GO:0045548
JSON
phenylalanine ammonia-lyase activity
Molecular Function
Definition (GO:0045548 GONUTS page)
Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
phenylalanine deaminase activity | related |
PAL activity | broad |
phe ammonia-lyase activity | related |
phenylalanine ammonium-lyase activity | related |
L-phenylalanine ammonia-lyase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.3.1.24 | |
EC | 4.3.1.25 | |
RHEA | 21384 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58095 | L-phenylalanine zwitterion |
has_participant | CHEBI | CHEBI:15669 | trans-cinnamate |
has_participant | CHEBI | CHEBI:28938 | ammonium |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045548 based on ALL annotations
The top 81 of 81 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phenylalanine ammonia-lyase activity
|
68,255.88 | 100.00 | 2,856 | 2,856 |
cinnamic acid biosynthetic process
|
59,229.18 | 68.52 | 2,185 | 2,518 |
phenylpropanoid metabolic process
|
13,274.51 | 18.35 | 2,185 | 11,235 |
L-phenylalanine catabolic process
|
2,136.86 | 3.13 | 2,832 | 90,460 |
ammonia-lyase activity
|
2,059.08 | 2.99 | 2,253 | 74,684 |
tyrosine ammonia-lyase activity
|
8,273.44 | 0.14 | 4 | 33 |
salicylic acid catabolic process
|
10,777.24 | 0.10 | 3 | 19 |
drought recovery
|
2,805.04 | 0.10 | 3 | 73 |
alkaloid biosynthetic process
|
3,174.69 | 0.07 | 2 | 43 |
L-phenylalanine metabolic process
|
2,133.00 | 0.07 | 2 | 64 |
Totals | 18905 | 245624242 |
No co-occurrence statistics for GO:0045548 based on MANUAL annotations
The top 24 of 24 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phenylalanine ammonia-lyase activity
|
12,664.70 | 100.00 | 102 | 102 |
cinnamic acid biosynthetic process
|
10,131.76 | 3.88 | 4 | 5 |
phenylpropanoid biosynthetic process
|
1,333.13 | 2.94 | 4 | 38 |
aromatic amino acid metabolic process
|
3,166.17 | 1.85 | 2 | 8 |
tyrosine ammonia-lyase activity
|
4,221.57 | 0.96 | 1 | 3 |
protein arginylation
|
3,166.17 | 0.95 | 1 | 4 |
lignin catabolic process
|
1,583.09 | 0.92 | 1 | 8 |
salicylic acid catabolic process
|
1,583.09 | 0.92 | 1 | 8 |
drought recovery
|
974.21 | 0.88 | 1 | 13 |
response to cycloheximide
|
703.59 | 0.84 | 1 | 18 |
Totals | 138 | 230446 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. |
2020-10-08 | Deleted | SYNONYM | phenylalanine ammonium-lyase activity |
2020-10-08 | Deleted | SYNONYM | L-phenylalanine ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | L-phenylalanine ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | phe ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | phenylalanine deaminase activity |
2020-10-08 | Deleted | SYNONYM | phenylalanine deaminase activity |
2020-10-08 | Deleted | SYNONYM | phe ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | phenylalanine ammonium-lyase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | phenylalanine ammonia-lyase activity |
2002-08-09 | Added | TERM | phenylalanine ammonia-lyase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. |
2020-10-08 | Deleted | SYNONYM | phenylalanine ammonium-lyase activity |
2020-10-08 | Deleted | SYNONYM | L-phenylalanine ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | L-phenylalanine ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | phe ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | phenylalanine deaminase activity |
2020-10-08 | Deleted | SYNONYM | phenylalanine deaminase activity |
2020-10-08 | Deleted | SYNONYM | phe ammonia-lyase activity |
2020-10-08 | Added | SYNONYM | phenylalanine ammonium-lyase activity |
2012-03-01 | Deleted | SYNONYM | L-tyrosine ammonia-lyase activity |
2012-03-01 | Added | DEFINITION | Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. |
2012-03-01 | Deleted | DEFINITION | Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3. |
2012-03-01 | Added | SYNONYM | phe ammonia-lyase activity |
2012-03-01 | Deleted | SYNONYM | PAL |
2012-03-01 | Deleted | SYNONYM | tyrase activity |
2012-03-01 | Deleted | SYNONYM | L-phenylalanine ammonia-lyase (trans-cinnamate-forming) |
2012-03-01 | Deleted | SYNONYM | tyrosine ammonia-lyase activity |
2012-03-01 | Added | SYNONYM | PAL activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3. |
2007-11-08 | Added | SYNONYM | phenylalanine deaminase activity |
2007-11-08 | Added | SYNONYM | tyrase activity |
2007-11-08 | Added | SYNONYM | tyrosine ammonia-lyase activity |
2007-11-08 | Added | SYNONYM | L-phenylalanine ammonia-lyase (trans-cinnamate-forming) |
2007-11-08 | Added | SYNONYM | phenylalanine ammonium-lyase activity |
2007-11-08 | Added | SYNONYM | PAL |
2007-11-08 | Added | SYNONYM | L-phenylalanine ammonia-lyase activity |
2007-11-08 | Added | SYNONYM | L-tyrosine ammonia-lyase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016841 (ammonia-lyase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Deleted | XREF | RHEA:21387 |
2018-07-13 | Added | XREF | RHEA:21384 |
2012-03-01 | Added | XREF | RHEA:21387 |
2012-03-01 | Added | XREF | EC:4.3.1.25 |
2012-03-01 | Added | XREF | EC:4.3.1.24 |
2012-03-01 | Deleted | XREF | MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN |
2012-03-01 | Deleted | XREF | EC:4.3.1.5 |
2003-10-27 | Added | XREF | MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN |
2002-08-09 | Added | XREF | EC:4.3.1.5 |
Timestamp | Action | Category | Detail |
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