This term is obsolete.
Note that this complex is conserved in fungi but has not been observed in metazoans.

GO:0042729 JSON

DASH complex

Cellular Component

Definition (GO:0042729 GONUTS page)

A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. PMID:11782438 PMID:11799062 PMID:15632076 PMID:15640796

Comments

Note that this complex is conserved in fungi but has not been observed in metazoans.

Secondary IDs

GO:0043925, GO:0043926

14,461 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DDD complex exact
condensed nuclear chromosome kinetochore-associated DASH complex exact
Dam1 complex exact
Duo1p-Dam1p-Dad1p complex exact

Ancestor Chart

Ancestor chart for GO:0042729
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0042729 DASH complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0000793 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y7L4 10116 A0A8I5Y7L4_RAT GO:0005694 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR013251 DASH complex subunit Spc19
InterPro IPR013958 DASH complex subunit Dad1
InterPro IPR013959 DASH complex subunit Dad4
InterPro IPR013960 DASH complex subunit Duo1
InterPro IPR013962 DASH complex subunit Dam1
InterPro IPR013963 DASH complex subunit Dad2
InterPro IPR013964 DASH complex subunit Ask1
InterPro IPR013965 DASH complex subunit Dad3
InterPro IPR013966 DASH complex subunit Spc34

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0042729 based on ALL annotations
The top 100 of 414 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DASH complex
13,683.76 100.00 14,246 14,246
attachment of spindle microtubules to kinetochore
8,372.12 52.24 11,131 18,193
mitotic spindle pole body
4,112.52 20.78 5,731 19,069
mitotic spindle
1,993.77 13.86 10,553 72,428
microtubule plus-end binding
2,430.95 12.00 3,846 21,649
chromosome, centromeric region
1,522.75 10.95 12,385 111,294
mitotic spindle polar microtubule
13,413.80 10.09 1,441 1,470
spindle
1,372.04 9.88 12,380 123,469
mitotic sister chromatid biorientation
5,973.34 9.80 1,599 3,663
kinetochore
1,256.76 9.06 12,390 134,904
Totals 169560 44579609
No co-occurrence statistics for GO:0042729 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DASH complex
8,554.96 100.00 151 151
protein transport along microtubule to mitotic spindle pole body
8,320.58 46.41 71 73
mitotic sister chromatid biorientation
4,963.18 36.89 76 131
attachment of spindle microtubules to kinetochore
2,168.86 19.83 72 284
mitotic spindle pole body
1,284.53 11.52 50 333
mitotic spindle polar microtubule
6,843.97 7.79 12 15
microtubule plus-end binding
613.99 6.14 45 627
positive regulation of attachment of spindle microtubules to kinetochore
838.72 4.12 10 102
spindle attachment to meiosis I kinetochore
757.08 3.94 10 113
mitotic spindle midzone
370.71 2.97 13 300
Totals 699 525950

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2023-08-14 Added RELATION part of GO:0000940 (outer kinetochore)
2023-08-14 Deleted RELATION is a GO:0180019 (Knl1/Spc105 complex)
2023-06-18 Added RELATION is a GO:0180019 (Knl1/Spc105 complex)
2023-06-18 Deleted RELATION part of GO:0000940 (outer kinetochore)
2021-03-28 Deleted DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.
2021-03-28 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2021-03-28 Added DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.
2021-03-28 Deleted RELATION is a GO:0000942 (condensed nuclear chromosome outer kinetochore)
2021-03-28 Added RELATION part of GO:0000940 (outer kinetochore)
Timestamp Action Category Detail
2003-05-10 Added TERM DASH complex
Timestamp Action Category Detail
2021-03-28 Deleted DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.
2021-03-28 Added DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.
2009-02-28 Added DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.
2009-02-28 Deleted DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complexes associate with kinetochores or microtubules and play a role spindle attachment, chromosome segregation and spindle stability.
2009-02-28 Added SYNONYM condensed nuclear chromosome kinetochore-associated DASH complex
2008-07-12 Deleted DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability.
2008-07-12 Added DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complexes associate with kinetochores or microtubules and play a role spindle attachment, chromosome segregation and spindle stability.
2008-05-13 Added DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability.
2008-05-12 Deleted DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability.
2007-08-09 Deleted SYNONYM DDD complex
2007-08-09 Deleted SYNONYM Dam1 complex
2007-08-09 Added SYNONYM Duo1p-Dam1p-Dad1p complex
2007-08-09 Added SYNONYM Dam1 complex
2007-08-09 Deleted SYNONYM Duo1p-Dam1p-Dad1p complex
2007-08-09 Added SYNONYM DDD complex
2007-05-27 Updated DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability.
2005-05-09 Added SYNONYM Dam1 complex
2004-04-19 Added SYNONYM Duo1p-Dam1p-Dad1p complex
2004-04-19 Added SYNONYM DDD complex
2004-04-16 Deleted SYNONYM DDD complex
2004-04-16 Deleted SYNONYM Duo1p-Dam1p-Dad1p complex
2004-03-18 Updated DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role chromosome segregation and spindle stability.
2003-07-08 Updated DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1. Associating with microtubules and kinetochores, the complex plays a role chromosome segregation and spindle stability.
2003-05-10 Added SYNONYM DDD complex
2003-05-10 Added DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1. Associating with microtubules and kineochores, the complex plays a role chromosome segregation and spindle stability.
2003-05-10 Added SYNONYM Duo1p-Dam1p-Dad1p complex
Timestamp Action Category Detail
2023-08-14 Added RELATION part of GO:0000940 (outer kinetochore)
2023-08-14 Deleted RELATION is a GO:0180019 (Knl1/Spc105 complex)
2023-06-18 Added RELATION is a GO:0180019 (Knl1/Spc105 complex)
2023-06-18 Deleted RELATION part of GO:0000940 (outer kinetochore)
2021-03-28 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2021-03-28 Deleted RELATION is a GO:0000942 (condensed nuclear chromosome outer kinetochore)
2021-03-28 Added RELATION part of GO:0000940 (outer kinetochore)
2012-10-29 Deleted RELATION is a GO:0043234 (protein complex)
2012-06-23 Deleted RELATION part of GO:0000778 (condensed nuclear chromosome kinetochore)
2012-06-23 Deleted RELATION is a GO:0044454 (obsolete nuclear chromosome part)
2012-06-23 Added RELATION is a GO:0000942 (condensed nuclear chromosome outer kinetochore)
2009-03-14 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2009-02-28 Added RELATION is a GO:0044454 (obsolete nuclear chromosome part)
2009-02-28 Added RELATION part of GO:0000778 (condensed nuclear chromosome kinetochore)
2008-10-02 Added RELATION is a GO:0044428 (obsolete nuclear part)
2008-07-12 Added RELATION is a GO:0043234 (protein complex)
2008-07-12 Deleted RELATION is a GO:0044454 (obsolete nuclear chromosome part)
2008-07-12 Deleted RELATION is a GO:0005875 (microtubule associated complex)
2008-07-12 Deleted RELATION part of GO:0005828 (kinetochore microtubule)
2008-07-12 Deleted RELATION part of GO:0000778 (condensed nuclear chromosome kinetochore)
2008-04-01 Updated RELATION is a GO:0005875 (microtubule associated complex)
2008-04-01 Updated RELATION part of GO:0000778 (condensed nuclear chromosome kinetochore)
2008-04-01 Updated RELATION part of GO:0005828 (kinetochore microtubule)
2008-04-01 Updated RELATION is a GO:0044454 (obsolete nuclear chromosome part)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2009-02-28 Added SECONDARY GO:0043926 (kinetochore-associated DASH complex)
2009-02-28 Added SECONDARY GO:0043925 (microtubule-associated DASH complex)
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