,754 18,340
histone H4K16 deacetylase activity, NAD-dependent
6,053.67 34.41 8,654 18,465
histone H3K9 deacetylase activity, NAD-dependent
5,944.85 33.95 8,654 18,803
histone deacetylase activity, NAD-dependent
3,343.17 25.77 15,081 58,267
Totals 186518 113389732
No co-occurrence statistics for GO:0036055 based on MANUAL annotations
The top 65 of 65 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-succinyllysine desuccinylase activity
21,386.86 100.00 66 66
protein-glutaryllysine deglutarylase activity
21,386.86 95.45 63 63
protein-malonyllysine demalonylase activity
21,386.86 51.52 34 34
histone H3K18 deacetylase activity, NAD-dependent
17,548.20 43.84 32 39
protein desuccinylation
21,386.86 19.70 13 13
regulation of ketone biosynthetic process
21,386.87 16.67 11 11
protein deacetylation
8,554.75 16.09 14 35
peptidyl-lysine desuccinylation
21,386.86 15.15 10 10
peptidyl-lysine demalonylation
21,386.86 15.15 10 10
protein demalonylation
21,386.87 12.12 8 8
Totals 694 811850

Change Log

Timestamp Action Category Detail
2025-02-15 Added RELATION is a GO:0141218 (NAD-dependent protein lysine deacylase activity)
2025-02-15 Deleted RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2025-02-15 Deleted DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2025-02-15 Added DEFINITION Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein].
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-09-01 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2019-10-20 Added XREF RHEA:47668
2019-10-20 Deleted DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2019-10-20 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2011-12-16 Added DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
Timestamp Action Category Detail
2011-12-16 Updated TERM protein-succinyllysine desuccinylase activity
2011-12-14 Added TERM succinyllysine desuccinylase activity
Timestamp Action Category Detail
2025-02-15 Deleted DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2025-02-15 Added DEFINITION Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein].
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-09-01 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2019-10-20 Deleted DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2019-10-20 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2011-12-16 Added DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2011-12-16 Deleted SYNONYM succinyl lysine desuccinylase activity
2011-12-16 Added SYNONYM succinyllysine desuccinylase activity
2011-12-16 Added SYNONYM succinyl lysine desuccinylase activity
2011-12-16 Added SYNONYM peptidyl-succinyllysine desuccinylase activity
2011-12-16 Deleted DEFINITION Catalysis of the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2011-12-14 Added DEFINITION Catalysis of the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2011-12-14 Added SYNONYM succinyl lysine desuccinylase activity
Timestamp Action Category Detail
2025-02-15 Added RELATION is a GO:0141218 (NAD-dependent protein lysine deacylase activity)
2025-02-15 Deleted RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2011-12-14 Added RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2011-12-14 Added RELATION part of GO:0036049 (peptidyl-lysine desuccinylation)
Timestamp Action Category Detail
2019-10-20 Added XREF RHEA:47668
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.