This term is obsolete.

GO:0043837 JSON

valine dehydrogenase (NAD+) activity

Molecular Function

Definition (GO:0043837 GONUTS page)

Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH. PMID:10612726 PMID:2803248

913 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
valine dehydrogenase (NAD) activity exact
ValDH related

Ancestor Chart

Ancestor chart for GO:0043837
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.4.1.23
RHEA 30763

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:11851 3-methyl-2-oxobutanoate
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57762 L-valine zwitterion
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:28938 ammonium

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043837 based on ALL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term PR S% #Together #Compared
valine dehydrogenase (NAD+) activity
213,514.55 100.00 913 913
L-leucine dehydrogenase activity
6,263.09 1.34 22 750
branched-chain amino acid catabolic process
2,731.12 1.28 846 66,139
valine catabolic process
2,526.25 1.18 845 71,418
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
2,092.69 0.98 909 92,744
amino acid metabolic process
359.51 0.17 909 539,854
nucleotide binding
102.14 0.05 881 1,841,736
oxidoreductase activity
16.37 0.01 913 11,906,003
cytoplasm
6.84 0.00 810 25,285,876
NADP binding
0.74 0.00 3 867,427
Totals 7053 46886346
No co-occurrence statistics for GO:0043837 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Totals 0 0

Change Log

Timestamp Action Category Detail
2024-03-21 Updated TERM valine dehydrogenase (NAD+) activity
2024-03-21 Added SYNONYM valine dehydrogenase (NAD) activity
2020-06-22 Added XREF RHEA:30763
2018-03-05 Deleted XREF EC:1.4.1
2018-03-05 Added XREF EC:1.4.1.23
2016-10-03 Deleted XREF EC:1.4.1.-
2016-10-03 Added XREF EC:1.4.1
2010-09-03 Deleted DEFINITION Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH.
2010-09-03 Added DEFINITION Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH.
2010-08-20 Added DEFINITION Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH.
Timestamp Action Category Detail
2024-03-21 Updated TERM valine dehydrogenase (NAD+) activity
2007-07-11 Added TERM valine dehydrogenase (NAD) activity
Timestamp Action Category Detail
2024-03-21 Added SYNONYM valine dehydrogenase (NAD) activity
2010-09-03 Deleted DEFINITION Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH.
2010-09-03 Added DEFINITION Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH.
2010-08-20 Added DEFINITION Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH.
2010-08-20 Deleted DEFINITION Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH.
2008-05-13 Added DEFINITION Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH.
2007-08-09 Added SYNONYM ValDH
2007-08-09 Deleted SYNONYM ValDH
2007-07-27 Added DEFINITION Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH.
2007-07-11 Added SYNONYM ValDH
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:30763
2018-03-05 Deleted XREF EC:1.4.1
2018-03-05 Added XREF EC:1.4.1.23
2016-10-03 Deleted XREF EC:1.4.1.-
2016-10-03 Added XREF EC:1.4.1
2007-07-11 Added XREF EC:1.4.1.-
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.