This term is obsolete.
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.

GO:0043065 JSON

positive regulation of apoptotic process

Biological Process

Definition (GO:0043065 GONUTS page)

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

Comments

This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.

102,926 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
pro-apoptosis related
positive regulation of apoptosis narrow
upregulation of apoptosis exact
up-regulation of apoptosis exact
up regulation of apoptosis exact
stimulation of apoptosis narrow
activation of apoptosis narrow

Ancestor Chart

Ancestor chart for GO:0043065
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043065

Child Term Relationship to
GO:0043065
positive regulation of epithelial cell apoptotic process
is_a
galectin complex
capable_of_part_of
positive regulation of apoptotic process involved in development
is_a
positive regulation of fibroblast apoptotic process
is_a
positive regulation of myeloid cell apoptotic process
is_a
positive regulation of myofibroblast cell apoptotic process
is_a
positive regulation of leukocyte apoptotic process
is_a
positive regulation of glial cell apoptotic process
is_a
positive regulation of fat cell apoptotic process
is_a
positive regulation of anoikis
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating cell death and apoptosis using the new guidelines Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0043065 positive regulation of apoptotic process Never in Taxon 4896 Schizosaccharomyces pombe

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2KB20 10116 A0A0G2KB20_RAT GO:0042981 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZMQ2 10116 A0A8I5ZMQ2_RAT GO:0042981 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AE08 10116 A0A8I6AE08_RAT GO:0042981 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J853 10116 A6J853_RAT GO:0042981 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZZ22 10116 D3ZZ22_RAT GO:0042981 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q4V925 7955 Q4V925_DANRE GO:0043065 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16888646
NOT-qualified manual protein Q66H07 10116 FANK1_RAT GO:0042981 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6DC66 7955 BOKA_DANRE GO:0043065 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16888646
NOT-qualified manual protein Q7T381 7955 BOKB_DANRE GO:0043065 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16888646
NOT-qualified manual protein Q9DAM9 10090 FANK1_MOUSE GO:0042981 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:31086747

Cross-references

Database ID Description
InterPro IPR010479 BH3-interacting domain death agonist
InterPro IPR010548 BNIP3
InterPro IPR017322 Receptor-interacting serine/threonine-protein kinase 2
InterPro IPR022316 Tumour necrosis factor receptor 12
InterPro IPR024140 Phorbol-12-myristate-13-acetate-induced protein 1
InterPro IPR031661 Bcl-2-binding component 3
InterPro IPR042832 PHLDA family
InterPro IPR042835 Pleckstrin homology domain-containing family N member 1
Reactome R-HSA-193648
Reactome R-HSA-205043

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043065 based on ALL annotations
The top 100 of 6,415 co-occurring terms
Co-occurring Term PR S% #Together #Compared
positive regulation of apoptotic process
3,421.60 100.00 57,913 57,913
apoptotic process
271.33 6.55 15,850 199,874
programmed cell death
827.34 5.72 4,039 16,704
mitochondrial outer membrane permeabilization
3,000.29 5.53 3,226 3,679
hippo signaling
686.40 5.50 4,081 20,343
negative regulation of cell population proliferation
367.51 4.95 4,871 45,350
mitochondrial envelope
418.50 4.15 3,428 28,027
regulation of organ growth
2,833.94 4.05 2,363 2,853
regulation of programmed cell death
1,142.12 3.82 2,398 7,184
apoptotic signaling pathway
715.51 3.75 2,528 12,089
Totals 241291 4352108
No co-occurrence statistics for GO:0043065 based on MANUAL annotations
The top 100 of 5,908 co-occurring terms
Co-occurring Term PR S% #Together #Compared
positive regulation of apoptotic process
570.55 100.00 2,474 2,474
intrinsic apoptotic signaling pathway in response to DNA damage
242.27 9.26 262 617
release of cytochrome c from mitochondria
420.30 8.66 221 300
extrinsic apoptotic signaling pathway in absence of ligand
378.65 8.55 221 333
channel activity
276.55 7.65 206 425
negative regulation of cell population proliferation
73.11 6.33 275 2,146
apoptotic process
65.71 5.06 205 1,780
mitochondrial outer membrane
42.14 4.56 264 3,574
programmed cell death
259.76 4.29 112 246
apoptotic signaling pathway
143.97 3.87 108 428
Totals 11852 173592

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-205043
2024-12-05 Added XREF Reactome:R-HSA-193648
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe)
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2012-07-07 Added SYNONYM pro-apoptosis
2011-11-26 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
2011-11-26 Added DEFINITION Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2011-11-26 Added SYNONYM positive regulation of apoptosis
Timestamp Action Category Detail
2011-11-26 Updated TERM positive regulation of apoptotic process
2004-01-22 Updated TERM positive regulation of apoptosis
2004-01-09 Added TERM positive regualtion of apoptosis
Timestamp Action Category Detail
2012-07-07 Added SYNONYM pro-apoptosis
2011-11-26 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
2011-11-26 Added DEFINITION Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2011-11-26 Added SYNONYM positive regulation of apoptosis
2008-05-13 Added DEFINITION Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
2008-05-12 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
2007-08-09 Added SYNONYM upregulation of apoptosis
2007-08-09 Added SYNONYM activation of apoptosis
2007-08-09 Added SYNONYM up regulation of apoptosis
2007-08-09 Added SYNONYM up-regulation of apoptosis
2007-08-09 Added SYNONYM stimulation of apoptosis
2007-08-09 Deleted SYNONYM upregulation of apoptosis
2007-08-09 Deleted SYNONYM up-regulation of apoptosis
2007-08-09 Deleted SYNONYM up regulation of apoptosis
2007-08-09 Deleted SYNONYM stimulation of apoptosis
2007-08-09 Deleted SYNONYM activation of apoptosis
2007-02-23 Added SYNONYM stimulation of apoptosis
2007-02-23 Added SYNONYM activation of apoptosis
2007-02-23 Added SYNONYM upregulation of apoptosis
2007-02-23 Added SYNONYM up-regulation of apoptosis
2007-02-23 Added SYNONYM up regulation of apoptosis
2006-05-04 Updated DEFINITION Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
2005-10-21 Updated DEFINITION Any process that activates or increases the rate, frequency or extent of cell death by apoptosis.
2004-01-09 Added DEFINITION Any process that activates or increases the rate of cell death by apoptosis.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0043068 (positive regulation of programmed cell death)
2008-04-01 Added RELATION positively regulates GO:0006915 (apoptotic process)
2008-04-01 Updated RELATION is a GO:0042981 (regulation of apoptotic process)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-205043
2024-12-05 Added XREF Reactome:R-HSA-193648
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe)
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
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