This term is obsolete.

GO:0044351 JSON

macropinocytosis

Biological Process

Definition (GO:0044351 GONUTS page)

An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. PMID:14732047

Secondary IDs

GO:1902538

729 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
single-organism macropinocytosis related
clathrin-independent pinocytosis broad

Ancestor Chart

Ancestor chart for GO:0044351
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0044351

Child Term Relationship to
GO:0044351
regulation of macropinocytosis
regulates
positive regulation of macropinocytosis
positively_regulates
extracellular exosome macropinocytosis
is_a
negative regulation of macropinocytosis
negatively_regulates

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A9K3Y7P9 10116 A0A9K3Y7P9_RAT GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B2RZ46 10116 B2RZ46_RAT GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O35509 10116 RB11B_RAT GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P35292 10090 RAB17_MOUSE GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9624171
NOT-qualified manual protein P46638 10090 RB11B_MOUSE GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10942597
NOT-qualified manual protein Q0WQ75 3702 VPS51_ARATH GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24757006
NOT-qualified manual protein Q5U1Y1 10116 RAB34_RAT GO:0044351 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q8MQJ7 7227 Q8MQJ7_DROME GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23406899
NOT-qualified manual protein Q9BZG1 9606 RAB34_HUMAN GO:0044351 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17881736
NOT-qualified manual protein Q9VU14 7227 Q9VU14_DROME GO:0006897 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23406899

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0044351 based on ALL annotations
The top 100 of 553 co-occurring terms
Co-occurring Term PR S% #Together #Compared
macropinocytosis
274,561.66 100.00 710 710
myeloid dendritic cell activation involved in immune response
193,523.64 20.59 160 227
positive regulation of lamellipodium organization
155,964.03 12.26 96 169
intermediate conductance calcium-activated potassium channel activity
262,081.58 11.76 84 88
membrane raft polarization
262,081.58 11.76 84 88
barbed-end actin filament uncapping
267,782.38 11.10 79 81
alpha-beta T cell activation
151,731.44 10.80 84 152
Pyrin domain binding
206,600.84 10.34 76 101
myosin I binding
199,923.55 10.16 75 103
NLRP6 inflammasome complex
160,512.97 9.95 76 130
Totals 8621 354044
No co-occurrence statistics for GO:0044351 based on MANUAL annotations
The top 100 of 494 co-occurring terms
Co-occurring Term PR S% #Together #Compared
macropinocytosis
17,941.65 100.00 72 72
myeloid dendritic cell activation involved in immune response
14,353.32 16.00 12 15
barbed-end actin filament uncapping
15,698.95 9.59 7 8
macropinosome
3,289.30 9.09 11 60
positive regulation of lamellipodium organization
9,660.89 8.97 7 13
NLRP6 inflammasome complex
10,764.99 7.89 6 10
Pyrin domain binding
9,786.36 7.79 6 11
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
7,176.66 7.41 6 15
regulation of interleukin-6 production
3,053.90 7.21 8 47
regulation of tumor necrosis factor production
2,563.09 7.14 9 63
Totals 591 11166

Change Log

Timestamp Action Category Detail
2017-08-13 Added SYNONYM single-organism macropinocytosis
2017-08-13 Added SECONDARY GO:1902538 (single-organism macropinocytosis)
2011-08-14 Added DEFINITION An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
2011-08-14 Added TERM macropinocytosis
2011-08-14 Added SYNONYM clathrin-independent pinocytosis
2011-08-14 Added RELATION is a GO:0006907 (pinocytosis)
Timestamp Action Category Detail
2011-08-14 Added TERM macropinocytosis
Timestamp Action Category Detail
2017-08-13 Added SYNONYM single-organism macropinocytosis
2011-08-14 Added DEFINITION An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
2011-08-14 Added SYNONYM clathrin-independent pinocytosis
Timestamp Action Category Detail
2011-08-14 Added RELATION is a GO:0006907 (pinocytosis)
Timestamp Action Category Detail
Timestamp Action Category Detail
2017-08-13 Added SECONDARY GO:1902538 (single-organism macropinocytosis)
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