This term is obsolete.

GO:0043409 JSON

negative regulation of MAPK cascade

Biological Process

Definition (GO:0043409 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.

45,800 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
down regulation of MAPK cascade exact
negative regulation of mitogen activated protein kinase kinase kinase cascade exact
negative regulation of mitogen-activated protein kinase cascade exact
negative regulation of mitogen activated protein kinase cascade exact
negative regulation of MAPKKK cascade exact
inhibition of MAPKKK cascade narrow
negative regulation of MAP kinase kinase kinase cascade exact
negative regulation of MAP kinase cascade exact
down regulation of MAPKKK cascade exact
down-regulation of MAPKKK cascade exact

Ancestor Chart

Ancestor chart for GO:0043409
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043409

Child Term Relationship to
GO:0043409
negative regulation of JNK cascade
is_a
negative regulation of p38MAPK cascade
is_a
negative regulation of pheromone response MAPK cascade
is_a
negative regulation of ERK1 and ERK2 cascade
is_a
negative regulation of MAP kinase activity
is_a
negative regulation of ERK5 cascade
is_a
negative regulation of stress-activated MAPK cascade
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A6JH76 10116 A6JH76_RAT GO:0043408 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B5DFG9 10116 B5DFG9_RAT GO:0043408 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1LXQ8 10116 F1LXQ8_RAT GO:0043408 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1M784 10116 F1M784_RAT GO:0043408 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q8K0B2-1 10090 LMBD1_MOUSE GO:0043408 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24078630
NOT-qualified manual protein Q9EQ32 10090 BCAP_MOUSE GO:0043408 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22187458

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0051389 obsolete inactivation of MAPKK activity consider GO:0043409
GO:0051390 obsolete inactivation of MAPKKK activity consider GO:0043409

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043409 based on ALL annotations
The top 100 of 1,842 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of MAPK cascade
6,827.26 100.00 28,553 28,553
MAP kinase tyrosine/serine/threonine phosphatase activity
4,827.34 34.81 11,615 16,427
protein tyrosine/threonine phosphatase activity
5,762.93 32.06 9,730 11,527
MAP kinase tyrosine phosphatase activity
5,749.46 31.78 9,650 11,459
MAP kinase phosphatase activity
5,653.84 22.23 6,654 8,035
protein tyrosine/serine/threonine phosphatase activity
3,137.50 18.74 6,863 14,934
MAP kinase serine/threonine phosphatase activity
592.03 7.18 8,393 96,787
RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
589.08 7.14 8,344 96,705
RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
589.08 7.14 8,344 96,705
RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
589.08 7.14 8,344 96,705
Totals 241134 7173124
No co-occurrence statistics for GO:0043409 based on MANUAL annotations
The top 100 of 1,584 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of MAPK cascade
1,913.78 100.00 675 675
protein tyrosine/threonine phosphatase activity
1,495.28 41.62 318 407
MAP kinase tyrosine/serine/threonine phosphatase activity
1,478.20 41.48 319 413
MAP kinase tyrosine phosphatase activity
1,484.83 41.12 315 406
MAP kinase phosphatase activity
1,138.70 15.74 119 200
protein tyrosine/serine/threonine phosphatase activity
770.11 15.33 134 333
endoderm formation
597.29 6.26 49 157
negative regulation of ERK1 and ERK2 cascade
151.09 3.89 48 608
phosphoprotein phosphatase activity
102.93 3.32 54 1,004
protein dephosphorylation
157.77 2.47 23 279
Totals 3272 45047

Change Log

Timestamp Action Category Detail
2020-11-24 Deleted RELATION is a GO:0001933 (negative regulation of protein phosphorylation)
2015-06-25 Deleted RELATION is a GO:0042326 (negative regulation of phosphorylation)
2015-04-24 Added RELATION is a GO:0001933 (negative regulation of protein phosphorylation)
2013-12-04 Added RELATION is a GO:1902532 (negative regulation of intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2013-11-28 Added RELATION is a GO:0042326 (negative regulation of phosphorylation)
2012-01-27 Added SYNONYM down-regulation of MAPK cascade
2012-01-27 Added SYNONYM negative regulation of MAPKKK cascade
2012-01-27 Added SYNONYM inhibition of MAPK cascade
2012-01-27 Added SYNONYM down regulation of MAPK cascade
Timestamp Action Category Detail
2012-01-27 Updated TERM negative regulation of MAPK cascade
2005-07-04 Added TERM negative regulation of MAPKKK cascade
Timestamp Action Category Detail
2012-01-27 Added SYNONYM down-regulation of MAPK cascade
2012-01-27 Added SYNONYM negative regulation of MAPKKK cascade
2012-01-27 Added SYNONYM inhibition of MAPK cascade
2012-01-27 Added SYNONYM down regulation of MAPK cascade
2012-01-27 Added SYNONYM downregulation of MAPK cascade
2012-01-27 Added SYNONYM negative regulation of MAP kinase cascade
2012-01-27 Added SYNONYM negative regulation of mitogen activated protein kinase cascade
2012-01-27 Added SYNONYM negative regulation of mitogen-activated protein kinase cascade
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2007-08-09 Deleted SYNONYM inhibition of MAPKKK cascade
2007-08-09 Deleted SYNONYM down-regulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM down regulation of MAPKKK cascade
2007-08-09 Added SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade
2007-08-09 Added SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2007-08-09 Added SYNONYM negative regulation of MAP kinase kinase kinase cascade
2007-08-09 Added SYNONYM inhibition of MAPKKK cascade
2007-08-09 Added SYNONYM downregulation of MAPKKK cascade
2007-08-09 Added SYNONYM down-regulation of MAPKKK cascade
2007-08-09 Added SYNONYM down regulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM downregulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM negative regulation of MAP kinase kinase kinase cascade
2007-02-23 Added SYNONYM down regulation of MAPKKK cascade
2007-02-23 Added SYNONYM inhibition of MAPKKK cascade
2007-02-23 Added SYNONYM downregulation of MAPKKK cascade
2007-02-23 Added SYNONYM down-regulation of MAPKKK cascade
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of signal transduction mediated by the MAPKKK cascade.
2005-07-04 Added SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade
2005-07-04 Added DEFINITION Any process that stops, prevents or reduces the rate of signal transduction mediated by the MAPKKK cascade.
2005-07-04 Added SYNONYM negative regulation of MAP kinase kinase kinase cascade
2005-07-04 Added SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
Timestamp Action Category Detail
2020-11-24 Deleted RELATION is a GO:0001933 (negative regulation of protein phosphorylation)
2015-06-25 Deleted RELATION is a GO:0042326 (negative regulation of phosphorylation)
2015-04-24 Added RELATION is a GO:0001933 (negative regulation of protein phosphorylation)
2013-12-04 Added RELATION is a GO:1902532 (negative regulation of intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2013-11-28 Added RELATION is a GO:0042326 (negative regulation of phosphorylation)
2008-10-02 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2008-10-02 Added RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2008-04-01 Updated RELATION is a GO:0043408 (regulation of MAPK cascade)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
2008-04-01 Added RELATION negatively regulates GO:0000165 (MAPK cascade)
Timestamp Action Category Detail
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.