GO:0043398
JSON
HLH domain binding
Molecular Function
Definition (GO:0043398 GONUTS page)
Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043398 based on ALL annotations
The top 100 of 476 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
HLH domain binding
|
746,891.94 | 100.00 | 261 | 261 |
metanephric cortex development
|
746,891.90 | 36.02 | 94 | 94 |
metanephric cortical collecting duct development
|
746,891.90 | 36.02 | 94 | 94 |
metanephric distal tubule development
|
746,891.90 | 36.02 | 94 | 94 |
negative regulation of stomach neuroendocrine cell differentiation
|
746,891.90 | 34.87 | 91 | 91 |
negative regulation of cell fate determination
|
746,891.90 | 34.87 | 91 | 91 |
renal interstitial fibroblast development
|
746,891.90 | 34.87 | 91 | 91 |
N-box binding
|
723,054.94 | 34.47 | 91 | 94 |
trochlear nerve development
|
707,991.30 | 34.21 | 91 | 96 |
renal artery morphogenesis
|
484,192.00 | 30.13 | 94 | 145 |
Totals | 8584 | 51236 |
No co-occurrence statistics for GO:0043398 based on MANUAL annotations
The top 100 of 436 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
HLH domain binding
|
143,533.22 | 100.00 | 9 | 9 |
metanephric cortex development
|
143,533.23 | 33.33 | 3 | 3 |
metanephric cortical collecting duct development
|
143,533.23 | 33.33 | 3 | 3 |
metanephric distal tubule development
|
143,533.23 | 33.33 | 3 | 3 |
renal artery morphogenesis
|
86,119.94 | 27.27 | 3 | 5 |
metanephric smooth muscle tissue development
|
61,514.24 | 23.08 | 3 | 7 |
maintenance of nucleus location
|
143,533.22 | 22.22 | 2 | 2 |
negative regulation of stomach neuroendocrine cell differentiation
|
143,533.22 | 22.22 | 2 | 2 |
negative regulation of cell fate determination
|
143,533.22 | 22.22 | 2 | 2 |
histone H3K deacetylase activity
|
143,533.22 | 22.22 | 2 | 2 |
Totals | 213 | 1678 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2021-05-24 | Added | DEFINITION | Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2008-05-13 | Added | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2008-04-01 | Updated | RELATION | is a GO:0019904 (protein domain specific binding) |
2005-07-01 | Added | TERM | HLH domain binding |
2005-07-01 | Added | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-07-01 | Added | TERM | HLH domain binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2021-05-24 | Added | DEFINITION | Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2008-05-13 | Added | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
2005-07-01 | Added | DEFINITION | Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0019904 (protein domain specific binding) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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