GO:0036524
JSON
protein deglycase activity
Molecular Function
Definition (GO:0036524 GONUTS page)
Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. PMID:14568004 PMID:25416785 PMID:26873906
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
protein deglycating enzyme | related |
glyoxylase III | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O88767 | 10116 | PARK7_RAT | GO:0036524 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q5E946 | 9913 | PARK7_BOVIN | GO:0036524 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q5XJ36 | 7955 | PARK7_DANRE | GO:0036524 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.5.1.124 | |
InterPro | IPR017283 | Protein/nucleic acid deglycase HchA |
MetaCyc | RXN-17630 | |
MetaCyc | RXN-17632 | |
MetaCyc | RXN-17634 | |
RHEA | 49548 | |
RHEA | 49552 | |
RHEA | 49556 | |
RHEA | 57188 | |
RHEA | 57192 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0036524 based on ALL annotations
The top 100 of 196 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein deglycase activity
|
77,264.68 | 100.00 | 2,523 | 2,523 |
glyoxal metabolic process
|
10,075.34 | 9.52 | 658 | 5,046 |
oxidoreductase activity, acting on peroxide as acceptor
|
8,308.44 | 8.21 | 651 | 6,054 |
lactate biosynthetic process
|
5,009.93 | 6.15 | 1,371 | 21,144 |
glyoxalase III activity
|
4,722.10 | 5.77 | 1,286 | 21,042 |
glycolate biosynthetic process
|
4,228.38 | 4.74 | 656 | 11,987 |
guanine deglycation
|
77,264.67 | 3.61 | 91 | 91 |
methylglyoxal metabolic process
|
62,647.04 | 3.54 | 90 | 111 |
guanine deglycation, glyoxal removal
|
77,264.68 | 3.53 | 89 | 89 |
guanine deglycation, methylglyoxal removal
|
77,264.68 | 3.53 | 89 | 89 |
Totals | 17895 | 1403626 |
No co-occurrence statistics for GO:0036524 based on MANUAL annotations
The top 100 of 170 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein deglycase activity
|
107,649.92 | 100.00 | 12 | 12 |
guanine deglycation
|
96,884.93 | 69.23 | 9 | 10 |
glyoxalase (glycolic acid-forming) activity
|
107,649.91 | 58.33 | 7 | 7 |
guanine deglycation, glyoxal removal
|
94,193.67 | 53.85 | 7 | 8 |
guanine deglycation, methylglyoxal removal
|
94,193.67 | 53.85 | 7 | 8 |
methylglyoxal catabolic process to lactate
|
92,271.35 | 46.15 | 6 | 7 |
positive regulation of oxidative phosphorylation uncoupler activity
|
92,271.35 | 46.15 | 6 | 7 |
detoxification of hydrogen peroxide
|
80,737.44 | 42.86 | 6 | 8 |
positive regulation of acute inflammatory response to antigenic stimulus
|
80,737.44 | 42.86 | 6 | 8 |
cellular detoxification of methylglyoxal
|
71,766.61 | 40.00 | 6 | 9 |
Totals | 308 | 8484 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-11 | Added | XREF | RHEA:57192 |
2024-05-11 | Added | XREF | RHEA:49552 |
2024-05-11 | Added | XREF | RHEA:57196 |
2024-05-11 | Added | XREF | RHEA:49556 |
2024-05-11 | Added | XREF | RHEA:57188 |
2024-05-11 | Added | XREF | RHEA:49548 |
2023-08-08 | Added | DEFINITION | Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. |
2023-08-08 | Deleted | DEFINITION | Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. |
2023-08-08 | Added | XREF | EC:3.5.1.124 |
2023-08-08 | Added | SYNONYM | glyoxylase III |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-08-06 | Added | TERM | protein deglycase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-08 | Added | DEFINITION | Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. |
2023-08-08 | Deleted | DEFINITION | Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. |
2023-08-08 | Added | SYNONYM | glyoxylase III |
2016-08-06 | Added | DEFINITION | Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. |
2016-08-06 | Added | SYNONYM | protein deglycating enzyme |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-08 | Added | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2023-08-08 | Deleted | RELATION | is a GO:0016836 (hydro-lyase activity) |
2022-02-17 | Deleted | RELATION | part of GO:0036525 (protein deglycation) |
2017-09-19 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2016-08-06 | Added | RELATION | is a GO:0016836 (hydro-lyase activity) |
2016-08-06 | Added | RELATION | part of GO:0036525 (protein deglycation) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-11 | Added | XREF | RHEA:57192 |
2024-05-11 | Added | XREF | RHEA:49552 |
2024-05-11 | Added | XREF | RHEA:57196 |
2024-05-11 | Added | XREF | RHEA:49556 |
2024-05-11 | Added | XREF | RHEA:57188 |
2024-05-11 | Added | XREF | RHEA:49548 |
2023-08-08 | Added | XREF | EC:3.5.1.124 |
2020-05-14 | Added | XREF | MetaCyc:RXN-17634 |
2020-05-14 | Added | XREF | MetaCyc:RXN-17630 |
2020-05-14 | Added | XREF | MetaCyc:RXN-17632 |
Timestamp | Action | Category | Detail |
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