GO:0042985
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negative regulation of amyloid precursor protein biosynthetic process
Biological Process
Definition (GO:0042985 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
negative regulation of amyloid precursor protein biosynthesis | exact |
negative regulation of amyloid precursor protein anabolism | exact |
negative regulation of APP biosynthetic process | exact |
inhibition of amyloid precursor protein biosynthetic process | narrow |
negative regulation of APP biosynthesis | exact |
down regulation of amyloid precursor protein biosynthetic process | exact |
down-regulation of amyloid precursor protein biosynthetic process | exact |
downregulation of amyloid precursor protein biosynthetic process | exact |
negative regulation of amyloid precursor protein synthesis | exact |
negative regulation of amyloid precursor protein formation | exact |
Ancestor Chart
Ancestor chart for GO:0042985
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0042985 based on ALL annotations
The top 100 of 282 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of amyloid precursor protein biosynthetic process
|
51,589.40 | 100.00 | 3,841 | 3,841 |
amyloid-beta binding
|
10,025.38 | 19.23 | 3,640 | 18,731 |
extracellular exosome
|
3,770.33 | 7.27 | 3,571 | 48,862 |
leucine zipper domain binding
|
5,424.12 | 1.95 | 90 | 856 |
embryonic cleavage
|
5,276.19 | 1.94 | 90 | 880 |
plasma cell differentiation
|
8,080.27 | 1.26 | 52 | 332 |
amyloid-beta metabolic process
|
1,100.57 | 1.12 | 88 | 4,125 |
negative regulation of neuron projection development
|
1,053.13 | 1.01 | 75 | 3,674 |
Golgi-associated vesicle membrane
|
664.16 | 0.89 | 108 | 8,389 |
melanosome organization
|
668.20 | 0.85 | 92 | 7,103 |
Totals | 22113 | 4697522 |
No co-occurrence statistics for GO:0042985 based on MANUAL annotations
The top 100 of 249 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of amyloid precursor protein biosynthetic process
|
14,551.89 | 100.00 | 97 | 97 |
amyloid-beta binding
|
1,951.40 | 12.75 | 70 | 522 |
negative regulation of amyloid-beta formation
|
1,105.21 | 3.53 | 6 | 79 |
miRNA-mediated gene silencing by inhibition of translation
|
582.08 | 3.05 | 11 | 275 |
negative regulation of vascular endothelial growth factor production
|
1,492.50 | 3.03 | 4 | 39 |
apolipoprotein A-I-mediated signaling pathway
|
3,637.97 | 2.83 | 3 | 12 |
organelle membrane
|
559.69 | 2.69 | 8 | 208 |
apolipoprotein A-I receptor activity
|
2,078.84 | 2.61 | 3 | 21 |
plasma membrane raft organization
|
1,984.35 | 2.59 | 3 | 22 |
positive regulation of engulfment of apoptotic cell
|
1,616.88 | 2.48 | 3 | 27 |
Totals | 413 | 9866 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2023-05-20 | Added | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2017-05-30 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2017-05-30 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. |
2017-05-29 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. |
2017-05-29 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2017-05-25 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2017-05-25 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. |
2017-01-21 | Deleted | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2016-06-22 | Added | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-01-15 | Updated | TERM | negative regulation of amyloid precursor protein biosynthetic process |
2003-10-15 | Added | TERM | negative regulation of amyloid precursor protein biosynthesis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-05-30 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2017-05-30 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. |
2017-05-29 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. |
2017-05-29 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2017-05-25 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2017-05-25 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2007-08-09 | Deleted | SYNONYM | negative regulation of amyloid precursor protein anabolism |
2007-08-09 | Deleted | SYNONYM | inhibition of amyloid precursor protein biosynthetic process |
2007-08-09 | Deleted | SYNONYM | downregulation of amyloid precursor protein biosynthetic process |
2007-08-09 | Deleted | SYNONYM | down-regulation of amyloid precursor protein biosynthetic process |
2007-08-09 | Deleted | SYNONYM | down regulation of amyloid precursor protein biosynthetic process |
2007-08-09 | Added | SYNONYM | negative regulation of amyloid precursor protein synthesis |
2007-08-09 | Added | SYNONYM | negative regulation of amyloid precursor protein formation |
2007-08-09 | Added | SYNONYM | negative regulation of amyloid precursor protein biosynthesis |
2007-08-09 | Added | SYNONYM | negative regulation of amyloid precursor protein anabolism |
2007-08-09 | Added | SYNONYM | negative regulation of APP biosynthetic process |
2007-08-09 | Added | SYNONYM | negative regulation of APP biosynthesis |
2007-08-09 | Added | SYNONYM | inhibition of amyloid precursor protein biosynthetic process |
2007-08-09 | Added | SYNONYM | downregulation of amyloid precursor protein biosynthetic process |
2007-08-09 | Added | SYNONYM | down-regulation of amyloid precursor protein biosynthetic process |
2007-08-09 | Added | SYNONYM | down regulation of amyloid precursor protein biosynthetic process |
2007-08-09 | Deleted | SYNONYM | negative regulation of amyloid precursor protein synthesis |
2007-08-09 | Deleted | SYNONYM | negative regulation of amyloid precursor protein formation |
2007-08-09 | Deleted | SYNONYM | negative regulation of APP biosynthetic process |
2007-08-09 | Deleted | SYNONYM | negative regulation of amyloid precursor protein biosynthesis |
2007-08-09 | Deleted | SYNONYM | negative regulation of APP biosynthesis |
2007-02-23 | Added | SYNONYM | inhibition of amyloid precursor protein biosynthetic process |
2007-02-23 | Added | SYNONYM | downregulation of amyloid precursor protein biosynthetic process |
2007-02-23 | Added | SYNONYM | down-regulation of amyloid precursor protein biosynthetic process |
2007-02-23 | Added | SYNONYM | down regulation of amyloid precursor protein biosynthetic process |
2007-01-15 | Added | SYNONYM | negative regulation of amyloid precursor protein biosynthesis |
2007-01-15 | Added | SYNONYM | negative regulation of APP biosynthetic process |
2006-05-04 | Updated | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2005-10-21 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate, frequency or extent of the biosynthesis of amyloid precursor protein (APP), the precursor of beta-amyloid. |
2005-08-10 | Added | SYNONYM | negative regulation of amyloid precursor protein formation |
2005-08-10 | Added | SYNONYM | negative regulation of amyloid precursor protein synthesis |
2005-08-10 | Added | SYNONYM | negative regulation of amyloid precursor protein anabolism |
2004-04-19 | Added | SYNONYM | negative regulation of APP biosynthesis |
2004-04-16 | Deleted | SYNONYM | negative regulation of APP biosynthesis |
2003-10-15 | Added | SYNONYM | negative regulation of APP biosynthesis |
2003-10-15 | Added | DEFINITION | Any process that stops, prevents or reduces the rate of the biosynthesis of amyloid precursor protein (APP), the precursor of beta-amyloid. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2023-05-20 | Added | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2017-01-21 | Deleted | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2016-06-22 | Added | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2013-02-02 | Deleted | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2013-01-09 | Added | RELATION | is a GO:0051248 (negative regulation of protein metabolic process) |
2010-01-12 | Deleted | RELATION | is a GO:0032269 (negative regulation of cellular protein metabolic process) |
2008-04-01 | Updated | RELATION | is a GO:0042984 (regulation of amyloid precursor protein biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0032269 (negative regulation of cellular protein metabolic process) |
2008-04-01 | Updated | RELATION | is a GO:0010561 (negative regulation of glycoprotein biosynthetic process) |
2008-04-01 | Added | RELATION | negatively regulates GO:0042983 (amyloid precursor protein biosynthetic process) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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