This term is obsolete.

GO:0043997 JSON

histone H4K12 acetyltransferase activity

Molecular Function

Definition (GO:0043997 GONUTS page)

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). PMID:18552846 PMID:19056256

23,761 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
histone acetylase activity (H4-K12 specific) exact
histone acetyltransferase activity (H4-K12 specific) exact
histone H4-K12 acetyltransferase activity exact
histone lysine N-acetyltransferase activity (H4-K12 specific) exact

Ancestor Chart

Ancestor chart for GO:0043997
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein D5VRB9 573063 ELP3_METIM GO:0061733 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25151136
NOT-qualified manual protein O35923 10116 BRCA2_RAT GO:0004402 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P29066 10116 ARRB1_RAT GO:0004402 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P49407 9606 ARRB1_HUMAN GO:0004402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16325578
NOT-qualified manual protein P51587 9606 BRCA2_HUMAN GO:0004402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9824164
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q02908 559292 ELP3_YEAST GO:0004402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17018299
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.3.1.48

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043997 based on ALL annotations
The top 100 of 1,179 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H4K12 acetyltransferase activity
8,348.99 100.00 23,734 23,734
histone H4K8 acetyltransferase activity
8,337.35 99.51 23,651 23,684
histone H4K5 acetyltransferase activity
8,337.35 99.51 23,651 23,684
histone H3K14 acetyltransferase activity
8,298.36 98.17 23,440 23,583
histone H3K23 acetyltransferase activity
8,348.26 96.57 22,922 22,924
histone H3K4 acetyltransferase activity
8,346.80 96.56 22,923 22,929
histone H2AK9 acetyltransferase activity
8,348.99 96.42 22,885 22,885
histone H2BK5 acetyltransferase activity
8,348.99 96.42 22,885 22,885
histone H2BK12 acetyltransferase activity
8,348.99 96.42 22,885 22,885
histone H3K36 acetyltransferase activity
8,348.99 96.42 22,885 22,885
Totals 578739 9731313
No co-occurrence statistics for GO:0043997 based on MANUAL annotations
The top 100 of 185 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H4K12 acetyltransferase activity
17,426.33 100.00 81 81
histone H4K5 acetyltransferase activity
16,102.81 83.91 73 79
histone H4K8 acetyltransferase activity
16,496.93 83.53 71 75
histone H3K14 acetyltransferase activity
12,945.28 52.53 52 70
regulation of DNA biosynthetic process
9,485.22 36.75 43 79
histone H4K16 acetyltransferase activity
4,282.74 17.06 29 118
MOZ/MORF histone acetyltransferase complex
3,150.52 14.16 32 177
DNA replication-dependent chromatin disassembly
10,250.78 11.36 10 17
regulation of cell growth
1,941.52 10.05 41 368
regulation of DNA replication
2,091.16 9.97 30 250
Totals 889 22486

Change Log

Timestamp Action Category Detail
2024-08-16 Added XREF EC:2.3.1.48
2022-07-30 Deleted RELATION part of GO:0043983 (obsolete histone H4-K12 acetylation)
2022-07-24 Updated TERM histone H4K12 acetyltransferase activity
2022-07-24 Added SYNONYM histone acetyltransferase activity (H4-K12 specific)
2022-07-24 Added SYNONYM histone H4-K12 acetyltransferase activity
2022-06-12 Added SYNONYM histone acetylase activity (H4-K12 specific)
2011-03-30 Added RELATION part of GO:0043983 (obsolete histone H4-K12 acetylation)
2010-09-24 Added DEFINITION Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12).
2010-09-24 Deleted DEFINITION Catalysis of the addition of an acetyl group onto lysine at position 12 of the histone H4 protein.
2009-01-31 Added SYNONYM histone lysine N-acetyltransferase activity (H4-K12 specific)
Timestamp Action Category Detail
2022-07-24 Updated TERM histone H4K12 acetyltransferase activity
2009-01-31 Added TERM histone acetyltransferase activity (H4-K12 specific)
Timestamp Action Category Detail
2022-07-24 Added SYNONYM histone acetyltransferase activity (H4-K12 specific)
2022-07-24 Added SYNONYM histone H4-K12 acetyltransferase activity
2022-06-12 Added SYNONYM histone acetylase activity (H4-K12 specific)
2010-09-24 Added DEFINITION Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12).
2010-09-24 Deleted DEFINITION Catalysis of the addition of an acetyl group onto lysine at position 12 of the histone H4 protein.
2009-01-31 Added SYNONYM histone lysine N-acetyltransferase activity (H4-K12 specific)
2009-01-31 Added DEFINITION Catalysis of the addition of an acetyl group onto lysine at position 12 of the histone H4 protein.
Timestamp Action Category Detail
2022-07-30 Deleted RELATION part of GO:0043983 (obsolete histone H4-K12 acetylation)
2011-03-30 Added RELATION part of GO:0043983 (obsolete histone H4-K12 acetylation)
2009-01-31 Added RELATION is a GO:0010485 (histone H4 acetyltransferase activity)
Timestamp Action Category Detail
2024-08-16 Added XREF EC:2.3.1.48
Timestamp Action Category Detail
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