This term is obsolete.

GO:0042296 JSON

ISG15 transferase activity

Molecular Function

Definition (GO:0042296 GONUTS page)

Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. PMID:12826404

500 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ISG15 conjugating enzyme activity narrow

Ancestor Chart

Ancestor chart for GO:0042296
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042296

Child Term Relationship to
GO:0042296
ISG15 conjugating enzyme activity
is_a
ISG15 ligase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
Reactome R-HSA-5653754

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0042296 based on ALL annotations
The top 37 of 37 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ISG15 transferase activity
438,395.75 100.00 452 452
ISG15-protein conjugation
258,350.55 58.93 452 767
positive regulation of G1/S transition of mitotic cell cycle
11,779.49 2.40 83 3,089
ubiquitin conjugating enzyme activity
5,668.14 1.27 189 14,618
regulation of defense response to virus
5,205.23 1.07 45 3,790
protein K48-linked ubiquitination
3,357.39 0.76 177 23,112
protein monoubiquitination
2,557.70 0.58 164 28,110
protein K63-linked ubiquitination
2,300.94 0.51 87 16,576
ubiquitin-like protein transferase activity
2,236.88 0.50 70 13,719
protein K11-linked ubiquitination
1,397.65 0.31 87 27,289
Totals 4352 142074735
No co-occurrence statistics for GO:0042296 based on MANUAL annotations
The top 30 of 30 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ISG15 transferase activity
23,924.29 100.00 59 59
ISG15-protein conjugation
16,040.15 67.05 59 88
protein K48-linked ubiquitination
1,137.83 4.63 38 799
protein K63-linked ubiquitination
583.52 2.32 19 779
protein K11-linked ubiquitination
537.94 2.15 19 845
positive regulation of G1/S transition of mitotic cell cycle
466.49 1.70 7 359
ubiquitin conjugating enzyme activity
402.43 1.68 49 2,913
PKR/eIFalpha signaling
11,962.15 1.67 1 2
ubiquitin-like protein transferase activity
598.11 1.46 2 80
protein monoubiquitination
324.18 1.27 10 738
Totals 422 677314

Change Log

Timestamp Action Category Detail
2025-01-26 Deleted XREF Reactome:R-HSA-9927247
2025-01-25 Added XREF Reactome:R-HSA-9927247
2025-01-24 Deleted XREF Reactome:R-HSA-9927247
2025-01-23 Added XREF Reactome:R-HSA-9927247
2025-01-17 Deleted XREF Reactome:R-HSA-9927247
2025-01-15 Added XREF Reactome:R-HSA-9927247
2024-12-28 Deleted XREF Reactome:R-HSA-9927247
2024-12-27 Added XREF Reactome:R-HSA-9927247
2024-12-13 Deleted XREF Reactome:R-HSA-9927247
2024-12-12 Added XREF Reactome:R-HSA-9927247
Timestamp Action Category Detail
2014-11-08 Updated TERM ISG15 transferase activity
2008-04-01 Updated TERM ISG15 ligase activity
2003-03-19 Updated TERM ISG15 conjugating enzyme activity
2002-06-07 Added TERM ISG15 conjugating enzyme
Timestamp Action Category Detail
2023-06-13 Deleted DEFINITION Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.
2023-06-13 Added DEFINITION Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.
2014-11-16 Deleted DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.
2014-11-16 Added DEFINITION Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.
2014-11-08 Deleted DEFINITION Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins.
2014-11-08 Added DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.
2014-11-08 Added SYNONYM ISG15 conjugating enzyme activity
2014-11-08 Deleted SYNONYM ISG15 conjugating enzyme activity
2008-05-13 Added DEFINITION Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins.
2008-05-12 Deleted DEFINITION Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins.
2008-04-01 Added SYNONYM ISG15 conjugating enzyme activity
2004-07-29 Added DEFINITION Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins.
Timestamp Action Category Detail
2008-04-01 Deleted RELATION is a GO:0008639 (small protein conjugating enzyme activity)
2008-04-01 Updated RELATION is a GO:0008639 (small protein conjugating enzyme activity)
2008-04-01 Added RELATION is a GO:0019787 (ubiquitin-like protein transferase activity)
Timestamp Action Category Detail
2025-01-26 Deleted XREF Reactome:R-HSA-9927247
2025-01-25 Added XREF Reactome:R-HSA-9927247
2025-01-24 Deleted XREF Reactome:R-HSA-9927247
2025-01-23 Added XREF Reactome:R-HSA-9927247
2025-01-17 Deleted XREF Reactome:R-HSA-9927247
2025-01-15 Added XREF Reactome:R-HSA-9927247
2024-12-28 Deleted XREF Reactome:R-HSA-9927247
2024-12-27 Added XREF Reactome:R-HSA-9927247
2024-12-13 Deleted XREF Reactome:R-HSA-9927247
2024-12-12 Added XREF Reactome:R-HSA-9927247
2019-04-01 Deleted XREF reactome:R-HSA-5653754
2019-04-01 Added XREF Reactome:R-HSA-5653754
2018-12-11 Added XREF reactome:R-HSA-5653754
Timestamp Action Category Detail
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