Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
GO:0045584
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negative regulation of cytotoxic T cell differentiation
Biological Process
Definition (GO:0045584 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
Comments
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
downregulation of cytotoxic T cell differentiation | exact |
down-regulation of cytotoxic T cell differentiation | exact |
down regulation of cytotoxic T cell differentiation | exact |
negative regulation of cytotoxic T cell development | related |
negative regulation of cytotoxic T lymphocyte differentiation | exact |
negative regulation of cytotoxic T-cell differentiation | exact |
inhibition of cytotoxic T cell differentiation | narrow |
negative regulation of cytotoxic T-lymphocyte differentiation | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0045584 | negative regulation of cytotoxic T cell differentiation | Never in Taxon | 4890 | Ascomycota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P16047 | 9031 | TGFB3_CHICK | GO:0007162 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:17587820 | |
NOT-qualified manual | protein | Q90999 | 9031 | TGFR2_CHICK | GO:0007162 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:17587820 | |
NOT-qualified manual | protein | Q90999 | 9031 | TGFR2_CHICK | GO:0022408 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045584 based on ALL annotations
The top 49 of 49 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of cytotoxic T cell differentiation
|
24,769,358.00 | 100.00 | 8 | 8 |
transmembrane receptor protein tyrosine kinase inhibitor activity
|
24,769,358.00 | 100.00 | 8 | 8 |
negative regulation of T cell costimulation
|
22,017,208.00 | 88.89 | 8 | 9 |
negative regulation of IP-10 production
|
1,869,385.40 | 7.55 | 8 | 106 |
Fc receptor mediated inhibitory signaling pathway
|
1,753,583.00 | 7.08 | 8 | 113 |
negative regulation of monocyte activation
|
1,548,084.90 | 6.25 | 8 | 128 |
negative regulation of signaling receptor activity
|
2,752,151.00 | 6.25 | 1 | 9 |
tolerance induction
|
1,238,467.90 | 5.00 | 8 | 160 |
positive regulation of CD8-positive, alpha-beta T cell differentiation
|
1,132,313.50 | 4.57 | 8 | 175 |
negative regulation of protein tyrosine kinase activity
|
1,032,056.56 | 3.23 | 1 | 24 |
Totals | 325 | 76352263 |
No co-occurrence statistics for GO:0045584 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
transmembrane receptor protein tyrosine kinase inhibitor activity
|
176,441.62 | 100.00 | 8 | 8 |
negative regulation of cytotoxic T cell differentiation
|
176,441.62 | 100.00 | 8 | 8 |
negative regulation of T cell costimulation
|
156,837.00 | 88.89 | 8 | 9 |
negative regulation of IP-10 production
|
108,579.45 | 61.54 | 8 | 13 |
negative regulation of monocyte activation
|
88,220.81 | 50.00 | 8 | 16 |
Fc receptor mediated inhibitory signaling pathway
|
78,418.50 | 44.44 | 8 | 18 |
tolerance induction
|
74,291.21 | 42.11 | 8 | 19 |
signaling receptor inhibitor activity
|
48,673.56 | 27.59 | 8 | 29 |
positive regulation of CD8-positive, alpha-beta T cell differentiation
|
48,673.56 | 27.59 | 8 | 29 |
negative regulation of interleukin-5 production
|
47,051.10 | 26.67 | 8 | 30 |
Totals | 311 | 204620 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4890 (Ascomycota) |
2010-10-15 | Added | SYNONYM | negative regulation of cytotoxic T cell development |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2008-04-01 | Updated | RELATION | is a GO:0045583 (regulation of cytotoxic T cell differentiation) |
2008-04-01 | Updated | RELATION | is a GO:0045581 (negative regulation of T cell differentiation) |
2008-04-01 | Added | RELATION | negatively regulates GO:0045065 (cytotoxic T cell differentiation) |
2007-08-09 | Added | SYNONYM | negative regulation of cytotoxic T lymphocyte differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-06-02 | Updated | TERM | negative regulation of cytotoxic T cell differentiation |
2002-08-14 | Added | TERM | negative regulation of cytotoxic T-cell differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-15 | Added | SYNONYM | negative regulation of cytotoxic T cell development |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2007-08-09 | Added | SYNONYM | negative regulation of cytotoxic T lymphocyte differentiation |
2007-08-09 | Added | SYNONYM | inhibition of cytotoxic T cell differentiation |
2007-08-09 | Added | SYNONYM | negative regulation of cytotoxic T-lymphocyte differentiation |
2007-08-09 | Added | SYNONYM | negative regulation of cytotoxic T-cell differentiation |
2007-08-09 | Added | SYNONYM | down regulation of cytotoxic T cell differentiation |
2007-08-09 | Added | SYNONYM | down-regulation of cytotoxic T cell differentiation |
2007-08-09 | Added | SYNONYM | downregulation of cytotoxic T cell differentiation |
2007-08-09 | Deleted | SYNONYM | inhibition of cytotoxic T cell differentiation |
2007-08-09 | Deleted | SYNONYM | downregulation of cytotoxic T cell differentiation |
2007-08-09 | Deleted | SYNONYM | down-regulation of cytotoxic T cell differentiation |
2007-08-09 | Deleted | SYNONYM | down regulation of cytotoxic T cell differentiation |
2007-08-09 | Deleted | SYNONYM | negative regulation of cytotoxic T-lymphocyte differentiation |
2007-08-09 | Deleted | SYNONYM | negative regulation of cytotoxic T-cell differentiation |
2007-08-09 | Deleted | SYNONYM | negative regulation of cytotoxic T lymphocyte differentiation |
2007-02-23 | Added | SYNONYM | downregulation of cytotoxic T cell differentiation |
2007-02-23 | Added | SYNONYM | inhibition of cytotoxic T cell differentiation |
2007-02-23 | Added | SYNONYM | down regulation of cytotoxic T cell differentiation |
2007-02-23 | Added | SYNONYM | down-regulation of cytotoxic T cell differentiation |
2006-05-04 | Updated | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. |
2005-10-21 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate, frequency or extent of cytotoxic T cell differentiation. |
2005-06-02 | Added | SYNONYM | negative regulation of cytotoxic T-cell differentiation |
2005-06-02 | Added | SYNONYM | negative regulation of cytotoxic T lymphocyte differentiation |
2005-06-02 | Added | SYNONYM | negative regulation of cytotoxic T-lymphocyte differentiation |
2005-05-26 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate of cytotoxic T cell differentiation. |
2002-11-27 | Added | DEFINITION | Any process that stops, prevents or reduces the rate of cytotoxic T-cell differentiation. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0045583 (regulation of cytotoxic T cell differentiation) |
2008-04-01 | Updated | RELATION | is a GO:0045581 (negative regulation of T cell differentiation) |
2008-04-01 | Added | RELATION | negatively regulates GO:0045065 (cytotoxic T cell differentiation) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4890 (Ascomycota) |
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