GO:0042296
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ISG15 transferase activity
Molecular Function
Definition (GO:0042296 GONUTS page)
Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. PMID:12826404
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ISG15 conjugating enzyme activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0042296
Child Term | Relationship to GO:0042296 |
---|---|
ISG15 conjugating enzyme activity
|
is_a |
ISG15 ligase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
Reactome | R-HSA-5653754 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0042296 based on ALL annotations
The top 39 of 39 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ISG15 transferase activity
|
444,051.90 | 100.00 | 439 | 439 |
ISG15-protein conjugation
|
259,918.38 | 58.53 | 439 | 750 |
positive regulation of G1/S transition of mitotic cell cycle
|
12,080.07 | 2.44 | 83 | 3,051 |
ubiquitin conjugating enzyme activity
|
5,807.75 | 1.28 | 181 | 13,839 |
regulation of defense response to virus
|
5,270.99 | 1.08 | 45 | 3,791 |
protein K48-linked ubiquitination
|
3,341.69 | 0.74 | 170 | 22,590 |
ubiquitin-like protein transferase activity
|
2,844.62 | 0.63 | 117 | 18,264 |
protein K63-linked ubiquitination
|
2,335.96 | 0.51 | 85 | 16,158 |
protein K11-linked ubiquitination
|
1,430.20 | 0.32 | 85 | 26,391 |
modification-dependent protein catabolic process
|
1,056.75 | 0.23 | 68 | 28,574 |
Totals | 4163 | 141966176 |
No co-occurrence statistics for GO:0042296 based on MANUAL annotations
The top 30 of 30 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ISG15 transferase activity
|
28,082.59 | 100.00 | 46 | 46 |
ISG15-protein conjugation
|
18,194.35 | 64.79 | 46 | 71 |
protein K48-linked ubiquitination
|
1,013.68 | 3.52 | 27 | 748 |
PKR/eIFalpha signaling
|
14,041.29 | 2.13 | 1 | 2 |
protein K63-linked ubiquitination
|
581.02 | 1.98 | 15 | 725 |
protein K11-linked ubiquitination
|
536.61 | 1.84 | 15 | 785 |
positive regulation of G1/S transition of mitotic cell cycle
|
569.79 | 1.82 | 7 | 345 |
ubiquitin-like protein transferase activity
|
758.99 | 1.69 | 2 | 74 |
ubiquitin conjugating enzyme activity
|
410.69 | 1.46 | 37 | 2,530 |
regulation of cyclin-dependent protein serine/threonine kinase activity
|
561.65 | 1.05 | 1 | 50 |
Totals | 336 | 627945 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | DEFINITION | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2023-06-13 | Added | DEFINITION | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5653754 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5653754 |
2018-12-11 | Added | XREF | reactome:R-HSA-5653754 |
2014-11-16 | Deleted | DEFINITION | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2014-11-16 | Added | DEFINITION | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2014-11-08 | Updated | TERM | ISG15 transferase activity |
2014-11-08 | Added | SYNONYM | ISG15 conjugating enzyme activity |
2014-11-08 | Deleted | SYNONYM | ISG15 conjugating enzyme activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-11-08 | Updated | TERM | ISG15 transferase activity |
2008-04-01 | Updated | TERM | ISG15 ligase activity |
2003-03-19 | Updated | TERM | ISG15 conjugating enzyme activity |
2002-06-07 | Added | TERM | ISG15 conjugating enzyme |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | DEFINITION | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2023-06-13 | Added | DEFINITION | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2014-11-16 | Deleted | DEFINITION | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2014-11-16 | Added | DEFINITION | Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2014-11-08 | Added | SYNONYM | ISG15 conjugating enzyme activity |
2014-11-08 | Deleted | SYNONYM | ISG15 conjugating enzyme activity |
2014-11-08 | Deleted | DEFINITION | Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins. |
2014-11-08 | Added | DEFINITION | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. |
2008-05-13 | Added | DEFINITION | Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins. |
2008-04-01 | Added | SYNONYM | ISG15 conjugating enzyme activity |
2004-07-29 | Added | DEFINITION | Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Added | RELATION | is a GO:0019787 (ubiquitin-like protein transferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0008639 (small protein conjugating enzyme activity) |
2008-04-01 | Deleted | RELATION | is a GO:0008639 (small protein conjugating enzyme activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-5653754 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5653754 |
2018-12-11 | Added | XREF | reactome:R-HSA-5653754 |
Timestamp | Action | Category | Detail |
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