GO:0043890
JSON
N-acetylgalactosamine-6-sulfatase activity
Molecular Function
Definition (GO:0043890 GONUTS page)
Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity | exact |
chondroitinase | broad |
chondroitin sulfatase | broad |
N-acetylgalactosamine-6-sulfate sulfatase activity | exact |
acetylgalactosamine 6-sulfatase activity | exact |
chondroitinsulfatase | broad |
galactose-6-sulfate sulfatase activity | exact |
N-acetylgalactosamine 6-sulfatase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.6.4 | |
InterPro | IPR035626 | N-acetylgalactosamine-6-sulfatase |
MetaCyc | 3.1.6.4-RXN | |
Reactome | R-HSA-1630304 | |
Reactome | R-HSA-2263490 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043890 based on ALL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-acetylgalactosamine-6-sulfatase activity
|
219,683.89 | 100.00 | 902 | 902 |
arylsulfatase activity
|
1,747.79 | 0.80 | 854 | 107,341 |
lysosome
|
691.52 | 0.31 | 820 | 260,499 |
N-acetylgalactosamine-4-sulfatase activity
|
3,278.86 | 0.27 | 3 | 201 |
sulfuric ester hydrolase activity
|
505.51 | 0.23 | 93 | 40,416 |
colon epithelial cell migration
|
4,624.92 | 0.20 | 2 | 95 |
chondroitin sulfate catabolic process
|
1,417.32 | 0.17 | 2 | 310 |
dermatan sulfate catabolic process
|
1,335.46 | 0.16 | 2 | 329 |
regulation of epithelial cell migration
|
1,135.32 | 0.16 | 2 | 387 |
anterior head development
|
1,098.42 | 0.15 | 2 | 400 |
Totals | 4454 | 127860145 |
No co-occurrence statistics for GO:0043890 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-acetylgalactosamine-6-sulfatase activity
|
282,306.60 | 100.00 | 5 | 5 |
N-acetylgalactosamine-4-sulfatase activity
|
169,383.97 | 42.86 | 3 | 5 |
colon epithelial cell migration
|
141,153.31 | 28.57 | 2 | 4 |
chondroitin sulfate catabolic process
|
35,288.33 | 10.53 | 2 | 16 |
dermatan sulfate catabolic process
|
35,288.33 | 10.53 | 2 | 16 |
anterior head development
|
33,212.54 | 10.00 | 2 | 17 |
sulfuric ester hydrolase activity
|
19,139.43 | 6.67 | 4 | 59 |
regulation of epithelial cell migration
|
19,469.42 | 6.25 | 2 | 29 |
response to pH
|
7,057.67 | 2.27 | 1 | 40 |
response to methylmercury
|
6,721.59 | 2.17 | 1 | 42 |
Totals | 43 | 27772 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2019-05-04 | Added | XREF | Reactome:R-HSA-2263490 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-2263490 |
2019-04-29 | Added | XREF | Reactome:R-HSA-2263490 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-2263490 |
2019-04-27 | Added | XREF | Reactome:R-HSA-2263490 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-2263490 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1630304 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1630304 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2263490 |
2018-12-11 | Added | XREF | reactome:R-HSA-1630304 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-08-12 | Added | TERM | N-acetylgalactosamine-6-sulfatase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-08-13 | Added | DEFINITION | Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
2010-08-13 | Deleted | DEFINITION | Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
2007-11-08 | Deleted | SYNONYM | N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase |
2007-11-08 | Added | SYNONYM | acetylgalactosamine 6-sulfatase activity |
2007-11-08 | Added | SYNONYM | galactose-6-sulfate sulfatase activity |
2007-11-08 | Added | SYNONYM | chondroitinsulfatase |
2007-11-08 | Added | SYNONYM | N-acetylgalactosamine 6-sulfatase activity |
2007-11-08 | Added | SYNONYM | N-acetylgalactosamine-6-sulfate sulfatase activity |
2007-11-08 | Deleted | SYNONYM | N-acetylgalactosamine 6-sulfatase |
2007-11-08 | Deleted | SYNONYM | N-acetylgalactosamine-6-sulfate sulfatase |
2007-11-08 | Deleted | SYNONYM | acetylgalactosamine 6-sulfatase |
2007-11-08 | Deleted | SYNONYM | galactose-6-sulfate sulfatase |
2007-11-08 | Added | SYNONYM | N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity |
2007-10-25 | Added | DEFINITION | Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
2007-08-12 | Added | SYNONYM | galactose-6-sulfate sulfatase |
2007-08-12 | Added | SYNONYM | chondroitinase |
2007-08-12 | Added | SYNONYM | chondroitin sulfatase |
2007-08-12 | Added | SYNONYM | acetylgalactosamine 6-sulfatase |
2007-08-12 | Added | SYNONYM | N-acetylgalactosamine-6-sulfate sulfatase |
2007-08-12 | Added | SYNONYM | N-acetylgalactosamine 6-sulfatase |
2007-08-12 | Added | SYNONYM | N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008484 (sulfuric ester hydrolase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-05-04 | Added | XREF | Reactome:R-HSA-2263490 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-2263490 |
2019-04-29 | Added | XREF | Reactome:R-HSA-2263490 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-2263490 |
2019-04-27 | Added | XREF | Reactome:R-HSA-2263490 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-2263490 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1630304 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1630304 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2263490 |
2018-12-11 | Added | XREF | reactome:R-HSA-1630304 |
2007-08-12 | Added | XREF | EC:3.1.6.4 |
2007-08-12 | Added | XREF | MetaCyc:3.1.6.4-RXN |
Timestamp | Action | Category | Detail |
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