This term is obsolete.

GO:0038007 JSON

netrin-activated signaling pathway

Biological Process

Definition (GO:0038007 GONUTS page)

The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. PMID:10399919 PMID:15960985 PMID:19785719 PMID:20108323

17,649 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
netrin-activated signalling pathway exact
netrin-activated signal transduction pathway exact
netrin signaling pathway exact
netrin-mediated signaling pathway exact

Ancestor Chart

Ancestor chart for GO:0038007
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0038007

Child Term Relationship to
GO:0038007
GO:0005042
netrin receptor activity
part_of
GO:1902843
positive regulation of netrin-activated signaling pathway
positively_regulates
GO:1990890
netrin receptor binding
part_of
GO:1902842
negative regulation of netrin-activated signaling pathway
negatively_regulates
GO:1902841
regulation of netrin-activated signaling pathway
regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
InterPro IPR037936 Netrin receptor UNC5

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0038007 based on ALL annotations
The top 100 of 380 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0038007
netrin-activated signaling pathway
22,682.56 100.00 8,736 8,736
GO:0005042
netrin receptor activity
22,682.56 97.71 8,536 8,536
GO:0033564
anterior/posterior axon guidance
19,865.67 28.13 2,560 2,923
GO:0008045
motor neuron axon guidance
1,295.59 3.76 865 15,144
GO:0007411
axon guidance
515.40 2.22 4,165 183,301
GO:1990791
dorsal root ganglion development
10,864.76 1.92 171 357
GO:1990890
netrin receptor binding
22,682.56 1.83 160 160
GO:0061643
chemorepulsion of axon
11,445.33 1.24 110 218
GO:0005043
netrin receptor activity involved in chemorepulsion
22,682.56 1.01 88 88
GO:2000243
positive regulation of reproductive process
8,655.19 0.98 87 228
Totals 30534 2683040
No co-occurrence statistics for GO:0038007 based on MANUAL annotations
The top 100 of 251 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0038007
netrin-activated signaling pathway
50,411.90 100.00 28 28
GO:1905815
regulation of dorsal/ventral axon guidance
31,022.70 24.24 8 13
GO:0061643
chemorepulsion of axon
23,879.32 23.68 9 19
GO:0061573
actin filament bundle retrograde transport
36,008.50 16.67 5 7
GO:0061163
endoplasmic reticulum polarization
31,507.43 16.13 5 8
GO:1990791
dorsal root ganglion development
12,602.97 13.04 6 24
GO:1990890
netrin receptor binding
28,806.80 12.90 4 7
GO:0032488
Cdc42 protein signal transduction
15,753.72 12.82 5 16
GO:0097628
distal tip cell migration
37,808.92 10.34 3 4
GO:0060327
cytoplasmic actin-based contraction involved in cell motility
9,335.54 10.00 5 27
Totals 306 11554

Change Log

Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2022-03-14 Deleted DEFINITION A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 Deleted DEFINITION The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 Added DEFINITION A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2011-06-12 Added DEFINITION The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2011-06-12 Added RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2011-06-12 Added TERM netrin-activated signaling pathway
2011-06-12 Added SYNONYM netrin signaling pathway
2011-06-12 Added SYNONYM netrin-activated signalling pathway
2011-06-12 Added SYNONYM netrin-mediated signaling pathway
Timestamp Action Category Detail
2011-06-12 Added TERM netrin-activated signaling pathway
Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2022-03-14 Deleted DEFINITION A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 Deleted DEFINITION The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 Added DEFINITION A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2011-06-12 Added DEFINITION The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2011-06-12 Added SYNONYM netrin signaling pathway
2011-06-12 Added SYNONYM netrin-activated signalling pathway
2011-06-12 Added SYNONYM netrin-mediated signaling pathway
2011-06-12 Added SYNONYM netrin-activated signal transduction pathway
Timestamp Action Category Detail
2011-06-12 Added RELATION is a GO:0007166 (cell surface receptor signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
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