This term is obsolete.
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

GO:0045584 JSON

negative regulation of cytotoxic T cell differentiation

Biological Process

Definition (GO:0045584 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation.

Comments

Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

8 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
downregulation of cytotoxic T cell differentiation exact
down-regulation of cytotoxic T cell differentiation exact
down regulation of cytotoxic T cell differentiation exact
negative regulation of cytotoxic T cell development related
negative regulation of cytotoxic T lymphocyte differentiation exact
negative regulation of cytotoxic T-cell differentiation exact
inhibition of cytotoxic T cell differentiation narrow
negative regulation of cytotoxic T-lymphocyte differentiation exact

Ancestor Chart

Ancestor chart for GO:0045584
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0045584 negative regulation of cytotoxic T cell differentiation Never in Taxon 4890 Ascomycota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P16047 9031 TGFB3_CHICK GO:0007162 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:17587820
NOT-qualified manual protein Q90999 9031 TGFR2_CHICK GO:0007162 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:17587820
NOT-qualified manual protein Q90999 9031 TGFR2_CHICK GO:0022408 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0045584 based on ALL annotations
The top 49 of 49 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of cytotoxic T cell differentiation
24,769,358.00 100.00 8 8
transmembrane receptor protein tyrosine kinase inhibitor activity
24,769,358.00 100.00 8 8
negative regulation of T cell costimulation
22,017,208.00 88.89 8 9
negative regulation of IP-10 production
1,869,385.40 7.55 8 106
Fc receptor mediated inhibitory signaling pathway
1,753,583.00 7.08 8 113
negative regulation of monocyte activation
1,548,084.90 6.25 8 128
negative regulation of signaling receptor activity
2,752,151.00 6.25 1 9
tolerance induction
1,238,467.90 5.00 8 160
positive regulation of CD8-positive, alpha-beta T cell differentiation
1,132,313.50 4.57 8 175
negative regulation of protein tyrosine kinase activity
1,032,056.56 3.23 1 24
Totals 325 76352263
No co-occurrence statistics for GO:0045584 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transmembrane receptor protein tyrosine kinase inhibitor activity
176,441.62 100.00 8 8
negative regulation of cytotoxic T cell differentiation
176,441.62 100.00 8 8
negative regulation of T cell costimulation
156,837.00 88.89 8 9
negative regulation of IP-10 production
108,579.45 61.54 8 13
negative regulation of monocyte activation
88,220.81 50.00 8 16
Fc receptor mediated inhibitory signaling pathway
78,418.50 44.44 8 18
tolerance induction
74,291.21 42.11 8 19
signaling receptor inhibitor activity
48,673.56 27.59 8 29
positive regulation of CD8-positive, alpha-beta T cell differentiation
48,673.56 27.59 8 29
negative regulation of interleukin-5 production
47,051.10 26.67 8 30
Totals 311 204620

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4890 (Ascomycota)
2010-10-15 Added SYNONYM negative regulation of cytotoxic T cell development
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2008-04-01 Updated RELATION is a GO:0045583 (regulation of cytotoxic T cell differentiation)
2008-04-01 Updated RELATION is a GO:0045581 (negative regulation of T cell differentiation)
2008-04-01 Added RELATION negatively regulates GO:0045065 (cytotoxic T cell differentiation)
2007-08-09 Added SYNONYM negative regulation of cytotoxic T lymphocyte differentiation
Timestamp Action Category Detail
2005-06-02 Updated TERM negative regulation of cytotoxic T cell differentiation
2002-08-14 Added TERM negative regulation of cytotoxic T-cell differentiation
Timestamp Action Category Detail
2010-10-15 Added SYNONYM negative regulation of cytotoxic T cell development
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2007-08-09 Added SYNONYM negative regulation of cytotoxic T lymphocyte differentiation
2007-08-09 Added SYNONYM inhibition of cytotoxic T cell differentiation
2007-08-09 Added SYNONYM negative regulation of cytotoxic T-lymphocyte differentiation
2007-08-09 Added SYNONYM negative regulation of cytotoxic T-cell differentiation
2007-08-09 Added SYNONYM down regulation of cytotoxic T cell differentiation
2007-08-09 Added SYNONYM down-regulation of cytotoxic T cell differentiation
2007-08-09 Added SYNONYM downregulation of cytotoxic T cell differentiation
2007-08-09 Deleted SYNONYM inhibition of cytotoxic T cell differentiation
2007-08-09 Deleted SYNONYM downregulation of cytotoxic T cell differentiation
2007-08-09 Deleted SYNONYM down-regulation of cytotoxic T cell differentiation
2007-08-09 Deleted SYNONYM down regulation of cytotoxic T cell differentiation
2007-08-09 Deleted SYNONYM negative regulation of cytotoxic T-lymphocyte differentiation
2007-08-09 Deleted SYNONYM negative regulation of cytotoxic T-cell differentiation
2007-08-09 Deleted SYNONYM negative regulation of cytotoxic T lymphocyte differentiation
2007-02-23 Added SYNONYM downregulation of cytotoxic T cell differentiation
2007-02-23 Added SYNONYM inhibition of cytotoxic T cell differentiation
2007-02-23 Added SYNONYM down regulation of cytotoxic T cell differentiation
2007-02-23 Added SYNONYM down-regulation of cytotoxic T cell differentiation
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of cytotoxic T cell differentiation.
2005-06-02 Added SYNONYM negative regulation of cytotoxic T-cell differentiation
2005-06-02 Added SYNONYM negative regulation of cytotoxic T lymphocyte differentiation
2005-06-02 Added SYNONYM negative regulation of cytotoxic T-lymphocyte differentiation
2005-05-26 Updated DEFINITION Any process that stops, prevents or reduces the rate of cytotoxic T cell differentiation.
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of cytotoxic T-cell differentiation.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0045583 (regulation of cytotoxic T cell differentiation)
2008-04-01 Updated RELATION is a GO:0045581 (negative regulation of T cell differentiation)
2008-04-01 Added RELATION negatively regulates GO:0045065 (cytotoxic T cell differentiation)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4890 (Ascomycota)
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