This term is obsolete.

GO:0045548 JSON

phenylalanine ammonia-lyase activity

Molecular Function

Definition (GO:0045548 GONUTS page)

Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate.

2,963 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
PAL activity broad
phenylalanine ammonium-lyase activity related
phe ammonia-lyase activity related
phenylalanine deaminase activity related
L-phenylalanine ammonia-lyase activity related

Ancestor Chart

Ancestor chart for GO:0045548
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Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 4.3.1.24
EC 4.3.1.25
RHEA 21384

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58095 L-phenylalanine zwitterion
has_participant CHEBI CHEBI:15669 trans-cinnamate
has_participant CHEBI CHEBI:28938 ammonium

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0045548 based on ALL annotations
The top 81 of 81 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0045548
phenylalanine ammonia-lyase activity
69,381.96 100.00 2,856 2,856
GO:0009800
cinnamic acid biosynthetic process
60,206.34 68.52 2,185 2,518
GO:0009698
phenylpropanoid metabolic process
12,122.15 16.58 2,185 12,506
GO:0016841
ammonia-lyase activity
4,020.20 5.71 2,253 38,883
GO:0006559
L-phenylalanine catabolic process
2,127.95 3.07 2,831 92,305
GO:0052883
tyrosine ammonia-lyase activity
8,672.75 0.14 4 32
GO:0046244
salicylic acid catabolic process
10,955.05 0.10 3 19
GO:0009819
drought recovery
2,851.31 0.10 3 73
GO:0009821
alkaloid biosynthetic process
3,227.07 0.07 2 43
GO:0006558
L-phenylalanine metabolic process
2,202.60 0.07 2 63
Totals 18670 255115100
No co-occurrence statistics for GO:0045548 based on MANUAL annotations
The top 24 of 24 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0045548
phenylalanine ammonia-lyase activity
12,949.85 100.00 109 109
GO:0009800
cinnamic acid biosynthetic process
10,359.88 3.64 4 5
GO:0009699
phenylpropanoid biosynthetic process
1,363.14 2.80 4 38
GO:0009072
aromatic amino acid metabolic process
3,237.46 1.74 2 8
GO:0052883
tyrosine ammonia-lyase activity
4,316.61 0.90 1 3
GO:0016598
protein arginylation
3,237.46 0.89 1 4
GO:0046274
lignin catabolic process
1,618.73 0.86 1 8
GO:0046244
salicylic acid catabolic process
1,618.73 0.86 1 8
GO:0009819
drought recovery
996.14 0.83 1 13
GO:0046898
response to cycloheximide
719.44 0.79 1 18
Totals 145 248969

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate.
2020-10-08 Deleted SYNONYM phenylalanine deaminase activity
2020-10-08 Deleted SYNONYM phe ammonia-lyase activity
2020-10-08 Added SYNONYM phenylalanine ammonium-lyase activity
2020-10-08 Added SYNONYM L-phenylalanine ammonia-lyase activity
2020-10-08 Added SYNONYM phe ammonia-lyase activity
2020-10-08 Added SYNONYM phenylalanine deaminase activity
2020-10-08 Deleted SYNONYM L-phenylalanine ammonia-lyase activity
2020-10-08 Deleted SYNONYM phenylalanine ammonium-lyase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM phenylalanine ammonia-lyase activity
2002-08-09 Added TERM phenylalanine ammonia-lyase
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate.
2020-10-08 Deleted SYNONYM phenylalanine deaminase activity
2020-10-08 Deleted SYNONYM phe ammonia-lyase activity
2020-10-08 Added SYNONYM phenylalanine ammonium-lyase activity
2020-10-08 Added SYNONYM L-phenylalanine ammonia-lyase activity
2020-10-08 Added SYNONYM phe ammonia-lyase activity
2020-10-08 Added SYNONYM phenylalanine deaminase activity
2020-10-08 Deleted SYNONYM L-phenylalanine ammonia-lyase activity
2020-10-08 Deleted SYNONYM phenylalanine ammonium-lyase activity
2012-03-01 Deleted DEFINITION Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3.
2012-03-01 Deleted SYNONYM L-phenylalanine ammonia-lyase (trans-cinnamate-forming)
2012-03-01 Deleted SYNONYM L-tyrosine ammonia-lyase activity
2012-03-01 Deleted SYNONYM tyrosine ammonia-lyase activity
2012-03-01 Added SYNONYM phe ammonia-lyase activity
2012-03-01 Added SYNONYM PAL activity
2012-03-01 Deleted SYNONYM PAL
2012-03-01 Deleted SYNONYM tyrase activity
2012-03-01 Added DEFINITION Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate.
2008-05-13 Added DEFINITION Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3.
2007-11-08 Added SYNONYM tyrosine ammonia-lyase activity
2007-11-08 Added SYNONYM tyrase activity
2007-11-08 Added SYNONYM L-phenylalanine ammonia-lyase (trans-cinnamate-forming)
2007-11-08 Added SYNONYM L-phenylalanine ammonia-lyase activity
2007-11-08 Added SYNONYM L-tyrosine ammonia-lyase activity
2007-11-08 Added SYNONYM PAL
2007-11-08 Added SYNONYM phenylalanine ammonium-lyase activity
2007-11-08 Added SYNONYM phenylalanine deaminase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016841 (ammonia-lyase activity)
Timestamp Action Category Detail
2018-07-13 Deleted XREF RHEA:21387
2018-07-13 Added XREF RHEA:21384
2012-03-01 Added XREF RHEA:21387
2012-03-01 Added XREF EC:4.3.1.25
2012-03-01 Added XREF EC:4.3.1.24
2012-03-01 Deleted XREF MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN
2012-03-01 Deleted XREF EC:4.3.1.5
2003-10-27 Added XREF MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN
2002-08-09 Added XREF EC:4.3.1.5
Timestamp Action Category Detail
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