This term is obsolete.

GO:0042059 JSON

negative regulation of epidermal growth factor receptor signaling pathway

Biological Process

Definition (GO:0042059 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

4,173 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation of EGFR signaling pathway exact
negative regulation of EGF receptor signalling pathway exact
inhibition of epidermal growth factor receptor signaling pathway narrow
downregulation of epidermal growth factor receptor signaling pathway exact
down-regulation of epidermal growth factor receptor signaling pathway exact
down regulation of epidermal growth factor receptor signaling pathway exact
negative regulation of EGF receptor signaling pathway exact

Ancestor Chart

Ancestor chart for GO:0042059
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042059

Child Term Relationship to
GO:0042059
negative regulation of epidermal growth factor-activated receptor activity
is_a
epidermal growth factor catabolic process
is_a
negative regulation of epidermal growth factor receptor signaling pathway involved in heart process
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0042059 based on ALL annotations
The top 100 of 1,098 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of epidermal growth factor receptor signaling pathway
50,048.47 100.00 3,895 3,895
regulation of keratinocyte differentiation
37,937.65 55.84 2,647 3,492
protein serine/threonine/tyrosine kinase activity
1,924.37 3.57 1,289 33,524
negative regulation of T cell receptor signaling pathway
3,044.91 2.64 174 2,860
regulation of platelet-derived growth factor receptor-alpha signaling pathway
18,457.59 2.55 104 282
regulation of Rap protein signal transduction
24,389.10 2.40 96 197
response to 1-oleoyl-sn-glycerol 3-phosphate
50,048.47 2.39 93 93
limb joint morphogenesis
16,447.02 2.28 93 283
integrin alpha1-beta1 complex
23,819.86 2.23 89 187
cellular extravasation
15,704.86 2.22 91 290
Totals 17851 408557
No co-occurrence statistics for GO:0042059 based on MANUAL annotations
The top 100 of 956 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of epidermal growth factor receptor signaling pathway
5,741.33 100.00 225 225
receptor tyrosine kinase binding
722.36 10.13 77 612
regulation of keratinocyte differentiation
2,563.09 9.77 25 56
membrane raft
408.69 6.35 83 1,166
multivesicular body, internal vesicle lumen
5,741.33 5.33 12 12
negative regulation of cardiocyte differentiation
5,741.33 5.33 12 12
epidermal growth factor binding
2,132.49 5.26 13 35
ERBB2-EGFR signaling pathway
2,017.22 5.22 13 37
epidermal growth factor receptor activity
1,820.42 5.14 13 41
morphogenesis of an epithelial fold
2,995.48 5.08 12 23
Totals 1496 19865

Change Log

Timestamp Action Category Detail
2012-07-26 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2012-07-26 Added RELATION is a GO:1901185 (negative regulation of ERBB signaling pathway)
2011-01-16 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2011-01-16 Deleted RELATION is a GO:0035467 (negative regulation of signaling pathway)
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2010-04-21 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-04-21 Added RELATION is a GO:0035467 (negative regulation of signaling pathway)
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Timestamp Action Category Detail
2004-02-12 Updated TERM negative regulation of epidermal growth factor receptor signaling pathway
2002-02-15 Added TERM negative regulation of EGF receptor signaling pathway
Timestamp Action Category Detail
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2007-08-09 Added SYNONYM downregulation of epidermal growth factor receptor signaling pathway
2007-08-09 Added SYNONYM inhibition of epidermal growth factor receptor signaling pathway
2007-08-09 Deleted SYNONYM negative regulation of EGFR signaling pathway
2007-08-09 Deleted SYNONYM negative regulation of EGF receptor signalling pathway
2007-08-09 Deleted SYNONYM negative regulation of EGF receptor signaling pathway
2007-08-09 Deleted SYNONYM downregulation of epidermal growth factor receptor signaling pathway
2007-08-09 Added SYNONYM down regulation of epidermal growth factor receptor signaling pathway
2007-08-09 Deleted SYNONYM inhibition of epidermal growth factor receptor signaling pathway
2007-08-09 Deleted SYNONYM down-regulation of epidermal growth factor receptor signaling pathway
2007-08-09 Deleted SYNONYM down regulation of epidermal growth factor receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of EGFR signaling pathway
2007-08-09 Added SYNONYM negative regulation of EGF receptor signalling pathway
2007-08-09 Added SYNONYM down-regulation of epidermal growth factor receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of EGF receptor signaling pathway
2007-02-23 Added SYNONYM down regulation of epidermal growth factor receptor signaling pathway
2007-02-23 Added SYNONYM inhibition of epidermal growth factor receptor signaling pathway
2007-02-23 Added SYNONYM downregulation of epidermal growth factor receptor signaling pathway
2007-02-23 Added SYNONYM down-regulation of epidermal growth factor receptor signaling pathway
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity.
2004-11-09 Added SYNONYM negative regulation of EGFR signaling pathway
2004-04-19 Added SYNONYM negative regulation of EGF receptor signaling pathway
2004-04-19 Added SYNONYM negative regulation of EGF receptor signalling pathway
2004-04-16 Deleted SYNONYM negative regulation of EGF receptor signalling pathway
2004-04-16 Deleted SYNONYM negative regulation of EGF receptor signaling pathway
2004-02-12 Updated DEFINITION Any process that stops, prevents or reduces the rate of epidermal growth factor receptor signaling pathway activity.
2004-02-12 Added SYNONYM negative regulation of EGF receptor signaling pathway
2003-11-13 Added SYNONYM negative regulation of EGF receptor signalling pathway
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of EGF receptor signaling pathway activity.
Timestamp Action Category Detail
2012-07-26 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2012-07-26 Added RELATION is a GO:1901185 (negative regulation of ERBB signaling pathway)
2011-01-16 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2011-01-16 Deleted RELATION is a GO:0035467 (negative regulation of signaling pathway)
2010-04-21 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-04-21 Added RELATION is a GO:0035467 (negative regulation of signaling pathway)
2008-04-01 Updated RELATION is a GO:0042058 (regulation of epidermal growth factor receptor signaling pathway)
2008-04-01 Added RELATION negatively regulates GO:0007173 (epidermal growth factor receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
Timestamp Action Category Detail
Timestamp Action Category Detail
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