This term is obsolete.

GO:0045830 JSON

positive regulation of isotype switching

Biological Process

Definition (GO:0045830 GONUTS page)

Any process that activates or increases the frequency, rate or extent of isotype switching.

3,676 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
up-regulation of isotype switching exact
up regulation of isotype switching exact
stimulation of isotype switching narrow
positive regulation of class switching exact
activation of isotype switching narrow
positive regulation of isotype switch recombination exact
positive regulation of class switch recombination exact
upregulation of isotype switching exact

Ancestor Chart

Ancestor chart for GO:0045830
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0045830

Child Term Relationship to
GO:0045830
positive regulation of isotype switching to IgE isotypes
is_a
positive regulation of isotype switching to IgG isotypes
is_a
positive regulation of isotype switching to IgD isotypes
is_a
positive regulation of isotype switching to IgA isotypes
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0045830 positive regulation of isotype switching Only in Taxon 7776 Gnathostomata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P63025 10116 VAMP3_RAT GO:0002639 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P9WNV7 83332 DNAJ2_MYCTU GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487
NOT-qualified manual protein Q15836 9606 VAMP3_HUMAN GO:0002639 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24055037
NOT-qualified manual protein Q8IZ20-1 9606 ZN683_HUMAN GO:0010628 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26179882
NOT-qualified manual protein Q90998 9031 Q90998_CHICK GO:0010468 3 NOT-qualified manual annotations exist with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q90999 9031 TGFR2_CHICK GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q96AE4 9606 FUBP1_HUMAN GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:8125259
NOT-qualified manual protein Q9USK2 284812 SET9_SCHPO GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15550243

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0045830 based on ALL annotations
The top 100 of 220 co-occurring terms
Co-occurring Term PR S% #Together #Compared
positive regulation of isotype switching
113,270.65 100.00 1,721 1,721
positive regulation of double-strand break repair via nonhomologous end joining
68,799.37 48.97 1,233 2,030
negative regulation of double-strand break repair via homologous recombination
18,031.28 14.78 1,160 7,287
regulation of double-strand break repair via nonhomologous end joining
40,798.91 13.45 304 844
regulation of double-strand break repair via homologous recombination
9,019.64 6.89 584 7,334
DNA deamination
40,625.95 6.11 118 329
DNA damage response, signal transduction resulting in transcription
106,116.70 5.15 89 95
protein-DNA covalent cross-linking activity
103,732.06 5.03 87 95
DNA-(abasic site) binding
52,326.12 4.67 85 184
HFE-transferrin receptor complex
23,730.57 4.65 97 463
Totals 13846 1376657
No co-occurrence statistics for GO:0045830 based on MANUAL annotations
The top 100 of 194 co-occurring terms
Co-occurring Term PR S% #Together #Compared
positive regulation of isotype switching
16,147.49 100.00 80 80
positive regulation of double-strand break repair via nonhomologous end joining
7,813.30 35.16 45 93
negative regulation of double-strand break repair via homologous recombination
2,523.05 13.51 40 256
transferrin receptor activity
8,970.83 11.36 10 18
telomere maintenance in response to DNA damage
4,152.21 8.49 9 35
transferrin transport
2,935.91 8.00 10 55
protein-DNA covalent cross-linking activity
13,840.70 7.41 6 7
chorion development
7,339.77 5.81 5 11
ubiquitin-modified histone reader activity
2,935.91 5.61 6 33
somatic diversification of immunoglobulins involved in immune response
6,459.00 4.65 4 10
Totals 688 35902

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7776 (Gnathostomata)
2022-11-26 Deleted RELATION is a GO:0051240 (positive regulation of multicellular organismal process)
2015-06-25 Deleted RELATION is a GO:0002699 (positive regulation of immune effector process)
2014-10-18 Added RELATION is a GO:0051094 (positive regulation of developmental process)
2014-10-18 Added RELATION is a GO:0002891 (positive regulation of immunoglobulin mediated immune response)
2014-10-18 Added RELATION is a GO:0051240 (positive regulation of multicellular organismal process)
2014-10-18 Added RELATION is a GO:0002639 (positive regulation of immunoglobulin production)
2010-10-03 Added RELATION is a GO:0002699 (positive regulation of immune effector process)
2008-05-13 Added DEFINITION Any process that activates or increases the frequency, rate or extent of isotype switching.
2008-05-12 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of isotype switching.
Timestamp Action Category Detail
2002-08-20 Added TERM positive regulation of isotype switching
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Any process that activates or increases the frequency, rate or extent of isotype switching.
2008-05-12 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of isotype switching.
2008-02-13 Added SYNONYM positive regulation of class switch recombination
2008-02-10 Added SYNONYM positive regulation of isotype switch recombination
2007-08-09 Added SYNONYM up regulation of isotype switching
2007-08-09 Deleted SYNONYM stimulation of isotype switching
2007-08-09 Added SYNONYM stimulation of isotype switching
2007-08-09 Added SYNONYM upregulation of isotype switching
2007-08-09 Added SYNONYM activation of isotype switching
2007-08-09 Added SYNONYM up-regulation of isotype switching
2007-08-09 Deleted SYNONYM upregulation of isotype switching
2007-08-09 Deleted SYNONYM up-regulation of isotype switching
2007-08-09 Deleted SYNONYM up regulation of isotype switching
2007-08-09 Deleted SYNONYM positive regulation of class switching
2007-08-09 Added SYNONYM positive regulation of class switching
2007-08-09 Deleted SYNONYM activation of isotype switching
2007-02-23 Added SYNONYM stimulation of isotype switching
2007-02-23 Added SYNONYM activation of isotype switching
2007-02-23 Added SYNONYM up-regulation of isotype switching
2007-02-23 Added SYNONYM upregulation of isotype switching
2007-02-23 Added SYNONYM up regulation of isotype switching
2006-09-21 Added SYNONYM positive regulation of class switching
2006-05-04 Updated DEFINITION Any process that activates or increases the frequency, rate or extent of isotype switching.
2005-10-21 Updated DEFINITION Any process that activates or increases the rate, frequency or extent of isotype switching.
2002-11-27 Added DEFINITION Any process that activates or increases the rate of isotype switching.
Timestamp Action Category Detail
2022-11-26 Deleted RELATION is a GO:0051240 (positive regulation of multicellular organismal process)
2015-06-25 Deleted RELATION is a GO:0002699 (positive regulation of immune effector process)
2014-10-18 Added RELATION is a GO:0051094 (positive regulation of developmental process)
2014-10-18 Added RELATION is a GO:0002891 (positive regulation of immunoglobulin mediated immune response)
2014-10-18 Added RELATION is a GO:0051240 (positive regulation of multicellular organismal process)
2014-10-18 Added RELATION is a GO:0002639 (positive regulation of immunoglobulin production)
2010-10-03 Added RELATION is a GO:0002699 (positive regulation of immune effector process)
2008-04-01 Updated RELATION is a GO:0045911 (positive regulation of DNA recombination)
2008-04-01 Updated RELATION is a GO:0045191 (regulation of isotype switching)
2008-04-01 Updated RELATION is a GO:0050871 (positive regulation of B cell activation)
2008-04-01 Added RELATION positively regulates GO:0045190 (isotype switching)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7776 (Gnathostomata)
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