This term is obsolete.

GO:0043890 JSON

N-acetylgalactosamine-6-sulfatase activity

Molecular Function

Definition (GO:0043890 GONUTS page)

Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.

905 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity exact
chondroitinase broad
chondroitin sulfatase broad
N-acetylgalactosamine-6-sulfate sulfatase activity exact
acetylgalactosamine 6-sulfatase activity exact
chondroitinsulfatase broad
galactose-6-sulfate sulfatase activity exact
N-acetylgalactosamine 6-sulfatase activity exact

Ancestor Chart

Ancestor chart for GO:0043890
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.1.6.4
InterPro IPR035626 N-acetylgalactosamine-6-sulfatase
MetaCyc 3.1.6.4-RXN
Reactome R-HSA-1630304
Reactome R-HSA-2263490

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043890 based on ALL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-acetylgalactosamine-6-sulfatase activity
219,683.89 100.00 902 902
arylsulfatase activity
1,747.79 0.80 854 107,341
lysosome
691.52 0.31 820 260,499
N-acetylgalactosamine-4-sulfatase activity
3,278.86 0.27 3 201
sulfuric ester hydrolase activity
505.51 0.23 93 40,416
colon epithelial cell migration
4,624.92 0.20 2 95
chondroitin sulfate catabolic process
1,417.32 0.17 2 310
dermatan sulfate catabolic process
1,335.46 0.16 2 329
regulation of epithelial cell migration
1,135.32 0.16 2 387
anterior head development
1,098.42 0.15 2 400
Totals 4454 127860145
No co-occurrence statistics for GO:0043890 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-acetylgalactosamine-6-sulfatase activity
282,306.60 100.00 5 5
N-acetylgalactosamine-4-sulfatase activity
169,383.97 42.86 3 5
colon epithelial cell migration
141,153.31 28.57 2 4
chondroitin sulfate catabolic process
35,288.33 10.53 2 16
dermatan sulfate catabolic process
35,288.33 10.53 2 16
anterior head development
33,212.54 10.00 2 17
sulfuric ester hydrolase activity
19,139.43 6.67 4 59
regulation of epithelial cell migration
19,469.42 6.25 2 29
response to pH
7,057.67 2.27 1 40
response to methylmercury
6,721.59 2.17 1 42
Totals 43 27772

Change Log

Timestamp Action Category Detail
2019-05-04 Added XREF Reactome:R-HSA-2263490
2019-04-30 Deleted XREF Reactome:R-HSA-2263490
2019-04-29 Added XREF Reactome:R-HSA-2263490
2019-04-28 Deleted XREF Reactome:R-HSA-2263490
2019-04-27 Added XREF Reactome:R-HSA-2263490
2019-04-23 Deleted XREF Reactome:R-HSA-2263490
2019-04-01 Added XREF Reactome:R-HSA-1630304
2019-04-01 Deleted XREF reactome:R-HSA-1630304
2019-04-01 Added XREF Reactome:R-HSA-2263490
2018-12-11 Added XREF reactome:R-HSA-1630304
Timestamp Action Category Detail
2007-08-12 Added TERM N-acetylgalactosamine-6-sulfatase activity
Timestamp Action Category Detail
2010-08-13 Added DEFINITION Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
2010-08-13 Deleted DEFINITION Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
2008-05-13 Added DEFINITION Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
2007-11-08 Deleted SYNONYM N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
2007-11-08 Added SYNONYM acetylgalactosamine 6-sulfatase activity
2007-11-08 Added SYNONYM galactose-6-sulfate sulfatase activity
2007-11-08 Added SYNONYM chondroitinsulfatase
2007-11-08 Added SYNONYM N-acetylgalactosamine 6-sulfatase activity
2007-11-08 Added SYNONYM N-acetylgalactosamine-6-sulfate sulfatase activity
2007-11-08 Deleted SYNONYM N-acetylgalactosamine 6-sulfatase
2007-11-08 Deleted SYNONYM N-acetylgalactosamine-6-sulfate sulfatase
2007-11-08 Deleted SYNONYM acetylgalactosamine 6-sulfatase
2007-11-08 Deleted SYNONYM galactose-6-sulfate sulfatase
2007-11-08 Added SYNONYM N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity
2007-10-25 Added DEFINITION Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
2007-08-12 Added SYNONYM galactose-6-sulfate sulfatase
2007-08-12 Added SYNONYM chondroitinase
2007-08-12 Added SYNONYM chondroitin sulfatase
2007-08-12 Added SYNONYM acetylgalactosamine 6-sulfatase
2007-08-12 Added SYNONYM N-acetylgalactosamine-6-sulfate sulfatase
2007-08-12 Added SYNONYM N-acetylgalactosamine 6-sulfatase
2007-08-12 Added SYNONYM N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008484 (sulfuric ester hydrolase activity)
Timestamp Action Category Detail
2019-05-04 Added XREF Reactome:R-HSA-2263490
2019-04-30 Deleted XREF Reactome:R-HSA-2263490
2019-04-29 Added XREF Reactome:R-HSA-2263490
2019-04-28 Deleted XREF Reactome:R-HSA-2263490
2019-04-27 Added XREF Reactome:R-HSA-2263490
2019-04-23 Deleted XREF Reactome:R-HSA-2263490
2019-04-01 Added XREF Reactome:R-HSA-1630304
2019-04-01 Deleted XREF reactome:R-HSA-1630304
2019-04-01 Added XREF Reactome:R-HSA-2263490
2018-12-11 Added XREF reactome:R-HSA-1630304
2007-08-12 Added XREF EC:3.1.6.4
2007-08-12 Added XREF MetaCyc:3.1.6.4-RXN
Timestamp Action Category Detail
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