This term is obsolete.

GO:0045003 JSON

double-strand break repair via synthesis-dependent strand annealing

Biological Process

Definition (GO:0045003 GONUTS page)

SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. PMID:10357855

28,292 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
SDSA broad
mitotic gene conversion related

Ancestor Chart

Ancestor chart for GO:0045003
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0045003

Child Term Relationship to
GO:0045003
DNA recombinase assembly
part_of
heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing
part_of
meiotic strand displacement involved in double-strand break repair via SDSA
part_of
DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
part_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Guidance for interpreting DNA repair investigations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I6A2U2 10116 A0A8I6A2U2_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GI31 10116 A0A8I6GI31_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J8M3 10116 A6J8M3_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K9T7 10116 A6K9T7_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K9T7 10116 A6K9T7_RAT GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8VU90 10090 ANKL1_MOUSE GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503
NOT-qualified manual protein A8VU90 10090 ANKL1_MOUSE GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503
NOT-qualified manual protein D3ZAQ9 10116 D3ZAQ9_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A332 10116 D4A332_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A332 10116 D4A332_RAT GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
Reactome R-HSA-5693554

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0045003 based on ALL annotations
The top 100 of 367 co-occurring terms
Co-occurring Term PR S% #Together #Compared
double-strand break repair via synthesis-dependent strand annealing
17,318.20 100.00 11,442 11,442
DNA translocase activity
6,474.72 23.58 4,458 11,924
resolution of mitotic recombination intermediates
16,710.55 21.94 2,530 2,622
t-circle formation
15,427.83 21.53 2,530 2,840
Rad51C-XRCC3 complex
6,786.93 16.62 2,563 6,540
telomere maintenance via recombination
3,739.29 12.43 2,591 12,000
replication fork
1,723.70 7.41 2,570 25,821
reciprocal meiotic recombination
1,437.26 7.37 4,549 54,813
four-way junction DNA binding
1,192.46 6.57 6,769 98,307
interstrand cross-link repair
1,089.86 5.70 4,295 68,249
Totals 109806 53765463
No co-occurrence statistics for GO:0045003 based on MANUAL annotations
The top 100 of 141 co-occurring terms
Co-occurring Term PR S% #Together #Compared
double-strand break repair via synthesis-dependent strand annealing
4,918.23 100.00 287 287
resolution of mitotic recombination intermediates
4,571.06 26.96 79 85
t-circle formation
3,924.65 25.73 79 99
Rad51C-XRCC3 complex
2,285.53 20.90 79 170
four-way junction DNA binding
1,133.93 19.74 166 720
DNA translocase activity
1,383.25 18.33 99 352
telomere maintenance via recombination
1,315.92 15.81 80 299
replication fork
599.60 9.23 79 648
four-way junction helicase activity
495.20 8.20 88 874
interstrand cross-link repair
436.22 7.45 91 1,026
Totals 1564 40377

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5693554
2008-05-13 Added DEFINITION SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.
2008-05-12 Deleted DEFINITION SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.
2008-04-01 Updated RELATION is a GO:0000724 (double-strand break repair via homologous recombination)
2007-08-09 Added SYNONYM mitotic gene conversion
2007-08-09 Deleted SYNONYM mitotic gene conversion
2007-08-09 Added SYNONYM SDSA
2007-08-09 Deleted SYNONYM SDSA
2004-04-19 Added SYNONYM SDSA
2004-04-16 Deleted SYNONYM SDSA
Timestamp Action Category Detail
2002-03-15 Added TERM double-strand break repair via synthesis-dependent strand annealing
Timestamp Action Category Detail
2008-05-13 Added DEFINITION SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.
2008-05-12 Deleted DEFINITION SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.
2007-08-09 Added SYNONYM mitotic gene conversion
2007-08-09 Deleted SYNONYM mitotic gene conversion
2007-08-09 Added SYNONYM SDSA
2007-08-09 Deleted SYNONYM SDSA
2004-04-19 Added SYNONYM SDSA
2004-04-16 Deleted SYNONYM SDSA
2002-11-27 Added DEFINITION SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.
2002-09-25 Added SYNONYM SDSA
2002-09-25 Added SYNONYM mitotic gene conversion
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0000724 (double-strand break repair via homologous recombination)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5693554
Timestamp Action Category Detail
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