Note that this complex is conserved in fungi but has not been observed in metazoans.
GO:0042729
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DASH complex
Cellular Component
Definition (GO:0042729 GONUTS page)
A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. PMID:11782438 PMID:11799062 PMID:15632076 PMID:15640796
Comments
Note that this complex is conserved in fungi but has not been observed in metazoans.
Secondary IDs
GO:0043925, GO:0043926
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
DDD complex | exact |
condensed nuclear chromosome kinetochore-associated DASH complex | exact |
Dam1 complex | exact |
Duo1p-Dam1p-Dad1p complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0042729 | DASH complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0000793 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y7L4 | 10116 | A0A8I5Y7L4_RAT | GO:0005694 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR013251 | DASH complex subunit Spc19 |
InterPro | IPR013958 | DASH complex subunit Dad1 |
InterPro | IPR013959 | DASH complex subunit Dad4 |
InterPro | IPR013960 | DASH complex subunit Duo1 |
InterPro | IPR013962 | DASH complex subunit Dam1 |
InterPro | IPR013963 | DASH complex subunit Dad2 |
InterPro | IPR013964 | DASH complex subunit Ask1 |
InterPro | IPR013965 | DASH complex subunit Dad3 |
InterPro | IPR013966 | DASH complex subunit Spc34 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0042729 based on ALL annotations
The top 100 of 414 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DASH complex
|
13,683.76 | 100.00 | 14,246 | 14,246 |
attachment of spindle microtubules to kinetochore
|
8,372.12 | 52.24 | 11,131 | 18,193 |
mitotic spindle pole body
|
4,112.52 | 20.78 | 5,731 | 19,069 |
mitotic spindle
|
1,993.77 | 13.86 | 10,553 | 72,428 |
microtubule plus-end binding
|
2,430.95 | 12.00 | 3,846 | 21,649 |
chromosome, centromeric region
|
1,522.75 | 10.95 | 12,385 | 111,294 |
mitotic spindle polar microtubule
|
13,413.80 | 10.09 | 1,441 | 1,470 |
spindle
|
1,372.04 | 9.88 | 12,380 | 123,469 |
mitotic sister chromatid biorientation
|
5,973.34 | 9.80 | 1,599 | 3,663 |
kinetochore
|
1,256.76 | 9.06 | 12,390 | 134,904 |
Totals | 169560 | 44579609 |
No co-occurrence statistics for GO:0042729 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DASH complex
|
8,554.96 | 100.00 | 151 | 151 |
protein transport along microtubule to mitotic spindle pole body
|
8,320.58 | 46.41 | 71 | 73 |
mitotic sister chromatid biorientation
|
4,963.18 | 36.89 | 76 | 131 |
attachment of spindle microtubules to kinetochore
|
2,168.86 | 19.83 | 72 | 284 |
mitotic spindle pole body
|
1,284.53 | 11.52 | 50 | 333 |
mitotic spindle polar microtubule
|
6,843.97 | 7.79 | 12 | 15 |
microtubule plus-end binding
|
613.99 | 6.14 | 45 | 627 |
positive regulation of attachment of spindle microtubules to kinetochore
|
838.72 | 4.12 | 10 | 102 |
spindle attachment to meiosis I kinetochore
|
757.08 | 3.94 | 10 | 113 |
mitotic spindle midzone
|
370.71 | 2.97 | 13 | 300 |
Totals | 699 | 525950 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2023-08-14 | Added | RELATION | part of GO:0000940 (outer kinetochore) |
2023-08-14 | Deleted | RELATION | is a GO:0180019 (Knl1/Spc105 complex) |
2023-06-18 | Added | RELATION | is a GO:0180019 (Knl1/Spc105 complex) |
2023-06-18 | Deleted | RELATION | part of GO:0000940 (outer kinetochore) |
2021-03-28 | Deleted | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. |
2021-03-28 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2021-03-28 | Added | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. |
2021-03-28 | Deleted | RELATION | is a GO:0000942 (condensed nuclear chromosome outer kinetochore) |
2021-03-28 | Added | RELATION | part of GO:0000940 (outer kinetochore) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-05-10 | Added | TERM | DASH complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-28 | Deleted | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. |
2021-03-28 | Added | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. |
2009-02-28 | Added | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. |
2009-02-28 | Deleted | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complexes associate with kinetochores or microtubules and play a role spindle attachment, chromosome segregation and spindle stability. |
2009-02-28 | Added | SYNONYM | condensed nuclear chromosome kinetochore-associated DASH complex |
2008-07-12 | Deleted | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability. |
2008-07-12 | Added | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complexes associate with kinetochores or microtubules and play a role spindle attachment, chromosome segregation and spindle stability. |
2008-05-13 | Added | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability. |
2008-05-12 | Deleted | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability. |
2007-08-09 | Deleted | SYNONYM | DDD complex |
2007-08-09 | Deleted | SYNONYM | Dam1 complex |
2007-08-09 | Added | SYNONYM | Duo1p-Dam1p-Dad1p complex |
2007-08-09 | Added | SYNONYM | Dam1 complex |
2007-08-09 | Deleted | SYNONYM | Duo1p-Dam1p-Dad1p complex |
2007-08-09 | Added | SYNONYM | DDD complex |
2007-05-27 | Updated | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability. |
2005-05-09 | Added | SYNONYM | Dam1 complex |
2004-04-19 | Added | SYNONYM | Duo1p-Dam1p-Dad1p complex |
2004-04-19 | Added | SYNONYM | DDD complex |
2004-04-16 | Deleted | SYNONYM | DDD complex |
2004-04-16 | Deleted | SYNONYM | Duo1p-Dam1p-Dad1p complex |
2004-03-18 | Updated | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role chromosome segregation and spindle stability. |
2003-07-08 | Updated | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1. Associating with microtubules and kinetochores, the complex plays a role chromosome segregation and spindle stability. |
2003-05-10 | Added | SYNONYM | DDD complex |
2003-05-10 | Added | DEFINITION | A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1. Associating with microtubules and kineochores, the complex plays a role chromosome segregation and spindle stability. |
2003-05-10 | Added | SYNONYM | Duo1p-Dam1p-Dad1p complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-14 | Added | RELATION | part of GO:0000940 (outer kinetochore) |
2023-08-14 | Deleted | RELATION | is a GO:0180019 (Knl1/Spc105 complex) |
2023-06-18 | Added | RELATION | is a GO:0180019 (Knl1/Spc105 complex) |
2023-06-18 | Deleted | RELATION | part of GO:0000940 (outer kinetochore) |
2021-03-28 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2021-03-28 | Deleted | RELATION | is a GO:0000942 (condensed nuclear chromosome outer kinetochore) |
2021-03-28 | Added | RELATION | part of GO:0000940 (outer kinetochore) |
2012-10-29 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2012-06-23 | Deleted | RELATION | part of GO:0000778 (condensed nuclear chromosome kinetochore) |
2012-06-23 | Deleted | RELATION | is a GO:0044454 (obsolete nuclear chromosome part) |
2012-06-23 | Added | RELATION | is a GO:0000942 (condensed nuclear chromosome outer kinetochore) |
2009-03-14 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2009-02-28 | Added | RELATION | is a GO:0044454 (obsolete nuclear chromosome part) |
2009-02-28 | Added | RELATION | part of GO:0000778 (condensed nuclear chromosome kinetochore) |
2008-10-02 | Added | RELATION | is a GO:0044428 (obsolete nuclear part) |
2008-07-12 | Added | RELATION | is a GO:0043234 (protein complex) |
2008-07-12 | Deleted | RELATION | is a GO:0044454 (obsolete nuclear chromosome part) |
2008-07-12 | Deleted | RELATION | is a GO:0005875 (microtubule associated complex) |
2008-07-12 | Deleted | RELATION | part of GO:0005828 (kinetochore microtubule) |
2008-07-12 | Deleted | RELATION | part of GO:0000778 (condensed nuclear chromosome kinetochore) |
2008-04-01 | Updated | RELATION | is a GO:0005875 (microtubule associated complex) |
2008-04-01 | Updated | RELATION | part of GO:0000778 (condensed nuclear chromosome kinetochore) |
2008-04-01 | Updated | RELATION | part of GO:0005828 (kinetochore microtubule) |
2008-04-01 | Updated | RELATION | is a GO:0044454 (obsolete nuclear chromosome part) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2009-02-28 | Added | SECONDARY | GO:0043926 (kinetochore-associated DASH complex) |
2009-02-28 | Added | SECONDARY | GO:0043925 (microtubule-associated DASH complex) |
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