This term is obsolete.
Note that this term can be used to describe the binding of a peptide to an MHC molecule.

GO:0042605 JSON

peptide antigen binding

Molecular Function

Definition (GO:0042605 GONUTS page)

Binding to an antigen peptide.

Comments

Note that this term can be used to describe the binding of a peptide to an MHC molecule.

Secondary IDs

GO:0042606, GO:0042607

14,728 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
endogenous peptide antigen binding narrow
exogenous peptide antigen binding narrow

Ancestor Chart

Ancestor chart for GO:0042605
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein A0A091DUB3 885580 A0A091DUB3_FUKDA GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein A0A097CK74 9606 A0A097CK74_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein A0A097CK82 9606 A0A097CK82_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein A0A097CK87 9606 A0A097CK87_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein A0A097CK88 9606 A0A097CK88_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein A0A097CKA4 9606 A0A097CKA4_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein A0A097CKB2 9606 A0A097CKB2_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein A0A0B8RST0 9825 A0A0B8RST0_PIG GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein B4DDZ1 9606 B4DDZ1_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092
IEA Review protein B4DV50 9606 B4DV50_HUMAN GO:0042605 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. IPR031092

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0004894 obsolete T cell receptor activity consider GO:0042605
GO:0042096 obsolete alpha-beta T cell receptor activity consider GO:0042605
GO:0042099 obsolete gamma-delta T cell receptor activity consider GO:0042605

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0042605 based on ALL annotations
The top 100 of 483 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peptide antigen binding
13,394.17 100.00 14,554 14,554
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
12,117.35 74.07 11,692 12,924
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
12,117.26 74.06 11,691 12,923
positive regulation of T cell mediated cytotoxicity
9,768.24 62.31 11,797 16,176
MHC class I protein complex
3,459.08 23.50 10,522 40,743
antigen processing and presentation of peptide antigen via MHC class I
3,456.37 23.48 10,514 40,744
lumenal side of endoplasmic reticulum membrane
2,713.90 18.75 10,403 51,343
phagocytic vesicle membrane
2,377.17 16.57 10,397 58,582
signaling receptor binding
863.07 6.34 11,692 181,451
T cell receptor complex
1,719.40 6.31 1,605 12,503
Totals 170725 3779345
No co-occurrence statistics for GO:0042605 based on MANUAL annotations
The top 100 of 425 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peptide antigen binding
2,189.49 100.00 590 590
MHC class II protein complex
2,080.02 44.04 266 280
peptide antigen assembly with MHC class II protein complex
2,087.65 40.86 246 258
MHC class II protein complex binding
1,889.88 39.11 246 285
antigen processing and presentation of exogenous peptide antigen via MHC class II
1,553.08 38.05 266 375
positive regulation of immune response
1,508.72 35.09 246 357
positive regulation of T cell activation
1,333.89 33.42 251 412
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
1,542.99 26.92 179 254
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
1,540.43 26.77 178 253
positive regulation of T cell mediated cytotoxicity
1,100.30 25.19 198 394
Totals 4768 33331

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with an antigen peptide.
2021-05-24 Added DEFINITION Binding to an antigen peptide.
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2011-06-05 Added DEFINITION Interacting selectively and non-covalently with an antigen peptide.
2011-06-05 Deleted DEFINITION Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2009-07-03 Deleted DEFINITION Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2008-08-29 Added SYNONYM exogenous peptide antigen binding
Timestamp Action Category Detail
2003-03-19 Added TERM peptide antigen binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with an antigen peptide.
2021-05-24 Added DEFINITION Binding to an antigen peptide.
2011-06-05 Added DEFINITION Interacting selectively and non-covalently with an antigen peptide.
2011-06-05 Deleted DEFINITION Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2009-07-03 Deleted DEFINITION Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2008-08-29 Added SYNONYM exogenous peptide antigen binding
2008-08-29 Added SYNONYM endogenous peptide antigen binding
2008-05-13 Added DEFINITION Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2008-05-12 Deleted DEFINITION Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
2003-03-26 Added DEFINITION Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003823 (antigen binding)
2008-04-01 Updated RELATION is a GO:0042277 (peptide binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2008-08-29 Added SECONDARY GO:0042606 (endogenous peptide antigen binding)
2008-08-29 Added SECONDARY GO:0042607 (exogenous peptide antigen binding)
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