This term is obsolete.

GO:0043398 JSON

HLH domain binding

Molecular Function

Definition (GO:0043398 GONUTS page)

Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.

265 annotations

Ancestor Chart

Ancestor chart for GO:0043398
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043398 based on ALL annotations
The top 100 of 476 co-occurring terms
Co-occurring Term PR S% #Together #Compared
HLH domain binding
746,891.94 100.00 261 261
metanephric cortex development
746,891.90 36.02 94 94
metanephric cortical collecting duct development
746,891.90 36.02 94 94
metanephric distal tubule development
746,891.90 36.02 94 94
negative regulation of stomach neuroendocrine cell differentiation
746,891.90 34.87 91 91
negative regulation of cell fate determination
746,891.90 34.87 91 91
renal interstitial fibroblast development
746,891.90 34.87 91 91
N-box binding
723,054.94 34.47 91 94
trochlear nerve development
707,991.30 34.21 91 96
renal artery morphogenesis
484,192.00 30.13 94 145
Totals 8584 51236
No co-occurrence statistics for GO:0043398 based on MANUAL annotations
The top 100 of 436 co-occurring terms
Co-occurring Term PR S% #Together #Compared
HLH domain binding
143,533.22 100.00 9 9
metanephric cortex development
143,533.23 33.33 3 3
metanephric cortical collecting duct development
143,533.23 33.33 3 3
metanephric distal tubule development
143,533.23 33.33 3 3
renal artery morphogenesis
86,119.94 27.27 3 5
metanephric smooth muscle tissue development
61,514.24 23.08 3 7
maintenance of nucleus location
143,533.22 22.22 2 2
negative regulation of stomach neuroendocrine cell differentiation
143,533.22 22.22 2 2
negative regulation of cell fate determination
143,533.22 22.22 2 2
histone H3K deacetylase activity
143,533.22 22.22 2 2
Totals 213 1678

Change Log

Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2021-05-24 Added DEFINITION Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2009-07-03 Deleted DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2008-05-13 Added DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2008-05-12 Deleted DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2008-04-01 Updated RELATION is a GO:0019904 (protein domain specific binding)
2005-07-01 Added TERM HLH domain binding
2005-07-01 Added DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
Timestamp Action Category Detail
2005-07-01 Added TERM HLH domain binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2021-05-24 Added DEFINITION Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2009-07-03 Deleted DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2008-05-13 Added DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2008-05-12 Deleted DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
2005-07-01 Added DEFINITION Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0019904 (protein domain specific binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.