This term is obsolete.
The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.

GO:0045252 JSON

oxoglutarate dehydrogenase complex

Cellular Component

Definition (GO:0045252 GONUTS page)

A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. PMID:10672230

Comments

The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.

70,234 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
KGDHC exact
dihydrolipoamide S-succinyltransferase complex exact
alpha-ketoglutarate dehydrogenase complex exact

Ancestor Chart

Ancestor chart for GO:0045252
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0045252 oxoglutarate dehydrogenase complex Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0D1E8X3 237631 A0A0D1E8X3_USTMA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A0G2JZ79 10116 SIR1_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1L8G9S0 8355 A0A1L8G9S0_XENLA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4L3K3 6945 A0A1S4L3K3_IXOSC GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A2K5ATM2 6239 A0A2K5ATM2_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATM9 6239 A0A2K5ATM9_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATP6 6239 A0A2K5ATP6_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR006255 Dihydrolipoamide succinyltransferase
Wikipedia Oxoglutarate_dehydrogenase_complex

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0009354 obsolete dihydrolipoamide S-succinyltransferase complex consider GO:0045252
GO:0005947 obsolete mitochondrial alpha-ketoglutarate dehydrogenase complex replaced_by GO:0045252
GO:0009353 obsolete mitochondrial oxoglutarate dehydrogenase complex replaced_by GO:0045252
GO:0045241 obsolete cytosolic alpha-ketoglutarate dehydrogenase complex replaced_by GO:0045252
GO:0045248 obsolete cytosolic oxoglutarate dehydrogenase complex replaced_by GO:0045252

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0045252 based on ALL annotations
The top 100 of 526 co-occurring terms
Co-occurring Term PR S% #Together #Compared
oxoglutarate dehydrogenase complex
2,779.60 100.00 70,132 70,132
oxoglutarate dehydrogenase (succinyl-transferring) activity
2,528.31 51.57 38,123 41,912
dihydrolipoyllysine-residue succinyltransferase activity
2,419.49 37.56 27,903 32,056
L-lysine catabolic process to acetyl-CoA via saccharopine
2,540.34 30.15 21,766 23,816
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
1,042.48 28.49 38,036 101,417
thiamine pyrophosphate binding
268.62 8.93 37,894 392,110
tricarboxylic acid cycle
250.86 8.92 61,812 684,903
2-oxoglutarate metabolic process
258.26 5.48 8,278 89,095
dihydrolipoyl dehydrogenase activity
248.84 5.24 7,874 87,954
lysine catabolic process
2,591.79 2.46 1,725 1,850
Totals 508672 49021383
No co-occurrence statistics for GO:0045252 based on MANUAL annotations
The top 100 of 207 co-occurring terms
Co-occurring Term PR S% #Together #Compared
oxoglutarate dehydrogenase complex
1,804.19 100.00 716 716
branched-chain amino acid catabolic process
1,344.74 30.08 240 322
2-oxoglutarate metabolic process
1,096.00 29.41 260 428
oxoglutarate dehydrogenase (succinyl-transferring) activity
1,722.18 28.93 210 220
dihydrolipoyl dehydrogenase activity
1,286.09 26.34 211 296
pyruvate metabolic process
358.39 13.29 205 1,032
response to nutrient
443.89 9.29 93 378
tricarboxylic acid cycle
173.10 7.95 227 2,366
flavin adenine dinucleotide binding
106.31 5.14 205 3,479
branched-chain alpha-ketoacid dehydrogenase complex
1,127.62 2.07 15 24
Totals 3215 82840

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_pir 439

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2024-02-24 Added XREF Wikipedia:Oxoglutarate_dehydrogenase_complex
2024-02-24 Added SYNONYM alpha-ketoglutarate dehydrogenase complex
2024-02-24 Added SYNONYM KGDHC
2024-02-24 Added DEFINITION A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
2024-02-24 Deleted DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2024-02-24 Added RELATION is a GO:0045239 (tricarboxylic acid cycle heteromeric enzyme complex)
2024-01-30 Added RELATION capable of GO:0034602 (oxoglutarate dehydrogenase (NAD+) activity)
2024-01-30 Deleted RELATION capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity)
2024-01-30 Deleted RELATION capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity)
Timestamp Action Category Detail
2002-05-10 Added TERM oxoglutarate dehydrogenase complex
Timestamp Action Category Detail
2024-02-24 Added SYNONYM alpha-ketoglutarate dehydrogenase complex
2024-02-24 Added SYNONYM KGDHC
2024-02-24 Added DEFINITION A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
2024-02-24 Deleted DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2022-11-22 Added DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2022-11-22 Deleted DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2022-01-12 Added DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2022-01-12 Deleted DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2008-05-13 Added DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2008-05-12 Deleted DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2007-08-09 Added SYNONYM dihydrolipoamide S-succinyltransferase complex
2007-08-09 Deleted SYNONYM dihydrolipoamide S-succinyltransferase complex
2005-08-10 Added SYNONYM dihydrolipoamide S-succinyltransferase complex
2005-02-02 Updated DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
2004-07-22 Updated DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix.
2003-10-23 Updated DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; GO:0004591 ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; GO:0004149 ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; GO:0004148 ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix (GO:0005759).
2002-11-27 Added DEFINITION A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; GO:0004591 ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; GO:0004149 ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; GO:0004148 ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide within the mitochondrial matrix (GO:0005759).
Timestamp Action Category Detail
2024-02-24 Added RELATION is a GO:0045239 (tricarboxylic acid cycle heteromeric enzyme complex)
2024-01-30 Added RELATION capable of GO:0034602 (oxoglutarate dehydrogenase (NAD+) activity)
2024-01-30 Deleted RELATION capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity)
2024-01-30 Deleted RELATION capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity)
2024-01-30 Deleted RELATION capable of GO:0004148 (dihydrolipoyl dehydrogenase activity)
2024-01-30 Deleted RELATION is a GO:1990234 (transferase complex)
2015-06-18 Added RELATION capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity)
2015-06-18 Added RELATION capable of GO:0004148 (dihydrolipoyl dehydrogenase activity)
2015-06-18 Added RELATION capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity)
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-08-15 Added RELATION is a GO:0045240 (alpha-ketoacid dehydrogenase complex)
2013-08-15 Deleted RELATION is a GO:0044424 (obsolete intracellular part)
2013-08-15 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044424 (obsolete intracellular part)
Timestamp Action Category Detail
2024-02-24 Added XREF Wikipedia:Oxoglutarate_dehydrogenase_complex
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2013-04-18 Updated SUBSET goslim_pir
2008-06-09 Added SUBSET goslim_pir
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