GO:0043997
JSON
histone H4K12 acetyltransferase activity
Molecular Function
Definition (GO:0043997 GONUTS page)
Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). PMID:18552846 PMID:19056256
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
histone acetylase activity (H4-K12 specific) | exact |
histone acetyltransferase activity (H4-K12 specific) | exact |
histone H4-K12 acetyltransferase activity | exact |
histone lysine N-acetyltransferase activity (H4-K12 specific) | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | D5VRB9 | 573063 | ELP3_METIM | GO:0061733 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25151136 | |
NOT-qualified manual | protein | O35923 | 10116 | BRCA2_RAT | GO:0004402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P29066 | 10116 | ARRB1_RAT | GO:0004402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P49407 | 9606 | ARRB1_HUMAN | GO:0004402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16325578 | |
NOT-qualified manual | protein | P51587 | 9606 | BRCA2_HUMAN | GO:0004402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9824164 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q02908 | 559292 | ELP3_YEAST | GO:0004402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17018299 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.1.48 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043997 based on ALL annotations
The top 100 of 1,179 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone H4K12 acetyltransferase activity
|
8,348.99 | 100.00 | 23,734 | 23,734 |
histone H4K8 acetyltransferase activity
|
8,337.35 | 99.51 | 23,651 | 23,684 |
histone H4K5 acetyltransferase activity
|
8,337.35 | 99.51 | 23,651 | 23,684 |
histone H3K14 acetyltransferase activity
|
8,298.36 | 98.17 | 23,440 | 23,583 |
histone H3K23 acetyltransferase activity
|
8,348.26 | 96.57 | 22,922 | 22,924 |
histone H3K4 acetyltransferase activity
|
8,346.80 | 96.56 | 22,923 | 22,929 |
histone H2AK9 acetyltransferase activity
|
8,348.99 | 96.42 | 22,885 | 22,885 |
histone H2BK5 acetyltransferase activity
|
8,348.99 | 96.42 | 22,885 | 22,885 |
histone H2BK12 acetyltransferase activity
|
8,348.99 | 96.42 | 22,885 | 22,885 |
histone H3K36 acetyltransferase activity
|
8,348.99 | 96.42 | 22,885 | 22,885 |
Totals | 578739 | 9731313 |
No co-occurrence statistics for GO:0043997 based on MANUAL annotations
The top 100 of 185 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone H4K12 acetyltransferase activity
|
17,426.33 | 100.00 | 81 | 81 |
histone H4K5 acetyltransferase activity
|
16,102.81 | 83.91 | 73 | 79 |
histone H4K8 acetyltransferase activity
|
16,496.93 | 83.53 | 71 | 75 |
histone H3K14 acetyltransferase activity
|
12,945.28 | 52.53 | 52 | 70 |
regulation of DNA biosynthetic process
|
9,485.22 | 36.75 | 43 | 79 |
histone H4K16 acetyltransferase activity
|
4,282.74 | 17.06 | 29 | 118 |
MOZ/MORF histone acetyltransferase complex
|
3,150.52 | 14.16 | 32 | 177 |
DNA replication-dependent chromatin disassembly
|
10,250.78 | 11.36 | 10 | 17 |
regulation of cell growth
|
1,941.52 | 10.05 | 41 | 368 |
regulation of DNA replication
|
2,091.16 | 9.97 | 30 | 250 |
Totals | 889 | 22486 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:2.3.1.48 |
2022-07-30 | Deleted | RELATION | part of GO:0043983 (obsolete histone H4-K12 acetylation) |
2022-07-24 | Updated | TERM | histone H4K12 acetyltransferase activity |
2022-07-24 | Added | SYNONYM | histone acetyltransferase activity (H4-K12 specific) |
2022-07-24 | Added | SYNONYM | histone H4-K12 acetyltransferase activity |
2022-06-12 | Added | SYNONYM | histone acetylase activity (H4-K12 specific) |
2011-03-30 | Added | RELATION | part of GO:0043983 (obsolete histone H4-K12 acetylation) |
2010-09-24 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). |
2010-09-24 | Deleted | DEFINITION | Catalysis of the addition of an acetyl group onto lysine at position 12 of the histone H4 protein. |
2009-01-31 | Added | SYNONYM | histone lysine N-acetyltransferase activity (H4-K12 specific) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-24 | Updated | TERM | histone H4K12 acetyltransferase activity |
2009-01-31 | Added | TERM | histone acetyltransferase activity (H4-K12 specific) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-24 | Added | SYNONYM | histone acetyltransferase activity (H4-K12 specific) |
2022-07-24 | Added | SYNONYM | histone H4-K12 acetyltransferase activity |
2022-06-12 | Added | SYNONYM | histone acetylase activity (H4-K12 specific) |
2010-09-24 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). |
2010-09-24 | Deleted | DEFINITION | Catalysis of the addition of an acetyl group onto lysine at position 12 of the histone H4 protein. |
2009-01-31 | Added | SYNONYM | histone lysine N-acetyltransferase activity (H4-K12 specific) |
2009-01-31 | Added | DEFINITION | Catalysis of the addition of an acetyl group onto lysine at position 12 of the histone H4 protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-30 | Deleted | RELATION | part of GO:0043983 (obsolete histone H4-K12 acetylation) |
2011-03-30 | Added | RELATION | part of GO:0043983 (obsolete histone H4-K12 acetylation) |
2009-01-31 | Added | RELATION | is a GO:0010485 (histone H4 acetyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:2.3.1.48 |
Timestamp | Action | Category | Detail |
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