GO:0043409
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negative regulation of MAPK cascade
Biological Process
Definition (GO:0043409 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
down regulation of MAPK cascade | exact |
negative regulation of mitogen activated protein kinase kinase kinase cascade | exact |
negative regulation of mitogen-activated protein kinase cascade | exact |
negative regulation of mitogen activated protein kinase cascade | exact |
negative regulation of MAPKKK cascade | exact |
inhibition of MAPKKK cascade | narrow |
negative regulation of MAP kinase kinase kinase cascade | exact |
negative regulation of MAP kinase cascade | exact |
down regulation of MAPKKK cascade | exact |
down-regulation of MAPKKK cascade | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0043409
Child Term | Relationship to GO:0043409 |
---|---|
negative regulation of JNK cascade
|
is_a |
negative regulation of p38MAPK cascade
|
is_a |
negative regulation of pheromone response MAPK cascade
|
is_a |
negative regulation of ERK1 and ERK2 cascade
|
is_a |
negative regulation of MAP kinase activity
|
is_a |
negative regulation of ERK5 cascade
|
is_a |
negative regulation of stress-activated MAPK cascade
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A6JH76 | 10116 | A6JH76_RAT | GO:0043408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B5DFG9 | 10116 | B5DFG9_RAT | GO:0043408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1LXQ8 | 10116 | F1LXQ8_RAT | GO:0043408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1M784 | 10116 | F1M784_RAT | GO:0043408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q8K0B2-1 | 10090 | LMBD1_MOUSE | GO:0043408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24078630 | |
NOT-qualified manual | protein | Q9EQ32 | 10090 | BCAP_MOUSE | GO:0043408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22187458 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0051389 | obsolete inactivation of MAPKK activity | consider GO:0043409 |
GO:0051390 | obsolete inactivation of MAPKKK activity | consider GO:0043409 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043409 based on ALL annotations
The top 100 of 1,842 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of MAPK cascade
|
6,827.26 | 100.00 | 28,553 | 28,553 |
MAP kinase tyrosine/serine/threonine phosphatase activity
|
4,827.34 | 34.81 | 11,615 | 16,427 |
protein tyrosine/threonine phosphatase activity
|
5,762.93 | 32.06 | 9,730 | 11,527 |
MAP kinase tyrosine phosphatase activity
|
5,749.46 | 31.78 | 9,650 | 11,459 |
MAP kinase phosphatase activity
|
5,653.84 | 22.23 | 6,654 | 8,035 |
protein tyrosine/serine/threonine phosphatase activity
|
3,137.50 | 18.74 | 6,863 | 14,934 |
MAP kinase serine/threonine phosphatase activity
|
592.03 | 7.18 | 8,393 | 96,787 |
RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
|
589.08 | 7.14 | 8,344 | 96,705 |
RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
|
589.08 | 7.14 | 8,344 | 96,705 |
RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
|
589.08 | 7.14 | 8,344 | 96,705 |
Totals | 241134 | 7173124 |
No co-occurrence statistics for GO:0043409 based on MANUAL annotations
The top 100 of 1,584 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of MAPK cascade
|
1,913.78 | 100.00 | 675 | 675 |
protein tyrosine/threonine phosphatase activity
|
1,495.28 | 41.62 | 318 | 407 |
MAP kinase tyrosine/serine/threonine phosphatase activity
|
1,478.20 | 41.48 | 319 | 413 |
MAP kinase tyrosine phosphatase activity
|
1,484.83 | 41.12 | 315 | 406 |
MAP kinase phosphatase activity
|
1,138.70 | 15.74 | 119 | 200 |
protein tyrosine/serine/threonine phosphatase activity
|
770.11 | 15.33 | 134 | 333 |
endoderm formation
|
597.29 | 6.26 | 49 | 157 |
negative regulation of ERK1 and ERK2 cascade
|
151.09 | 3.89 | 48 | 608 |
phosphoprotein phosphatase activity
|
102.93 | 3.32 | 54 | 1,004 |
protein dephosphorylation
|
157.77 | 2.47 | 23 | 279 |
Totals | 3272 | 45047 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
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2020-11-24 | Deleted | RELATION | is a GO:0001933 (negative regulation of protein phosphorylation) |
2015-06-25 | Deleted | RELATION | is a GO:0042326 (negative regulation of phosphorylation) |
2015-04-24 | Added | RELATION | is a GO:0001933 (negative regulation of protein phosphorylation) |
2013-12-04 | Added | RELATION | is a GO:1902532 (negative regulation of intracellular signal transduction) |
2013-12-04 | Deleted | RELATION | is a GO:0010741 (negative regulation of intracellular protein kinase cascade) |
2013-11-28 | Added | RELATION | is a GO:0042326 (negative regulation of phosphorylation) |
2012-01-27 | Added | SYNONYM | down-regulation of MAPK cascade |
2012-01-27 | Added | SYNONYM | negative regulation of MAPKKK cascade |
2012-01-27 | Added | SYNONYM | inhibition of MAPK cascade |
2012-01-27 | Added | SYNONYM | down regulation of MAPK cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-01-27 | Updated | TERM | negative regulation of MAPK cascade |
2005-07-04 | Added | TERM | negative regulation of MAPKKK cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-01-27 | Added | SYNONYM | down-regulation of MAPK cascade |
2012-01-27 | Added | SYNONYM | negative regulation of MAPKKK cascade |
2012-01-27 | Added | SYNONYM | inhibition of MAPK cascade |
2012-01-27 | Added | SYNONYM | down regulation of MAPK cascade |
2012-01-27 | Added | SYNONYM | downregulation of MAPK cascade |
2012-01-27 | Added | SYNONYM | negative regulation of MAP kinase cascade |
2012-01-27 | Added | SYNONYM | negative regulation of mitogen activated protein kinase cascade |
2012-01-27 | Added | SYNONYM | negative regulation of mitogen-activated protein kinase cascade |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
2007-08-09 | Deleted | SYNONYM | inhibition of MAPKKK cascade |
2007-08-09 | Deleted | SYNONYM | down-regulation of MAPKKK cascade |
2007-08-09 | Deleted | SYNONYM | down regulation of MAPKKK cascade |
2007-08-09 | Added | SYNONYM | negative regulation of mitogen-activated protein kinase kinase kinase cascade |
2007-08-09 | Added | SYNONYM | negative regulation of mitogen activated protein kinase kinase kinase cascade |
2007-08-09 | Added | SYNONYM | negative regulation of MAP kinase kinase kinase cascade |
2007-08-09 | Added | SYNONYM | inhibition of MAPKKK cascade |
2007-08-09 | Added | SYNONYM | downregulation of MAPKKK cascade |
2007-08-09 | Added | SYNONYM | down-regulation of MAPKKK cascade |
2007-08-09 | Added | SYNONYM | down regulation of MAPKKK cascade |
2007-08-09 | Deleted | SYNONYM | negative regulation of mitogen-activated protein kinase kinase kinase cascade |
2007-08-09 | Deleted | SYNONYM | downregulation of MAPKKK cascade |
2007-08-09 | Deleted | SYNONYM | negative regulation of mitogen activated protein kinase kinase kinase cascade |
2007-08-09 | Deleted | SYNONYM | negative regulation of MAP kinase kinase kinase cascade |
2007-02-23 | Added | SYNONYM | down regulation of MAPKKK cascade |
2007-02-23 | Added | SYNONYM | inhibition of MAPKKK cascade |
2007-02-23 | Added | SYNONYM | downregulation of MAPKKK cascade |
2007-02-23 | Added | SYNONYM | down-regulation of MAPKKK cascade |
2006-05-04 | Updated | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
2005-10-21 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate, frequency or extent of signal transduction mediated by the MAPKKK cascade. |
2005-07-04 | Added | SYNONYM | negative regulation of mitogen-activated protein kinase kinase kinase cascade |
2005-07-04 | Added | DEFINITION | Any process that stops, prevents or reduces the rate of signal transduction mediated by the MAPKKK cascade. |
2005-07-04 | Added | SYNONYM | negative regulation of MAP kinase kinase kinase cascade |
2005-07-04 | Added | SYNONYM | negative regulation of mitogen activated protein kinase kinase kinase cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-24 | Deleted | RELATION | is a GO:0001933 (negative regulation of protein phosphorylation) |
2015-06-25 | Deleted | RELATION | is a GO:0042326 (negative regulation of phosphorylation) |
2015-04-24 | Added | RELATION | is a GO:0001933 (negative regulation of protein phosphorylation) |
2013-12-04 | Added | RELATION | is a GO:1902532 (negative regulation of intracellular signal transduction) |
2013-12-04 | Deleted | RELATION | is a GO:0010741 (negative regulation of intracellular protein kinase cascade) |
2013-11-28 | Added | RELATION | is a GO:0042326 (negative regulation of phosphorylation) |
2008-10-02 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2008-10-02 | Added | RELATION | is a GO:0010741 (negative regulation of intracellular protein kinase cascade) |
2008-04-01 | Updated | RELATION | is a GO:0043408 (regulation of MAPK cascade) |
2008-04-01 | Updated | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2008-04-01 | Added | RELATION | negatively regulates GO:0000165 (MAPK cascade) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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