This term is obsolete.

GO:0044194 JSON

cytolytic granule

Cellular Component

Definition (GO:0044194 GONUTS page)

A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. PMID:11052265 PMID:12766758

1,371 annotations

Ancestor Chart

Ancestor chart for GO:0044194
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0044194

Child Term Relationship to
GO:0044194
cytolytic granule membrane
part_of
cytolytic granule lumen
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0044194 cytolytic granule Never in Taxon 4751 Fungi
GO:0044194 cytolytic granule Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0D1E8X3 237631 A0A0D1E8X3_USTMA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A0G2JZ79 10116 SIR1_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1L8G9S0 8355 A0A1L8G9S0_XENLA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4L3K3 6945 A0A1S4L3K3_IXOSC GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A2K5ATM2 6239 A0A2K5ATM2_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATM9 6239 A0A2K5ATM9_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATP6 6239 A0A2K5ATP6_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
UniProtKB-SubCell SL-0543 Cytolytic granule

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0044194 based on ALL annotations
The top 100 of 279 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cytolytic granule
221,521.34 100.00 880 880
granzyme-mediated programmed cell death signaling pathway
94,557.21 18.27 213 499
leukocyte mediated cytotoxicity
55,656.78 11.35 151 601
positive regulation of killing of cells of another organism
183,482.33 9.14 82 99
positive regulation of natural killer cell degranulation
90,962.88 8.48 85 207
regulation of organelle transport along microtubule
85,200.52 8.37 85 221
syntaxin-3 binding
180,138.23 8.25 74 91
phagolysosome membrane
67,488.58 7.91 85 279
cytolytic granule membrane
45,797.67 7.46 92 445
immune response to tumor cell
100,311.56 7.45 72 159
Totals 6175 1026342
No co-occurrence statistics for GO:0044194 based on MANUAL annotations
The top 100 of 124 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cytolytic granule
24,842.29 100.00 52 52
cytolytic granule membrane
14,905.37 15.52 9 15
natural killer cell mediated cytotoxicity directed against tumor cell target
24,842.29 13.46 7 7
granzyme-mediated programmed cell death signaling pathway
4,699.89 12.50 14 74
natural killer cell degranulation
5,996.42 9.46 7 29
natural killer cell mediated cytotoxicity
3,229.50 9.35 13 100
killing of cells of another organism
2,947.39 8.97 14 118
CD4-positive, alpha-beta T cell activation
4,347.40 8.24 7 40
immune response to tumor cell
10,646.69 5.36 3 7
cytolytic granule lumen
24,842.29 3.85 2 2
Totals 392 144107

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2009-10-23 Added TERM cytolytic granule
2009-10-23 Added RELATION is a GO:0005764 (lysosome)
2009-10-23 Added DEFINITION A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
Timestamp Action Category Detail
2009-10-23 Added TERM cytolytic granule
Timestamp Action Category Detail
2009-10-23 Added DEFINITION A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
Timestamp Action Category Detail
2009-10-23 Added RELATION is a GO:0005764 (lysosome)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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