GO:0043729
JSON
2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
Molecular Function
Definition (GO:0043729 GONUTS page)
Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+.
Ancestor Chart
Ancestor chart for GO:0043729
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.5.1.102 | |
RHEA | 27282 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:59545 | 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate(2-) |
has_participant | CHEBI | CHEBI:15740 | formate |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:57258 | 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043729 based on ALL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
|
1,821,857.80 | 100.00 | 107 | 107 |
F420-0 metabolic process
|
18,863.24 | 1.03 | 91 | 8,789 |
creatinine catabolic process
|
2,082.12 | 0.10 | 1 | 875 |
ferrous iron binding
|
1,128.60 | 0.06 | 91 | 146,898 |
creatininase activity
|
811.88 | 0.04 | 1 | 2,244 |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
|
661.49 | 0.04 | 107 | 294,695 |
riboflavin biosynthetic process
|
587.04 | 0.03 | 107 | 332,069 |
creatine biosynthetic process
|
358.63 | 0.02 | 1 | 5,080 |
hydrolase activity
|
17.01 | 0.00 | 107 | 11,461,355 |
protein homodimerization activity
|
8.89 | 0.00 | 1 | 204,841 |
Totals | 722 | 40715433 |
No co-occurrence statistics for GO:0043729 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Totals | 0 | 0 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-14 | Deleted | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate. |
2022-01-14 | Added | XREF | RHEA:27282 |
2022-01-14 | Deleted | RELATION | is a GO:0016829 (lyase activity) |
2022-01-14 | Added | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2022-01-14 | Added | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+. |
2022-01-14 | Added | XREF | EC:3.5.1.102 |
2019-04-01 | Deleted | XREF | EC:4 |
2016-10-03 | Added | XREF | EC:4 |
2016-10-03 | Deleted | XREF | EC:4.-.-.- |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-04-30 | Added | TERM | 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-14 | Deleted | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate. |
2022-01-14 | Added | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate. |
2007-05-27 | Added | DEFINITION | Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-14 | Deleted | RELATION | is a GO:0016829 (lyase activity) |
2022-01-14 | Added | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2008-04-01 | Updated | RELATION | is a GO:0016829 (lyase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-14 | Added | XREF | RHEA:27282 |
2022-01-14 | Added | XREF | EC:3.5.1.102 |
2019-04-01 | Deleted | XREF | EC:4 |
2016-10-03 | Added | XREF | EC:4 |
2016-10-03 | Deleted | XREF | EC:4.-.-.- |
2007-04-30 | Added | XREF | EC:4.-.-.- |
Timestamp | Action | Category | Detail |
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