This term is obsolete.

GO:0043335 JSON

protein unfolding

Biological Process

Definition (GO:0043335 GONUTS page)

The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.

75,150 annotations

Ancestor Chart

Ancestor chart for GO:0043335
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Ancestor chart

Cross-references

Database ID Description
InterPro IPR013461 ATP-dependent Clp protease ATP-binding subunit ClpA

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043335 based on ALL annotations
The top 100 of 379 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein unfolding
2,596.35 100.00 75,082 75,082
'de novo' cotranslational protein folding
2,085.95 45.64 38,572 48,010
chaperone-mediated protein folding
790.15 23.63 38,572 126,743
proteasome-activating activity
2,422.27 22.27 16,990 18,211
positive regulation of proteasomal protein catabolic process
2,264.59 21.90 16,990 19,479
protein folding chaperone
670.44 20.75 38,575 149,386
HslUV protease complex
532.76 12.06 16,985 82,775
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
307.15 9.76 26,842 226,896
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
307.15 9.76 26,842 226,896
peptidyl-prolyl cis-trans isomerase activity
219.20 7.82 38,572 456,863
Totals 768018 92045973
No co-occurrence statistics for GO:0043335 based on MANUAL annotations
The top 100 of 223 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein unfolding
3,253.90 100.00 397 397
protein import into peroxisome matrix
1,036.35 23.40 186 584
'de novo' cotranslational protein folding
1,179.73 22.97 153 422
chaperone-mediated protein folding
419.77 10.70 153 1,186
peroxisomal membrane
252.77 7.16 189 2,433
ribosome binding
195.28 5.48 154 2,566
protein folding chaperone
192.94 5.43 155 2,614
peptidyl-prolyl cis-trans isomerase activity
168.02 4.77 153 2,963
protein import into peroxisome matrix, receptor recycling
916.59 4.46 20 71
protein transporter activity
800.14 3.39 15 61
Totals 2363 160505

Change Log

Timestamp Action Category Detail
2021-03-12 Deleted RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-23 Added RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-08 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2015-10-08 Added RELATION is a GO:0009987 (cellular process)
2008-05-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2008-05-12 Deleted DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
2005-03-13 Added TERM protein unfolding
2005-03-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
Timestamp Action Category Detail
2005-03-13 Added TERM protein unfolding
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2008-05-12 Deleted DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
2005-03-13 Added DEFINITION The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
Timestamp Action Category Detail
2021-03-12 Deleted RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-23 Added RELATION has part GO:0061741 (obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy)
2015-10-08 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2015-10-08 Added RELATION is a GO:0009987 (cellular process)
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
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