GO:0045003
JSON
double-strand break repair via synthesis-dependent strand annealing
Biological Process
Definition (GO:0045003 GONUTS page)
SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. PMID:10357855
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
SDSA | broad |
mitotic gene conversion | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0045003
Child Term | Relationship to GO:0045003 |
---|---|
heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing
|
part_of |
meiotic strand displacement involved in double-strand break repair via SDSA
|
part_of |
DNA recombinase assembly
|
part_of |
DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
|
part_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Guidance for interpreting DNA repair investigations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I6A2U2 | 10116 | A0A8I6A2U2_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GI31 | 10116 | A0A8I6GI31_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J8M3 | 10116 | A6J8M3_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
NOT-qualified manual | protein | D3ZAQ9 | 10116 | D3ZAQ9_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045003 based on ALL annotations
The top 100 of 359 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
double-strand break repair via synthesis-dependent strand annealing
|
17,755.61 | 100.00 | 10,979 | 10,979 |
DNA translocase activity
|
6,633.93 | 23.68 | 4,312 | 11,541 |
resolution of mitotic recombination intermediates
|
17,087.62 | 21.49 | 2,379 | 2,472 |
t-circle formation
|
15,708.66 | 21.07 | 2,379 | 2,689 |
Rad51C-XRCC3 complex
|
6,858.18 | 16.28 | 2,411 | 6,242 |
telomere maintenance via recombination
|
3,734.80 | 12.12 | 2,440 | 11,600 |
reciprocal meiotic recombination
|
1,480.98 | 7.42 | 4,403 | 52,788 |
replication fork
|
1,723.35 | 7.22 | 2,416 | 24,892 |
four-way junction DNA binding
|
1,178.30 | 6.34 | 6,449 | 97,179 |
interstrand cross-link repair
|
1,108.92 | 5.66 | 4,129 | 66,112 |
Totals | 108469 | 35630415 |
No co-occurrence statistics for GO:0045003 based on MANUAL annotations
The top 100 of 143 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
double-strand break repair via synthesis-dependent strand annealing
|
5,046.09 | 100.00 | 256 | 256 |
resolution of mitotic recombination intermediates
|
4,613.57 | 24.43 | 64 | 70 |
t-circle formation
|
3,844.64 | 23.19 | 64 | 84 |
DNA translocase activity
|
1,605.57 | 20.18 | 91 | 286 |
Rad51C-XRCC3 complex
|
2,196.94 | 18.88 | 64 | 147 |
four-way junction DNA binding
|
1,090.02 | 18.45 | 143 | 662 |
telomere maintenance via recombination
|
1,175.61 | 13.83 | 65 | 279 |
four-way junction helicase activity
|
511.00 | 8.28 | 80 | 790 |
interstrand cross-link repair
|
449.38 | 7.51 | 83 | 932 |
replication fork
|
331.57 | 5.49 | 64 | 974 |
Totals | 1394 | 38123 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. |
2008-05-12 | Deleted | DEFINITION | SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. |
2008-04-01 | Updated | RELATION | is a GO:0000724 (double-strand break repair via homologous recombination) |
2007-08-09 | Deleted | SYNONYM | SDSA |
2007-08-09 | Added | SYNONYM | mitotic gene conversion |
2007-08-09 | Deleted | SYNONYM | mitotic gene conversion |
2007-08-09 | Added | SYNONYM | SDSA |
2004-04-19 | Added | SYNONYM | SDSA |
2004-04-16 | Deleted | SYNONYM | SDSA |
2002-11-27 | Added | DEFINITION | SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-03-15 | Added | TERM | double-strand break repair via synthesis-dependent strand annealing |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. |
2008-05-12 | Deleted | DEFINITION | SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. |
2007-08-09 | Deleted | SYNONYM | SDSA |
2007-08-09 | Added | SYNONYM | mitotic gene conversion |
2007-08-09 | Deleted | SYNONYM | mitotic gene conversion |
2007-08-09 | Added | SYNONYM | SDSA |
2004-04-19 | Added | SYNONYM | SDSA |
2004-04-16 | Deleted | SYNONYM | SDSA |
2002-11-27 | Added | DEFINITION | SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. |
2002-09-25 | Added | SYNONYM | mitotic gene conversion |
2002-09-25 | Added | SYNONYM | SDSA |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0000724 (double-strand break repair via homologous recombination) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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