This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
GO:0036055
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protein-succinyllysine desuccinylase activity
Molecular Function
Definition (GO:0036055 GONUTS page)
Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. PMID:22076378
Comments
This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
succinyl lysine desuccinylase activity | broad |
succinyllysine desuccinylase activity | broad |
peptidyl-succinyllysine desuccinylase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR027546 | Sirtuin, class III |
RHEA | 47668 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:87832 | 2''-O-succinyl-ADP-D-ribose(3-) |
has_participant | CHEBI | CHEBI:87830 | N(6)-succinyl-L-lysine(1-) residue |
has_participant | CHEBI | CHEBI:17154 | nicotinamide |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:29969 | L-lysinium residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0036055 based on ALL annotations
The top 100 of 185 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-succinyllysine desuccinylase activity
|
12,916.69 | 100.00 | 15,341 | 15,341 |
protein-malonyllysine demalonylase activity
|
12,916.69 | 99.32 | 15,236 | 15,236 |
NAD-dependent protein lysine deacetylase activity
|
7,300.96 | 53.60 | 13,989 | 24,749 |
histone H3K4 deacetylase activity, NAD-dependent
|
6,558.38 | 36.47 | 8,654 | 17,044 |
histone H3K56 deacetylase activity, NAD-dependent
|
6,557.99 | 36.47 | 8,654 | 17,045 |
histone H3K14 deacetylase activity, NAD-dependent
|
6,531.17 | 36.36 | 8,654 | 17,115 |
histone H3K18 deacetylase activity, NAD-dependent
|
6,165.36 | 35.12 | 8,754 | 18,340 |
histone H4K16 deacetylase activity, NAD-dependent
|
6,053.67 | 34.41 | 8,654 | 18,465 |
histone H3K9 deacetylase activity, NAD-dependent
|
5,944.85 | 33.95 | 8,654 | 18,803 |
histone deacetylase activity, NAD-dependent
|
3,343.17 | 25.77 | 15,081 | 58,267 |
Totals | 186518 | 113389732 |
No co-occurrence statistics for GO:0036055 based on MANUAL annotations
The top 65 of 65 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-succinyllysine desuccinylase activity
|
21,386.86 | 100.00 | 66 | 66 |
protein-glutaryllysine deglutarylase activity
|
21,386.86 | 95.45 | 63 | 63 |
protein-malonyllysine demalonylase activity
|
21,386.86 | 51.52 | 34 | 34 |
histone H3K18 deacetylase activity, NAD-dependent
|
17,548.20 | 43.84 | 32 | 39 |
protein desuccinylation
|
21,386.86 | 19.70 | 13 | 13 |
regulation of ketone biosynthetic process
|
21,386.87 | 16.67 | 11 | 11 |
protein deacetylation
|
8,554.75 | 16.09 | 14 | 35 |
peptidyl-lysine desuccinylation
|
21,386.86 | 15.15 | 10 | 10 |
peptidyl-lysine demalonylation
|
21,386.86 | 15.15 | 10 | 10 |
protein demalonylation
|
21,386.87 | 12.12 | 8 | 8 |
Totals | 694 | 811850 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2025-02-15 | Added | RELATION | is a GO:0141218 (NAD-dependent protein lysine deacylase activity) |
2025-02-15 | Deleted | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2025-02-15 | Deleted | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2025-02-15 | Added | DEFINITION | Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2019-10-20 | Added | XREF | RHEA:47668 |
2019-10-20 | Deleted | DEFINITION | Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
2019-10-20 | Added | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2011-12-16 | Added | DEFINITION | Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-12-16 | Updated | TERM | protein-succinyllysine desuccinylase activity |
2011-12-14 | Added | TERM | succinyllysine desuccinylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2025-02-15 | Deleted | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2025-02-15 | Added | DEFINITION | Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2019-10-20 | Deleted | DEFINITION | Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
2019-10-20 | Added | DEFINITION | Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2011-12-16 | Added | DEFINITION | Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
2011-12-16 | Deleted | SYNONYM | succinyl lysine desuccinylase activity |
2011-12-16 | Added | SYNONYM | succinyllysine desuccinylase activity |
2011-12-16 | Added | SYNONYM | succinyl lysine desuccinylase activity |
2011-12-16 | Added | SYNONYM | peptidyl-succinyllysine desuccinylase activity |
2011-12-16 | Deleted | DEFINITION | Catalysis of the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
2011-12-14 | Added | DEFINITION | Catalysis of the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. |
2011-12-14 | Added | SYNONYM | succinyl lysine desuccinylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2025-02-15 | Added | RELATION | is a GO:0141218 (NAD-dependent protein lysine deacylase activity) |
2025-02-15 | Deleted | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2011-12-14 | Added | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2011-12-14 | Added | RELATION | part of GO:0036049 (peptidyl-lysine desuccinylation) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-10-20 | Added | XREF | RHEA:47668 |
Timestamp | Action | Category | Detail |
---|
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