GO:0045747
JSON
positive regulation of Notch signaling pathway
Biological Process
Definition (GO:0045747 GONUTS page)
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| activation of Notch signaling pathway | narrow |
| positive regulation of Notch signalling pathway | exact |
| positive regulation of N signalling pathway | exact |
| stimulation of Notch signaling pathway | narrow |
| up regulation of Notch signaling pathway | exact |
| up-regulation of Notch signaling pathway | exact |
| upregulation of Notch signaling pathway | exact |
| positive regulation of N signaling pathway | exact |
Ancestor Chart
Ancestor chart for GO:0045747
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
| Ontology Development Project | |
|---|---|
| signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
| Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
|---|---|---|---|---|---|
| GO:0045747 | positive regulation of Notch signaling pathway | Never in Taxon | 4751 | Fungi |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | B0BN23 | 10116 | B0BN23_RAT | GO:0008593 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | O95858 | 9606 | TSN15_HUMAN | GO:0008593 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23091066 | |
| NOT-qualified manual | protein | Q5FVK6 | 10116 | C2D1B_RAT | GO:0008593 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | Q66HA5 | 10116 | C2D1A_RAT | GO:0008593 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | Q8BRN9 | 10090 | C2D1B_MOUSE | GO:0008593 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:26720614 | |
| NOT-qualified manual | protein | Q8K1A6 | 10090 | C2D1A_MOUSE | GO:0008593 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:26720614 |
Replaces
This term can be used instead of these obsolete terms:
| GO Identifier | GO Term Name | Reason |
|---|---|---|
| GO:0035481 | obsolete positive regulation of Notch signaling pathway involved in heart induction | consider GO:0045747 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045747 based on ALL annotations
The top 100 of 1,949 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
positive regulation of Notch signaling pathway
|
23,779.53 | 100.00 | 8,333 | 8,333 |
|
regulation of clathrin-dependent endocytosis
|
9,852.36 | 14.47 | 1,516 | 3,659 |
|
AP-2 adaptor complex binding
|
7,615.08 | 13.12 | 1,516 | 4,734 |
|
UDP-xylosyltransferase activity
|
4,419.82 | 9.93 | 1,465 | 7,882 |
|
negative regulation of stem cell differentiation
|
8,004.99 | 5.46 | 510 | 1,515 |
|
negative regulation of neuron differentiation
|
3,122.82 | 5.00 | 623 | 4,744 |
|
regulation of neurogenesis
|
3,136.47 | 4.82 | 588 | 4,458 |
|
neuronal stem cell population maintenance
|
4,868.25 | 4.18 | 416 | 2,032 |
|
Notch binding
|
1,424.99 | 4.15 | 992 | 16,554 |
|
inhibition of neuroepithelial cell differentiation
|
19,579.81 | 4.10 | 345 | 419 |
| Totals | 39274 | 286134 | ||
No co-occurrence statistics for GO:0045747 based on MANUAL annotations
The top 100 of 1,739 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
positive regulation of Notch signaling pathway
|
4,056.13 | 100.00 | 348 | 348 |
|
regulation of clathrin-dependent endocytosis
|
1,979.39 | 14.81 | 61 | 125 |
|
AP-2 adaptor complex binding
|
1,874.42 | 14.56 | 61 | 132 |
|
phosphatase regulator activity
|
2,392.08 | 6.32 | 23 | 39 |
|
heart induction
|
1,670.17 | 5.56 | 21 | 51 |
|
pulmonary valve morphogenesis
|
1,234.47 | 5.30 | 21 | 69 |
|
aortic valve morphogenesis
|
764.68 | 5.15 | 23 | 122 |
|
regulation of bone mineralization
|
680.96 | 4.98 | 23 | 137 |
|
UDP-xylosyltransferase activity
|
366.66 | 4.78 | 32 | 354 |
|
Notch binding
|
275.84 | 4.63 | 44 | 647 |
| Totals | 1568 | 12089 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2019-09-29 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
| 2011-01-16 | Deleted | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2011-01-16 | Added | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2010-04-21 | Deleted | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2010-04-21 | Added | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2008-05-13 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. |
| 2008-05-12 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. |
| 2008-04-01 | Updated | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2008-04-01 | Added | RELATION | positively regulates GO:0007219 (Notch signaling pathway) |
| 2008-04-01 | Updated | RELATION | is a GO:0008593 (regulation of Notch signaling pathway) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2004-02-14 | Updated | TERM | positive regulation of Notch signaling pathway |
| 2003-08-07 | Updated | TERM | positive regulation of N signaling pathway |
| 2002-08-20 | Added | TERM | positive regulation of N receptor signaling pathway |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-05-13 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. |
| 2008-05-12 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. |
| 2007-09-10 | Added | SYNONYM | positive regulation of Notch signalling pathway |
| 2007-09-10 | Deleted | SYNONYM | positive regulation of Notch signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | activation of Notch signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | stimulation of Notch signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | up-regulation of Notch signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | positive regulation of Notch signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | positive regulation of N signalling pathway |
| 2007-08-09 | Deleted | SYNONYM | positive regulation of N signaling pathway |
| 2007-08-09 | Added | SYNONYM | activation of Notch signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | upregulation of Notch signaling pathway |
| 2007-08-09 | Added | SYNONYM | upregulation of Notch signaling pathway |
| 2007-08-09 | Added | SYNONYM | up-regulation of Notch signaling pathway |
| 2007-08-09 | Added | SYNONYM | up regulation of Notch signaling pathway |
| 2007-08-09 | Added | SYNONYM | stimulation of Notch signaling pathway |
| 2007-08-09 | Added | SYNONYM | positive regulation of Notch signaling pathway |
| 2007-08-09 | Added | SYNONYM | positive regulation of N signalling pathway |
| 2007-08-09 | Added | SYNONYM | positive regulation of N signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | up regulation of Notch signaling pathway |
| 2007-02-23 | Added | SYNONYM | activation of Notch signaling pathway |
| 2007-02-23 | Added | SYNONYM | stimulation of Notch signaling pathway |
| 2007-02-23 | Added | SYNONYM | up regulation of Notch signaling pathway |
| 2007-02-23 | Added | SYNONYM | up-regulation of Notch signaling pathway |
| 2007-02-23 | Added | SYNONYM | upregulation of Notch signaling pathway |
| 2006-05-04 | Updated | DEFINITION | Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. |
| 2005-10-21 | Updated | DEFINITION | Any process that activates or increases the rate, frequency or extent of the Notch signaling pathway. |
| 2004-04-19 | Added | SYNONYM | positive regulation of Notch signaling pathway |
| 2004-04-19 | Added | SYNONYM | positive regulation of N signaling pathway |
| 2004-04-19 | Added | SYNONYM | positive regulation of N signalling pathway |
| 2004-04-16 | Deleted | SYNONYM | positive regulation of N signalling pathway |
| 2004-04-16 | Deleted | SYNONYM | positive regulation of N signaling pathway |
| 2004-04-16 | Deleted | SYNONYM | positive regulation of Notch signaling pathway |
| 2004-02-14 | Added | SYNONYM | positive regulation of N signaling pathway |
| 2003-11-13 | Added | SYNONYM | positive regulation of N signalling pathway |
| 2003-08-07 | Updated | DEFINITION | Any process that activates or increases the rate of the Notch signaling pathway. |
| 2003-08-07 | Added | SYNONYM | positive regulation of Notch signaling pathway |
| 2002-11-27 | Added | DEFINITION | Any process that activates or increases the rate of N receptor signaling pathway activity. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2011-01-16 | Deleted | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2011-01-16 | Added | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2010-04-21 | Deleted | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2010-04-21 | Added | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2008-04-01 | Updated | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2008-04-01 | Added | RELATION | positively regulates GO:0007219 (Notch signaling pathway) |
| 2008-04-01 | Updated | RELATION | is a GO:0008593 (regulation of Notch signaling pathway) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2019-09-29 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
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