GO:0039554
JSON
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
Biological Process
Definition (GO:0039554 GONUTS page)
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. PMID:19019954 PMID:33727702
Secondary IDs
GO:0039539
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
Inhibition of host MDA5 by virus | related |
suppression by virus of host MDA-5 activity | related |
inhibition of host IFIH1/MDA5 by virus | related |
suppression by virus of host IFIH1 signaling pathway | related |
suppression by virus of host MDA-5 signalling pathway | related |
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity | narrow |
inhibition by virus of host MDA-5 signaling | related |
suppression by virus of host MDA-5 signaling pathway | related |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0039554 | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity | Never in Taxon | 33090 | Viridiplantae | |
GO:0039554 | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity | Never in Taxon | 33208 | Metazoa | |
GO:0039554 | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity | Never in Taxon | 4895 | Schizosaccharomyces |
More information on taxon constraints in GO is available here
Cross-references
Database | ID | Description |
---|---|---|
UniProtKB-KW | KW-1089 | Inhibition of host MDA5 by virus |
VZ | 603 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0039554 based on ALL annotations
The top 98 of 98 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
|
58,893.89 | 100.00 | 3,310 | 3,310 |
symbiont-mediated perturbation of host cellular process
|
26,680.23 | 45.23 | 3,298 | 7,280 |
symbiont-mediated suppression of host mRNA export from nucleus
|
24,336.04 | 38.59 | 2,826 | 6,839 |
host cell cytoplasmic vesicle membrane
|
14,807.52 | 24.09 | 2,819 | 11,212 |
T=pseudo3 icosahedral viral capsid
|
11,179.28 | 18.39 | 2,827 | 14,893 |
host cell cytoplasmic vesicle
|
10,371.18 | 17.09 | 2,819 | 16,008 |
induction by virus of host autophagy
|
5,525.89 | 9.23 | 2,826 | 30,119 |
endocytosis involved in viral entry into host cell
|
3,113.64 | 5.24 | 2,818 | 53,302 |
symbiont genome entry into host cell via pore formation in plasma membrane
|
2,275.86 | 3.84 | 2,819 | 72,949 |
cysteine-type endopeptidase activity
|
898.77 | 1.52 | 2,827 | 185,246 |
Totals | 106177 | 184490428 |
No co-occurrence statistics for GO:0039554 based on MANUAL annotations
The top 4 of 4 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
|
645,899.50 | 100.00 | 2 | 2 |
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
|
129,179.90 | 16.67 | 1 | 5 |
ubiquitin-like ligase-substrate adaptor activity
|
339.41 | 0.05 | 1 | 1,903 |
protein binding
|
15.45 | 0.00 | 1 | 41,817 |
Totals | 5 | 43727 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:33208 (Metazoa) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:33090 (Viridiplantae) |
2023-12-26 | Added | DEFINITION | A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
2023-12-26 | Added | SYNONYM | suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity |
2023-12-26 | Deleted | DEFINITION | Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
2023-12-26 | Added | XREF | VZ:603 |
2023-12-26 | Updated | TERM | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity |
2021-08-22 | Deleted | RELATION | is a GO:0039539 (suppression by virus of host MDA-5 signaling pathway) |
2021-08-22 | Deleted | RELATION | is a GO:0039509 (obsolete suppression by virus of host pattern recognition receptor activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Updated | TERM | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity |
2021-08-22 | Updated | TERM | suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity |
2012-04-28 | Added | TERM | suppression by virus of host MDA-5 activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | DEFINITION | A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
2023-12-26 | Added | SYNONYM | suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity |
2023-12-26 | Deleted | DEFINITION | Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
2021-08-22 | Deleted | SYNONYM | Inhibition of host MDA5 by virus |
2021-08-22 | Added | SYNONYM | inhibition by virus of host MDA-5 signaling |
2021-08-22 | Added | SYNONYM | suppression by virus of host IFIH1 signaling pathway |
2021-08-22 | Added | SYNONYM | suppression by virus of host MDA-5 signaling pathway |
2021-08-22 | Added | SYNONYM | Inhibition of host MDA5 by virus |
2021-08-22 | Added | SYNONYM | suppression by virus of host MDA-5 activity |
2021-08-22 | Added | SYNONYM | suppression by virus of host MDA-5 signalling pathway |
2021-08-22 | Added | DEFINITION | Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
2021-08-22 | Deleted | DEFINITION | Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
2015-04-10 | Added | SYNONYM | Inhibition of host MDA5 by virus |
2015-04-10 | Deleted | SYNONYM | Inhibition of host MDA5 by virus |
2012-04-28 | Added | DEFINITION | Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
2012-04-28 | Added | SYNONYM | inhibition of host IFIH1/MDA5 by virus |
2012-04-28 | Added | SYNONYM | Inhibition of host MDA5 by virus |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-08-22 | Deleted | RELATION | is a GO:0039539 (suppression by virus of host MDA-5 signaling pathway) |
2021-08-22 | Deleted | RELATION | is a GO:0039509 (obsolete suppression by virus of host pattern recognition receptor activity) |
2021-08-22 | Added | RELATION | is a GO:0039537 (symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway) |
2012-04-28 | Added | RELATION | is a GO:0039509 (obsolete suppression by virus of host pattern recognition receptor activity) |
2012-04-28 | Added | RELATION | is a GO:0039539 (suppression by virus of host MDA-5 signaling pathway) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | XREF | VZ:603 |
2021-08-22 | Deleted | XREF | VZ:603 |
2012-04-28 | Added | XREF | VZ:603 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:33208 (Metazoa) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:33090 (Viridiplantae) |
2021-08-22 | Added | SECONDARY | GO:0039539 (suppression by virus of host MDA-5 signaling pathway) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link