This term is obsolete.
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

GO:0045063 JSON

T-helper 1 cell differentiation

Biological Process

Definition (GO:0045063 GONUTS page)

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.

Comments

Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

1,062 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
T-helper 1 cell development related

Ancestor Chart

Ancestor chart for GO:0045063
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0045063

Child Term Relationship to
GO:0045063
regulation of T-helper 1 cell differentiation
regulates
positive regulation of T-helper 1 cell differentiation
positively_regulates
negative regulation of T-helper 1 cell differentiation
negatively_regulates
T-helper 1 cell lineage commitment
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0045063 T-helper 1 cell differentiation Only in Taxon 7776 Gnathostomata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein D4A055 10116 CACB4_RAT GO:0030217 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTS6 10116 E9PTS6_RAT GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P01127 9606 PDGFB_HUMAN GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P05622 10090 PGFRB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P12919 9685 PDGFB_FELCA GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P31240 10090 PDGFB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000545 T-helper 1 cell

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0045063 based on ALL annotations
The top 100 of 488 co-occurring terms
Co-occurring Term PR S% #Together #Compared
T-helper 1 cell differentiation
263,075.28 100.00 741 741
lymphocyte activation involved in immune response
263,075.28 13.50 100 100
keratinocyte activation
170,828.11 12.58 100 154
response to cisplatin
154,750.17 12.33 100 170
B cell receptor apoptotic signaling pathway
152,950.75 12.30 100 172
positive regulation of T-helper 17 cell differentiation
119,579.67 11.61 100 220
response to folic acid
106,941.18 11.27 100 246
response to Gram-positive bacterium
106,941.18 11.27 100 246
forebrain neuroblast division
161,179.92 10.93 87 142
positive regulation of inhibitory synapse assembly
129,404.59 10.90 91 185
Totals 9454 130287
No co-occurrence statistics for GO:0045063 based on MANUAL annotations
The top 100 of 454 co-occurring terms
Co-occurring Term PR S% #Together #Compared
T-helper 1 cell differentiation
26,912.48 100.00 48 48
interleukin-12-mediated signaling pathway
6,077.01 9.72 7 31
interleukin-18 receptor complex
14,951.38 9.62 5 9
interleukin-18 receptor activity
5,540.80 9.33 7 34
interleukin-18 binding
7,020.65 9.23 6 23
leukocyte proliferation
5,980.55 8.70 6 27
response to interleukin-6
4,709.68 8.64 7 40
lymphocyte activation involved in immune response
26,912.48 8.33 4 4
transcription preinitiation complex assembly
26,912.48 8.33 4 4
positive regulation of inhibitory synapse assembly
7,475.69 8.20 5 18
Totals 411 4379

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7776 (Gnathostomata)
2011-01-19 Added DEFINITION The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
2011-01-19 Deleted DEFINITION The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2010-12-17 Added DEFINITION The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2010-10-15 Added SYNONYM T-helper 1 cell development
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2008-04-01 Updated RELATION is a GO:0042093 (T-helper cell differentiation)
2008-04-01 Updated RELATION part of GO:0042088 (T-helper 1 type immune response)
Timestamp Action Category Detail
2002-08-22 Updated TERM T-helper 1 cell differentiation
2002-04-11 Added TERM Th1 cell differentiation
Timestamp Action Category Detail
2011-01-19 Added DEFINITION The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
2011-01-19 Deleted DEFINITION The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2010-12-17 Added DEFINITION The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2010-10-15 Added SYNONYM T-helper 1 cell development
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2005-06-02 Updated DEFINITION The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2005-05-26 Updated DEFINITION Processes whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2005-01-21 Updated DEFINITION Processes whereby a relatively unspecialized T-cell acquires the specialized features of a Th1 cell.
2002-11-27 Added DEFINITION The process whereby a relatively unspecialized T-cell acquires specialized features of a Th1 cell.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0042093 (T-helper cell differentiation)
2008-04-01 Updated RELATION part of GO:0042088 (T-helper 1 type immune response)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7776 (Gnathostomata)
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