GO:0045880
JSON
positive regulation of smoothened signaling pathway
Biological Process
Definition (GO:0045880 GONUTS page)
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
Secondary IDs
GO:0045878
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| up regulation of smoothened signaling pathway | exact |
| up-regulation of smoothened signaling pathway | exact |
| stimulation of smoothened signaling pathway | narrow |
| positive regulation of smoothened signalling pathway | exact |
| activation of smoothened signaling pathway | narrow |
| positive regulation of smoothened receptor activity by patched | related |
| positive regulation of smoothened by patched | related |
| positive regulation of hedgehog signaling pathway | exact |
| positive regulation of hh signaling pathway | exact |
| upregulation of smoothened signaling pathway | exact |
Ancestor Chart
Ancestor chart for GO:0045880
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0045880
| Child Term | Relationship to GO:0045880 |
|---|---|
|
positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
| Ontology Development Project | |
|---|---|
| signalling | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045880 based on ALL annotations
The top 100 of 1,572 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
positive regulation of smoothened signaling pathway
|
58,297.99 | 100.00 | 3,399 | 3,399 |
|
positive regulation of mesenchymal cell proliferation
|
15,291.27 | 10.35 | 496 | 1,891 |
|
mesenchymal cell proliferation
|
12,741.42 | 7.01 | 318 | 1,455 |
|
smooth muscle tissue development
|
12,050.86 | 6.72 | 308 | 1,490 |
|
embryonic digestive tract morphogenesis
|
12,219.13 | 6.57 | 297 | 1,417 |
|
spinal cord dorsal/ventral patterning
|
23,849.18 | 6.48 | 243 | 594 |
|
dorsal/ventral neural tube patterning
|
13,152.28 | 5.91 | 252 | 1,117 |
|
spinal cord motor neuron differentiation
|
8,443.96 | 5.70 | 292 | 2,016 |
|
embryonic limb morphogenesis
|
5,344.99 | 5.42 | 398 | 4,341 |
|
midbrain development
|
6,029.61 | 5.37 | 341 | 3,297 |
| Totals | 23791 | 255965 | ||
No co-occurrence statistics for GO:0045880 based on MANUAL annotations
The top 100 of 1,409 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
positive regulation of smoothened signaling pathway
|
6,084.19 | 100.00 | 232 | 232 |
|
cholesterol-protein transferase activity
|
3,532.76 | 7.35 | 18 | 31 |
|
positive regulation of mesenchymal cell proliferation
|
1,068.22 | 6.76 | 23 | 131 |
|
smoothened signaling pathway
|
470.17 | 6.49 | 67 | 867 |
|
patched binding
|
842.99 | 6.13 | 23 | 166 |
|
self proteolysis
|
977.82 | 5.52 | 18 | 112 |
|
embryonic limb morphogenesis
|
531.37 | 4.54 | 20 | 229 |
|
negative regulation of smoothened signaling pathway
|
422.03 | 4.33 | 24 | 346 |
|
mesenchymal cell proliferation
|
930.52 | 4.28 | 13 | 85 |
|
epithelial tube branching involved in lung morphogenesis
|
811.23 | 3.87 | 12 | 90 |
| Totals | 1177 | 16174 | ||
Change Log
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2011-01-16 | Added | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2011-01-16 | Deleted | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2010-05-23 | Added | SYNONYM | positive regulation of hedgehog signaling pathway |
| 2010-05-23 | Added | SYNONYM | positive regulation of hh signaling pathway |
| 2010-04-21 | Deleted | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2010-04-21 | Added | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2008-05-13 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| 2008-05-12 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| 2008-04-01 | Updated | RELATION | is a GO:0008589 (regulation of smoothened signaling pathway) |
| 2008-04-01 | Added | RELATION | positively regulates GO:0007224 (smoothened signaling pathway) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2004-12-17 | Updated | TERM | positive regulation of smoothened signaling pathway |
| 2002-08-20 | Added | TERM | positive regulation of smoothened receptor signaling pathway |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2010-05-23 | Added | SYNONYM | positive regulation of hedgehog signaling pathway |
| 2010-05-23 | Added | SYNONYM | positive regulation of hh signaling pathway |
| 2008-05-13 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| 2008-05-12 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| 2008-01-21 | Added | SYNONYM | positive regulation of smoothened receptor activity by patched |
| 2008-01-21 | Added | SYNONYM | positive regulation of smoothened by patched |
| 2007-08-09 | Added | SYNONYM | upregulation of smoothened signaling pathway |
| 2007-08-09 | Added | SYNONYM | up-regulation of smoothened signaling pathway |
| 2007-08-09 | Added | SYNONYM | up regulation of smoothened signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | up-regulation of smoothened signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | up regulation of smoothened signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | stimulation of smoothened signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | activation of smoothened signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | positive regulation of smoothened signalling pathway |
| 2007-08-09 | Added | SYNONYM | stimulation of smoothened signaling pathway |
| 2007-08-09 | Added | SYNONYM | positive regulation of smoothened signalling pathway |
| 2007-08-09 | Added | SYNONYM | activation of smoothened signaling pathway |
| 2007-08-09 | Deleted | SYNONYM | upregulation of smoothened signaling pathway |
| 2007-02-23 | Added | SYNONYM | upregulation of smoothened signaling pathway |
| 2007-02-23 | Added | SYNONYM | up-regulation of smoothened signaling pathway |
| 2007-02-23 | Added | SYNONYM | up regulation of smoothened signaling pathway |
| 2007-02-23 | Added | SYNONYM | stimulation of smoothened signaling pathway |
| 2007-02-23 | Added | SYNONYM | activation of smoothened signaling pathway |
| 2006-05-04 | Updated | DEFINITION | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| 2005-10-21 | Updated | DEFINITION | Any process that activates or increases the rate, frequency or extent of smoothened signaling. |
| 2004-12-17 | Added | SYNONYM | positive regulation of smoothened signalling pathway |
| 2004-12-17 | Deleted | SYNONYM | positive regulation of smoothened receptor signalling pathway |
| 2004-12-17 | Updated | DEFINITION | Any process that activates or increases the rate of smoothened signaling. |
| 2004-04-19 | Added | SYNONYM | positive regulation of smoothened receptor signalling pathway |
| 2004-04-16 | Deleted | SYNONYM | positive regulation of smoothened receptor signalling pathway |
| 2003-11-13 | Added | SYNONYM | positive regulation of smoothened receptor signalling pathway |
| 2002-11-27 | Added | DEFINITION | Any process that activates or increases the rate of smoothened receptor signaling pathway activity. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2011-01-16 | Added | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2011-01-16 | Deleted | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2010-04-21 | Deleted | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| 2010-04-21 | Added | RELATION | is a GO:0035468 (positive regulation of signaling pathway) |
| 2008-04-01 | Updated | RELATION | is a GO:0008589 (regulation of smoothened signaling pathway) |
| 2008-04-01 | Added | RELATION | positively regulates GO:0007224 (smoothened signaling pathway) |
| 2008-04-01 | Updated | RELATION | is a GO:0009967 (positive regulation of signal transduction) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-01-21 | Added | SECONDARY | GO:0045878 (positive regulation of smoothened activity) |
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