The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.
GO:0045252
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oxoglutarate dehydrogenase complex
Cellular Component
Definition (GO:0045252 GONUTS page)
A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. PMID:10672230
Comments
The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
KGDHC | exact |
dihydrolipoamide S-succinyltransferase complex | exact |
alpha-ketoglutarate dehydrogenase complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0045252 | oxoglutarate dehydrogenase complex | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0D1E8X3 | 237631 | A0A0D1E8X3_USTMA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A0G2JZ79 | 10116 | SIR1_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1L8G9S0 | 8355 | A0A1L8G9S0_XENLA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4L3K3 | 6945 | A0A1S4L3K3_IXOSC | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A2K5ATM2 | 6239 | A0A2K5ATM2_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATM9 | 6239 | A0A2K5ATM9_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATP6 | 6239 | A0A2K5ATP6_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR006255 | Dihydrolipoamide succinyltransferase |
Wikipedia | Oxoglutarate_dehydrogenase_complex |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0009354 | obsolete dihydrolipoamide S-succinyltransferase complex | consider GO:0045252 |
GO:0005947 | obsolete mitochondrial alpha-ketoglutarate dehydrogenase complex | replaced_by GO:0045252 |
GO:0009353 | obsolete mitochondrial oxoglutarate dehydrogenase complex | replaced_by GO:0045252 |
GO:0045241 | obsolete cytosolic alpha-ketoglutarate dehydrogenase complex | replaced_by GO:0045252 |
GO:0045248 | obsolete cytosolic oxoglutarate dehydrogenase complex | replaced_by GO:0045252 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045252 based on ALL annotations
The top 100 of 526 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxoglutarate dehydrogenase complex
|
2,779.60 | 100.00 | 70,132 | 70,132 |
oxoglutarate dehydrogenase (succinyl-transferring) activity
|
2,528.31 | 51.57 | 38,123 | 41,912 |
dihydrolipoyllysine-residue succinyltransferase activity
|
2,419.49 | 37.56 | 27,903 | 32,056 |
L-lysine catabolic process to acetyl-CoA via saccharopine
|
2,540.34 | 30.15 | 21,766 | 23,816 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
|
1,042.48 | 28.49 | 38,036 | 101,417 |
thiamine pyrophosphate binding
|
268.62 | 8.93 | 37,894 | 392,110 |
tricarboxylic acid cycle
|
250.86 | 8.92 | 61,812 | 684,903 |
2-oxoglutarate metabolic process
|
258.26 | 5.48 | 8,278 | 89,095 |
dihydrolipoyl dehydrogenase activity
|
248.84 | 5.24 | 7,874 | 87,954 |
lysine catabolic process
|
2,591.79 | 2.46 | 1,725 | 1,850 |
Totals | 508672 | 49021383 |
No co-occurrence statistics for GO:0045252 based on MANUAL annotations
The top 100 of 207 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxoglutarate dehydrogenase complex
|
1,804.19 | 100.00 | 716 | 716 |
branched-chain amino acid catabolic process
|
1,344.74 | 30.08 | 240 | 322 |
2-oxoglutarate metabolic process
|
1,096.00 | 29.41 | 260 | 428 |
oxoglutarate dehydrogenase (succinyl-transferring) activity
|
1,722.18 | 28.93 | 210 | 220 |
dihydrolipoyl dehydrogenase activity
|
1,286.09 | 26.34 | 211 | 296 |
pyruvate metabolic process
|
358.39 | 13.29 | 205 | 1,032 |
response to nutrient
|
443.89 | 9.29 | 93 | 378 |
tricarboxylic acid cycle
|
173.10 | 7.95 | 227 | 2,366 |
flavin adenine dinucleotide binding
|
106.31 | 5.14 | 205 | 3,479 |
branched-chain alpha-ketoacid dehydrogenase complex
|
1,127.62 | 2.07 | 15 | 24 |
Totals | 3215 | 82840 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_pir | 439 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2024-02-24 | Added | XREF | Wikipedia:Oxoglutarate_dehydrogenase_complex |
2024-02-24 | Added | SYNONYM | alpha-ketoglutarate dehydrogenase complex |
2024-02-24 | Added | SYNONYM | KGDHC |
2024-02-24 | Added | DEFINITION | A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. |
2024-02-24 | Deleted | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2024-02-24 | Added | RELATION | is a GO:0045239 (tricarboxylic acid cycle heteromeric enzyme complex) |
2024-01-30 | Added | RELATION | capable of GO:0034602 (oxoglutarate dehydrogenase (NAD+) activity) |
2024-01-30 | Deleted | RELATION | capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity) |
2024-01-30 | Deleted | RELATION | capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-05-10 | Added | TERM | oxoglutarate dehydrogenase complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | SYNONYM | alpha-ketoglutarate dehydrogenase complex |
2024-02-24 | Added | SYNONYM | KGDHC |
2024-02-24 | Added | DEFINITION | A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. |
2024-02-24 | Deleted | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2022-11-22 | Added | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2022-11-22 | Deleted | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2022-01-12 | Added | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2022-01-12 | Deleted | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2008-05-13 | Added | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2008-05-12 | Deleted | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2007-08-09 | Added | SYNONYM | dihydrolipoamide S-succinyltransferase complex |
2007-08-09 | Deleted | SYNONYM | dihydrolipoamide S-succinyltransferase complex |
2005-08-10 | Added | SYNONYM | dihydrolipoamide S-succinyltransferase complex |
2005-02-02 | Updated | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). |
2004-07-22 | Updated | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. |
2003-10-23 | Updated | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; GO:0004591 ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; GO:0004149 ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; GO:0004148 ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix (GO:0005759). |
2002-11-27 | Added | DEFINITION | A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; GO:0004591 ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; GO:0004149 ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; GO:0004148 ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide within the mitochondrial matrix (GO:0005759). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | RELATION | is a GO:0045239 (tricarboxylic acid cycle heteromeric enzyme complex) |
2024-01-30 | Added | RELATION | capable of GO:0034602 (oxoglutarate dehydrogenase (NAD+) activity) |
2024-01-30 | Deleted | RELATION | capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity) |
2024-01-30 | Deleted | RELATION | capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity) |
2024-01-30 | Deleted | RELATION | capable of GO:0004148 (dihydrolipoyl dehydrogenase activity) |
2024-01-30 | Deleted | RELATION | is a GO:1990234 (transferase complex) |
2015-06-18 | Added | RELATION | capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity) |
2015-06-18 | Added | RELATION | capable of GO:0004148 (dihydrolipoyl dehydrogenase activity) |
2015-06-18 | Added | RELATION | capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity) |
2013-11-28 | Added | RELATION | is a GO:1990234 (transferase complex) |
2013-08-15 | Added | RELATION | is a GO:0045240 (alpha-ketoacid dehydrogenase complex) |
2013-08-15 | Deleted | RELATION | is a GO:0044424 (obsolete intracellular part) |
2013-08-15 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | is a GO:0044424 (obsolete intracellular part) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | XREF | Wikipedia:Oxoglutarate_dehydrogenase_complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2013-04-18 | Updated | SUBSET | goslim_pir |
2008-06-09 | Added | SUBSET | goslim_pir |
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