GO:0044325
JSON
transmembrane transporter binding
Molecular Function
Definition (GO:0044325 GONUTS page)
Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. PMID:33199372
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ion channel binding | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR037658 | Voltage-dependent calcium channel beta subunit-associated regulatory protein |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0042980 | obsolete cystic fibrosis transmembrane conductance regulator binding | replaced_by GO:0044325 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0044325 based on ALL annotations
The top 100 of 3,285 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
transmembrane transporter binding
|
3,814.55 | 100.00 | 51,104 | 51,104 |
positive regulation of synaptic transmission
|
2,526.57 | 21.57 | 12,382 | 18,694 |
cytoskeleton of presynaptic active zone
|
2,211.37 | 20.60 | 12,377 | 21,350 |
regulation of synaptic plasticity
|
1,975.05 | 19.77 | 12,385 | 23,920 |
calcium ion-regulated exocytosis of neurotransmitter
|
1,884.75 | 19.42 | 12,385 | 25,066 |
regulation of synaptic vesicle exocytosis
|
2,590.41 | 18.49 | 10,352 | 15,244 |
regulation of membrane potential
|
1,181.55 | 17.02 | 14,017 | 45,253 |
potassium channel regulator activity
|
1,392.12 | 15.14 | 10,504 | 28,782 |
presynaptic membrane
|
917.87 | 13.97 | 12,774 | 53,087 |
regulation of potassium ion transmembrane transport
|
1,709.42 | 12.54 | 7,577 | 16,908 |
Totals | 368301 | 5719625 |
No co-occurrence statistics for GO:0044325 based on MANUAL annotations
The top 100 of 3,040 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
transmembrane transporter binding
|
1,097.54 | 100.00 | 1,177 | 1,177 |
potassium channel regulator activity
|
436.98 | 14.31 | 215 | 540 |
voltage-gated potassium channel complex
|
245.65 | 14.15 | 327 | 1,461 |
potassium channel activator activity
|
1,050.83 | 11.41 | 135 | 141 |
regulation of heart rate by cardiac conduction
|
585.66 | 9.86 | 127 | 238 |
regulation of potassium ion transmembrane transport
|
483.09 | 8.62 | 114 | 259 |
regulation of ventricular cardiac muscle cell membrane repolarization
|
659.79 | 8.35 | 104 | 173 |
ventricular cardiac muscle cell action potential
|
1,005.22 | 8.26 | 98 | 107 |
voltage-gated potassium channel activity
|
190.82 | 8.04 | 153 | 880 |
protein localization to plasma membrane
|
105.33 | 6.28 | 181 | 1,886 |
Totals | 6080 | 56265 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-15 | Updated | TERM | transmembrane transporter binding |
2021-05-15 | Added | DEFINITION | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2021-05-15 | Deleted | DEFINITION | Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. |
2021-05-15 | Added | SYNONYM | ion channel binding |
2021-02-17 | Added | RELATION | has part GO:0008200 (ion channel inhibitor activity) |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2010-08-06 | Added | RELATION | is a GO:0005515 (protein binding) |
2010-08-06 | Added | TERM | ion channel binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-15 | Updated | TERM | transmembrane transporter binding |
2010-08-06 | Added | TERM | ion channel binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-15 | Added | DEFINITION | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2021-05-15 | Deleted | DEFINITION | Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. |
2021-05-15 | Added | SYNONYM | ion channel binding |
2010-08-06 | Added | DEFINITION | Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Added | RELATION | has part GO:0008200 (ion channel inhibitor activity) |
2010-08-06 | Added | RELATION | is a GO:0005515 (protein binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
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