This term is obsolete.

GO:0042985 JSON

negative regulation of amyloid precursor protein biosynthetic process

Biological Process

Definition (GO:0042985 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.

3,866 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation of amyloid precursor protein biosynthesis exact
negative regulation of amyloid precursor protein anabolism exact
negative regulation of APP biosynthetic process exact
inhibition of amyloid precursor protein biosynthetic process narrow
negative regulation of APP biosynthesis exact
down regulation of amyloid precursor protein biosynthetic process exact
down-regulation of amyloid precursor protein biosynthetic process exact
downregulation of amyloid precursor protein biosynthetic process exact
negative regulation of amyloid precursor protein synthesis exact
negative regulation of amyloid precursor protein formation exact

Ancestor Chart

Ancestor chart for GO:0042985
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Ancestor chart

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0042985 based on ALL annotations
The top 100 of 282 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of amyloid precursor protein biosynthetic process
51,589.40 100.00 3,841 3,841
amyloid-beta binding
10,025.38 19.23 3,640 18,731
extracellular exosome
3,770.33 7.27 3,571 48,862
leucine zipper domain binding
5,424.12 1.95 90 856
embryonic cleavage
5,276.19 1.94 90 880
plasma cell differentiation
8,080.27 1.26 52 332
amyloid-beta metabolic process
1,100.57 1.12 88 4,125
negative regulation of neuron projection development
1,053.13 1.01 75 3,674
Golgi-associated vesicle membrane
664.16 0.89 108 8,389
melanosome organization
668.20 0.85 92 7,103
Totals 22113 4697522
No co-occurrence statistics for GO:0042985 based on MANUAL annotations
The top 100 of 249 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of amyloid precursor protein biosynthetic process
14,551.89 100.00 97 97
amyloid-beta binding
1,951.40 12.75 70 522
negative regulation of amyloid-beta formation
1,105.21 3.53 6 79
miRNA-mediated gene silencing by inhibition of translation
582.08 3.05 11 275
negative regulation of vascular endothelial growth factor production
1,492.50 3.03 4 39
apolipoprotein A-I-mediated signaling pathway
3,637.97 2.83 3 12
organelle membrane
559.69 2.69 8 208
apolipoprotein A-I receptor activity
2,078.84 2.61 3 21
plasma membrane raft organization
1,984.35 2.59 3 22
positive regulation of engulfment of apoptotic cell
1,616.88 2.48 3 27
Totals 413 9866

Change Log

Timestamp Action Category Detail
2023-06-13 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2023-05-20 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2017-05-30 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-30 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-29 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-29 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-01-21 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2016-06-22 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
Timestamp Action Category Detail
2007-01-15 Updated TERM negative regulation of amyloid precursor protein biosynthetic process
2003-10-15 Added TERM negative regulation of amyloid precursor protein biosynthesis
Timestamp Action Category Detail
2017-05-30 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-30 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-29 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-29 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein anabolism
2007-08-09 Deleted SYNONYM inhibition of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM downregulation of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM down-regulation of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM down regulation of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein synthesis
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein formation
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein biosynthesis
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein anabolism
2007-08-09 Added SYNONYM negative regulation of APP biosynthetic process
2007-08-09 Added SYNONYM negative regulation of APP biosynthesis
2007-08-09 Added SYNONYM inhibition of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM downregulation of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM down-regulation of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM down regulation of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein synthesis
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein formation
2007-08-09 Deleted SYNONYM negative regulation of APP biosynthetic process
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein biosynthesis
2007-08-09 Deleted SYNONYM negative regulation of APP biosynthesis
2007-02-23 Added SYNONYM inhibition of amyloid precursor protein biosynthetic process
2007-02-23 Added SYNONYM downregulation of amyloid precursor protein biosynthetic process
2007-02-23 Added SYNONYM down-regulation of amyloid precursor protein biosynthetic process
2007-02-23 Added SYNONYM down regulation of amyloid precursor protein biosynthetic process
2007-01-15 Added SYNONYM negative regulation of amyloid precursor protein biosynthesis
2007-01-15 Added SYNONYM negative regulation of APP biosynthetic process
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of the biosynthesis of amyloid precursor protein (APP), the precursor of beta-amyloid.
2005-08-10 Added SYNONYM negative regulation of amyloid precursor protein formation
2005-08-10 Added SYNONYM negative regulation of amyloid precursor protein synthesis
2005-08-10 Added SYNONYM negative regulation of amyloid precursor protein anabolism
2004-04-19 Added SYNONYM negative regulation of APP biosynthesis
2004-04-16 Deleted SYNONYM negative regulation of APP biosynthesis
2003-10-15 Added SYNONYM negative regulation of APP biosynthesis
2003-10-15 Added DEFINITION Any process that stops, prevents or reduces the rate of the biosynthesis of amyloid precursor protein (APP), the precursor of beta-amyloid.
Timestamp Action Category Detail
2023-06-13 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2023-05-20 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2017-01-21 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2016-06-22 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2013-02-02 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2013-01-09 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2010-01-12 Deleted RELATION is a GO:0032269 (negative regulation of cellular protein metabolic process)
2008-04-01 Updated RELATION is a GO:0042984 (regulation of amyloid precursor protein biosynthetic process)
2008-04-01 Updated RELATION is a GO:0032269 (negative regulation of cellular protein metabolic process)
2008-04-01 Updated RELATION is a GO:0010561 (negative regulation of glycoprotein biosynthetic process)
2008-04-01 Added RELATION negatively regulates GO:0042983 (amyloid precursor protein biosynthetic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
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