This term is obsolete.

GO:0042985 JSON

negative regulation of amyloid precursor protein biosynthetic process

Biological Process

Definition (GO:0042985 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.

3,772 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation of APP biosynthesis exact
down regulation of amyloid precursor protein biosynthetic process exact
negative regulation of amyloid precursor protein anabolism exact
negative regulation of amyloid precursor protein biosynthesis exact
negative regulation of amyloid precursor protein formation exact
negative regulation of amyloid precursor protein synthesis exact
negative regulation of APP biosynthetic process exact
down-regulation of amyloid precursor protein biosynthetic process exact
downregulation of amyloid precursor protein biosynthetic process exact
inhibition of amyloid precursor protein biosynthetic process narrow

Ancestor Chart

Ancestor chart for GO:0042985
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Ancestor chart

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0042985 based on ALL annotations
The top 100 of 282 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of amyloid precursor protein biosynthetic process
51,955.97 100.00 3,752 3,752
amyloid-beta binding
10,023.12 19.08 3,551 18,407
extracellular exosome
3,770.05 7.22 3,483 48,000
embryonic cleavage
5,845.05 2.02 90 800
leucine zipper domain binding
5,449.93 1.99 90 858
plasma cell differentiation
8,425.29 1.34 54 333
amyloid-beta metabolic process
1,106.82 1.12 86 4,037
negative regulation of neuron projection development
1,044.77 1.01 74 3,680
Golgi-associated vesicle membrane
708.04 0.93 108 7,925
melanosome organization
690.35 0.87 92 6,924
Totals 21657 4595894
No co-occurrence statistics for GO:0042985 based on MANUAL annotations
The top 100 of 254 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of amyloid precursor protein biosynthetic process
14,195.59 100.00 91 91
amyloid-beta binding
1,865.54 12.45 64 487
negative regulation of amyloid-beta formation
1,120.70 3.73 6 76
negative regulation of vascular endothelial growth factor production
1,455.96 3.17 4 39
miRNA-mediated gene silencing by inhibition of translation
567.82 3.10 11 275
apolipoprotein A-I-mediated signaling pathway
3,548.90 3.00 3 12
apolipoprotein A-I receptor activity
2,661.67 2.88 3 16
organelle membrane
567.82 2.83 8 200
plasma membrane raft organization
1,935.76 2.73 3 22
positive regulation of engulfment of apoptotic cell
1,577.29 2.61 3 27
Totals 402 9124

Change Log

Timestamp Action Category Detail
2023-06-13 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2023-05-20 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2017-05-30 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-30 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-29 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-29 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-01-21 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2016-06-22 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
Timestamp Action Category Detail
2007-01-15 Updated TERM negative regulation of amyloid precursor protein biosynthetic process
2003-10-15 Added TERM negative regulation of amyloid precursor protein biosynthesis
Timestamp Action Category Detail
2017-05-30 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-30 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-29 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2017-05-29 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2017-05-25 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2007-08-09 Deleted SYNONYM downregulation of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM inhibition of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM negative regulation of APP biosynthetic process
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein biosynthesis
2007-08-09 Added SYNONYM down-regulation of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM down-regulation of amyloid precursor protein biosynthetic process
2007-08-09 Deleted SYNONYM down regulation of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein formation
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein synthesis
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein synthesis
2007-08-09 Added SYNONYM down regulation of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM downregulation of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM inhibition of amyloid precursor protein biosynthetic process
2007-08-09 Added SYNONYM negative regulation of APP biosynthesis
2007-08-09 Added SYNONYM negative regulation of APP biosynthetic process
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein anabolism
2007-08-09 Added SYNONYM negative regulation of amyloid precursor protein biosynthesis
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein formation
2007-08-09 Deleted SYNONYM negative regulation of amyloid precursor protein anabolism
2007-08-09 Deleted SYNONYM negative regulation of APP biosynthesis
2007-02-23 Added SYNONYM down-regulation of amyloid precursor protein biosynthetic process
2007-02-23 Added SYNONYM downregulation of amyloid precursor protein biosynthetic process
2007-02-23 Added SYNONYM inhibition of amyloid precursor protein biosynthetic process
2007-02-23 Added SYNONYM down regulation of amyloid precursor protein biosynthetic process
2007-01-15 Added SYNONYM negative regulation of APP biosynthetic process
2007-01-15 Added SYNONYM negative regulation of amyloid precursor protein biosynthesis
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of the biosynthesis of amyloid precursor protein (APP), the precursor of beta-amyloid.
2005-08-10 Added SYNONYM negative regulation of amyloid precursor protein formation
2005-08-10 Added SYNONYM negative regulation of amyloid precursor protein synthesis
2005-08-10 Added SYNONYM negative regulation of amyloid precursor protein anabolism
2004-04-19 Added SYNONYM negative regulation of APP biosynthesis
2004-04-16 Deleted SYNONYM negative regulation of APP biosynthesis
2003-10-15 Added DEFINITION Any process that stops, prevents or reduces the rate of the biosynthesis of amyloid precursor protein (APP), the precursor of beta-amyloid.
2003-10-15 Added SYNONYM negative regulation of APP biosynthesis
Timestamp Action Category Detail
2023-06-13 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2023-05-20 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2017-01-21 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2016-06-22 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2013-02-02 Deleted RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2013-01-09 Added RELATION is a GO:0051248 (negative regulation of protein metabolic process)
2010-01-12 Deleted RELATION is a GO:0032269 (negative regulation of cellular protein metabolic process)
2008-04-01 Added RELATION negatively regulates GO:0042983 (amyloid precursor protein biosynthetic process)
2008-04-01 Updated RELATION is a GO:0010561 (negative regulation of glycoprotein biosynthetic process)
2008-04-01 Updated RELATION is a GO:0042984 (regulation of amyloid precursor protein biosynthetic process)
2008-04-01 Updated RELATION is a GO:0032269 (negative regulation of cellular protein metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
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