GO:0042092
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type 2 immune response
Biological Process
Definition (GO:0042092 GONUTS page)
An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. PMID:18000958 PMID:18007680 PMID:20065995 PMID:20200518
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
T-helper 2 type immune response | narrow |
Th2 immune response | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0042092
Child Term | Relationship to GO:0042092 |
---|---|
negative regulation of type 2 immune response
|
negatively_regulates |
T-helper 2 cell cytokine production
|
part_of |
positive regulation of type 2 immune response
|
positively_regulates |
regulation of type 2 immune response
|
regulates |
T-helper 2 cell differentiation
|
part_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0042092 | type 2 immune response | Never in Taxon | 4895 | Schizosaccharomyces |
More information on taxon constraints in GO is available here
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0042092 based on ALL annotations
The top 100 of 359 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
type 2 immune response
|
727,383.50 | 100.00 | 268 | 268 |
regulation of memory T cell differentiation
|
719,726.80 | 34.94 | 94 | 95 |
negative regulation of plasma cell differentiation
|
719,645.44 | 34.57 | 93 | 94 |
negative regulation of mononuclear cell proliferation
|
410,547.78 | 27.14 | 92 | 163 |
negative regulation of mast cell cytokine production
|
395,225.72 | 27.09 | 94 | 173 |
transitional two stage B cell differentiation
|
727,383.50 | 26.49 | 71 | 71 |
eosinophil mediated immunity
|
727,383.50 | 26.49 | 71 | 71 |
mononuclear cell proliferation
|
380,223.22 | 26.14 | 92 | 176 |
protein localization to P-body
|
653,724.40 | 25.72 | 71 | 79 |
eosinophil homeostasis
|
600,514.25 | 25.09 | 71 | 86 |
Totals | 6137 | 202286 |
No co-occurrence statistics for GO:0042092 based on MANUAL annotations
The top 100 of 319 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
type 2 immune response
|
36,908.54 | 100.00 | 35 | 35 |
transitional two stage B cell differentiation
|
36,908.54 | 17.14 | 6 | 6 |
eosinophil mediated immunity
|
36,908.54 | 17.14 | 6 | 6 |
protein localization to P-body
|
15,817.95 | 13.95 | 6 | 14 |
regulation of memory T cell differentiation
|
30,757.12 | 13.89 | 5 | 6 |
B cell affinity maturation
|
14,763.42 | 13.64 | 6 | 15 |
leukocyte activation involved in inflammatory response
|
13,840.70 | 13.33 | 6 | 16 |
eosinophil homeostasis
|
13,026.55 | 13.04 | 6 | 17 |
interleukin-17A-mediated signaling pathway
|
11,072.56 | 12.24 | 6 | 20 |
negative regulation of mast cell cytokine production
|
14,195.59 | 11.63 | 5 | 13 |
Totals | 417 | 6304 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2011-03-06 | Deleted | RELATION | is a GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains) |
2011-03-06 | Added | RELATION | is a GO:0006955 (immune response) |
2010-10-11 | Updated | TERM | type 2 immune response |
2010-10-11 | Added | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. |
2010-10-11 | Deleted | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. |
2010-10-11 | Added | SYNONYM | T-helper 2 type immune response |
2010-10-11 | Added | SYNONYM | Th2 immune response |
2010-10-11 | Deleted | SYNONYM | Th2 immune response |
2008-05-13 | Added | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-11 | Updated | TERM | type 2 immune response |
2002-02-19 | Added | TERM | T-helper 2 type immune response |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-11 | Added | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. |
2010-10-11 | Deleted | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. |
2010-10-11 | Added | SYNONYM | T-helper 2 type immune response |
2010-10-11 | Added | SYNONYM | Th2 immune response |
2010-10-11 | Deleted | SYNONYM | Th2 immune response |
2008-05-13 | Added | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. |
2008-05-12 | Deleted | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. |
2007-08-09 | Added | SYNONYM | Th2 immune response |
2007-08-09 | Deleted | SYNONYM | Th2 immune response |
2006-09-21 | Added | SYNONYM | Th2 immune response |
2006-09-19 | Added | DEFINITION | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-03-06 | Deleted | RELATION | is a GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains) |
2011-03-06 | Added | RELATION | is a GO:0006955 (immune response) |
2008-04-01 | Updated | RELATION | is a GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
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