GO:0043837
JSON
valine dehydrogenase (NAD+) activity
Molecular Function
Definition (GO:0043837 GONUTS page)
Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH. PMID:10612726 PMID:2803248
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
valine dehydrogenase (NAD) activity | exact |
ValDH | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.4.1.23 | |
RHEA | 30763 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:11851 | 3-methyl-2-oxobutanoate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57762 | L-valine zwitterion |
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:28938 | ammonium |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043837 based on ALL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
valine dehydrogenase (NAD+) activity
|
213,514.55 | 100.00 | 913 | 913 |
L-leucine dehydrogenase activity
|
6,263.09 | 1.34 | 22 | 750 |
branched-chain amino acid catabolic process
|
2,731.12 | 1.28 | 846 | 66,139 |
valine catabolic process
|
2,526.25 | 1.18 | 845 | 71,418 |
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
|
2,092.69 | 0.98 | 909 | 92,744 |
amino acid metabolic process
|
359.51 | 0.17 | 909 | 539,854 |
nucleotide binding
|
102.14 | 0.05 | 881 | 1,841,736 |
oxidoreductase activity
|
16.37 | 0.01 | 913 | 11,906,003 |
cytoplasm
|
6.84 | 0.00 | 810 | 25,285,876 |
NADP binding
|
0.74 | 0.00 | 3 | 867,427 |
Totals | 7053 | 46886346 |
No co-occurrence statistics for GO:0043837 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Totals | 0 | 0 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Updated | TERM | valine dehydrogenase (NAD+) activity |
2024-03-21 | Added | SYNONYM | valine dehydrogenase (NAD) activity |
2020-06-22 | Added | XREF | RHEA:30763 |
2018-03-05 | Deleted | XREF | EC:1.4.1 |
2018-03-05 | Added | XREF | EC:1.4.1.23 |
2016-10-03 | Deleted | XREF | EC:1.4.1.- |
2016-10-03 | Added | XREF | EC:1.4.1 |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH. |
2010-08-20 | Added | DEFINITION | Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Updated | TERM | valine dehydrogenase (NAD+) activity |
2007-07-11 | Added | TERM | valine dehydrogenase (NAD) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | SYNONYM | valine dehydrogenase (NAD) activity |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH. |
2010-08-20 | Added | DEFINITION | Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + ammonia + NADH. |
2010-08-20 | Deleted | DEFINITION | Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH. |
2007-08-09 | Added | SYNONYM | ValDH |
2007-08-09 | Deleted | SYNONYM | ValDH |
2007-07-27 | Added | DEFINITION | Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH. |
2007-07-11 | Added | SYNONYM | ValDH |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:30763 |
2018-03-05 | Deleted | XREF | EC:1.4.1 |
2018-03-05 | Added | XREF | EC:1.4.1.23 |
2016-10-03 | Deleted | XREF | EC:1.4.1.- |
2016-10-03 | Added | XREF | EC:1.4.1 |
2007-07-11 | Added | XREF | EC:1.4.1.- |
Timestamp | Action | Category | Detail |
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