Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
GO:0045063
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T-helper 1 cell differentiation
Biological Process
Definition (GO:0045063 GONUTS page)
The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
Comments
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
T-helper 1 cell development | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0045063
Child Term | Relationship to GO:0045063 |
---|---|
regulation of T-helper 1 cell differentiation
|
regulates |
positive regulation of T-helper 1 cell differentiation
|
positively_regulates |
negative regulation of T-helper 1 cell differentiation
|
negatively_regulates |
T-helper 1 cell lineage commitment
|
part_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0045063 | T-helper 1 cell differentiation | Only in Taxon | 7776 | Gnathostomata |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | D4A055 | 10116 | CACB4_RAT | GO:0030217 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTS6 | 10116 | E9PTS6_RAT | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P01127 | 9606 | PDGFB_HUMAN | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163 | |
NOT-qualified manual | protein | P05622 | 10090 | PGFRB_MOUSE | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163 | |
NOT-qualified manual | protein | P12919 | 9685 | PDGFB_FELCA | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | P31240 | 10090 | PDGFB_MOUSE | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
results_in_acquisition_of_features_of | CL | CL:0000545 | T-helper 1 cell |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045063 based on ALL annotations
The top 100 of 488 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
T-helper 1 cell differentiation
|
263,075.28 | 100.00 | 741 | 741 |
lymphocyte activation involved in immune response
|
263,075.28 | 13.50 | 100 | 100 |
keratinocyte activation
|
170,828.11 | 12.58 | 100 | 154 |
response to cisplatin
|
154,750.17 | 12.33 | 100 | 170 |
B cell receptor apoptotic signaling pathway
|
152,950.75 | 12.30 | 100 | 172 |
positive regulation of T-helper 17 cell differentiation
|
119,579.67 | 11.61 | 100 | 220 |
response to folic acid
|
106,941.18 | 11.27 | 100 | 246 |
response to Gram-positive bacterium
|
106,941.18 | 11.27 | 100 | 246 |
forebrain neuroblast division
|
161,179.92 | 10.93 | 87 | 142 |
positive regulation of inhibitory synapse assembly
|
129,404.59 | 10.90 | 91 | 185 |
Totals | 9454 | 130287 |
No co-occurrence statistics for GO:0045063 based on MANUAL annotations
The top 100 of 454 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
T-helper 1 cell differentiation
|
26,912.48 | 100.00 | 48 | 48 |
interleukin-12-mediated signaling pathway
|
6,077.01 | 9.72 | 7 | 31 |
interleukin-18 receptor complex
|
14,951.38 | 9.62 | 5 | 9 |
interleukin-18 receptor activity
|
5,540.80 | 9.33 | 7 | 34 |
interleukin-18 binding
|
7,020.65 | 9.23 | 6 | 23 |
leukocyte proliferation
|
5,980.55 | 8.70 | 6 | 27 |
response to interleukin-6
|
4,709.68 | 8.64 | 7 | 40 |
lymphocyte activation involved in immune response
|
26,912.48 | 8.33 | 4 | 4 |
transcription preinitiation complex assembly
|
26,912.48 | 8.33 | 4 | 4 |
positive regulation of inhibitory synapse assembly
|
7,475.69 | 8.20 | 5 | 18 |
Totals | 411 | 4379 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7776 (Gnathostomata) |
2011-01-19 | Added | DEFINITION | The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. |
2011-01-19 | Deleted | DEFINITION | The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2010-12-17 | Deleted | DEFINITION | The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2010-12-17 | Added | DEFINITION | The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2010-10-15 | Added | SYNONYM | T-helper 1 cell development |
2008-05-13 | Added | DEFINITION | The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2008-05-12 | Deleted | DEFINITION | The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2008-04-01 | Updated | RELATION | is a GO:0042093 (T-helper cell differentiation) |
2008-04-01 | Updated | RELATION | part of GO:0042088 (T-helper 1 type immune response) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-08-22 | Updated | TERM | T-helper 1 cell differentiation |
2002-04-11 | Added | TERM | Th1 cell differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-01-19 | Added | DEFINITION | The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. |
2011-01-19 | Deleted | DEFINITION | The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2010-12-17 | Deleted | DEFINITION | The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2010-12-17 | Added | DEFINITION | The process in which a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2010-10-15 | Added | SYNONYM | T-helper 1 cell development |
2008-05-13 | Added | DEFINITION | The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2008-05-12 | Deleted | DEFINITION | The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2005-06-02 | Updated | DEFINITION | The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2005-05-26 | Updated | DEFINITION | Processes whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. |
2005-01-21 | Updated | DEFINITION | Processes whereby a relatively unspecialized T-cell acquires the specialized features of a Th1 cell. |
2002-11-27 | Added | DEFINITION | The process whereby a relatively unspecialized T-cell acquires specialized features of a Th1 cell. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0042093 (T-helper cell differentiation) |
2008-04-01 | Updated | RELATION | part of GO:0042088 (T-helper 1 type immune response) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7776 (Gnathostomata) |
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