This term is obsolete.

GO:0039554 JSON

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity

Biological Process

Definition (GO:0039554 GONUTS page)

A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. PMID:19019954 PMID:33727702

Secondary IDs

GO:0039539

3,312 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Inhibition of host MDA5 by virus related
suppression by virus of host MDA-5 activity related
inhibition of host IFIH1/MDA5 by virus related
suppression by virus of host IFIH1 signaling pathway related
suppression by virus of host MDA-5 signalling pathway related
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity narrow
inhibition by virus of host MDA-5 signaling related
suppression by virus of host MDA-5 signaling pathway related

Ancestor Chart

Ancestor chart for GO:0039554
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity Never in Taxon 33090 Viridiplantae
GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity Never in Taxon 33208 Metazoa
GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity Never in Taxon 4895 Schizosaccharomyces

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
UniProtKB-KW KW-1089 Inhibition of host MDA5 by virus
VZ 603

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0039554 based on ALL annotations
The top 98 of 98 co-occurring terms
Co-occurring Term PR S% #Together #Compared
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
58,893.89 100.00 3,310 3,310
symbiont-mediated perturbation of host cellular process
26,680.23 45.23 3,298 7,280
symbiont-mediated suppression of host mRNA export from nucleus
24,336.04 38.59 2,826 6,839
host cell cytoplasmic vesicle membrane
14,807.52 24.09 2,819 11,212
T=pseudo3 icosahedral viral capsid
11,179.28 18.39 2,827 14,893
host cell cytoplasmic vesicle
10,371.18 17.09 2,819 16,008
induction by virus of host autophagy
5,525.89 9.23 2,826 30,119
endocytosis involved in viral entry into host cell
3,113.64 5.24 2,818 53,302
symbiont genome entry into host cell via pore formation in plasma membrane
2,275.86 3.84 2,819 72,949
cysteine-type endopeptidase activity
898.77 1.52 2,827 185,246
Totals 106177 184490428
No co-occurrence statistics for GO:0039554 based on MANUAL annotations
The top 4 of 4 co-occurring terms
Co-occurring Term PR S% #Together #Compared
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
645,899.50 100.00 2 2
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
129,179.90 16.67 1 5
ubiquitin-like ligase-substrate adaptor activity
339.41 0.05 1 1,903
protein binding
15.45 0.00 1 41,817
Totals 5 43727

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:33208 (Metazoa)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:33090 (Viridiplantae)
2023-12-26 Added DEFINITION A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
2023-12-26 Added SYNONYM suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity
2023-12-26 Deleted DEFINITION Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
2023-12-26 Added XREF VZ:603
2023-12-26 Updated TERM symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
2021-08-22 Deleted RELATION is a GO:0039539 (suppression by virus of host MDA-5 signaling pathway)
2021-08-22 Deleted RELATION is a GO:0039509 (obsolete suppression by virus of host pattern recognition receptor activity)
Timestamp Action Category Detail
2023-12-26 Updated TERM symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
2021-08-22 Updated TERM suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity
2012-04-28 Added TERM suppression by virus of host MDA-5 activity
Timestamp Action Category Detail
2023-12-26 Added DEFINITION A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
2023-12-26 Added SYNONYM suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity
2023-12-26 Deleted DEFINITION Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
2021-08-22 Deleted SYNONYM Inhibition of host MDA5 by virus
2021-08-22 Added SYNONYM inhibition by virus of host MDA-5 signaling
2021-08-22 Added SYNONYM suppression by virus of host IFIH1 signaling pathway
2021-08-22 Added SYNONYM suppression by virus of host MDA-5 signaling pathway
2021-08-22 Added SYNONYM Inhibition of host MDA5 by virus
2021-08-22 Added SYNONYM suppression by virus of host MDA-5 activity
2021-08-22 Added SYNONYM suppression by virus of host MDA-5 signalling pathway
2021-08-22 Added DEFINITION Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
2021-08-22 Deleted DEFINITION Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
2015-04-10 Added SYNONYM Inhibition of host MDA5 by virus
2015-04-10 Deleted SYNONYM Inhibition of host MDA5 by virus
2012-04-28 Added DEFINITION Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
2012-04-28 Added SYNONYM inhibition of host IFIH1/MDA5 by virus
2012-04-28 Added SYNONYM Inhibition of host MDA5 by virus
Timestamp Action Category Detail
2021-08-22 Deleted RELATION is a GO:0039539 (suppression by virus of host MDA-5 signaling pathway)
2021-08-22 Deleted RELATION is a GO:0039509 (obsolete suppression by virus of host pattern recognition receptor activity)
2021-08-22 Added RELATION is a GO:0039537 (symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway)
2012-04-28 Added RELATION is a GO:0039509 (obsolete suppression by virus of host pattern recognition receptor activity)
2012-04-28 Added RELATION is a GO:0039539 (suppression by virus of host MDA-5 signaling pathway)
Timestamp Action Category Detail
2023-12-26 Added XREF VZ:603
2021-08-22 Deleted XREF VZ:603
2012-04-28 Added XREF VZ:603
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:33208 (Metazoa)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:33090 (Viridiplantae)
2021-08-22 Added SECONDARY GO:0039539 (suppression by virus of host MDA-5 signaling pathway)
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