This term is obsolete.

GO:0043729 JSON

2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity

Molecular Function

Definition (GO:0043729 GONUTS page)

Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+.

107 annotations

Ancestor Chart

Ancestor chart for GO:0043729
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.5.1.102
RHEA 27282

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:59545 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate(2-)
has_participant CHEBI CHEBI:15740 formate
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:57258 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043729 based on ALL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
1,821,857.80 100.00 107 107
F420-0 metabolic process
18,863.24 1.03 91 8,789
creatinine catabolic process
2,082.12 0.10 1 875
ferrous iron binding
1,128.60 0.06 91 146,898
creatininase activity
811.88 0.04 1 2,244
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
661.49 0.04 107 294,695
riboflavin biosynthetic process
587.04 0.03 107 332,069
creatine biosynthetic process
358.63 0.02 1 5,080
hydrolase activity
17.01 0.00 107 11,461,355
protein homodimerization activity
8.89 0.00 1 204,841
Totals 722 40715433
No co-occurrence statistics for GO:0043729 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Totals 0 0

Change Log

Timestamp Action Category Detail
2022-01-14 Deleted DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
2022-01-14 Added XREF RHEA:27282
2022-01-14 Deleted RELATION is a GO:0016829 (lyase activity)
2022-01-14 Added RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2022-01-14 Added DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+.
2022-01-14 Added XREF EC:3.5.1.102
2019-04-01 Deleted XREF EC:4
2016-10-03 Added XREF EC:4
2016-10-03 Deleted XREF EC:4.-.-.-
2008-05-13 Added DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
Timestamp Action Category Detail
2007-04-30 Added TERM 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
Timestamp Action Category Detail
2022-01-14 Deleted DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
2022-01-14 Added DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
2007-05-27 Added DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
Timestamp Action Category Detail
2022-01-14 Deleted RELATION is a GO:0016829 (lyase activity)
2022-01-14 Added RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2008-04-01 Updated RELATION is a GO:0016829 (lyase activity)
Timestamp Action Category Detail
2022-01-14 Added XREF RHEA:27282
2022-01-14 Added XREF EC:3.5.1.102
2019-04-01 Deleted XREF EC:4
2016-10-03 Added XREF EC:4
2016-10-03 Deleted XREF EC:4.-.-.-
2007-04-30 Added XREF EC:4.-.-.-
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.