GO:0042059
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negative regulation of epidermal growth factor receptor signaling pathway
Biological Process
Definition (GO:0042059 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
negative regulation of EGFR signaling pathway | exact |
negative regulation of EGF receptor signalling pathway | exact |
inhibition of epidermal growth factor receptor signaling pathway | narrow |
downregulation of epidermal growth factor receptor signaling pathway | exact |
down-regulation of epidermal growth factor receptor signaling pathway | exact |
down regulation of epidermal growth factor receptor signaling pathway | exact |
negative regulation of EGF receptor signaling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0042059
Child Term | Relationship to GO:0042059 |
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negative regulation of epidermal growth factor-activated receptor activity
|
is_a |
epidermal growth factor catabolic process
|
is_a |
negative regulation of epidermal growth factor receptor signaling pathway involved in heart process
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0042059 based on ALL annotations
The top 100 of 1,098 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of epidermal growth factor receptor signaling pathway
|
50,048.47 | 100.00 | 3,895 | 3,895 |
regulation of keratinocyte differentiation
|
37,937.65 | 55.84 | 2,647 | 3,492 |
protein serine/threonine/tyrosine kinase activity
|
1,924.37 | 3.57 | 1,289 | 33,524 |
negative regulation of T cell receptor signaling pathway
|
3,044.91 | 2.64 | 174 | 2,860 |
regulation of platelet-derived growth factor receptor-alpha signaling pathway
|
18,457.59 | 2.55 | 104 | 282 |
regulation of Rap protein signal transduction
|
24,389.10 | 2.40 | 96 | 197 |
response to 1-oleoyl-sn-glycerol 3-phosphate
|
50,048.47 | 2.39 | 93 | 93 |
limb joint morphogenesis
|
16,447.02 | 2.28 | 93 | 283 |
integrin alpha1-beta1 complex
|
23,819.86 | 2.23 | 89 | 187 |
cellular extravasation
|
15,704.86 | 2.22 | 91 | 290 |
Totals | 17851 | 408557 |
No co-occurrence statistics for GO:0042059 based on MANUAL annotations
The top 100 of 956 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of epidermal growth factor receptor signaling pathway
|
5,741.33 | 100.00 | 225 | 225 |
receptor tyrosine kinase binding
|
722.36 | 10.13 | 77 | 612 |
regulation of keratinocyte differentiation
|
2,563.09 | 9.77 | 25 | 56 |
membrane raft
|
408.69 | 6.35 | 83 | 1,166 |
multivesicular body, internal vesicle lumen
|
5,741.33 | 5.33 | 12 | 12 |
negative regulation of cardiocyte differentiation
|
5,741.33 | 5.33 | 12 | 12 |
epidermal growth factor binding
|
2,132.49 | 5.26 | 13 | 35 |
ERBB2-EGFR signaling pathway
|
2,017.22 | 5.22 | 13 | 37 |
epidermal growth factor receptor activity
|
1,820.42 | 5.14 | 13 | 41 |
morphogenesis of an epithelial fold
|
2,995.48 | 5.08 | 12 | 23 |
Totals | 1496 | 19865 |
Change Log
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Timestamp | Action | Category | Detail |
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2012-07-26 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2012-07-26 | Added | RELATION | is a GO:1901185 (negative regulation of ERBB signaling pathway) |
2011-01-16 | Added | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2011-01-16 | Deleted | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2010-04-21 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2010-04-21 | Added | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
Timestamp | Action | Category | Detail |
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2004-02-12 | Updated | TERM | negative regulation of epidermal growth factor receptor signaling pathway |
2002-02-15 | Added | TERM | negative regulation of EGF receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2007-08-09 | Added | SYNONYM | downregulation of epidermal growth factor receptor signaling pathway |
2007-08-09 | Added | SYNONYM | inhibition of epidermal growth factor receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of EGFR signaling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of EGF receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of EGF receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | downregulation of epidermal growth factor receptor signaling pathway |
2007-08-09 | Added | SYNONYM | down regulation of epidermal growth factor receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | inhibition of epidermal growth factor receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | down-regulation of epidermal growth factor receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | down regulation of epidermal growth factor receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of EGFR signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of EGF receptor signalling pathway |
2007-08-09 | Added | SYNONYM | down-regulation of epidermal growth factor receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of EGF receptor signaling pathway |
2007-02-23 | Added | SYNONYM | down regulation of epidermal growth factor receptor signaling pathway |
2007-02-23 | Added | SYNONYM | inhibition of epidermal growth factor receptor signaling pathway |
2007-02-23 | Added | SYNONYM | downregulation of epidermal growth factor receptor signaling pathway |
2007-02-23 | Added | SYNONYM | down-regulation of epidermal growth factor receptor signaling pathway |
2006-05-04 | Updated | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
2005-10-21 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity. |
2004-11-09 | Added | SYNONYM | negative regulation of EGFR signaling pathway |
2004-04-19 | Added | SYNONYM | negative regulation of EGF receptor signaling pathway |
2004-04-19 | Added | SYNONYM | negative regulation of EGF receptor signalling pathway |
2004-04-16 | Deleted | SYNONYM | negative regulation of EGF receptor signalling pathway |
2004-04-16 | Deleted | SYNONYM | negative regulation of EGF receptor signaling pathway |
2004-02-12 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate of epidermal growth factor receptor signaling pathway activity. |
2004-02-12 | Added | SYNONYM | negative regulation of EGF receptor signaling pathway |
2003-11-13 | Added | SYNONYM | negative regulation of EGF receptor signalling pathway |
2002-11-27 | Added | DEFINITION | Any process that stops, prevents or reduces the rate of EGF receptor signaling pathway activity. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-07-26 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2012-07-26 | Added | RELATION | is a GO:1901185 (negative regulation of ERBB signaling pathway) |
2011-01-16 | Added | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2011-01-16 | Deleted | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2010-04-21 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2010-04-21 | Added | RELATION | is a GO:0035467 (negative regulation of signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0042058 (regulation of epidermal growth factor receptor signaling pathway) |
2008-04-01 | Added | RELATION | negatively regulates GO:0007173 (epidermal growth factor receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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