This term is obsolete.

GO:0043335 JSON

protein unfolding

Biological Process

Definition (GO:0043335 GONUTS page)

The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.

76,120 annotations

Ancestor Chart

Ancestor chart for GO:0043335
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Ancestor chart

Cross-references

Database ID Description
InterPro IPR013461 ATP-dependent Clp protease ATP-binding subunit ClpA

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043335 based on ALL annotations
The top 100 of 368 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein unfolding
2,605.83 100.00 76,043 76,043
'de novo' cotranslational protein folding
2,083.78 45.59 39,141 48,947
chaperone-mediated protein folding
789.05 23.56 39,141 129,263
proteasome-activating activity
2,420.44 22.18 17,156 18,470
positive regulation of proteasomal protein catabolic process
2,264.38 21.82 17,156 19,743
protein folding chaperone
668.75 20.66 39,144 152,527
HslUV protease complex
534.22 12.03 17,151 83,660
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
307.03 9.65 26,462 224,589
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
307.03 9.65 26,462 224,589
peptidyl-prolyl cis-trans isomerase activity
217.85 7.75 39,141 468,194
Totals 775176 93132735
No co-occurrence statistics for GO:0043335 based on MANUAL annotations
The top 100 of 220 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein unfolding
3,368.81 100.00 419 419
protein import into peroxisome matrix
1,057.09 23.24 198 631
'de novo' cotranslational protein folding
1,209.51 22.96 163 454
chaperone-mediated protein folding
422.40 10.48 163 1,300
peroxisomal membrane
258.55 7.08 201 2,619
ribosome binding
198.02 5.39 164 2,790
protein folding chaperone
191.87 5.24 165 2,897
peptidyl-prolyl cis-trans isomerase activity
167.36 4.61 163 3,281
protein import into peroxisome matrix, receptor recycling
948.96 4.26 20 71
protein transporter activity
815.04 3.22 15 62
Totals 2483 171201

Change Log

Timestamp Action Category Detail
2021-03-12 Deleted RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-23 Added RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-08 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2015-10-08 Added RELATION is a GO:0009987 (cellular process)
2008-05-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2008-05-12 Deleted DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
2005-03-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2005-03-13 Added TERM protein unfolding
Timestamp Action Category Detail
2005-03-13 Added TERM protein unfolding
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2008-05-12 Deleted DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2005-03-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
Timestamp Action Category Detail
2021-03-12 Deleted RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-23 Added RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-08 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2015-10-08 Added RELATION is a GO:0009987 (cellular process)
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
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