GO:0044351
JSON
macropinocytosis
Biological Process
Definition (GO:0044351 GONUTS page)
An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. PMID:14732047
Secondary IDs
GO:1902538
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
single-organism macropinocytosis | related |
clathrin-independent pinocytosis | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0044351
Child Term | Relationship to GO:0044351 |
---|---|
regulation of macropinocytosis
|
regulates |
positive regulation of macropinocytosis
|
positively_regulates |
extracellular exosome macropinocytosis
|
is_a |
negative regulation of macropinocytosis
|
negatively_regulates |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A9K3Y7P9 | 10116 | A0A9K3Y7P9_RAT | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B2RZ46 | 10116 | B2RZ46_RAT | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O35509 | 10116 | RB11B_RAT | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P35292 | 10090 | RAB17_MOUSE | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9624171 | |
NOT-qualified manual | protein | P46638 | 10090 | RB11B_MOUSE | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10942597 | |
NOT-qualified manual | protein | Q0WQ75 | 3702 | VPS51_ARATH | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24757006 | |
NOT-qualified manual | protein | Q5U1Y1 | 10116 | RAB34_RAT | GO:0044351 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q8MQJ7 | 7227 | Q8MQJ7_DROME | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23406899 | |
NOT-qualified manual | protein | Q9BZG1 | 9606 | RAB34_HUMAN | GO:0044351 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17881736 | |
NOT-qualified manual | protein | Q9VU14 | 7227 | Q9VU14_DROME | GO:0006897 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23406899 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0044351 based on ALL annotations
The top 100 of 553 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
macropinocytosis
|
274,561.66 | 100.00 | 710 | 710 |
myeloid dendritic cell activation involved in immune response
|
193,523.64 | 20.59 | 160 | 227 |
positive regulation of lamellipodium organization
|
155,964.03 | 12.26 | 96 | 169 |
intermediate conductance calcium-activated potassium channel activity
|
262,081.58 | 11.76 | 84 | 88 |
membrane raft polarization
|
262,081.58 | 11.76 | 84 | 88 |
barbed-end actin filament uncapping
|
267,782.38 | 11.10 | 79 | 81 |
alpha-beta T cell activation
|
151,731.44 | 10.80 | 84 | 152 |
Pyrin domain binding
|
206,600.84 | 10.34 | 76 | 101 |
myosin I binding
|
199,923.55 | 10.16 | 75 | 103 |
NLRP6 inflammasome complex
|
160,512.97 | 9.95 | 76 | 130 |
Totals | 8621 | 354044 |
No co-occurrence statistics for GO:0044351 based on MANUAL annotations
The top 100 of 494 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
macropinocytosis
|
17,941.65 | 100.00 | 72 | 72 |
myeloid dendritic cell activation involved in immune response
|
14,353.32 | 16.00 | 12 | 15 |
barbed-end actin filament uncapping
|
15,698.95 | 9.59 | 7 | 8 |
macropinosome
|
3,289.30 | 9.09 | 11 | 60 |
positive regulation of lamellipodium organization
|
9,660.89 | 8.97 | 7 | 13 |
NLRP6 inflammasome complex
|
10,764.99 | 7.89 | 6 | 10 |
Pyrin domain binding
|
9,786.36 | 7.79 | 6 | 11 |
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
|
7,176.66 | 7.41 | 6 | 15 |
regulation of interleukin-6 production
|
3,053.90 | 7.21 | 8 | 47 |
regulation of tumor necrosis factor production
|
2,563.09 | 7.14 | 9 | 63 |
Totals | 591 | 11166 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2017-08-13 | Added | SYNONYM | single-organism macropinocytosis |
2017-08-13 | Added | SECONDARY | GO:1902538 (single-organism macropinocytosis) |
2011-08-14 | Added | DEFINITION | An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. |
2011-08-14 | Added | TERM | macropinocytosis |
2011-08-14 | Added | SYNONYM | clathrin-independent pinocytosis |
2011-08-14 | Added | RELATION | is a GO:0006907 (pinocytosis) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-08-14 | Added | TERM | macropinocytosis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-08-13 | Added | SYNONYM | single-organism macropinocytosis |
2011-08-14 | Added | DEFINITION | An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. |
2011-08-14 | Added | SYNONYM | clathrin-independent pinocytosis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-08-14 | Added | RELATION | is a GO:0006907 (pinocytosis) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-08-13 | Added | SECONDARY | GO:1902538 (single-organism macropinocytosis) |
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