This term is obsolete.

GO:0036524 JSON

protein deglycase activity

Molecular Function

Definition (GO:0036524 GONUTS page)

Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. PMID:14568004 PMID:25416785 PMID:26873906

Acknowledgement

This term was created by the GO Consortium with support from: PARK image

2,538 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protein deglycating enzyme related
glyoxylase III exact

Ancestor Chart

Ancestor chart for GO:0036524
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O88767 10116 PARK7_RAT GO:0036524 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q5E946 9913 PARK7_BOVIN GO:0036524 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q5XJ36 7955 PARK7_DANRE GO:0036524 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 3.5.1.124
InterPro IPR017283 Protein/nucleic acid deglycase HchA
MetaCyc RXN-17630
MetaCyc RXN-17632
MetaCyc RXN-17634
RHEA 49548
RHEA 49552
RHEA 49556
RHEA 57188
RHEA 57192

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0036524 based on ALL annotations
The top 100 of 196 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein deglycase activity
77,264.68 100.00 2,523 2,523
glyoxal metabolic process
10,075.34 9.52 658 5,046
oxidoreductase activity, acting on peroxide as acceptor
8,308.44 8.21 651 6,054
lactate biosynthetic process
5,009.93 6.15 1,371 21,144
glyoxalase III activity
4,722.10 5.77 1,286 21,042
glycolate biosynthetic process
4,228.38 4.74 656 11,987
guanine deglycation
77,264.67 3.61 91 91
methylglyoxal metabolic process
62,647.04 3.54 90 111
guanine deglycation, glyoxal removal
77,264.68 3.53 89 89
guanine deglycation, methylglyoxal removal
77,264.68 3.53 89 89
Totals 17895 1403626
No co-occurrence statistics for GO:0036524 based on MANUAL annotations
The top 100 of 170 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein deglycase activity
107,649.92 100.00 12 12
guanine deglycation
96,884.93 69.23 9 10
glyoxalase (glycolic acid-forming) activity
107,649.91 58.33 7 7
guanine deglycation, glyoxal removal
94,193.67 53.85 7 8
guanine deglycation, methylglyoxal removal
94,193.67 53.85 7 8
methylglyoxal catabolic process to lactate
92,271.35 46.15 6 7
positive regulation of oxidative phosphorylation uncoupler activity
92,271.35 46.15 6 7
detoxification of hydrogen peroxide
80,737.44 42.86 6 8
positive regulation of acute inflammatory response to antigenic stimulus
80,737.44 42.86 6 8
cellular detoxification of methylglyoxal
71,766.61 40.00 6 9
Totals 308 8484

Change Log

Timestamp Action Category Detail
2024-05-11 Added XREF RHEA:57192
2024-05-11 Added XREF RHEA:49552
2024-05-11 Added XREF RHEA:57196
2024-05-11 Added XREF RHEA:49556
2024-05-11 Added XREF RHEA:57188
2024-05-11 Added XREF RHEA:49548
2023-08-08 Added DEFINITION Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal.
2023-08-08 Deleted DEFINITION Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein.
2023-08-08 Added XREF EC:3.5.1.124
2023-08-08 Added SYNONYM glyoxylase III
Timestamp Action Category Detail
2016-08-06 Added TERM protein deglycase activity
Timestamp Action Category Detail
2023-08-08 Added DEFINITION Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal.
2023-08-08 Deleted DEFINITION Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein.
2023-08-08 Added SYNONYM glyoxylase III
2016-08-06 Added DEFINITION Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein.
2016-08-06 Added SYNONYM protein deglycating enzyme
Timestamp Action Category Detail
2023-08-08 Added RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2023-08-08 Deleted RELATION is a GO:0016836 (hydro-lyase activity)
2022-02-17 Deleted RELATION part of GO:0036525 (protein deglycation)
2017-09-19 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2016-08-06 Added RELATION is a GO:0016836 (hydro-lyase activity)
2016-08-06 Added RELATION part of GO:0036525 (protein deglycation)
Timestamp Action Category Detail
2024-05-11 Added XREF RHEA:57192
2024-05-11 Added XREF RHEA:49552
2024-05-11 Added XREF RHEA:57196
2024-05-11 Added XREF RHEA:49556
2024-05-11 Added XREF RHEA:57188
2024-05-11 Added XREF RHEA:49548
2023-08-08 Added XREF EC:3.5.1.124
2020-05-14 Added XREF MetaCyc:RXN-17634
2020-05-14 Added XREF MetaCyc:RXN-17630
2020-05-14 Added XREF MetaCyc:RXN-17632
Timestamp Action Category Detail
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