GO:0045830
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positive regulation of isotype switching
Biological Process
Definition (GO:0045830 GONUTS page)
Any process that activates or increases the frequency, rate or extent of isotype switching.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
up-regulation of isotype switching | exact |
up regulation of isotype switching | exact |
stimulation of isotype switching | narrow |
positive regulation of class switching | exact |
activation of isotype switching | narrow |
positive regulation of isotype switch recombination | exact |
positive regulation of class switch recombination | exact |
upregulation of isotype switching | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0045830
Child Term | Relationship to GO:0045830 |
---|---|
positive regulation of isotype switching to IgE isotypes
|
is_a |
positive regulation of isotype switching to IgG isotypes
|
is_a |
positive regulation of isotype switching to IgD isotypes
|
is_a |
positive regulation of isotype switching to IgA isotypes
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0045830 | positive regulation of isotype switching | Only in Taxon | 7776 | Gnathostomata |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P63025 | 10116 | VAMP3_RAT | GO:0002639 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P9WNV7 | 83332 | DNAJ2_MYCTU | GO:0010468 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487 | |
NOT-qualified manual | protein | Q15836 | 9606 | VAMP3_HUMAN | GO:0002639 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24055037 | |
NOT-qualified manual | protein | Q8IZ20-1 | 9606 | ZN683_HUMAN | GO:0010628 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26179882 | |
NOT-qualified manual | protein | Q90998 | 9031 | Q90998_CHICK | GO:0010468 | 3 NOT-qualified manual annotations exist with evidence code ECO:0000315 from this reference: PMID:11500982 | |
NOT-qualified manual | protein | Q90999 | 9031 | TGFR2_CHICK | GO:0010468 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982 | |
NOT-qualified manual | protein | Q96AE4 | 9606 | FUBP1_HUMAN | GO:0010468 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:8125259 | |
NOT-qualified manual | protein | Q9USK2 | 284812 | SET9_SCHPO | GO:0010468 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15550243 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045830 based on ALL annotations
The top 100 of 220 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
positive regulation of isotype switching
|
113,270.65 | 100.00 | 1,721 | 1,721 |
positive regulation of double-strand break repair via nonhomologous end joining
|
68,799.37 | 48.97 | 1,233 | 2,030 |
negative regulation of double-strand break repair via homologous recombination
|
18,031.28 | 14.78 | 1,160 | 7,287 |
regulation of double-strand break repair via nonhomologous end joining
|
40,798.91 | 13.45 | 304 | 844 |
regulation of double-strand break repair via homologous recombination
|
9,019.64 | 6.89 | 584 | 7,334 |
DNA deamination
|
40,625.95 | 6.11 | 118 | 329 |
DNA damage response, signal transduction resulting in transcription
|
106,116.70 | 5.15 | 89 | 95 |
protein-DNA covalent cross-linking activity
|
103,732.06 | 5.03 | 87 | 95 |
DNA-(abasic site) binding
|
52,326.12 | 4.67 | 85 | 184 |
HFE-transferrin receptor complex
|
23,730.57 | 4.65 | 97 | 463 |
Totals | 13846 | 1376657 |
No co-occurrence statistics for GO:0045830 based on MANUAL annotations
The top 100 of 194 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
positive regulation of isotype switching
|
16,147.49 | 100.00 | 80 | 80 |
positive regulation of double-strand break repair via nonhomologous end joining
|
7,813.30 | 35.16 | 45 | 93 |
negative regulation of double-strand break repair via homologous recombination
|
2,523.05 | 13.51 | 40 | 256 |
transferrin receptor activity
|
8,970.83 | 11.36 | 10 | 18 |
telomere maintenance in response to DNA damage
|
4,152.21 | 8.49 | 9 | 35 |
transferrin transport
|
2,935.91 | 8.00 | 10 | 55 |
protein-DNA covalent cross-linking activity
|
13,840.70 | 7.41 | 6 | 7 |
chorion development
|
7,339.77 | 5.81 | 5 | 11 |
ubiquitin-modified histone reader activity
|
2,935.91 | 5.61 | 6 | 33 |
somatic diversification of immunoglobulins involved in immune response
|
6,459.00 | 4.65 | 4 | 10 |
Totals | 688 | 35902 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7776 (Gnathostomata) |
2022-11-26 | Deleted | RELATION | is a GO:0051240 (positive regulation of multicellular organismal process) |
2015-06-25 | Deleted | RELATION | is a GO:0002699 (positive regulation of immune effector process) |
2014-10-18 | Added | RELATION | is a GO:0051094 (positive regulation of developmental process) |
2014-10-18 | Added | RELATION | is a GO:0002891 (positive regulation of immunoglobulin mediated immune response) |
2014-10-18 | Added | RELATION | is a GO:0051240 (positive regulation of multicellular organismal process) |
2014-10-18 | Added | RELATION | is a GO:0002639 (positive regulation of immunoglobulin production) |
2010-10-03 | Added | RELATION | is a GO:0002699 (positive regulation of immune effector process) |
2008-05-13 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of isotype switching. |
2008-05-12 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of isotype switching. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-08-20 | Added | TERM | positive regulation of isotype switching |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of isotype switching. |
2008-05-12 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of isotype switching. |
2008-02-13 | Added | SYNONYM | positive regulation of class switch recombination |
2008-02-10 | Added | SYNONYM | positive regulation of isotype switch recombination |
2007-08-09 | Added | SYNONYM | up regulation of isotype switching |
2007-08-09 | Deleted | SYNONYM | stimulation of isotype switching |
2007-08-09 | Added | SYNONYM | stimulation of isotype switching |
2007-08-09 | Added | SYNONYM | upregulation of isotype switching |
2007-08-09 | Added | SYNONYM | activation of isotype switching |
2007-08-09 | Added | SYNONYM | up-regulation of isotype switching |
2007-08-09 | Deleted | SYNONYM | upregulation of isotype switching |
2007-08-09 | Deleted | SYNONYM | up-regulation of isotype switching |
2007-08-09 | Deleted | SYNONYM | up regulation of isotype switching |
2007-08-09 | Deleted | SYNONYM | positive regulation of class switching |
2007-08-09 | Added | SYNONYM | positive regulation of class switching |
2007-08-09 | Deleted | SYNONYM | activation of isotype switching |
2007-02-23 | Added | SYNONYM | stimulation of isotype switching |
2007-02-23 | Added | SYNONYM | activation of isotype switching |
2007-02-23 | Added | SYNONYM | up-regulation of isotype switching |
2007-02-23 | Added | SYNONYM | upregulation of isotype switching |
2007-02-23 | Added | SYNONYM | up regulation of isotype switching |
2006-09-21 | Added | SYNONYM | positive regulation of class switching |
2006-05-04 | Updated | DEFINITION | Any process that activates or increases the frequency, rate or extent of isotype switching. |
2005-10-21 | Updated | DEFINITION | Any process that activates or increases the rate, frequency or extent of isotype switching. |
2002-11-27 | Added | DEFINITION | Any process that activates or increases the rate of isotype switching. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-26 | Deleted | RELATION | is a GO:0051240 (positive regulation of multicellular organismal process) |
2015-06-25 | Deleted | RELATION | is a GO:0002699 (positive regulation of immune effector process) |
2014-10-18 | Added | RELATION | is a GO:0051094 (positive regulation of developmental process) |
2014-10-18 | Added | RELATION | is a GO:0002891 (positive regulation of immunoglobulin mediated immune response) |
2014-10-18 | Added | RELATION | is a GO:0051240 (positive regulation of multicellular organismal process) |
2014-10-18 | Added | RELATION | is a GO:0002639 (positive regulation of immunoglobulin production) |
2010-10-03 | Added | RELATION | is a GO:0002699 (positive regulation of immune effector process) |
2008-04-01 | Updated | RELATION | is a GO:0045911 (positive regulation of DNA recombination) |
2008-04-01 | Updated | RELATION | is a GO:0045191 (regulation of isotype switching) |
2008-04-01 | Updated | RELATION | is a GO:0050871 (positive regulation of B cell activation) |
2008-04-01 | Added | RELATION | positively regulates GO:0045190 (isotype switching) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7776 (Gnathostomata) |
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