This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
GO:0043065
JSON
positive regulation of apoptotic process
Biological Process
Definition (GO:0043065 GONUTS page)
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
Comments
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
pro-apoptosis | related |
positive regulation of apoptosis | narrow |
upregulation of apoptosis | exact |
up-regulation of apoptosis | exact |
up regulation of apoptosis | exact |
stimulation of apoptosis | narrow |
activation of apoptosis | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0043065
Child Term | Relationship to GO:0043065 |
---|---|
positive regulation of epithelial cell apoptotic process
|
is_a |
galectin complex
|
capable_of_part_of |
positive regulation of apoptotic process involved in development
|
is_a |
positive regulation of fibroblast apoptotic process
|
is_a |
positive regulation of myeloid cell apoptotic process
|
is_a |
positive regulation of myofibroblast cell apoptotic process
|
is_a |
positive regulation of leukocyte apoptotic process
|
is_a |
positive regulation of glial cell apoptotic process
|
is_a |
positive regulation of fat cell apoptotic process
|
is_a |
positive regulation of anoikis
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating cell death and apoptosis using the new guidelines | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0043065 | positive regulation of apoptotic process | Never in Taxon | 4896 | Schizosaccharomyces pombe |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2KB20 | 10116 | A0A0G2KB20_RAT | GO:0042981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZMQ2 | 10116 | A0A8I5ZMQ2_RAT | GO:0042981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AE08 | 10116 | A0A8I6AE08_RAT | GO:0042981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J853 | 10116 | A6J853_RAT | GO:0042981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZZ22 | 10116 | D3ZZ22_RAT | GO:0042981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q4V925 | 7955 | Q4V925_DANRE | GO:0043065 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16888646 | |
NOT-qualified manual | protein | Q66H07 | 10116 | FANK1_RAT | GO:0042981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q6DC66 | 7955 | BOKA_DANRE | GO:0043065 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16888646 | |
NOT-qualified manual | protein | Q7T381 | 7955 | BOKB_DANRE | GO:0043065 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16888646 | |
NOT-qualified manual | protein | Q9DAM9 | 10090 | FANK1_MOUSE | GO:0042981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:31086747 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR010479 | BH3-interacting domain death agonist |
InterPro | IPR010548 | BNIP3 |
InterPro | IPR017322 | Receptor-interacting serine/threonine-protein kinase 2 |
InterPro | IPR022316 | Tumour necrosis factor receptor 12 |
InterPro | IPR024140 | Phorbol-12-myristate-13-acetate-induced protein 1 |
InterPro | IPR031661 | Bcl-2-binding component 3 |
InterPro | IPR042832 | PHLDA family |
InterPro | IPR042835 | Pleckstrin homology domain-containing family N member 1 |
Reactome | R-HSA-193648 | |
Reactome | R-HSA-205043 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043065 based on ALL annotations
The top 100 of 6,415 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
positive regulation of apoptotic process
|
3,421.60 | 100.00 | 57,913 | 57,913 |
apoptotic process
|
271.33 | 6.55 | 15,850 | 199,874 |
programmed cell death
|
827.34 | 5.72 | 4,039 | 16,704 |
mitochondrial outer membrane permeabilization
|
3,000.29 | 5.53 | 3,226 | 3,679 |
hippo signaling
|
686.40 | 5.50 | 4,081 | 20,343 |
negative regulation of cell population proliferation
|
367.51 | 4.95 | 4,871 | 45,350 |
mitochondrial envelope
|
418.50 | 4.15 | 3,428 | 28,027 |
regulation of organ growth
|
2,833.94 | 4.05 | 2,363 | 2,853 |
regulation of programmed cell death
|
1,142.12 | 3.82 | 2,398 | 7,184 |
apoptotic signaling pathway
|
715.51 | 3.75 | 2,528 | 12,089 |
Totals | 241291 | 4352108 |
No co-occurrence statistics for GO:0043065 based on MANUAL annotations
The top 100 of 5,908 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
positive regulation of apoptotic process
|
570.55 | 100.00 | 2,474 | 2,474 |
intrinsic apoptotic signaling pathway in response to DNA damage
|
242.27 | 9.26 | 262 | 617 |
release of cytochrome c from mitochondria
|
420.30 | 8.66 | 221 | 300 |
extrinsic apoptotic signaling pathway in absence of ligand
|
378.65 | 8.55 | 221 | 333 |
channel activity
|
276.55 | 7.65 | 206 | 425 |
negative regulation of cell population proliferation
|
73.11 | 6.33 | 275 | 2,146 |
apoptotic process
|
65.71 | 5.06 | 205 | 1,780 |
mitochondrial outer membrane
|
42.14 | 4.56 | 264 | 3,574 |
programmed cell death
|
259.76 | 4.29 | 112 | 246 |
apoptotic signaling pathway
|
143.97 | 3.87 | 108 | 428 |
Totals | 11852 | 173592 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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- Term
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-205043 |
2024-12-05 | Added | XREF | Reactome:R-HSA-193648 |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe) |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2012-07-07 | Added | SYNONYM | pro-apoptosis |
2011-11-26 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. |
2011-11-26 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
2011-11-26 | Added | SYNONYM | positive regulation of apoptosis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-11-26 | Updated | TERM | positive regulation of apoptotic process |
2004-01-22 | Updated | TERM | positive regulation of apoptosis |
2004-01-09 | Added | TERM | positive regualtion of apoptosis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-07-07 | Added | SYNONYM | pro-apoptosis |
2011-11-26 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. |
2011-11-26 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
2011-11-26 | Added | SYNONYM | positive regulation of apoptosis |
2008-05-13 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. |
2008-05-12 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. |
2007-08-09 | Added | SYNONYM | upregulation of apoptosis |
2007-08-09 | Added | SYNONYM | activation of apoptosis |
2007-08-09 | Added | SYNONYM | up regulation of apoptosis |
2007-08-09 | Added | SYNONYM | up-regulation of apoptosis |
2007-08-09 | Added | SYNONYM | stimulation of apoptosis |
2007-08-09 | Deleted | SYNONYM | upregulation of apoptosis |
2007-08-09 | Deleted | SYNONYM | up-regulation of apoptosis |
2007-08-09 | Deleted | SYNONYM | up regulation of apoptosis |
2007-08-09 | Deleted | SYNONYM | stimulation of apoptosis |
2007-08-09 | Deleted | SYNONYM | activation of apoptosis |
2007-02-23 | Added | SYNONYM | stimulation of apoptosis |
2007-02-23 | Added | SYNONYM | activation of apoptosis |
2007-02-23 | Added | SYNONYM | upregulation of apoptosis |
2007-02-23 | Added | SYNONYM | up-regulation of apoptosis |
2007-02-23 | Added | SYNONYM | up regulation of apoptosis |
2006-05-04 | Updated | DEFINITION | Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. |
2005-10-21 | Updated | DEFINITION | Any process that activates or increases the rate, frequency or extent of cell death by apoptosis. |
2004-01-09 | Added | DEFINITION | Any process that activates or increases the rate of cell death by apoptosis. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0043068 (positive regulation of programmed cell death) |
2008-04-01 | Added | RELATION | positively regulates GO:0006915 (apoptotic process) |
2008-04-01 | Updated | RELATION | is a GO:0042981 (regulation of apoptotic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-205043 |
2024-12-05 | Added | XREF | Reactome:R-HSA-193648 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe) |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
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