This term is obsolete.
This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.

GO:0036055 JSON

protein-succinyllysine desuccinylase activity

Molecular Function

Definition (GO:0036055 GONUTS page)

Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. PMID:22076378

Comments

This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.

15,311 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
succinyl lysine desuccinylase activity broad
succinyllysine desuccinylase activity broad
peptidyl-succinyllysine desuccinylase activity exact

Ancestor Chart

Ancestor chart for GO:0036055
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
InterPro IPR027546 Sirtuin, class III
RHEA 47668

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:87832 2''-O-succinyl-ADP-D-ribose(3-)
has_participant CHEBI CHEBI:87830 N(6)-succinyl-L-lysine(1-) residue
has_participant CHEBI CHEBI:17154 nicotinamide
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:29969 L-lysinium residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0036055 based on ALL annotations
The top 100 of 187 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-succinyllysine desuccinylase activity
12,783.71 100.00 15,249 15,249
protein-malonyllysine demalonylase activity
12,783.71 99.50 15,172 15,172
NAD-dependent protein lysine deacetylase activity
7,297.19 54.14 13,924 24,393
histone H3K4 deacetylase activity, NAD-dependent
6,550.05 37.36 8,840 17,253
histone H3K14 deacetylase activity, NAD-dependent
6,523.20 37.25 8,840 17,324
histone H3K56 deacetylase activity, NAD-dependent
6,507.05 37.18 8,840 17,367
histone H3K18 deacetylase activity, NAD-dependent
6,139.89 35.85 8,931 18,595
histone H4K16 deacetylase activity, NAD-dependent
6,018.75 35.10 8,840 18,776
histone H3K9 deacetylase activity, NAD-dependent
5,929.38 34.71 8,840 19,059
histone deacetylase activity, NAD-dependent
3,357.23 26.13 14,970 57,003
Totals 186653 111251199
No co-occurrence statistics for GO:0036055 based on MANUAL annotations
The top 67 of 67 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-succinyllysine desuccinylase activity
25,329.39 100.00 51 51
protein-malonyllysine demalonylase activity
25,329.39 98.04 50 50
protein-glutaryllysine deglutarylase activity
25,329.39 84.31 43 43
histone H3K18 deacetylase activity, NAD-dependent
18,762.51 34.48 20 27
protein desuccinylation
25,329.39 25.49 13 13
regulation of ketone biosynthetic process
25,329.39 21.57 11 11
peptidyl-lysine desuccinylation
25,329.39 19.61 10 10
peptidyl-lysine demalonylation
25,329.39 19.61 10 10
protein deacetylation
10,131.76 19.44 14 35
protein demalonylation
25,329.39 15.69 8 8
Totals 526 761076

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2019-10-20 Deleted DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2019-10-20 Added XREF RHEA:47668
2019-10-20 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2011-12-16 Added DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2011-12-16 Added SYNONYM succinyllysine desuccinylase activity
2011-12-16 Deleted DEFINITION Catalysis of the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2011-12-16 Added SYNONYM peptidyl-succinyllysine desuccinylase activity
2011-12-16 Deleted SYNONYM succinyl lysine desuccinylase activity
Timestamp Action Category Detail
2011-12-16 Updated TERM protein-succinyllysine desuccinylase activity
2011-12-14 Added TERM succinyllysine desuccinylase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2019-10-20 Deleted DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2019-10-20 Added DEFINITION Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2011-12-16 Added DEFINITION Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2011-12-16 Added SYNONYM succinyllysine desuccinylase activity
2011-12-16 Deleted DEFINITION Catalysis of the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
2011-12-16 Added SYNONYM peptidyl-succinyllysine desuccinylase activity
2011-12-16 Deleted SYNONYM succinyl lysine desuccinylase activity
2011-12-16 Added SYNONYM succinyl lysine desuccinylase activity
2011-12-14 Added SYNONYM succinyl lysine desuccinylase activity
2011-12-14 Added DEFINITION Catalysis of the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
Timestamp Action Category Detail
2011-12-14 Added RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2011-12-14 Added RELATION part of GO:0036049 (peptidyl-lysine desuccinylation)
Timestamp Action Category Detail
2019-10-20 Added XREF RHEA:47668
Timestamp Action Category Detail
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