Note that this term can be used to describe the binding of a peptide to an MHC molecule.
GO:0042605
JSON
peptide antigen binding
Molecular Function
Definition (GO:0042605 GONUTS page)
Binding to an antigen peptide.
Comments
Note that this term can be used to describe the binding of a peptide to an MHC molecule.
Secondary IDs
GO:0042606, GO:0042607
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
endogenous peptide antigen binding | narrow |
exogenous peptide antigen binding | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | A0A091DUB3 | 885580 | A0A091DUB3_FUKDA | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | A0A097CK74 | 9606 | A0A097CK74_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | A0A097CK82 | 9606 | A0A097CK82_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | A0A097CK87 | 9606 | A0A097CK87_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | A0A097CK88 | 9606 | A0A097CK88_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | A0A097CKA4 | 9606 | A0A097CKA4_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | A0A097CKB2 | 9606 | A0A097CKB2_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | A0A0B8RST0 | 9825 | A0A0B8RST0_PIG | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | B4DDZ1 | 9606 | B4DDZ1_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
IEA Review | protein | B4DV50 | 9606 | B4DV50_HUMAN | GO:0042605 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 20th April 2015. | IPR031092 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0004894 | obsolete T cell receptor activity | consider GO:0042605 |
GO:0042096 | obsolete alpha-beta T cell receptor activity | consider GO:0042605 |
GO:0042099 | obsolete gamma-delta T cell receptor activity | consider GO:0042605 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0042605 based on ALL annotations
The top 100 of 483 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peptide antigen binding
|
13,394.17 | 100.00 | 14,554 | 14,554 |
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
|
12,117.35 | 74.07 | 11,692 | 12,924 |
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
|
12,117.26 | 74.06 | 11,691 | 12,923 |
positive regulation of T cell mediated cytotoxicity
|
9,768.24 | 62.31 | 11,797 | 16,176 |
MHC class I protein complex
|
3,459.08 | 23.50 | 10,522 | 40,743 |
antigen processing and presentation of peptide antigen via MHC class I
|
3,456.37 | 23.48 | 10,514 | 40,744 |
lumenal side of endoplasmic reticulum membrane
|
2,713.90 | 18.75 | 10,403 | 51,343 |
phagocytic vesicle membrane
|
2,377.17 | 16.57 | 10,397 | 58,582 |
signaling receptor binding
|
863.07 | 6.34 | 11,692 | 181,451 |
T cell receptor complex
|
1,719.40 | 6.31 | 1,605 | 12,503 |
Totals | 170725 | 3779345 |
No co-occurrence statistics for GO:0042605 based on MANUAL annotations
The top 100 of 425 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peptide antigen binding
|
2,189.49 | 100.00 | 590 | 590 |
MHC class II protein complex
|
2,080.02 | 44.04 | 266 | 280 |
peptide antigen assembly with MHC class II protein complex
|
2,087.65 | 40.86 | 246 | 258 |
MHC class II protein complex binding
|
1,889.88 | 39.11 | 246 | 285 |
antigen processing and presentation of exogenous peptide antigen via MHC class II
|
1,553.08 | 38.05 | 266 | 375 |
positive regulation of immune response
|
1,508.72 | 35.09 | 246 | 357 |
positive regulation of T cell activation
|
1,333.89 | 33.42 | 251 | 412 |
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
|
1,542.99 | 26.92 | 179 | 254 |
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
|
1,540.43 | 26.77 | 178 | 253 |
positive regulation of T cell mediated cytotoxicity
|
1,100.30 | 25.19 | 198 | 394 |
Totals | 4768 | 33331 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with an antigen peptide. |
2021-05-24 | Added | DEFINITION | Binding to an antigen peptide. |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2011-06-05 | Added | DEFINITION | Interacting selectively and non-covalently with an antigen peptide. |
2011-06-05 | Deleted | DEFINITION | Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2008-08-29 | Added | SYNONYM | exogenous peptide antigen binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Added | TERM | peptide antigen binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with an antigen peptide. |
2021-05-24 | Added | DEFINITION | Binding to an antigen peptide. |
2011-06-05 | Added | DEFINITION | Interacting selectively and non-covalently with an antigen peptide. |
2011-06-05 | Deleted | DEFINITION | Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2008-08-29 | Added | SYNONYM | exogenous peptide antigen binding |
2008-08-29 | Added | SYNONYM | endogenous peptide antigen binding |
2008-05-13 | Added | DEFINITION | Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
2003-03-26 | Added | DEFINITION | Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0003823 (antigen binding) |
2008-04-01 | Updated | RELATION | is a GO:0042277 (peptide binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2008-08-29 | Added | SECONDARY | GO:0042606 (endogenous peptide antigen binding) |
2008-08-29 | Added | SECONDARY | GO:0042607 (exogenous peptide antigen binding) |
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