GO:0044194
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cytolytic granule
Cellular Component
Definition (GO:0044194 GONUTS page)
A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. PMID:11052265 PMID:12766758
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0044194
Child Term | Relationship to GO:0044194 |
---|---|
cytolytic granule membrane
|
part_of |
cytolytic granule lumen
|
part_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0044194 | cytolytic granule | Never in Taxon | 4751 | Fungi | |
GO:0044194 | cytolytic granule | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0D1E8X3 | 237631 | A0A0D1E8X3_USTMA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A0G2JZ79 | 10116 | SIR1_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1L8G9S0 | 8355 | A0A1L8G9S0_XENLA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4L3K3 | 6945 | A0A1S4L3K3_IXOSC | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A2K5ATM2 | 6239 | A0A2K5ATM2_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATM9 | 6239 | A0A2K5ATM9_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATP6 | 6239 | A0A2K5ATP6_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
UniProtKB-SubCell | SL-0543 | Cytolytic granule |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0044194 based on ALL annotations
The top 100 of 279 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytolytic granule
|
221,521.34 | 100.00 | 880 | 880 |
granzyme-mediated programmed cell death signaling pathway
|
94,557.21 | 18.27 | 213 | 499 |
leukocyte mediated cytotoxicity
|
55,656.78 | 11.35 | 151 | 601 |
positive regulation of killing of cells of another organism
|
183,482.33 | 9.14 | 82 | 99 |
positive regulation of natural killer cell degranulation
|
90,962.88 | 8.48 | 85 | 207 |
regulation of organelle transport along microtubule
|
85,200.52 | 8.37 | 85 | 221 |
syntaxin-3 binding
|
180,138.23 | 8.25 | 74 | 91 |
phagolysosome membrane
|
67,488.58 | 7.91 | 85 | 279 |
cytolytic granule membrane
|
45,797.67 | 7.46 | 92 | 445 |
immune response to tumor cell
|
100,311.56 | 7.45 | 72 | 159 |
Totals | 6175 | 1026342 |
No co-occurrence statistics for GO:0044194 based on MANUAL annotations
The top 100 of 124 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytolytic granule
|
24,842.29 | 100.00 | 52 | 52 |
cytolytic granule membrane
|
14,905.37 | 15.52 | 9 | 15 |
natural killer cell mediated cytotoxicity directed against tumor cell target
|
24,842.29 | 13.46 | 7 | 7 |
granzyme-mediated programmed cell death signaling pathway
|
4,699.89 | 12.50 | 14 | 74 |
natural killer cell degranulation
|
5,996.42 | 9.46 | 7 | 29 |
natural killer cell mediated cytotoxicity
|
3,229.50 | 9.35 | 13 | 100 |
killing of cells of another organism
|
2,947.39 | 8.97 | 14 | 118 |
CD4-positive, alpha-beta T cell activation
|
4,347.40 | 8.24 | 7 | 40 |
immune response to tumor cell
|
10,646.69 | 5.36 | 3 | 7 |
cytolytic granule lumen
|
24,842.29 | 3.85 | 2 | 2 |
Totals | 392 | 144107 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2009-10-23 | Added | TERM | cytolytic granule |
2009-10-23 | Added | RELATION | is a GO:0005764 (lysosome) |
2009-10-23 | Added | DEFINITION | A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-10-23 | Added | TERM | cytolytic granule |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-10-23 | Added | DEFINITION | A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-10-23 | Added | RELATION | is a GO:0005764 (lysosome) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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